메뉴 건너뛰기




Volumn 22, Issue 5, 2012, Pages 367-372

Rare PPARA variants and extreme response to fenofibrate in the Genetics of Lipid-Lowering Drugs and Diet Network Study

Author keywords

clinical trials; DNA sequence analysis; lipids; peroxisome proliferator activated receptor

Indexed keywords

FENOFIBRATE; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; TRIACYLGLYCEROL;

EID: 84862779585     PISSN: 17446872     EISSN: 17446880     Source Type: Journal    
DOI: 10.1097/FPC.0b013e328351a486     Document Type: Article
Times cited : (11)

References (42)
  • 1
    • 0032993467 scopus 로고    scopus 로고
    • Pathophysiology of triglyceride-rich lipoproteins in atherothrombosis: Clinical aspects
    • Hodis HN, Mack WJ, Krauss RM, Alaupovic P. Pathophysiology of triglyceride-rich lipoproteins in atherothrombosis: clinical aspects. Clin Cardiol 1999; 22 (6, Suppl):II15-II20. (Pubitemid 29265095)
    • (1999) Clinical Cardiology , vol.22 , Issue.6 SUPPL.
    • Hodis, H.N.1    Mack, W.J.2    Krauss, R.M.3    Alaupovic, P.4
  • 2
    • 0035897696 scopus 로고    scopus 로고
    • Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III)
    • Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
    • Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III). JAMA 2001; 285:2486-2497.
    • (2001) JAMA , vol.285 , pp. 2486-2497
  • 3
    • 63849198178 scopus 로고    scopus 로고
    • Hypertriglyceridemia and its pharmacologic treatment among US adults
    • Ford ES, Li C, Zhao G, Pearson WS, Mokdad AH. Hypertriglyceridemia and its pharmacologic treatment among US adults. Arch Intern Med 2009; 169:572-578.
    • (2009) Arch Intern Med , vol.169 , pp. 572-578
    • Ford, E.S.1    Li, C.2    Zhao, G.3    Pearson, W.S.4    Mokdad, A.H.5
  • 4
    • 79751506305 scopus 로고    scopus 로고
    • Triglycerides and atherogenic dyslipidaemia: Extending treatment beyond statins in the high-risk cardiovascular patient
    • Watts GF, Karpe F. Triglycerides and atherogenic dyslipidaemia: extending treatment beyond statins in the high-risk cardiovascular patient. Heart 2011; 97:350-356.
    • (2011) Heart , vol.97 , pp. 350-356
    • Watts, G.F.1    Karpe, F.2
  • 5
    • 0032858275 scopus 로고    scopus 로고
    • Detection, quantification, and characterization of potentially atherogenic triglyceride-rich remnant lipoproteins
    • Cohn JS, Marcoux C, Davignon J. Detection, quantification, and characterization of potentially atherogenic triglyceride-rich remnant lipoproteins. Arterioscler Thromb Vasc Biol 1999; 19: 2474-2486. (Pubitemid 29477850)
    • (1999) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.19 , Issue.10 , pp. 2474-2486
    • Cohn, J.S.1    Marcoux, C.2    Davignon, J.3
  • 6
    • 67651160487 scopus 로고    scopus 로고
    • Triglycerides as vascular risk factors: New epidemiologic insights
    • Kannel WB, Vasan RS. Triglycerides as vascular risk factors: new epidemiologic insights. Curr Opin Cardiol 2009; 24:345-350.
    • (2009) Curr Opin Cardiol , vol.24 , pp. 345-350
    • Kannel, W.B.1    Vasan, R.S.2
  • 8
    • 79151484278 scopus 로고    scopus 로고
    • Management of dyslipidemias with fibrates, alone and in combination with statins: Role of delayed-release fenofibric acid
    • Moutzouri E, Kei A, Elisaf MS, Milionis HJ. Management of dyslipidemias with fibrates, alone and in combination with statins: role of delayed-release fenofibric acid. Vasc Health Risk Manag 2010; 6:525-539.
    • (2010) Vasc Health Risk Manag , vol.6 , pp. 525-539
    • Moutzouri, E.1    Kei, A.2    Elisaf, M.S.3    Milionis, H.J.4
  • 9
    • 0036382889 scopus 로고    scopus 로고
    • Micronised fenofibrate: An updated review of its clinical efficacy in the management of dyslipidaemia
    • Keating GM, Ormrod D. Micronised fenofibrate: an updated review of its clinical efficacy in the management of dyslipidaemia. Drugs 2002; 62: 1909-1944.
