Compartmental tissue distribution of antibody therapeutics: Experimental approaches and interpretations

AAPS Journal

Volumn 14, Issue 3, 2012, Pages 612-618

  Boswell, C Andrew ^a   Bumbaca, Daniela ^a   Fielder, Paul J ^a   Khawli, Leslie A ^a  

^a GENENTECH INC   (United States)

Author keywords

antibody; biodistribution; compartmental analysis; pharmacokinetics; physiology

Indexed keywords

AMIDE; ANTIGEN; CELL SURFACE PROTEIN; CHELATE; ESTER; FC RECEPTOR; GADOLINIUM 153; HALOGEN; INDIUM 111; IODINE 125; LIGAND; LUTETIUM 177; METAL; MONOCLONAL ANTIBODY; PENTETATE INDIUM IN 111; PENTETIC ACID; RADIOHALOGEN; RADIOISOTOPE; RADIOMETAL; SULFIDE; TECHNETIUM 99M; TETRAXETAN; THIOUREA; TRACER; UNCLASSIFIED DRUG;

CELL MEMBRANE; DRUG MECHANISM; DRUG UPTAKE; EXTRACELLULAR SPACE; HUMAN; IMMUNOLOGY; INTERSTITIAL SPACE; INTERSTITIUM; LIGAND BINDING; MOLECULAR PROBE; NEUROLOGY; NONHUMAN; ONCOLOGY; OPHTHALMOLOGY; PROTEIN BINDING; RADIOMETRY; RECEPTOR OCCUPANCY; REVIEW; SOLID TUMOR; TARGET CELL; TISSUE DISTRIBUTION; VASCULAR ENDOTHELIUM;

ANIMALS; ANTIBODIES; HUMANS; TISSUE DISTRIBUTION;

EID: 84862769765     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: 10.1208/s12248-012-9374-1     Document Type: Review

References (40)

