Roflumilast enhances the renal protective effects of retinoids in an HIV-1 transgenic mouse model of rapidly progressive renal failure

Kidney International

Volumn 81, Issue 9, 2012, Pages 856-864

  Zhong, Yifei ^a,b   Wu, Yingwei ^c   Liu, Ruijie ^b   Deng, Yueyi ^a   Mallipattu, Sandeep K ^b   Klotman, Paul E ^d   Chuang, Peter Y ^b   He, John C ^b,e  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c TONGJI UNIVERSITY   (China)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

^e VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

collapsing glomerulopathy; glomerular disease; HIV nephropathy; podocyte; signaling

Indexed keywords

4 [(5,6,7,8 TETRAHYDRO 5,5,8,8 TETRAMETHYL 2 NAPHTHYL)CARBOXAMIDO]BENZOIC ACID; ALBUMIN; CREATININE; CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; NITROGEN; PHOSPHODIESTERASE IV INHIBITOR; RETINOIC ACID; RETINOIC ACID RECEPTOR; RETINOID; ROFLUMILAST; UREA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DRUG POTENTIATION; FEMALE; HISTOPATHOLOGY; IN VITRO STUDY; KIDNEY FAILURE; MALE; MICROALBUMINURIA; MOUSE; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEINURIA; RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS; RENAL PROTECTION; TRANSGENIC MOUSE; UREA NITROGEN BLOOD LEVEL;

EID: 84862776598     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2011.467     Document Type: Article

References (34)