    • (2002) Drugs , vol.62 , pp. 1909-1944
    • Keating, G.M.1    Ormrod, D.2
  • 10
    • 78549293092 scopus 로고    scopus 로고
    • Comparison of the efficacy of fibrates on hypertriglyceridemic phenotypes with different genetic and clinical characteristics
    • Brisson D, Methot J, Tremblay K, Tremblay M, Perron P, Gaudet D. Comparison of the efficacy of fibrates on hypertriglyceridemic phenotypes with different genetic and clinical characteristics. Pharmacogenet Genomics 2010; 20:742-747.
    • (2010) Pharmacogenet Genomics , vol.20 , pp. 742-747
    • Brisson, D.1    Methot, J.2    Tremblay, K.3    Tremblay, M.4    Perron, P.5    Gaudet, D.6
  • 11
    • 16544370435 scopus 로고    scopus 로고
    • Pharmacogenetics of lipid diseases
    • Ordovas JM. Pharmacogenetics of lipid diseases. Hum Genomics 2004; 1:111-125.
    • (2004) Hum Genomics , vol.1 , pp. 111-125
    • Ordovas, J.M.1
  • 13
    • 77951533290 scopus 로고    scopus 로고
    • Genome-wide association of lipid-lowering response to statins in combined study populations
    • Barber MJ, Mangravite LM, Hyde CL, Chasman DI, Smith JD, McCarty CA, et al. Genome-wide association of lipid-lowering response to statins in combined study populations. PLoS One 2010; 5:e9763. Available at http://www. pubmedcentral.nih.gov/articlerender.fcgi?artid=2842298&tool= pmcentrez&rendertype=abstract.
    • (2010) PLoS One , vol.5
    • Barber, M.J.1    Mangravite, L.M.2    Hyde, C.L.3    Chasman, D.I.4    Smith, J.D.5    McCarty, C.A.6
  • 16
    • 0023026497 scopus 로고
    • Effects of fenofibrate on plasma lipids. Double-blind, multicenter study in patients with Type IIA or IIB hyperlipidemia
    • Brown WV, Dujovne CA, Farquhar JW, Feldman EB, Grundy SM, Knopp RH, et al. Effects of fenofibrate on plasma lipids: double-blind, multicenter study in patients with type IIA or IIB hyperlipidemia. Arteriosclerosis 1986; 6: 670-678. Available at http://www.ncbi.nlm.nih.gov/pubmed/3535757. (Pubitemid 17190167)
    • (1986) Arteriosclerosis , vol.6 , Issue.6 , pp. 670-678
    • Brown, W.V.1    Dujovne, C.A.2    Farquhar, J.W.3
  • 17
    • 0038706100 scopus 로고    scopus 로고
    • Molecular characterisation of six alternatively spliced variants and a novel promoter in human peroxisome proliferator-activated receptor α
    • DOI 10.1016/S0006-291X(03)00731-9
    • Chew CH, Samian MR, Najimudin N, Tengku-Muhammad TS. Molecular characterisation of six alternatively spliced variants and a novel promoter in human peroxisome proliferator-activated receptor alpha. Biochem Biophys Res Commun 2003; 305:235-243. Available at http://www.ncbi.nlm.nih.gov/pubmed/ 12745064. (Pubitemid 36555458)
    • (2003) Biochemical and Biophysical Research Communications , vol.305 , Issue.2 , pp. 235-243
    • Chew, C.-H.1    Samian, M.R.2    Najimudin, N.3    Tengku-Muhammad, T.S.4
  • 18
    • 79959702195 scopus 로고    scopus 로고
    • Common variants in the periostin gene influence development of atherosclerosis in young persons
    • Hixson JE, Shimmin LC, Montasser ME, Kim D-K, Zhong Y, Ibarguen H, et al. Common variants in the periostin gene influence development of atherosclerosis in young persons. Arterioscl Thromb Vasc Biol 2011; 31:1661-1667. Available at http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3116984&tool= pmcentrez&rendertype=abstract.
    • (2011) Arterioscl Thromb Vasc Biol , vol.31 , pp. 1661-1667
    • Hixson, J.E.1    Shimmin, L.C.2    Montasser, M.E.3    Kim, D.-K.4    Zhong, Y.5    Ibarguen, H.6
  • 19
    • 50949095168 scopus 로고    scopus 로고
    • Methods for detecting associations with rare variants for common diseases: Application to analysis of sequence data
    • Li B, Leal SM. Methods for detecting associations with rare variants for common diseases: application to analysis of sequence data. Am J Human Genet 2008; 83:311-321. Available at http://www.pubmedcentral.nih.gov/articlerender. fcgi?artid=2842185&tool=pmcentrez&rendertype=abstract.