1. W Wang EQ Wang JP Balthasar 2008 Monoclonal antibody pharmacokinetics and pharmacodynamics Clin Pharmacol Ther 84 5 548 558 18784655 10.1038/clpt.2008. 170 1:CAS:528:DC%2BD1cXht1OisLvM
2. JM Reichert VE Valge-Archer 2007 Development trends for monoclonal antibody cancer therapeutics Nat Rev Drug Discov 6 5 349 356 17431406 10.1038/nrd2241 1:CAS:528:DC%2BD2sXkslyiu7g%3D
3. H Wiig O Tenstad PO Iversen R Kalluri R Bjerkvig 2010 Interstitial fluid: the overlooked component of the tumor microenvironment? Fibrogenesis Tissue Repair 3 12 20653943 10.1186/1755-1536-3-12
4. RK Jain 1987 Transport of molecules in the tumor interstitium: a review Cancer Res 47 12 3039 3051 3555767 1:CAS:528:DyaL2sXksFKlu7Y%3D
5. AI Minchinton IF Tannock 2006 Drug penetration in solid tumours Nat Rev Cancer 6 8 583 592 16862189 10.1038/nrc1893 1:CAS:528:DC%2BD28XntFGlu7w%3D
6. GM Thurber SC Zajic KD Wittrup 2007 Theoretic criteria for antibody penetration into solid tumors and micrometastases J Nucl Med 48 6 995 999 17504872 10.2967/jnumed.106.037069 1:CAS:528:DC%2BD2sXhtVert7fE
7. CA Boswell DB Tesar K Mukhyala FP Theil PJ Fielder LA Khawli 2010 Effects of charge on antibody tissue distribution and pharmacokinetics Bioconjug Chem 21 12 2153 2163 21053952 10.1021/bc100261d 1:CAS:528:DC%2BC3cXhtlynsb3N
8. DG Levitt 2003 The pharmacokinetics of the interstitial space in humans BMC Clin Pharmacol 3 3 12890292 10.1186/1472-6904-3-3
9. H Wiig CC Gyenge O Tenstad 2005 The interstitial distribution of macromolecules in rat tumours is influenced by the negatively charged matrix components J Physiol 567 Pt 2 557 567 15994186 10.1113/jphysiol.2005.089615 1:CAS:528:DC%2BD2MXhtVaqur%2FO
10. C Sung RJ Youle RL Dedrick 1990 Pharmacokinetic analysis of immunotoxin uptake in solid tumors: role of plasma kinetics, capillary permeability, and binding Cancer Res 50 22 7382 7392 2224866 1:CAS:528:DyaK3MXhslSlug%3D%3D
11. DG Covell J Barbet OD Holton CD Black RJ Parker JN Weinstein 1986 Pharmacokinetics of monoclonal immunoglobulin G1, F(ab')2, and Fab' in mice Cancer Res 46 8 3969 3978 3731067 1:CAS:528:DyaL28XltFehtbY%3D
12. JN Weinstein RR Eger DG Covell CD Black J Mulshine JA Carrasquillo, et al. 1987 The pharmacology of monoclonal antibodies Ann N Y Acad Sci 507 199 210 3327413 10.1111/j.1749-6632.1987.tb45802.x 1:CAS:528:DyaL1cXmt1Grs7k%3D
13. M Tabrizi C Funelas H Suria 2010 Application of quantitative pharmacology in development of therapeutic monoclonal antibodies AAPS J 12 4 592 601 20652780 10.1208/s12248-010-9220-2 1:CAS:528:DC%2BC3cXhsFCqsbbO
14. OD Holton CD Black RJ Parker DG Covell J Barbet SM Sieber, et al. 1987 Biodistribution of monoclonal IgG1, F(ab')2, and Fab' in mice after intravenous injection. Comparison between anti-B cell (anti-Lyb8.2) and irrelevant (MOPC-21) antibodies J Immunol 139 9 3041 3049 3499463 1:CAS:528:DyaL1cXitVantw%3D%3D
15. CV Pastuskovas EE Mundo SP Williams TK Nayak J Ho S Ulufatu, et al. 2012 Effects of anti-VEGF on pharmacokinetics, biodistribution and tumor penetration of trastuzumab in a preclinical breast cancer model Mol Cancer Ther 11 3 752 762 10.1158/1535-7163.mct-11-0742-t 22222630 10.1158/1535-7163.MCT-11-0742-T 1:CAS:528:DC%2BC38XjtlKisb8%3D
16. D Bumbaca H Xiang CA Boswell RE Port SL Stainton EE Mundo, et al. 2012 Maximizing anti-neuropilin-1 tumour exposure requires saturation of non-tumour tissue antigenic sinks in mice Br J Pharmacol 166 1 368 377 22074316 10.1111/j.1476-5381.2011.01777.x 1:CAS:528:DC%2BC38XmsVaqt7s%3D
17. DR Mould B Green 2010 Pharmacokinetics and pharmacodynamics of monoclonal antibodies: concepts and lessons for drug development BioDrugs 24 1 23 39 10.2165/11530560-000000000-00000 20055530 10.2165/11530560-000000000-00000 1:CAS:528:DC%2BC3cXislSrtro%3D
18. MA Tabrizi CM Tseng LK Roskos 2006 Elimination mechanisms of therapeutic monoclonal antibodies Drug Discov Today 11 1-2 81 88 16478695 10.1016/S1359-6446(05)03638-X 1:CAS:528:DC%2BD28XhsFygt70%3D
19. S Prabhu CA Boswell D Leipold LA Khawli D Li D Lu, et al. 2011 Antibody delivery of drugs and radionuclides: factors influencing clinical pharmacology Ther Deliv 2 6 769 791 10.4155/tde.11.41 10.4155/tde.11.41 1:CAS:528: DC%2BC3MXovVKqsL8%3D
20. R Chizzonite T Truitt FJ Podlaski AG Wolitzky PM Quinn P Nunes, et al. 1991 IL-12: monoclonal antibodies specific for the 40-kDa subunit block receptor binding and biologic activity on activated human lymphoblasts J Immunol 147 5 1548 1556 1715362 1:CAS:528:DyaK3MXmsFekt74%3D
21. CA Boswell MW Brechbiel 2007 Development of radioimmunotherapeutic and diagnostic antibodies: an inside-out view Nucl Med Biol 34 7 757 778 17921028 10.1016/j.nucmedbio.2007.04.001 1:CAS:528:DC%2BD2sXhtFeiu77K
