메뉴 건너뛰기




Volumn 24, Issue 1, 2009, Pages 21-27

Pharmacodynamic monitoring of calcineurin inhibitor therapy: Is there a clinical benefit?

Author keywords

Calcineurin inhibitor; Pharmacodynamic; Renal transplantation; Therapeutic drug monitoring

Indexed keywords

BASILIXIMAB; CALCINEURIN; CALCINEURIN INHIBITOR; CYTOKINE; GAMMA INTERFERON; HLA ANTIBODY; INTERLEUKIN 2;

EID: 58049219003     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfn556     Document Type: Review
Times cited : (40)

References (74)
  • 1
    • 0034594881 scopus 로고    scopus 로고
    • Improved graft survival after renal transplantation in the United States, 1988 to 1996
    • Hariharan S, Johnson CP, Bresnahan BA et al. Improved graft survival after renal transplantation in the United States, 1988 to 1996. N Engl J Med 2000; 342: 605-612
    • (2000) N Engl J Med , vol.342 , pp. 605-612
    • Hariharan, S.1    Johnson, C.P.2    Bresnahan, B.A.3
  • 2
    • 0031001622 scopus 로고    scopus 로고
    • FK506 Kidney Transplant Study Group. A comparison of tacrolimus (FK506) and cyclosporine for immunosuppression after cadaveric renal transplantation
    • Pirsch JD, Miller J, Deierhoi MH et al. FK506 Kidney Transplant Study Group. A comparison of tacrolimus (FK506) and cyclosporine for immunosuppression after cadaveric renal transplantation. Transplantation 1997; 63: 977-983
    • (1997) Transplantation , vol.63 , pp. 977-983
    • Pirsch, J.D.1    Miller, J.2    Deierhoi, M.H.3
  • 3
    • 4143127834 scopus 로고    scopus 로고
    • Calcineurin inhibitor nephrotoxicity: Longitudinal assessment by protocol histology
    • Nankivell BJ, Borrows RJ, Fung CL et al. Calcineurin inhibitor nephrotoxicity: longitudinal assessment by protocol histology. Transplantation 2004; 78: 557-565
    • (2004) Transplantation , vol.78 , pp. 557-565
    • Nankivell, B.J.1    Borrows, R.J.2    Fung, C.L.3
  • 4
    • 0036780469 scopus 로고    scopus 로고
    • Cyclosporin A toxicity of the renal allograft - a late complication and potentially reversible
    • Sommerer C, Hergesell O, Nahm AM et al. Cyclosporin A toxicity of the renal allograft - a late complication and potentially reversible. Nephron 2002; 92: 339-345
    • (2002) Nephron , vol.92 , pp. 339-345
    • Sommerer, C.1    Hergesell, O.2    Nahm, A.M.3
  • 5
    • 0032574187 scopus 로고    scopus 로고
    • Effect of long-term immunosuppression in kidney - graft recipients on cancer incidence: Randomised comparison of two cyclosporin regimens
    • Dantal J, Hourmant M, Cantarovich D et al. Effect of long-term immunosuppression in kidney - graft recipients on cancer incidence: randomised comparison of two cyclosporin regimens. Lancet 1998; 351: 623-628
    • (1998) Lancet , vol.351 , pp. 623-628
    • Dantal, J.1    Hourmant, M.2    Cantarovich, D.3
  • 7
    • 33646350026 scopus 로고    scopus 로고
    • Slowing the progression of chronic allograft nephropathy by conversion from cyclosporine to tacrolimus: A randomized controlled trial
    • Meier M, Nitschke M, Weidtmann B et al. Slowing the progression of chronic allograft nephropathy by conversion from cyclosporine to tacrolimus: a randomized controlled trial. Transplantation 2006; 81: 1035-1040
    • (2006) Transplantation , vol.81 , pp. 1035-1040
    • Meier, M.1    Nitschke, M.2    Weidtmann, B.3
  • 8
    • 0024976004 scopus 로고
    • Cyclosporine
    • Kahan BD. Cyclosporine. N Engl J Med 1989; 321: 1725-1738
    • (1989) N Engl J Med , vol.321 , pp. 1725-1738
    • Kahan, B.D.1
  • 9
    • 0029789453 scopus 로고    scopus 로고
    • Variable oral absorption of cyclosporine. A biopharmaceutical risk factor for chronic renal allograft rejection
    • Kahan BD, Welsh M, Schoenberg L et al. Variable oral absorption of cyclosporine. A biopharmaceutical risk factor for chronic renal allograft rejection. Transplantation 1996; 62: 599-606
    • (1996) Transplantation , vol.62 , pp. 599-606
    • Kahan, B.D.1    Welsh, M.2    Schoenberg, L.3
  • 10
    • 0036150427 scopus 로고    scopus 로고
    • Two-hour cyclosporine concentration determination: An appropriate tool to monitor neoral therapy?