    • (2008) Am J Human Genet , vol.83 , pp. 311-321
    • Li, B.1    Leal, S.M.2
  • 20
    • 61449168010 scopus 로고    scopus 로고
    • A groupwise association test for rare mutations using a weighted sum statistic
    • Madsen BE, Browning SR. A groupwise association test for rare mutations using a weighted sum statistic. PLoS Genet 2009; 5:e1000384. Available at http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2633048&tool= pmcentrez&rendertype=abstract.
    • (2009) PLoS Genet , vol.5
    • Madsen, B.E.1    Browning, S.R.2
  • 21
    • 80054750776 scopus 로고    scopus 로고
    • A data-driven method for identifying rare variants with heterogeneous trait effects
    • Zhang Q, Irvin MR, Arnett DK, Province MA, Borecki I. A data-driven method for identifying rare variants with heterogeneous trait effects. Genet Epidemiol 2011; 35:679-685. Available at http://www.ncbi.nlm.nih.gov/pubmed/ 21818776.
    • (2011) Genet Epidemiol , vol.35 , pp. 679-685
    • Zhang, Q.1    Irvin, M.R.2    Arnett, D.K.3    Province, M.A.4    Borecki, I.5
  • 22
    • 13444269543 scopus 로고    scopus 로고
    • Haploview: Analysis and visualization of LD and haplotype maps
    • DOI 10.1093/bioinformatics/bth457
    • Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005; 21:263-265. Available athttp://www.ncbi.nlm.nih.gov/pubmed/15297300. (Pubitemid 40202029)
    • (2005) Bioinformatics , vol.21 , Issue.2 , pp. 263-265
    • Barrett, J.C.1    Fry, B.2    Maller, J.3    Daly, M.J.4
  • 23
    • 0033957472 scopus 로고    scopus 로고
    • DbSNP: A database of single nucleotide polymorphisms
    • Smigielski EM, Sirotkin K,Ward M, Sherry ST. dbSNP: a database of single nucleotide polymorphisms. Nucleic Acid Res 2000; 28:352-355. vailable at http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=102496&tool= pmcentrez&rendertype=abstract. (Pubitemid 30047805)
    • (2000) Nucleic Acids Research , vol.28 , Issue.1 , pp. 352-355
    • Smigielski, E.M.1    Sirotkin, K.2    Ward, M.3    Sherry, S.T.4
  • 24
    • 68049123311 scopus 로고    scopus 로고
    • Analysis of genomic DNA with the UCSC genome browser
    • Pevsner J. Analysis of genomic DNA with the UCSC genome browser. Methods Mol Biol 2009; 537:277-301.
    • (2009) Methods Mol Biol , vol.537 , pp. 277-301
    • Pevsner, J.1
  • 25
    • 79955550445 scopus 로고    scopus 로고
    • A user's guide to the encyclopedia of DNA elements (ENCODE)
    • Myers RM, Stamatoyannopoulos J, Snyder M, Dunham I, Hardison RC, Bernstein BE, et al. A user's guide to the encyclopedia of DNA elements (ENCODE). PLoS Biol 2011; 9:e1001046. Available at http://www.pubmedcentral.nih. gov/articlerender.fcgi?artid=3079585&tool=pmcentrez&rendertype=abstract.
