Development and validation of a sensitive LC-MS/MS method with electrospray ionization for quantitation of rhein in human plasma: Application to a pharmacokinetic study

Biomedical Chromatography

Volumn 22, Issue 6, 2008, Pages 616-624

  Layek, Buddhadev ^a   Kumar, T Santosh ^a   Trivedi, Ravi Kumar ^a   Mullangi, Ramesh ^a   Srinivas, Nuggehally R ^a  

^a DR REDDY'S LABORATORIES LTD   (India)

Author keywords

Human plasma; LC MS MS; Pharmacokinetics; Rhein; Validation

Indexed keywords

ACETONITRILE; ELECTROSPRAY IONIZATION; PLASMA (HUMAN);

CELECOXIB; HUMAN PLASMAS; INTERNAL STANDARDS; IONIZATION TECHNIQUES; LC-MS-MS; LC.MS/MS; MULTIPLE-REACTION MONITORING MODES; PHARMACOKINETIC STUDIES; RHEIN; VALIDATION;

PHARMACOKINETICS;

ACETONITRILE; AMMONIUM ACETATE; CELECOXIB; DIACETYLRHEIN; METHANOL; RHEIN;

ACCURACY; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CORRELATION COEFFICIENT; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG HALF LIFE; DRUG ISOLATION; DRUG STABILITY; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; ELUTION; HUMAN; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; QUANTITATIVE ANALYSIS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

EID: 46949097546     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.977     Document Type: Article

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