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Volumn 413, Issue 17-18, 2012, Pages 1379-1386

Calcineurin inhibitors and NFAT-regulated gene expression

Author keywords

Ciclosporin A; Gene expression; Immune monitoring; Monitoring; NFAT; Tacrolimus

Indexed keywords

CALCINEURIN; CALCINEURIN INHIBITOR; CYCLOSPORIN A; FINGOLIMOD; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 2; MYCOPHENOLIC ACID; TACROLIMUS; TRANSCRIPTION FACTOR NFAT; TUMOR NECROSIS FACTOR ALPHA;

EID: 84862759750     PISSN: 00098981     EISSN: 18733492     Source Type: Journal    
DOI: 10.1016/j.cca.2011.09.041     Document Type: Review
Times cited : (42)

References (62)
  • 1
    • 33645694582 scopus 로고    scopus 로고
    • Immunosuppression: evolution in practice and trends, 1994-2004
    • Meier-Kriesche H.U., Li S., Gruessner R.W., et al. Immunosuppression: evolution in practice and trends, 1994-2004. Am J Transplant 2006, 6:1111-1131.
    • (2006) Am J Transplant , vol.6 , pp. 1111-1131
    • Meier-Kriesche, H.U.1    Li, S.2    Gruessner, R.W.3
  • 3
    • 1442338509 scopus 로고    scopus 로고
    • Lack of improvement in renal allograft survival despite a marked decrease in acute rejection rates over the most recent era
    • Meier-Kriesche H.U., Schold J.D., Srinivas T.R., Kaplan B. Lack of improvement in renal allograft survival despite a marked decrease in acute rejection rates over the most recent era. Am J Transplant 2004, 4:378-383.
    • (2004) Am J Transplant , vol.4 , pp. 378-383
    • Meier-Kriesche, H.U.1    Schold, J.D.2    Srinivas, T.R.3    Kaplan, B.4
  • 4
    • 70350500090 scopus 로고    scopus 로고
    • Immunosuppressive drugs in kidney transplantation: impact on patient survival, and incidence of cardiovascular disease, malignancy and infection
    • Marcén R. Immunosuppressive drugs in kidney transplantation: impact on patient survival, and incidence of cardiovascular disease, malignancy and infection. Drugs 2009, 69:2227-2243.
    • (2009) Drugs , vol.69 , pp. 2227-2243
    • Marcén, R.1
  • 7
    • 0034720514 scopus 로고    scopus 로고
    • Cancer risk in patients on dialysis and after renal transplantation
    • Birkeland S.A., Løkkegaard H., Storm H.H. Cancer risk in patients on dialysis and after renal transplantation. Lancet 2000, 355:1886-1887.
    • (2000) Lancet , vol.355 , pp. 1886-1887
    • Birkeland, S.A.1    Løkkegaard, H.2    Storm, H.H.3
  • 8
    • 0035086066 scopus 로고    scopus 로고
    • Approaching the therapeutic window for cyclosporine in kidney transplantation: a prospective study
    • Mahalati K., Belitsky P., West K., et al. Approaching the therapeutic window for cyclosporine in kidney transplantation: a prospective study. J Am Soc Nephrol 2001, 12:828-833.
    • (2001) J Am Soc Nephrol , vol.12 , pp. 828-833
    • Mahalati, K.1    Belitsky, P.2    West, K.3
  • 9
    • 0036334289 scopus 로고    scopus 로고
    • Comparison of trough, 2-hour, and limited AUC blood sampling for monitoring cyclosporin (Neoral) at day 7 post-renal transplantation and incidence of rejection in the first month
    • Morris R.G., Russ G.R., Cervelli M.J., Juneja R., McDonald S.P., Mathew T.H. Comparison of trough, 2-hour, and limited AUC blood sampling for monitoring cyclosporin (Neoral) at day 7 post-renal transplantation and incidence of rejection in the first month. Ther Drug Monit 2002, 24:479-486.