    • (2011) PLoS Biol , vol.9
    • Myers, R.M.1    Stamatoyannopoulos, J.2    Snyder, M.3    Dunham, I.4    Hardison, R.C.5    Bernstein, B.E.6
  • 26
    • 43949096896 scopus 로고    scopus 로고
    • Polymorphisms in the peroxisome proliferator activated receptor α gene are associated with levels of apolipoprotein CIII and triglyceride in African-Americans but not Caucasians
    • DOI 10.1016/j.atherosclerosis.2007.10.004, PII S0021915007006569
    • Shin M-J, Kanaya AM, Krauss RM. Polymorphisms in the peroxisome proliferator activated receptor alpha gene are associated with levels of apolipoprotein CIII and triglyceride in African-Americans but not Caucasians. Atherosclerosis 2008; 198:313-319. Available at http://www.pubmedcentral.nih. gov/articlerender.fcgi?artid=2678963&tool=pmcentrez&rendertype=abstract. (Pubitemid 351707390)
    • (2008) Atherosclerosis , vol.198 , Issue.2 , pp. 313-319
    • Shin, M.-J.1    Kanaya, A.M.2    Krauss, R.M.3
  • 27
    • 33744813015 scopus 로고    scopus 로고
    • The L162V polymorphism at the peroxisome proliferator activated receptor alpha locus modulates the risk of cardiovascular events associated with insulin resistance and diabetes mellitus: The Veterans Affairs HDL Intervention Trial (VA-HIT)
    • DOI 10.1016/j.atherosclerosis.2005.08.034, PII S0021915005005824
    • Tai ES, Collins D, Robins SJ, O'Connor JJ, Bloomfield HE, Ordovas JM, et al.The L162V polymorphism at the peroxisome proliferator activated receptor alpha locus modulates the risk of cardiovascular events associated with insulin resistance and diabetes mellitus: the Veterans Affairs HDL Intervention Trial (VA-HIT). Atherosclerosis 2006; 187:153-160. Availableat http://www.ncbi.nlm. nih.gov/pubmed/16221474. (Pubitemid 43833359)
    • (2006) Atherosclerosis , vol.187 , Issue.1 , pp. 153-160
    • Tai, E.S.1    Collins, D.2    Robins, S.J.3    O'Connor Jr., J.J.4    Bloomfield, H.E.5    Ordovas, J.M.6    Schaefer, E.J.7    Brousseau, M.E.8
  • 28
    • 14944384748 scopus 로고    scopus 로고
    • Polyunsaturated fatty acids interact with the PPARA-L162V polymorphism to affect plasma triglyceride and apolipoprotein C-III concentrations in the Framingham Heart Study
    • Tai ES, Corella D, Demissie S, Cupples LA, Coltell O, Schaefer EJ, et al. Polyunsaturated fatty acids interact with the PPARA-L162V polymorphism to affect plasma triglyceride and apolipoprotein C-III concentrations in the Framingham Heart Study. J Nutrit 2005; 135:397-403. Available at http://www.ncbi.nlm.nih.gov/pubmed/15735069. (Pubitemid 40365194)
    • (2005) Journal of Nutrition , vol.135 , Issue.3 , pp. 397-403
    • Tai, E.S.1    Corella, D.2    Demissie, S.3    Cupples, L.A.4    Coltell, O.5    Schaefer, E.J.6    Tucker, K.L.7    Ordovas, J.M.8
  • 29
    • 0036799545 scopus 로고    scopus 로고
    • The allelic architecture of human disease genes: Common disease - Common variant... or not?
    • Pritchard JK, Cox NJ. The allelic architecture of human disease genes: common disease-common variantyor not? Human Mol Genet 2002;11:2417-2423. Available at http://www.ncbi.nlm.nih.gov/pubmed/12351577. (Pubitemid 35174705)
    • (2002) Human Molecular Genetics , vol.11 , Issue.20 , pp. 2417-2423
    • Pritchard, J.K.1    Cox, N.J.2
  • 31
    • 70349956433 scopus 로고    scopus 로고
    • Finding the missing heritability of complex diseases
    • Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ, et al. Finding the missing heritability of complex diseases. Nature 2009; 461:747-753. Available at http://www.pubmedcentral.nih.gov/articlerender.fcgi? artid=2831613&tool=pmcentrez&rendertype=abstract.
    • (2009) Nature , vol.461 , pp. 747-753
    • Manolio, T.A.1    Collins, F.S.2    Cox, N.J.3    Goldstein, D.B.4    Hindorff, L.A.5    Hunter, D.J.6
  • 32
    • 80051827842 scopus 로고    scopus 로고
    • Optimum designs for next-generation sequencing to discover rare variants for common complex disease
    • Shi G, Rao DC. Optimum designs for next-generation sequencing to discover rare variants for common complex disease. Genet Epidemiol 2011;35:572-579. Available at http://www.ncbi.nlm.nih.gov/pubmed/21618604.
    • (2011) Genet Epidemiol , vol.35 , pp. 572-579
    • Shi, G.1    Rao, D.C.2
  • 33
    • 33750127491 scopus 로고    scopus 로고
    • Variations on a gene: Rare and common variants in ABCA1 and their impact on HDL cholesterol levels and atherosclerosis
    • Brunham LR, Singaraja RR, Hayden MR. Variations on a gene: rare and common variants in ABCA1 and their impact on HDL cholesterol levels and atherosclerosis. Ann Rev Nutrit 2006; 26:105-129. Available at http://www.ncbi.nlm.nih.gov/pubmed/16704350.