    • Oellerich M, Armstrong VW. Two-hour cyclosporine concentration determination: an appropriate tool to monitor neoral therapy? Ther Drug Monit 2002; 24: 40-46
    • (2002) Ther Drug Monit , vol.24 , pp. 40-46
    • Oellerich, M.1    Armstrong, V.W.2
  • 11
    • 0242300598 scopus 로고    scopus 로고
    • 2 monitoring in maintenance renal transplant recipients: Is it worthwhile?
    • 2 monitoring in maintenance renal transplant recipients: is it worthwhile? Transplantation 2003; 76: 1236-1238
    • (2003) Transplantation , vol.76 , pp. 1236-1238
    • Midtvedt, K.1    Fauchald, P.2    Bergan, S.3
  • 12
    • 0347917073 scopus 로고    scopus 로고
    • 2 monitoring in stable renal allograft recipients on maintenance immunosuppression
    • 2 monitoring in stable renal allograft recipients on maintenance immunosuppression. Nephrol Dial Transplant 2004; 19: 215-222
    • (2004) Nephrol Dial Transplant , vol.19 , pp. 215-222
    • Einecke, G.1    Mai, I.2    Fritsche, L.3
  • 13
    • 1542422139 scopus 로고    scopus 로고
    • A randomized, prospective multicenter pharmacoepidemiologic study of cyclosporine microemulson in stable renal graft recipients. Report of the Canadian Neoral Renal Transplantation Study Group
    • Keown P, Cole E, Muirhead N et al. A randomized, prospective multicenter pharmacoepidemiologic study of cyclosporine microemulson in stable renal graft recipients. Report of the Canadian Neoral Renal Transplantation Study Group. Transplantation 1996; 62: 1744-1752
    • (1996) Transplantation , vol.62 , pp. 1744-1752
    • Keown, P.1    Cole, E.2    Muirhead, N.3
  • 14
    • 0036487978 scopus 로고    scopus 로고
    • Cyclosporine microemulsion (Neoral) absorption profiling and sparse-sample predictors during the first 3 months after renal transplantation
    • International Neoral Study Group
    • International Neoral Study Group. Cyclosporine microemulsion (Neoral) absorption profiling and sparse-sample predictors during the first 3 months after renal transplantation. Am J Transplant 2002; 2: 148-156
    • (2002) Am J Transplant , vol.2 , pp. 148-156
  • 15
    • 0033565808 scopus 로고    scopus 로고
    • Neoral monitoring by simplified sparse sampling area under the concentration-time curve: Its relationship to acute rejection and cyclosporine nephrotoxicity early after kidney transplantation
    • Mahalati K, Belitsky P, Sketris I et al. Neoral monitoring by simplified sparse sampling area under the concentration-time curve: its relationship to acute rejection and cyclosporine nephrotoxicity early after kidney transplantation. Transplantation 1999; 68: 55-62
    • (1999) Transplantation , vol.68 , pp. 55-62
    • Mahalati, K.1    Belitsky, P.2    Sketris, I.3
  • 16
    • 0036334289 scopus 로고    scopus 로고
    • Comparison of trough, 2-hour, and limited AUC blood sampling for monitoring cyclosporin (Neoral) at day 7 post-renal transplantation and incidence of rejection in the first month
    • Morris RG, Russ GR, Cervelli MJ et al. Comparison of trough, 2-hour, and limited AUC blood sampling for monitoring cyclosporin (Neoral) at day 7 post-renal transplantation and incidence of rejection in the first month. Ther Drug Monit 2002; 24: 479-486