    • (2002) Ther Drug Monit , vol.24 , pp. 479-486
    • Morris, R.G.1    Russ, G.R.2    Cervelli, M.J.3    Juneja, R.4    McDonald, S.P.5    Mathew, T.H.6
  • 10
    • 0037093525 scopus 로고    scopus 로고
    • Patient management by Neoral C(2) monitoring: an international consensus statement
    • on behalf of the CONCERT group
    • Levy G., Thervet E., Lake J., Uchida K. Patient management by Neoral C(2) monitoring: an international consensus statement. Transplantation 2002, 73(9 Suppl.):S12-S18. on behalf of the CONCERT group.
    • (2002) Transplantation , vol.73 , Issue.9 SUPPL.
    • Levy, G.1    Thervet, E.2    Lake, J.3    Uchida, K.4
  • 11
    • 0036487978 scopus 로고    scopus 로고
    • Cyclosporine microemulsion (Neoral) absorption profiling and sparse-sample predictors during the first 3 months after renal transplantation
    • International Neoral Study Group
    • International Neoral Study Group Cyclosporine microemulsion (Neoral) absorption profiling and sparse-sample predictors during the first 3 months after renal transplantation. Am J Transplant 2002, 2:148-156.
    • (2002) Am J Transplant , vol.2 , pp. 148-156
  • 12
    • 34250792130 scopus 로고    scopus 로고
    • The clinical benefits of cyclosporine C2-level monitoring: a systematic review
    • Knight S.R., Morris P.J. The clinical benefits of cyclosporine C2-level monitoring: a systematic review. Transplantation 2007, 83:1525-1535.
    • (2007) Transplantation , vol.83 , pp. 1525-1535
    • Knight, S.R.1    Morris, P.J.2
  • 13
    • 65349115890 scopus 로고    scopus 로고
    • Opportunities to optimize tacrolimus therapy in solid organ transplantation: report of the European consensus conference
    • Wallemacq P., Armstrong V.W., Brunet M., et al. Opportunities to optimize tacrolimus therapy in solid organ transplantation: report of the European consensus conference. Ther Drug Monit 2009, 31:139-152.
    • (2009) Ther Drug Monit , vol.31 , pp. 139-152
    • Wallemacq, P.1    Armstrong, V.W.2    Brunet, M.3
  • 14
    • 20144375595 scopus 로고    scopus 로고
    • Efficacy and safety outcomes among de novo renal transplant recipients managed by C2 monitoring of cyclosporine a microemulsion: results of a 12-month, randomized, multicenter study
    • Stefoni S., Midtved K., Cole E., et al. Efficacy and safety outcomes among de novo renal transplant recipients managed by C2 monitoring of cyclosporine a microemulsion: results of a 12-month, randomized, multicenter study. Transplantation 2005, 79:577-583.
    • (2005) Transplantation , vol.79 , pp. 577-583
    • Stefoni, S.1    Midtved, K.2    Cole, E.3
  • 15
    • 14944364123 scopus 로고    scopus 로고
    • Results of a three-year prospective study of C2 monitoring in long-term renal transplant recipients receiving cyclosporine microemulsion
    • Citterio F., Scata M.C., Romagnoli J., Nanni G., Castagneto M. Results of a three-year prospective study of C2 monitoring in long-term renal transplant recipients receiving cyclosporine microemulsion. Transplantation 2005, 79:802-806.
    • (2005) Transplantation , vol.79 , pp. 802-806
    • Citterio, F.1    Scata, M.C.2    Romagnoli, J.3    Nanni, G.4    Castagneto, M.5
  • 16
    • 78449261994 scopus 로고    scopus 로고
    • A transient increase of calcineurin phosphatase activity in living-donor kidney transplant recipients with acute rejection
    • Fukudo M., Yano I., Katsura T., et al. A transient increase of calcineurin phosphatase activity in living-donor kidney transplant recipients with acute rejection. Drug Metab Pharmacokinet 2010, 25:411-417.