    • (2006) Ann Rev Nutrit , vol.26 , pp. 105-129
    • Brunham, L.R.1    Singaraja, R.R.2    Hayden, M.R.3
  • 34
    • 3843056691 scopus 로고    scopus 로고
    • Multiple rare alleles contribute to low plasma levels of HDL cholesterol
    • DOI 10.1126/science.1099870
    • Cohen JC, Kiss RS, Pertsemlidis A, Marcel YL, McPherson R, Hobbs HH. Multiple rare alleles contribute to low plasma levels of HDL cholesterol. Science 2004; 305:869-872. Available at http://www.ncbi.nlm.nih.gov/pubmed/ 15297675. (Pubitemid 39038422)
    • (2004) Science , vol.305 , Issue.5685 , pp. 869-872
    • Cohen, J.C.1    Kiss, R.S.2    Pertsemlidis, A.3    Marcel, Y.L.4    McPherson, R.5    Hobbs, H.H.6
  • 36
    • 34047177395 scopus 로고    scopus 로고
    • Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL
    • DOI 10.1038/ng1984, PII NG1984
    • Romeo S, Pennacchio LA, Fu Y, Boerwinkle E, Tybjaerg-Hansen A, Hobbs HH, et al. Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL. Nat Genet 2007; 39:513-516.Available at http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2762948&tool= pmcentrez&rendertype=abstract. (Pubitemid 46514768)
    • (2007) Nature Genetics , vol.39 , Issue.4 , pp. 513-516
    • Romeo, S.1    Pennacchio, L.A.2    Fu, Y.3    Boerwinkle, E.4    Tybjaerg-Hansen, A.5    Hobbs, H.H.6    Cohen, J.C.7
  • 37
    • 38349178429 scopus 로고    scopus 로고
    • Novel rare mutations and promoter haplotypes in ABCA1 contribute to low-HDL-C levels
    • Slatter TL, Jones GT,Williams MJA, van Rij AM, McCormick SPA. Novel rare mutations and promoter haplotypes in ABCA1 contribute to low-HDL-C levels. Clin Genet 2008; 73:179-184. Available at http://www.ncbi.nlm.nih.gov/pubmed/ 18199144.
    • (2008) Clin Genet , vol.73 , pp. 179-184
    • Slatter, T.L.1    Gtwilliams Mja, J.2    Van Rij, A.M.3    Spa, M.4
  • 39
    • 33846504706 scopus 로고    scopus 로고
    • A "silent" polymorphism in the MDR1 gene changes substrate specificity
    • DOI 10.1126/science.1135308
    • Kimchi-Sarfaty C, Oh JM, Kim I-W, Sauna ZE, Calcagno AM, Ambudkar SV, et al. A 'silent' polymorphism in the MDR1 gene changes substrate specificity. Science 2007; 315:525-528. Available at http://www.ncbi.nlm.nih.gov/pubmed/ 17185560. (Pubitemid 46175758)
    • (2007) Science , vol.315 , Issue.5811 , pp. 525-528
    • Kimchi-Sarfaty, C.1    Oh, J.M.2    Kim, I.-W.3    Sauna, Z.E.4    Calcagno, A.M.5    Ambudkar, S.V.6    Gottesman, M.M.7
  • 40
    • 0141794167 scopus 로고    scopus 로고
    • Effects of baseline level of triglycerides on changes in lipid levels from combined fluvastatin + fibrate (bezafibrate, fenofibrate, or gemfibrozil)
    • DOI 10.1016/S0002-9149(03)00885-3
    • Farnier M, Salko T, Isaacsohn JL, Troendle AJ, Dejager S, Gonasun L. Effects of baseline level of triglycerides on changes in lipid levels from combined fluvastatin+ fibrate (bezafibrate, fenofibrate, or gemfibrozil). Am J Cardiol2003; 92:794-797. Available at http://www.ncbi.nlm.nih.gov/pubmed/ 14516878. (Pubitemid 37163572)
    • (2003) American Journal of Cardiology , vol.92 , Issue.7 , pp. 794-797
    • Farnier, M.1    Salko, T.2    Isaacsohn, J.L.3    Troendle, A.J.4    Dejager, S.5    Gonasun, L.6
  • 42
    • 64749095070 scopus 로고    scopus 로고
    • Effects of fenofibrate treatment on cardiovascular disease risk in 9,795 individuals with type 2 diabetes and various components of the metabolic syndrome: The Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study
    • Scott R, O'Brien R, Fulcher G, Pardy C, D'Emden M, Tse D, et al. Effects of fenofibrate treatment on cardiovascular disease risk in 9,795 individuals with type 2 diabetes and various components of the metabolic syndrome: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study. Diabetes Care 2009; 32:493-498. Available at http://www.pubmedcentral.nih.gov/ articlerender.fcgi?artid=2646035&tool=pmcentrez&rendertype=abstract.
    • (2009) Diabetes Care , vol.32 , pp. 493-498
    • Scott, R.1    O'brien, R.2    Fulcher, G.3    Pardy, C.4    D'emden, M.5    Tse, D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.