Assessment of CD4 T-lymphocyte reactivity by the Cylex ImmuKnow assay in patients following allogeneic hematopoietic SCT

Bone Marrow Transplantation

Volumn 45, Issue 3, 2010, Pages 527-533

  Gesundheit, B ^a   Budowski, E ^a   Israeli, M ^b   Shapira, M Y ^a   Resnick, I B ^a   Bringer, R ^a   Azar, Y ^a   Samuel, S ^a   Dray, L ^a   Amar, A ^a   Kristt, D ^c   Or, R ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b BAR ILAN UNIVERSITY   (Israel)

^c RABIN MEDICAL CENTER   (Israel)

Author keywords

Immune function and monitoring; Immune reconstitution after HSCT; Infectious complication

Indexed keywords

CD4 ANTIGEN;

ACUTE GRAFT VERSUS HOST DISEASE; ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADRENOLEUKODYSTROPHY; ADULT; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; APLASTIC ANEMIA; ARTICLE; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; CHILD; CHRONIC MYELOID LEUKEMIA; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GRAFT REJECTION; HISTOCOMPATIBILITY; HODGKIN DISEASE; HUMAN; IMMUNOASSAY; IMMUNOCOMPETENCE; IMMUNOCOMPROMISED PATIENT; IMMUNOLOGICAL MONITORING; IMMUNOREACTIVITY; ISRAEL; LEUKOCYTE COUNT; MALE; MULTIPLE MYELOMA; NONHODGKIN LYMPHOMA; OVARY CANCER; PREDICTION; PRIORITY JOURNAL; SEPSIS; THALASSEMIA MAJOR;

ADENOSINE TRIPHOSPHATE; ADOLESCENT; ADULT; CASE-CONTROL STUDIES; CD4-POSITIVE T-LYMPHOCYTES; CHILD; CHILD, PRESCHOOL; FEMALE; HEMATOLOGIC NEOPLASMS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; IMMUNOCOMPETENCE; IMMUNOCOMPROMISED HOST; IMMUNOLOGIC TESTS; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; MONITORING, IMMUNOLOGIC; OPPORTUNISTIC INFECTIONS; TRANSPLANTATION, HOMOLOGOUS; YOUNG ADULT;

EID: 77949405454     PISSN: 02683369     EISSN: 14765365     Source Type: Journal    
DOI: 10.1038/bmt.2009.182     Document Type: Article

References (23)