    • (2002) Ther Drug Monit , vol.24 , pp. 479-486
    • Morris, R.G.1    Russ, G.R.2    Cervelli, M.J.3
  • 18
    • 0035086066 scopus 로고    scopus 로고
    • Approaching the therapeutic window for cyclosporine in kidney transplantation: A prospective study
    • Mahalati K, Belitsky P, West K et al. Approaching the therapeutic window for cyclosporine in kidney transplantation: a prospective study. J Am Soc Nephrol 2001; 12: 828-833
    • (2001) J Am Soc Nephrol , vol.12 , pp. 828-833
    • Mahalati, K.1    Belitsky, P.2    West, K.3
  • 19
    • 30344473298 scopus 로고    scopus 로고
    • Evolution of the absorption profile of cyclosporine A in renal transplant recipients: A longitudinal study of the de novo and maintenance phase
    • Büchler M, Chadban S, Cole E et al. Evolution of the absorption profile of cyclosporine A in renal transplant recipients: a longitudinal study of the de novo and maintenance phase. Nephrol Dial Transplant 2006; 21: 197-202
    • (2006) Nephrol Dial Transplant , vol.21 , pp. 197-202
    • Büchler, M.1    Chadban, S.2    Cole, E.3
  • 20
    • 0034743294 scopus 로고    scopus 로고
    • 2 monitoring strategy for optimising cyclosporine immunosuppression from the Neoral formulation. Bio Drugs 2001; 15: 279-290
    • 2 monitoring strategy for optimising cyclosporine immunosuppression from the Neoral formulation. Bio Drugs 2001; 15: 279-290
  • 21
    • 14944364123 scopus 로고    scopus 로고
    • 2 monitoring in long-term renal transplant recipients receiving cyclosporinemicroemulsion
    • 2 monitoring in long-term renal transplant recipients receiving cyclosporinemicroemulsion. Transplantation 2005; 79: 802-806
    • (2005) Transplantation , vol.79 , pp. 802-806
    • Citterio, F.1    Scata, M.C.2    Romagnoli, J.3
  • 22
    • 20144375595 scopus 로고    scopus 로고
    • 2 monitoring of cyclosporine a microemulsion: Results of a 12-month, randomized, multicenter study
    • 2 monitoring of cyclosporine a microemulsion: results of a 12-month, randomized, multicenter study. Transplantation 2005; 79: 577-583
    • (2005) Transplantation , vol.79 , pp. 577-583
    • Stefoni, S.1    Midtved, K.2    Cole, E.3
  • 25
    • 0242721632 scopus 로고    scopus 로고
    • Basiliximab widens the therapeutic window for AUC-monitored neoral therapy early after kidney transplantation
    • Balbontin F, Kiberd B, Singh D et al. Basiliximab widens the therapeutic window for AUC-monitored neoral therapy early after kidney transplantation. Transplant Proc 2003; 35: 2409-2411
    • (2003) Transplant Proc , vol.35 , pp. 2409-2411
    • Balbontin, F.1    Kiberd, B.2    Singh, D.3
  • 26
    • 0035671414 scopus 로고    scopus 로고
    • 2 level monitoring in de novo renal transplant recipients: The Toronto General Hospital experience
    • 2 level monitoring in de novo renal transplant recipients: the Toronto General Hospital experience. Transplant Proc 2001; 33: 3098-3099
    • (2001) Transplant Proc , vol.33 , pp. 3098-3099
    • Maham, N.1    Cardella, C.2    Cattran, D.3
  • 27
    • 33749818836 scopus 로고    scopus 로고
    • 0 monitoring in improving clinical outcomes in adult liver transplant recipients?
