Confronting the challenge: Individualized immune monitoring after organ transplantation using the cellular immune function assay

Clinica Chimica Acta

Volumn 413, Issue 17-18, 2012, Pages 1374-1378

  Israeli, Moshe ^a   Klein, Tirza ^a   Brandhorst, Gunnar ^b   Oellerich, Michael ^b  

^a RABIN MEDICAL CENTER   (Israel)

^b UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

Author keywords

ATP; Biomarker; Cellular immune function; Immune monitoring; Rejection; Transplantation

Indexed keywords

ADENOSINE TRIPHOSPHATE;

ACUTE GRAFT REJECTION; ALLOIMMUNITY; CD4+ T LYMPHOCYTE; CELLULAR IMMUNE FUNCTION ASSAY; CELLULAR IMMUNITY; CLINICAL PROTOCOL; DRUG BLOOD LEVEL; DRUG MONITORING; GRAFT RECIPIENT; HEALTH CARE UTILIZATION; HUMAN; IMMUNOASSAY; IMMUNOLOGICAL MONITORING; IMMUNOSUPPRESSIVE TREATMENT; LONGITUDINAL STUDY; NON INVASIVE MEASUREMENT; NONHUMAN; ORGAN TRANSPLANTATION; PATIENT CARE; PATIENT MONITORING; PREDICTIVE VALUE; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE ACTIVATION;

HUMANS; IMMUNITY, CELLULAR; MONITORING, IMMUNOLOGIC; ORGAN TRANSPLANTATION;

EID: 84862763048     PISSN: 00098981     EISSN: 18733492     Source Type: Journal    
DOI: 10.1016/j.cca.2012.01.033     Document Type: Review

References (27)

1. del Pozo J.L. Update and actual trends on bacterial infections following liver transplantation. World J Gastroenterol 2008, 14:4977-4983.
2. Fishman J.A. Infection in solid-organ transplant recipients. N Engl J Med 2007, 357:2601-2614.
3. Wavamunno M.D., Chapman J.R. Individualization of immunosuppression: concepts and rationale. Curr Opin Organ Transplant 2008, 13:604-608.
4. Taylor R.M., Franck L.S., Gibson F., Donaldson N., Dhawan A. Study of the factors affecting health-related quality of life in adolescents after liver transplantation. Am J Transplant 2009, 9:1179-1188.
5. Ryffel B., Mihatsch M.J., Fisher G.L. Immuno-suppression and cancer: the ciclosporin case. Drug Chem Toxicol 1992, 15:95-115.
6. Martinenghi S., Dell'Antonio G., Secchi A., Di Carlo V., Pozza G. Cancer arising after pancreas and/or kidney transplantation in a series of 99 diabetic patients. Diabetes Care 1997, 20:272-275.
7. Sampson V.B., Dunn S.P., Rymeski B., et al. Failure of immunosuppressive drug levels to predict T-cell reactivity in pediatric transplant patients. J Pediatr Surg 2008, 43:1134-1141.
8. Wieland E., Olbricht C.J., Susal C., et al. Biomarkers as a tool for management of immunosuppression in transplant patients. Ther Drug Monit 2010, 32:560-572.
9. Sawitzki B., Pascher A., Babel N., et al. Can we use biomarkers and functional assays to implement personalized therapies in transplantation?. Transplantation 2009, 15(87):1595-1601.
10. Kowalski R., Post D., Schneider M.C., et al. Immune cell function testing: an adjunct to therapeutic drug monitoring in transplant patient management. Clin Transplant 2003, 17:77-88.
11. Kowalski R.J., Post D.R., Mannon R.B., et al. Assessing relative risks of infection and rejection: a meta-analysis using an immune function assay. Transplantation 2006, 82:663-668.
12. Israeli M., Yussim A., Mor E., et al. Preceding the rejection: in search for a comprehensive post-transplant immune monitoring platform. Transpl Immunol 2007, 18:7-12.
13. Akhlaghi F., Gohh R.Y. The level of ATP production in mitogen-stimulated CD4+ lymphocytes is independent of the time of ingestion of immunosuppressive agents. Ther Drug Monit 2010, 32:116-117.
14. + T cells as a predictor for infection and allograft rejection in trough-level guided pediatric liver transplant recipients under calcineurin-inhibitor therapy. Ther Drug Monit 2012, 34:4-10.
15. Hooper E., Hawkins D.M., Kowalski R.J., et al. Establishing pediatric immune response zones using the Cylex Immuknow assay. Clin Transplant 2005, 19:834-839.
16. Israeli M., Klein T., Sredni B., et al. Immuknow: a new parameter in immune monitoring of pediatric liver transplantation recipients. Liver Transpl 2008, 14:893-898.
17. Israeli M., Ben-Gal T., Yaari V., et al. Optimizing individualized therapy of heart transplantation recipients through non-invasive longitudinal immune monitoring. Transplantation 2010, 89:968-976.
18. Cheng J.W., Shi Y.H., Fan J., et al. An immune function assay predicts post-transplant recurrence in patients with hepatocellular carcinoma. J Cancer Res Clin Oncol 2011, 137(10):1445-1453.
19. Berglund D., Bengtsson M., Biglarnia A., et al. Screening of mortality in transplant patients using an assay for immune function. Transpl Immunol 2011 May, 24(4):246-250.
20. Manga K., Serban G., Schwartz J., et al. Increased adenosine triphosphate production by peripheral blood CD4+ cells in patients with hematologic malignancies treated with stem cell mobilization agents. Hum Immunol 2010 Jul, 71(7):652-658.
21. Gesundheit B., Budowski E., Israeli M., et al. Assessment of CD4 T-lymphocyte reactivity by the Cylex ImmuKnow assay in patients following allogeneic hematopoietic SCT. Bone Marrow Transplant 2010 Mar, 45(3):527-533.
22. Huskey J., Gralla J., Wiseman A.C. Single time point immune function assay (ImmuKnow) testing does not aid in the prediction of future opportunistic infections or acute rejection. Clin J Am Soc Nephrol 2011 Feb, 6(2):423-429.
23. Bhorade S., Janata K., Vigneswaran W., et al. Cylex ImmuKnow assay levels are lower in lung transplant recipients with infection. J Heart Lung Transplant 2008, 27:990-994.
24. Millán O., Sánchez-Fueyo A., Rimola A., et al. Is the intracellular ATP concentration of CD4+ T-Cells a predictive biomarker of immune status in stable transplant recipients?. Transplantation 2009, 88(3 Suppl):78-84.
25. Sanchez-Velasco P., Rodrigo E., Valero R., et al. Intracellular ATP concentrations of CD4 cells in kidney transplant patients with and without infection. Clin Transplant 2008, 22:55-60.
26. Kobashigawa J.A., Kiyosaki K.K., Patel J.K., et al. Benefit of immune monitoring in heart transplant patients using ATP production in activated lymphocytes. J Heart Lung Transplant 2010, 29(5):504-508.
27. Husain S., Raza K., Pilewski J., et al. Experience with immune monitoring in lung transplant recipients: correlation of low immune function with infection. Transplantation 2009, 87:1852-1857.