1. Busca A, Lovisone E, Aliberti S, Locatelli F, Serra A, Scaravaglio P et al., Immune reconstitution and early infectious complications following nonmyeloablative hematopoietic stem cell transplantation. Hematology 2003; 8: 303-311.
2. Ball LM, Lankester AC, Bredius RG, Fibbe WE, van Tol MJ, Egeler RM et al., Graft dysfunction and delayed immune reconstitution following haploidentical peripheral blood hematopoietic stem cell transplantation. Bone Marrow Transplant 2005; 35(Suppl 1): S35-S38.
3. Wu CJ, Ritz J. Induction of tumor immunity following allogeneic stem cell transplantation. Adv Immunol 2006; 90: 133-173.
4. Kristt D, Stein J, Yaniv I, Klein T. Assessing quantitative chimerism longitudinally: technical considerations, clinical applications and routine feasibility. Bone Marrow Transplant 2007; 39: 255-268.
5. Kowalski RJ, Post DR, Mannon RB, Sebastian A, Wright HI, Sigle G et al., Assessing relative risks of infection and rejection: a meta-analysis using immune function assay. Transplantation 2006; 39: 663-668.
6. Israeli M, Yussim A, Mor E, Sredni B, Klein I. Preceeding the rejection: in search for a comprehensive post-transplant immune monitoring platform. Transpl Immunol 2007; 18: 7-12.
7. Rodrigo E, Arias M. A practical approach to immune monitoring in kidney transplantation. Minerva Urol Nefrol 2007; 59: 337-352.
8. Jin Y, Hernandez A, Fuller L, Rosen A, Cirocco R, Esquenazi V et al., A novel approach to detect donor/ recipient immune responses between HLA-identical pairs. Hum Immunol 2007; 68: 350-361.
9. Cadillo-Chá vez R, de Echegaray S, Santiago-Delpín EA, Rodríguez-Trinidad AT, Camacho-Carrazo B, Alfaro T. Assessing the risk of infection and rejection in Hispanic renal transplant recipients by means of an adenosine triphosphate release assay. Transplant Proc 2006; 38: 918-920.
10. Lee TC, Goss JA, Rooney CM, Heslop HE, Barshes NR, Caldwell YM. Quantification of a low cellular immune response to aid in identification of pediatric liver transplant recipients at high-risk for EBV infection. Clin Transplant 2006; 20: 689-694.
11. Zeevi A, Husain S, Spichty KJ, Raza K, Woodcock JB, Zaldonis D. Recovery of functional memory T cells in lung transplant recipients following induction therapy with alemtuzumab. Am J Transplant 2007; 7: 471-475.
12. Visner GA, Goldfarb SB. Post-transplant monitoring of pediatric lung transplant recipients. Curr Opin Pediatr 2007; 19: 321-326.
13. Zeevi A, Britz JA, Bentlejewski CA, Guaspari D, Tong W, Bond G et al., Monitoring immune function during tacrolimustapering in small bowel transplant recipients. Transpl Immunol 2005; 15: 17-24.
14. Thai NL, Blisard D, Tom K, Basu A, Smetanka C, Tan H et al., Pancreas transplantation under alemtuzumab (Campath- 1H) and tacrolimus: correlation between low T-cell responses and infection. Transplantation 2006; 18: 1649-1652.
15. Knight RJ, Kerman RH, McKissick E, Lawless A, Podder H, Katz S et al., A pilot study of immuno-suppression minimization after pancreas-kidney transplantation utilizing thymoglobulin induction and sirolimus maintenance therapy. Transplant Proc 2005; 37: 3538-3541.
16. Kowalski RJ, Post DR, Mannon RB, Sebastian A, Wright HI, Sigle G et al., Assessing relative risks of infection and rejection: a meta-analysis using an immune function assay. Transplantation 2006; 82: 663-668. Comment in: Nat Clin Pract Nephrol. 2007; 3:196-197
17. Kowalski R, Post D, Schneider MC, Britz J, Thomas J, Deierhoi M et al., Immune cell function testing: an adjunct to therapeutic drug monitoring in transplant patient management. Clin Transplant 2003; 17: 77-88.
18. Pacheco-Silva A. Immune function, as assessed by the ImmuKnow assay, correlates with clinical outcomes in transplant recipients. Nat Clin Pract Nephrol 2007; 3: 196-197.
19. Hooper E, Hawkins DM, Kowalski RJ, Post DR, Britz JA, Brooks KC et al., Establishing pediatric immune response zones using the Cylex ImmuKnow assay. Clin Transplant 2005; 19: 834-839.
20. Or R, Shapira MY, Resnick I, Amar A, Acherstein A, Samuel S et al., Nonmyeloablative allogeneic stem cell transplantation for the treatment of chronic myeloid leukemia in the first chronic phase. Blood 2003, 441-445.
21. Chen X, Hale GA, Barfield R, Benaim E, Leung WH, Knowles J et al., Rapid immune reconstitution after a reduced-intensity conditioning regimen and a CD3-depleted haploidentical stem cell graft for paediatric refractory haematological malignancies. Br J Haematol 2006; 135: 524-532.
22. Bleyer WA, Blaese RM, Bujak JS, Herzig GP, Graw Jr RG. Long-term remission from acute myelogenous leukemia after bone marrow transplantation and recovery from acute graftversus- host reaction and prolonged immunoincompetence. Blood 1975; 45: 171-181.
23. Chen X, Hale GA, Neale GA, Knowles J, Barfield RC, Wang YD et al., A novel approach for the analysis of T-cell reconstitution by using a T-cell receptor beta-based oligonucleotide microarray in hematopoietic stem cell transplantation. Exp Hematol 2007; 35: 831-841