    • 0 monitoring in improving clinical outcomes in adult liver transplant recipients? Ther Drug Monit 2006; 28: 637-642
    • (2006) Ther Drug Monit , vol.28 , pp. 637-642
    • Marin, J.G.1    Levine, M.2    Ensom, M.H.3
  • 28
    • 34250792130 scopus 로고    scopus 로고
    • 2-level monitoring: A systematic review
    • 2-level monitoring: a systematic review. Transplantation 2007; 83: 1525-1535
    • (2007) Transplantation , vol.83 , pp. 1525-1535
    • Knight, S.R.1    Morris, P.J.2
  • 29
    • 33745492158 scopus 로고    scopus 로고
    • Biomarkers: The link between therapeutic drug monitoring and pharmacodynamics
    • Oellerich M, Barten MJ, Armstrong VW. Biomarkers: the link between therapeutic drug monitoring and pharmacodynamics. Ther Drug Monit 2006; 28: 35-38
    • (2006) Ther Drug Monit , vol.28 , pp. 35-38
    • Oellerich, M.1    Barten, M.J.2    Armstrong, V.W.3
  • 30
    • 0345490699 scopus 로고    scopus 로고
    • Assessment of immunosuppressive drug interaction: Inhibition of lymphocyte function in peripheral human blood
    • Barten MJ, Dhein S, Chang H et al. Assessment of immunosuppressive drug interaction: inhibition of lymphocyte function in peripheral human blood. J Immunol Methods 2003; 283: 99-114
    • (2003) J Immunol Methods , vol.283 , pp. 99-114
    • Barten, M.J.1    Dhein, S.2    Chang, H.3
  • 31
    • 0345144025 scopus 로고    scopus 로고
    • Quantification of immunosuppression by flow cytometry in stable renal transplant recipients
    • Stalder M, Birsan T, Holm B et al. Quantification of immunosuppression by flow cytometry in stable renal transplant recipients. Ther Drug Monit 2003; 25: 22-27
    • (2003) Ther Drug Monit , vol.25 , pp. 22-27
    • Stalder, M.1    Birsan, T.2    Holm, B.3
  • 32
    • 3142532435 scopus 로고    scopus 로고
    • In vitro evaluation of the effects of candidate immunosuppressive drugs: Flow cytometry and quantitative real-time PCRas two independent and correlated read-outs
    • Flores MG, Zhang S, Ha A et al. In vitro evaluation of the effects of candidate immunosuppressive drugs: flow cytometry and quantitative real-time PCRas two independent and correlated read-outs. J Immunol Methods 2004; 289: 123-135
    • (2004) J Immunol Methods , vol.289 , pp. 123-135
    • Flores, M.G.1    Zhang, S.2    Ha, A.3
  • 33
    • 0029881170 scopus 로고    scopus 로고
    • Cytokines and cell surface markers in prediction of cardiac allograft rejection
    • Chang DM, Ding YA, Kuo SY et al. Cytokines and cell surface markers in prediction of cardiac allograft rejection. Immunol Invest 1996; 25: 13-21
    • (1996) Immunol Invest , vol.25 , pp. 13-21
    • Chang, D.M.1    Ding, Y.A.2    Kuo, S.Y.3
  • 34
    • 0029980847 scopus 로고    scopus 로고
    • Pre-transplant cytotoxic donor T-cell activity specific to patient HLA class I antigens correlating with mortality after unrelated BMT
    • Speiser DE, Loliger CC, Siren MK et al. Pre-transplant cytotoxic donor T-cell activity specific to patient HLA class I antigens correlating with mortality after unrelated BMT. Br J Haematol 1996; 93: 935-939
    • (1996) Br J Haematol , vol.93 , pp. 935-939
    • Speiser, D.E.1    Loliger, C.C.2    Siren, M.K.3
  • 35
    • 0034662242 scopus 로고    scopus 로고
    • Donor-specific T-cell reactivity identifies kidney transplant patients in whom immunosuppressive therapy can be safely reduced
