N-Acetyl lysyl-tRNA synthetases evolved by a CcdB-based selection possess N-acetyl lysine specificity in vitro and in vivo

FEBS Letters

Volumn 586, Issue 6, 2012, Pages 729-733

  Umehara, Takuya ^a   Kim, Jihyo ^b   Lee, Sangsik ^b   Guo, Li Tao ^a   Söll, Dieter ^a   Park, Hee Sung ^a,b  

^a YALE UNIVERSITY   (United States)

^b Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

Author keywords

CcdB; Directed evolution; N Acetyl lysyl tRNA synthetase

Indexed keywords

AMINO ACID; AMINO ACID TRANSFER RNA LIGASE; LYSINE DERIVATIVE; N ACETYLLYSINE; N ACETYLLYSYL TRANSFER RNA SYNTHETASE; PYRROLYSYL TRANSFER RNA SYNTHETASE; UNCLASSIFIED DRUG;

ARTICLE; CCDB GENE; CONTROLLED STUDY; DIRECTED MOLECULAR EVOLUTION; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME SYNTHESIS; GENE; GENE PRODUCT; IN VITRO STUDY; IN VIVO STUDY; METHANOSARCINA MAZEI; NONHUMAN; PRIORITY JOURNAL;

BACTERIAL PROTEINS; DIRECTED MOLECULAR EVOLUTION; LYSINE; LYSINE-TRNA LIGASE; METHANOSARCINA; PROTEIN PROCESSING, POST-TRANSLATIONAL; RNA, TRANSFER, AMINO ACYL; SUBSTRATE SPECIFICITY;

METHANOSARCINA MAZEI;

EID: 84862778261     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2012.01.029     Document Type: Article

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