    • (2010) Drug Metab Pharmacokinet , vol.25 , pp. 411-417
    • Fukudo, M.1    Yano, I.2    Katsura, T.3
  • 17
    • 0033571210 scopus 로고    scopus 로고
    • The temporal profile of calcineurin inhibition by cyclosporine in vivo
    • Halloran P.F., Helms L.M., Kung L., Noujaim J. The temporal profile of calcineurin inhibition by cyclosporine in vivo. Transplantation 1999, 68:1356-1361.
    • (1999) Transplantation , vol.68 , pp. 1356-1361
    • Halloran, P.F.1    Helms, L.M.2    Kung, L.3    Noujaim, J.4
  • 18
    • 0032846279 scopus 로고    scopus 로고
    • Inhibition of stimulated interleukin-2 production in whole blood: a practical measure of the cyclosporine effect
    • Stein C.M., Murray J.J., Wood A.J. Inhibition of stimulated interleukin-2 production in whole blood: a practical measure of the cyclosporine effect. Clin Chem 1999, 45:1477-1484.
    • (1999) Clin Chem , vol.45 , pp. 1477-1484
    • Stein, C.M.1    Murray, J.J.2    Wood, A.J.3
  • 19
    • 0036893274 scopus 로고    scopus 로고
    • Delayed cytokine mRNA expression kinetics after T-lymphocyte co-stimulation: a quantitative measure of the efficacy of cyclosporine A-based immunosuppression
    • Hartel C., Fricke L., Schumacher N., Kirchner H., Müller-Steinhardt M. Delayed cytokine mRNA expression kinetics after T-lymphocyte co-stimulation: a quantitative measure of the efficacy of cyclosporine A-based immunosuppression. Clin Chem 2002, 48:2225-2231.
    • (2002) Clin Chem , vol.48 , pp. 2225-2231
    • Hartel, C.1    Fricke, L.2    Schumacher, N.3    Kirchner, H.4    Müller-Steinhardt, M.5
  • 20
    • 1642533461 scopus 로고    scopus 로고
    • Sensitivity of whole-blood T lymphocytes in individual patients to tacrolimus (FK 506): impact of interleukin-2 mRNA expression as surrogate measure of immunosuppressive effect
    • Hartel C., Schumacher N., Fricke L., Ebel B., Kirchner H., Müller-Steinhardt M. Sensitivity of whole-blood T lymphocytes in individual patients to tacrolimus (FK 506): impact of interleukin-2 mRNA expression as surrogate measure of immunosuppressive effect. Clin Chem 2004, 50:141-151.
    • (2004) Clin Chem , vol.50 , pp. 141-151
    • Hartel, C.1    Schumacher, N.2    Fricke, L.3    Ebel, B.4    Kirchner, H.5    Müller-Steinhardt, M.6
  • 21
    • 0026503434 scopus 로고
    • Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A
    • Fruman D.A., Klee C.B., Bierer B.E., Burakoff S.J. Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A. Proc Natl Acad Sci U S A 1992, 89:3686-3690.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 3686-3690
    • Fruman, D.A.1    Klee, C.B.2    Bierer, B.E.3    Burakoff, S.J.4
  • 22
    • 0026632557 scopus 로고
    • FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin
    • O'Keefe S.J., Tamura J., Kincaid R.L., Tocci M.J., O'Neill E.A. FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin. Nature 1992, 357:692-694.
    • (1992) Nature , vol.357 , pp. 692-694
    • O'Keefe, S.J.1    Tamura, J.2    Kincaid, R.L.3    Tocci, M.J.4    O'Neill, E.A.5
  • 23
    • 0026643141 scopus 로고
    • Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation
    • Clipstone N.A., Crabtree G.R. Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation. Nature 1992, 357:695-697.
    • (1992) Nature , vol.357 , pp. 695-697
    • Clipstone, N.A.1    Crabtree, G.R.2
  • 24
    • 0033532171 scopus 로고    scopus 로고
    • Recognition of NFATp/AP-1 composite elements within genes induced upon the activation of immune cells
    • Kel A., Kel-Margoulis O., Babenko V., Wingender E. Recognition of NFATp/AP-1 composite elements within genes induced upon the activation of immune cells. J Mol Biol 1999, 288:353-376.