1. Collins AJ, Foley RN, Herzog C et al. US renal data system 2010 annual data report. Am J Kidney Dis 2011; 57: A8, e1-526.
2. Wyatt CM, Klotman PE. HIV-associated nephropathy in the era of antiretroviral therapy. Am J Med 2007; 120: 488-492. (Pubitemid 46764627)
3. Lucas GM, Eustace JA, Sozio S et al. Highly active antiretroviral therapy and the incidence of HIV-1-associated nephropathy: a 12-year cohort study. AIDS 2004; 18: 541-546. (Pubitemid 38365883)
4. Wolf G, Chen S, Ziyadeh FN. From the periphery of the glomerular capillary wall toward the center of disease: podocyte injury comes of age in diabetic nephropathy. Diabetes 2005; 54: 1626-1634. (Pubitemid 40770751)
5. Kriz W, Gretz N, Lemley KV. Progression of glomerular diseases: is the podocyte the culprit? Kidney Int 1998; 54: 687-697. (Pubitemid 28397387)
6. Barisoni L, Kriz W, Mundel P et al. The dysregulated podocyte phenotype: a novel concept in the pathogenesis of collapsing idiopathic focal segmental glomerulosclerosis and HIV-associated nephropathy. J Am Soc Nephrol 1999; 10: 51-61. (Pubitemid 29034942)
7. Barisoni L, Bruggeman LA, Mundel P et al. HIV-1 induces renal epithelial dedifferentiation in a transgenic model of HIV-associated nephropathy. Kidney Int 2000; 58: 173-181. (Pubitemid 30429862)
8. Sunamoto M, Husain M, He JC et al. Critical role for Nef in HIV-1-induced podocyte dedifferentiation. Kidney Int 2003; 64: 1695-1701. (Pubitemid 37323698)
9. Zhao Q, Tao J, Zhu Q et al. Rapid induction of cAMP/PKA pathway during retinoic acid-induced acute promyelocytic leukemia cell differentiation. Leukemia 2004; 18: 285-292. (Pubitemid 38240044)
10. Zhong J, Zuo Y, Ma J et al. Expression of HIV-1 genes in podocytes alone can lead to the full spectrum of HIV-1-associated nephropathy. Kidney Int 2005; 68: 1048-1060. (Pubitemid 43246421)
11. Xu Q, Lucio-Cazana J, Kitamura M et al. Retinoids in nephrology: promises and pitfalls. Kidney Int 2004; 66: 2119-2131. (Pubitemid 41115275)
12. He JC, Lu TC, Fleet M et al. Retinoic acid inhibits HIV-1-induced podocyte proliferation through the cAMP pathway. J Am Soc Nephrol 2007; 18: 93-102. (Pubitemid 46053425)
13. Vaughan MR, Pippin JW, Griffin SV et al. ATRA induces podocyte differentiation and alters nephrin and podocin expression in vitro and in vivo. Kidney Int 2005; 68: 133-144. (Pubitemid 43181370)
14. Lu TC, He JC, Wang ZH et al. HIV-1 Nef disrupts the podocyte actin cytoskeleton by interacting with diaphanous interacting protein. J Biol Chem 2008; 283: 8173-8182.
15. Parrella E, Gianni M, Cecconi V et al. Phosphodiesterase IV inhibition by piclamilast potentiates the cytodifferentiating action of retinoids in myeloid leukemia cells. Cross-talk between the cAMP and the retinoic acid signaling pathways. J Biol Chem 2004; 279: 42026-42040. (Pubitemid 39313654)
16. Ratnam KK, Feng X, Chuang PY et al. Role of the retinoic acid receptor-alpha in HIV-associated nephropathy. Kidney Int 2011; 79: 624-634.
17. Lu TC, Wang Z, Feng X et al. Retinoic acid utilizes CREB and USF1 in a transcriptional feed-forward loop in order to stimulate MKP1 expression in human immunodeficiency virus-infected podocytes. Mol Cell Biol 2008; 28: 5785-5794.
18. Feng X, Lu TC, Chuang PY et al. Reduction of Stat3 activity attenuates HIV-induced kidney injury. J Am Soc Nephrol 2009; 20: 2138-2146.
19. Thorner PS, Ho M, Eremina V et al. Podocytes contribute to the formation of glomerular crescents. J Am Soc Nephrol 2008; 19: 495-502. (Pubitemid 351355393)
20. Evans TR, Kaye SB. Retinoids: present role and future potential. Br J Cancer 1999; 80: 1-8. (Pubitemid 29210079)
21. Gronemeyer H, Miturski R. Molecular mechanisms of retinoid action. Cell Mol Biol Lett 2001; 6: 3-52. (Pubitemid 32397341)
22. Benkoussa M, Brand C, Delmotte MH et al. Retinoic acid receptors inhibit AP1 activation by regulating extracellular signal-regulated kinase and CBP recruitment to an AP1-responsive promoter. Mol Cell Biol 2002; 22: 4522-4534. (Pubitemid 34620390)
23. Na SY, Kang BY, Chung SW et al. Retinoids inhibit interleukin-12 production in macrophages through physical associations of retinoid X receptor and NFkappaB. J Biol Chem 1999; 274: 7674-7680.
24. Balmer JE, Blomhoff R. Gene expression regulation by retinoic acid. J Lipid Res 2002; 43: 1773-1808. (Pubitemid 35315797)
25. Radominska-Pandya A, Chen G, Czernik PJ et al. Direct interaction of all-trans-retinoic acid with protein kinase C (PKC). Implications for PKC signaling and cancer therapy. J Biol Chem 2000; 275: 22324-22330. (Pubitemid 30621817)
26. Hong HY, Varvayanis S, Yen A. Retinoic acid causes MEK-dependent RAF phosphorylation through RARalpha plus RXR activation in HL-60 cells. Differentiation 2001; 68: 55-66. (Pubitemid 34203528)
27. Canon E, Cosgaya JM, Scsucova S et al. Rapid effects of retinoic acid on CREB and ERK phosphorylation in neuronal cells. Mol Biol Cell 2004; 15: 5583-5592. (Pubitemid 39564749)
28. Lonze BE, Ginty DD. Function and regulation of CREB family transcription factors in the nervous system. Neuron 2002; 35: 605-623. (Pubitemid 35229980)
29. Bek M, Nusing R, Kowark P et al. Characterization of prostanoid receptors in podocytes. J Am Soc Nephrol 1999; 10: 2084-2093. (Pubitemid 29453485)
30. Endlich N, Endlich K. cAMP pathway in podocytes. Microsc Res Tech 2002; 57: 228-231. (Pubitemid 34553254)
31. Lu TC, He JC, Klotman P. Animal models of HIV-associated nephropathy. Curr Opin Nephrol Hypertens 2006; 15: 233-237.
32. Kopp JB, Klotman ME, Adler SH et al. Progressive glomerulosclerosis and enhanced renal accumulation of basement membrane components in mice transgenic for human immunodeficiency virus type 1 genes. Proc Natl Acad Sci USA 1992; 89: 1577-1581.
33. D'Agati V. Pathologic classification of focal segmental glomerulosclerosis. Semin Nephrol 2003; 23: 117-134. (Pubitemid 36397094)
34. Takemoto M, Asker N, Gerhardt H et al. A new method for large scale isolation of kidney glomeruli from mice. Am J Pathol 2002; 161: 799-805. (Pubitemid 34988366)