22. DA Wall T Maack 1985 Endocytic uptake, transport, and catabolism of proteins by epithelial cells Am J Physiol 248 1 Pt 1 C12 C20 3881040 1:CAS:528:DyaL2MXptlCgsw%3D%3D
23. CA Boswell EE Mundo C Zhang D Bumbaca NR Valle KR Kozak, et al. 2011 Impact of drug conjugation on pharmacokinetics and tissue distribution of anti-STEAP1 antibody-drug conjugates in rats Bioconjug Chem 22 10 1994 2004 21913715 10.1021/bc200212a 1:CAS:528:DC%2BC3MXht1GgtbzJ
24. LB Shih SR Thorpe GL Griffiths H Diril GL Ong HJ Hansen, et al. 1994 The processing and fate of antibodies and their radiolabels bound to the surface of tumor cells in vitro: a comparison of nine radiolabels J Nucl Med 35 5 899 908 8176479 1:CAS:528:DyaK2cXlt1yqs78%3D
25. RM Perera R Zoncu TG Johns M Pypaert FT Lee I Mellman, et al. 2007 Internalization, intracellular trafficking, and biodistribution of monoclonal antibody 806: a novel anti-epidermal growth factor receptor antibody Neoplasia 9 12 1099 1110 18084617 10.1593/neo.07721 1:CAS:528:DC%2BD1cXltleisro%3D
26. A Morell WD Terry TA Waldmann 1970 Metabolic properties of IgG subclasses in man J Clin Invest 49 4 673 680 5443170 10.1172/JCI106279 1:CAS:528:DyaE3cXht12qtrc%3D
27. HL Spiegelberg BG Fishkin HM Grey 1968 Catabolism of human gammaG-immunoglobulins of different heavy chain subclasses. I. Catabolism of gammaG-myeloma proteins in man J Clin Invest 47 10 2323 2330 4175542 10.1172/JCI105917 1:CAS:528:DyaF1MXhvVOn
28. BE Rogers FN Franano JR Duncan WB Edwards CJ Anderson JM Connett, et al. 1995 Identification of metabolites of 111In-diethylenetriaminepentaacetic acid-monoclonal antibodies and antibody fragments in vivo Cancer Res 55 23 Suppl 5714s 5720s 7493333 1:CAS:528:DyaK2MXps12ht7Y%3D
29. BA Ploeger PH van der Graaf M Danhof 2009 Incorporating receptor theory in mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling Drug Metab Pharmacokinet 24 1 3 15 19252332 10.2133/dmpk.24.3 1:CAS:528: DC%2BD1MXks1Whu74%3D
30. Kenakin T. Receptor theory. Current Protocols in Pharmacology. 2008; Unit 1.2. doi: 10.1002/0471141755.ph0102s41.
31. FE Yang RS Brown KF Koral AC Clavo GA Jackson RL Wahl 1992 Quantitative autoradiographic evaluation of the influence of protein dose on monoclonal antibody distribution in human ovarian adenocarcinoma xenografts Cancer Immunol Immunother 35 6 365 372 1394341 10.1007/BF01789014 1:CAS:528:DyaK3sXht1SjsLo%3D
32. GM Thurber MM Schmidt KD Wittrup 2008 Factors determining antibody distribution in tumors Trends Pharmacol Sci 29 2 57 61 18179828 1:CAS:528:DC%2BD1cXhslOjsLw%3D
33. RA Beckman R von Roemeling AM Scott 2011 Monoclonal antibody dose determination and biodistribution into solid tumors Ther Deliv 2 3 333 344 10.4155/tde.10.91 10.4155/tde.10.91 1:CAS:528:DC%2BC3MXivFyksLY%3D
34. LT Baxter H Zhu DG Mackensen WF Butler RK Jain 1995 Biodistribution of monoclonal antibodies: scale-up from mouse to human using a physiologically based pharmacokinetic model Cancer Res 55 20 4611 4622 7553638 1:CAS:528:DyaK2MXoslWmsLo%3D
35. CA Boswell GZ Ferl EE Mundo MG Schweiger J Marik MP Reich, et al. 2010 Development and evaluation of a novel method for preclinical measurement of tissue vascular volume Mol Pharm 12 12
36. CA Boswell GZ Ferl EE Mundo D Bumbaca MG Schweiger FP Theil, et al. 2011 Effects of anti-VEGF on predicted antibody biodistribution: roles of vascular volume, interstitial volume, and blood flow PLoS One 6 3 e17874 21436893 10.1371/journal.pone.0017874 1:CAS:528:DC%2BC3MXjvVykt74%3D
37. H Wiig K Aukland O Tenstad 2003 Isolation of interstitial fluid from rat mammary tumors by a centrifugation method Am J Physiol Heart Circ Physiol 284 1 H416 H424 12388326 1:CAS:528:DC%2BD3sXmvF2huw%3D%3D
38. JW Lee M Kelley LE King J Yang H Salimi-Moosavi MT Tang, et al. 2011 Bioanalytical approaches to quantify "total" and "free" therapeutic antibodies and their targets: technical challenges and PK/PD applications over the course of drug development AAPS J 13 1 99 110 21240643 10.1208/s12248-011-9251-3 1:CAS:528:DC%2BC3MXhsFWhu7Y%3D
39. M Danhof J de Jongh EC De Lange O Della Pasqua BA Ploeger RA Voskuyl 2007 Mechanism-based pharmacokinetic-pharmacodynamic modeling: biophase distribution, receptor theory, and dynamical systems analysis Annu Rev Pharmacol Toxicol 47 357 400 17067280 10.1146/annurev.pharmtox.47.120505.105154 1:CAS:528:DC%2BD2sXit1altL0%3D
40. TR Shockley K Lin C Sung JA Nagy RG Tompkins RL Dedrick, et al. 1992 A quantitative analysis of tumor specific monoclonal antibody uptake by human melanoma xenografts: effects of antibody immunological properties and tumor antigen expression levels Cancer Res 52 2 357 366 1728407 1:CAS:528: DyaK38XhsVOjs7Y%3D