    • (1999) J Mol Biol , vol.288 , pp. 353-376
    • Kel, A.1    Kel-Margoulis, O.2    Babenko, V.3    Wingender, E.4
  • 26
    • 40449093233 scopus 로고    scopus 로고
    • Variation in leukocyte subset concentrations affects calcineurin activity measurement: implications for pharmacodynamic monitoring strategies
    • van Rossum H.H., Romijn F.P., Sellar K.J., et al. Variation in leukocyte subset concentrations affects calcineurin activity measurement: implications for pharmacodynamic monitoring strategies. Clin Chem 2008, 54:517-524.
    • (2008) Clin Chem , vol.54 , pp. 517-524
    • van Rossum, H.H.1    Romijn, F.P.2    Sellar, K.J.3
  • 27
    • 10744226204 scopus 로고    scopus 로고
    • Pharmacodynamic approach to immunosuppressive therapies using calcineurin inhibitors and mycophenolate mofetil
    • Millan O., Brunet M., Campistol J.M., et al. Pharmacodynamic approach to immunosuppressive therapies using calcineurin inhibitors and mycophenolate mofetil. Clin Chem 2003, 49:1891-1899.
    • (2003) Clin Chem , vol.49 , pp. 1891-1899
    • Millan, O.1    Brunet, M.2    Campistol, J.M.3
  • 28
    • 10744219578 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic correlations of cyclosporine therapy in stable renal transplant patients: evaluation of long-term target C(2)
    • Brunet M., Campistol J.M., Millán O., et al. Pharmacokinetic and pharmacodynamic correlations of cyclosporine therapy in stable renal transplant patients: evaluation of long-term target C(2). Int Immunopharmacol 2003, 3:987-999.
    • (2003) Int Immunopharmacol , vol.3 , pp. 987-999
    • Brunet, M.1    Campistol, J.M.2    Millán, O.3
  • 29
    • 0345490699 scopus 로고    scopus 로고
    • Assessment of immunosuppressive drug interactions: inhibition of lymphocyte function in peripheral human blood
    • Barten M.J., Dhein S., Chang H., et al. Assessment of immunosuppressive drug interactions: inhibition of lymphocyte function in peripheral human blood. J Immunol Methods 2003, 283:99-114.
    • (2003) J Immunol Methods , vol.283 , pp. 99-114
    • Barten, M.J.1    Dhein, S.2    Chang, H.3
  • 30
    • 33846227941 scopus 로고    scopus 로고
    • Pharmacodynamics of T-cell function for monitoring immunosuppression
    • Barten M.J., Tarnok A., Garbade J., et al. Pharmacodynamics of T-cell function for monitoring immunosuppression. Cell Prolif 2007, 40:50-63.
    • (2007) Cell Prolif , vol.40 , pp. 50-63
    • Barten, M.J.1    Tarnok, A.2    Garbade, J.3
  • 31
    • 1142310583 scopus 로고    scopus 로고
    • Monitoring of NFAT-regulated gene expression in the peripheral blood of allograft recipients: a novel perspective toward individually optimized drug doses of cyclosporine A
    • Giese T., Zeier M., Schemmer P., et al. Monitoring of NFAT-regulated gene expression in the peripheral blood of allograft recipients: a novel perspective toward individually optimized drug doses of cyclosporine A. Transplantation 2004, 77:339-344.
    • (2004) Transplantation , vol.77 , pp. 339-344
    • Giese, T.1    Zeier, M.2    Schemmer, P.3
  • 32
    • 77649235913 scopus 로고    scopus 로고
    • How to do successful gene expression analysis using real-time PCR
    • Derveaux S., Vandesompele J., Hellemans J. How to do successful gene expression analysis using real-time PCR. Methods 2010, 50:227-230.
    • (2010) Methods , vol.50 , pp. 227-230
    • Derveaux, S.1    Vandesompele, J.2    Hellemans, J.3
  • 33
    • 4344653892 scopus 로고    scopus 로고
    • Analysis of NFAT-regulated gene expression in vivo: a novel perspective for optimal individualized doses of calcineurin inhibitors
    • Giese T., Zeier M., Meuer S. Analysis of NFAT-regulated gene expression in vivo: a novel perspective for optimal individualized doses of calcineurin inhibitors. Nephrol Dial Transplant 2004, 19(suppl. 4):iv55-iv60.
    • (2004) Nephrol Dial Transplant , vol.19 , Issue.SUPPL. 4
    • Giese, T.1    Zeier, M.2    Meuer, S.3
  • 34
    • 77957258769 scopus 로고    scopus 로고
    • Biomarkers as a tool for management of immunosuppression in transplant patients
    • Wieland E., Olbricht C.J., Süsal C., et al. Biomarkers as a tool for management of immunosuppression in transplant patients. Ther Drug Monit 2010, 32:560-572.
    • (2010) Ther Drug Monit , vol.32 , pp. 560-572
    • Wieland, E.1    Olbricht, C.J.2    Süsal, C.3
  • 35
    • 1642580757 scopus 로고    scopus 로고
    • Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
    • Matloubian M., Lo C.G., Cinamon G., et al. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature 2004, 427:355-360.
    • (2004) Nature , vol.427 , pp. 355-360
    • Matloubian, M.1    Lo, C.G.2    Cinamon, G.3
  • 36
    • 45449099491 scopus 로고    scopus 로고
    • Activity of nuclear factor of activated T cells is independent of the number of peripheral lymphocytes in FTY720-treated patients
    • Sommerer C., Morath C., Giese T., Meuer S., Zeier M. Activity of nuclear factor of activated T cells is independent of the number of peripheral lymphocytes in FTY720-treated patients. Transplant Proc 2008, 40:1416-1418.
    • (2008) Transplant Proc , vol.40 , pp. 1416-1418
    • Sommerer, C.1    Morath, C.2    Giese, T.3    Meuer, S.4    Zeier, M.5
  • 37
    • 38149059079 scopus 로고    scopus 로고
    • Ciclosporin A tapering monitored by NFAT-regulated gene expression: a new concept of individual immunosuppression
    • Sommerer C., Giese T., Schmidt J., Meuer S., Zeier M. Ciclosporin A tapering monitored by NFAT-regulated gene expression: a new concept of individual immunosuppression. Transplantation 2008, 85:15-21.
    • (2008) Transplantation , vol.85 , pp. 15-21
    • Sommerer, C.1    Giese, T.2    Schmidt, J.3    Meuer, S.4    Zeier, M.5
  • 38
    • 78349293045 scopus 로고    scopus 로고
    • Pharmacodynamic monitoring of cyclosporine A by NFAT-regulated gene expression and the relationship with infectious complications in pediatric renal transplant recipients
    • Billing H., Giese T., Sommerer C., et al. Pharmacodynamic monitoring of cyclosporine A by NFAT-regulated gene expression and the relationship with infectious complications in pediatric renal transplant recipients. Pediatr Transplant 2010, 14:844-851.
    • (2010) Pediatr Transplant , vol.14 , pp. 844-851
    • Billing, H.1    Giese, T.2    Sommerer, C.3
  • 39
    • 33751531164 scopus 로고    scopus 로고
    • Pharmacodynamic monitoring of cyclosporine a in renal allograft recipients shows a quantitative relationship between immunosuppression and the occurrence of recurrent infections and malignancies
    • Sommerer C., Konstandin M., Dengler T., et al. Pharmacodynamic monitoring of cyclosporine a in renal allograft recipients shows a quantitative relationship between immunosuppression and the occurrence of recurrent infections and malignancies. Transplantation 2006, 82:1280-1285.
    • (2006) Transplantation , vol.82 , pp. 1280-1285
    • Sommerer, C.1    Konstandin, M.2    Dengler, T.3
  • 40
    • 77953359811 scopus 로고    scopus 로고
    • Individualized monitoring of nuclear factor of activated T cells-regulated gene expression in FK506-treated kidney transplant recipients
    • Sommerer C., Zeier M., Meuer S., Giese T. Individualized monitoring of nuclear factor of activated T cells-regulated gene expression in FK506-treated kidney transplant recipients. Transplantation 2010, 89:1417-1423.
    • (2010) Transplantation , vol.89 , pp. 1417-1423
    • Sommerer, C.1    Zeier, M.2    Meuer, S.3    Giese, T.4
  • 41
    • 35748980556 scopus 로고    scopus 로고
    • Pharmacodynamic cyclosporine A monitoring: relation of gene expression in lymphocytes to cyclosporine blood levels in cardiac allograft recipients
    • Konstandin M.H., Sommerer C., Doesch A., et al. Pharmacodynamic cyclosporine A monitoring: relation of gene expression in lymphocytes to cyclosporine blood levels in cardiac allograft recipients. Transpl Int 2007, 20:1036-1043.
    • (2007) Transpl Int , vol.20 , pp. 1036-1043
    • Konstandin, M.H.1    Sommerer, C.2    Doesch, A.3
  • 42
    • 52649095428 scopus 로고    scopus 로고
    • Pharmacodynamic immune monitoring of NFAT-regulated genes predicts skin cancer in elderly long-term renal transplant recipients
    • Sommerer C., Hartschuh W., Enk A., Meuer S., Zeier M., Giese T. Pharmacodynamic immune monitoring of NFAT-regulated genes predicts skin cancer in elderly long-term renal transplant recipients. Clin Transplant 2008, 22:549-554.
    • (2008) Clin Transplant , vol.22 , pp. 549-554
    • Sommerer, C.1    Hartschuh, W.2    Enk, A.3    Meuer, S.4    Zeier, M.5    Giese, T.6
  • 43
    • 58049219003 scopus 로고    scopus 로고
    • Pharmacodynamic monitoring of calcineurin inhibitor therapy: is there a clinical benefit?
    • Sommerer C., Giese T., Meuer S., Zeier M. Pharmacodynamic monitoring of calcineurin inhibitor therapy: is there a clinical benefit?. Nephrol Dial Transplant 2009, 24:21-27.
    • (2009) Nephrol Dial Transplant , vol.24 , pp. 21-27
    • Sommerer, C.1    Giese, T.2    Meuer, S.3    Zeier, M.4
  • 44
    • 77952571260 scopus 로고    scopus 로고
    • Approaches towards individualized immune intervention
    • Giese T., Sommerer C., Zeier M., Meuer S. Approaches towards individualized immune intervention. Dig Dis 2010, 28:45-50.
    • (2010) Dig Dis , vol.28 , pp. 45-50
    • Giese, T.1    Sommerer, C.2    Zeier, M.3    Meuer, S.4
  • 45
    • 84862774280 scopus 로고    scopus 로고
    • Immunomonitoring of NFAT-regulated gene expression: clinical benefit of clinical stable renal allograft recipients
    • [Abstract #P198]
    • Sommerer C., Zeier M., Meuer S., Giese T. Immunomonitoring of NFAT-regulated gene expression: clinical benefit of clinical stable renal allograft recipients. Ther Drug Monit 2011, 33:469. [Abstract #P198].
    • (2011) Ther Drug Monit , vol.33 , pp. 469
    • Sommerer, C.1    Zeier, M.2    Meuer, S.3    Giese, T.4
  • 46
    • 84862771411 scopus 로고    scopus 로고
    • Monitoring of NFAT-regulated gene expression for safe tapering of CNI immunosuppression in BK virus positive renal transplant patients
    • [Abstract #4003]
    • Sommerer C., Beimler J., Meuer S., Giese T., Zeier M. Monitoring of NFAT-regulated gene expression for safe tapering of CNI immunosuppression in BK virus positive renal transplant patients. J Am Soc Nephrol 2007, 18:1000. [Abstract #4003].
    • (2007) J Am Soc Nephrol , vol.18 , pp. 1000
    • Sommerer, C.1    Beimler, J.2    Meuer, S.3    Giese, T.4    Zeier, M.5
  • 47
    • 84862770115 scopus 로고    scopus 로고
    • Residual NFAT-regulated gene expression as prognostic indicator for ciclosporin A induced gingival overgrowth
    • [Abstract #1720]
    • Sommerer C., Dannewitz B., Kruck E.M., Giese T., Meuer S., Zeier M. Residual NFAT-regulated gene expression as prognostic indicator for ciclosporin A induced gingival overgrowth. Am J Transplant 2010, 10(Suppl. 4):529. [Abstract #1720].
    • (2010) Am J Transplant , vol.10 , Issue.SUPPL. 4 , pp. 529
    • Sommerer, C.1    Dannewitz, B.2    Kruck, E.M.3    Giese, T.4    Meuer, S.5    Zeier, M.6
  • 48
    • 84862767946 scopus 로고    scopus 로고
    • Pharmacodynamic monitoring of CsA therapy in the early posttransplant period
    • [Abstract #MO518]
    • Sommerer C., Zeier M., Meuer S., Giese T. Pharmacodynamic monitoring of CsA therapy in the early posttransplant period. Kidney Int 2011, (Suppl.):1000. [Abstract #MO518].
    • (2011) Kidney Int , Issue.SUPPL. , pp. 1000
    • Sommerer, C.1    Zeier, M.2    Meuer, S.3    Giese, T.4
  • 49
    • 80051802715 scopus 로고    scopus 로고
    • Pharmacodynamic disparities in tacrolimus treated patients developing CMV viremia
    • Sommerer C., Zeier M., Czock D., Schnitzler P., Meuer S., Giese T. Pharmacodynamic disparities in tacrolimus treated patients developing CMV viremia. Ther Drug Monit 2011, 33:373-379.
    • (2011) Ther Drug Monit , vol.33 , pp. 373-379
    • Sommerer, C.1    Zeier, M.2    Czock, D.3    Schnitzler, P.4    Meuer, S.5    Giese, T.6
  • 50
    • 0034721108 scopus 로고    scopus 로고
    • Immunophilins may limit calcineurin inhibition by cyclosporine and tacrolimus at high drug concentrations
    • Kung L., Halloran P.F. Immunophilins may limit calcineurin inhibition by cyclosporine and tacrolimus at high drug concentrations. Transplantation 2000, 70:327-335.
    • (2000) Transplantation , vol.70 , pp. 327-335
    • Kung, L.1    Halloran, P.F.2
  • 51
    • 75649088107 scopus 로고    scopus 로고
    • Pharmacodynamic monitoring of calcineurin inhibition therapy: principles, performance, and perspectives
    • van Rossum H.H., de Fijter J.W., van Pelt J. Pharmacodynamic monitoring of calcineurin inhibition therapy: principles, performance, and perspectives. Ther Drug Monit 2010, 32:3-10.
    • (2010) Ther Drug Monit , vol.32 , pp. 3-10
    • van Rossum, H.H.1    de Fijter, J.W.2    van Pelt, J.3
  • 52
    • 13244279503 scopus 로고    scopus 로고
    • Distinct inhibitory effects of tacrolimus and cyclosporin A on calcineurin phosphatase activity
    • Fukudo M., Yano I., Masuda S., Okuda M., Inui K. Distinct inhibitory effects of tacrolimus and cyclosporin A on calcineurin phosphatase activity. J Pharmacol Exp Ther 2005, 312:816-825.
    • (2005) J Pharmacol Exp Ther , vol.312 , pp. 816-825
    • Fukudo, M.1    Yano, I.2    Masuda, S.3    Okuda, M.4    Inui, K.5
  • 53
    • 79953167881 scopus 로고    scopus 로고
    • Immunomonitoring of nuclear factor of activated T cells-regulated gene expression: the first clinical trial in liver allograft recipients
    • Zahn A., Schott N., Hinz U., et al. Immunomonitoring of nuclear factor of activated T cells-regulated gene expression: the first clinical trial in liver allograft recipients. Liver Transpl 2011, 17:466-473.
    • (2011) Liver Transpl , vol.17 , pp. 466-473
    • Zahn, A.1    Schott, N.2    Hinz, U.3
  • 54
    • 79953168015 scopus 로고    scopus 로고
    • Monitoring of nuclear factor of activated T-cell regulated gene expression in de novo and long-term liver transplant recipients treated with cyclosporine A
    • Herden U., Kromminga A., Hagel C., et al. Monitoring of nuclear factor of activated T-cell regulated gene expression in de novo and long-term liver transplant recipients treated with cyclosporine A. Ther Drug Monit 2011, 33:185-191.
    • (2011) Ther Drug Monit , vol.33 , pp. 185-191
    • Herden, U.1    Kromminga, A.2    Hagel, C.3
  • 55
    • 84875626172 scopus 로고    scopus 로고
    • Differential suppression of NFAT-regulated genes on ciclosporin A therapy in paediatric and adult renal allograft recipients
    • [Abstract #P010]
    • Billing H., Sommerer C., Giese T., Meuer S., Tönshoff B., Czock D. Differential suppression of NFAT-regulated genes on ciclosporin A therapy in paediatric and adult renal allograft recipients. Klin Padiatr 2011, 223:S38. [Abstract #P010].
    • (2011) Klin Padiatr , vol.223
    • Billing, H.1    Sommerer, C.2    Giese, T.3    Meuer, S.4    Tönshoff, B.5    Czock, D.6
  • 56
    • 65549124916 scopus 로고    scopus 로고
    • Potent early immune response after kidney transplantation in patients of the European senior transplant program
    • Pratschke J., Merk V., Reutzel-Selke A., et al. Potent early immune response after kidney transplantation in patients of the European senior transplant program. Transplantation 2009, 87:992-1000.
    • (2009) Transplantation , vol.87 , pp. 992-1000
    • Pratschke, J.1    Merk, V.2    Reutzel-Selke, A.3
  • 58
    • 52449116523 scopus 로고    scopus 로고
    • Non-melanoma skin cancer incidence and risk factors after kidney transplantation: a Canadian experience
    • Comeau S., Jensen L., Cockfield S.M., Sapijaszko M., Gourishankar S. Non-melanoma skin cancer incidence and risk factors after kidney transplantation: a Canadian experience. Transplantation 2008, 86:535-541.
    • (2008) Transplantation , vol.86 , pp. 535-541
    • Comeau, S.1    Jensen, L.2    Cockfield, S.M.3    Sapijaszko, M.4    Gourishankar, S.5
  • 60
    • 84875635259 scopus 로고    scopus 로고
    • Pharmacodynamic monitoring of ciclosporin A in renal transplant recipients >65years reveals risk of opportunistic infection.
    • in press.
    • Sommerer C, Schnitzler P, Meuer S, Zeier M, Giese T. Pharmacodynamic monitoring of ciclosporin A in renal transplant recipients >65years reveals risk of opportunistic infection. Ther Drug Monit in press.
    • Ther Drug Monit
    • Sommerer, C.1    Schnitzler, P.2    Meuer, S.3    Zeier, M.4    Giese, T.5
  • 61
    • 3042651960 scopus 로고    scopus 로고
    • Defective inhibition of peripheral CD8+ T cell IL-2 production by anti-calcineurin drugs during acute liver allograft rejection
    • Boleslawski E., Conti F., Sanquer S., et al. Defective inhibition of peripheral CD8+ T cell IL-2 production by anti-calcineurin drugs during acute liver allograft rejection. Transplantation 2004, 77:1815-1820.
    • (2004) Transplantation , vol.77 , pp. 1815-1820
    • Boleslawski, E.1    Conti, F.2    Sanquer, S.3
  • 62
    • 78149284732 scopus 로고    scopus 로고
    • Biomarkers of immunoregulatory status in stable liver transplant recipients undergoing weaning of immunosuppressive therapy
    • Millán O., Benitez C., Guillén D., et al. Biomarkers of immunoregulatory status in stable liver transplant recipients undergoing weaning of immunosuppressive therapy. Clin Immunol 2010, 137:337-346.
    • (2010) Clin Immunol , vol.137 , pp. 337-346
    • Millán, O.1    Benitez, C.2    Guillén, D.3


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