    • van Besouw NM, Van Der Mast BJ, de KP et al. Donor-specific T-cell reactivity identifies kidney transplant patients in whom immunosuppressive therapy can be safely reduced. Transplantation 2000; 70: 136-143
    • (2000) Transplantation , vol.70 , pp. 136-143
    • van Besouw, N.M.1    Van Der2    Mast, B.J.3    de, K.P.4
  • 36
    • 0028209501 scopus 로고
    • Failure of in vitro T-cell assays to predict clinical outcome after human kidney transplantation
    • Steinmann J, Kaden J, May G et al. Failure of in vitro T-cell assays to predict clinical outcome after human kidney transplantation. J Clin Lab Anal 1994; 8: 137-162
    • (1994) J Clin Lab Anal , vol.8 , pp. 137-162
    • Steinmann, J.1    Kaden, J.2    May, G.3
  • 37
    • 0033783795 scopus 로고    scopus 로고
    • Switch from cyclosporine A to tacrolimus in renal transplant recipients: Impact on Th1, Th2, and monokine responses
    • Weimer R, Melk A, Daniel V et al. Switch from cyclosporine A to tacrolimus in renal transplant recipients: impact on Th1, Th2, and monokine responses. Hum Immunol 2000; 61: 884-887
    • (2000) Hum Immunol , vol.61 , pp. 884-887
    • Weimer, R.1    Melk, A.2    Daniel, V.3
  • 38
    • 33750713319 scopus 로고    scopus 로고
    • Desensitization strategies enabling successful renal transplantation in highly sensitized patients
    • Beimler JH, Süsal C, Zeier M. Desensitization strategies enabling successful renal transplantation in highly sensitized patients. Clin Transplant 2006; 20: 7-12
    • (2006) Clin Transplant , vol.20 , pp. 7-12
    • Beimler, J.H.1    Süsal, C.2    Zeier, M.3
  • 39
    • 0036014948 scopus 로고    scopus 로고
    • Identification of highly responsive kidney transplant recipients using pre-transplant soluble CD30
    • Süsal C, Pelzl S, Döhler B et al. Identification of highly responsive kidney transplant recipients using pre-transplant soluble CD30. J Am Soc Nephrol 2002; 13: 1650-1656
    • (2002) J Am Soc Nephrol , vol.13 , pp. 1650-1656
    • Süsal, C.1    Pelzl, S.2    Döhler, B.3
  • 40
    • 33745767080 scopus 로고    scopus 로고
    • Post-transplant sCD30 and neopterin as predictors of chronic allograft nephropathy: Impact of different immunosuppressive regimens
    • Weimer R, Süsal C, Yildiz S et al. Post-transplant sCD30 and neopterin as predictors of chronic allograft nephropathy: impact of different immunosuppressive regimens. Am J Transpl 2006; 6: 1865-1874
    • (2006) Am J Transpl , vol.6 , pp. 1865-1874
    • Weimer, R.1    Süsal, C.2    Yildiz, S.3
  • 41
    • 0037626590 scopus 로고    scopus 로고
    • Immune cell function testing: An adjunct to therapeutic drug monitoring in transplant patient management
    • Kowalski RJ, Post DR, Schneider MC et al. Immune cell function testing: an adjunct to therapeutic drug monitoring in transplant patient management. Clin Transplant 2003; 17: 77-88
    • (2003) Clin Transplant , vol.17 , pp. 77-88
    • Kowalski, R.J.1    Post, D.R.2    Schneider, M.C.3
  • 42
    • 33748690103 scopus 로고    scopus 로고
    • Assessing relative risks of infection and rejection: A meta-analysis using an immune function assay
    • Kowalski RJ, Post DR, Mannon RB et al. Assessing relative risks of infection and rejection: a meta-analysis using an immune function assay. Transplantation 2006; 82: 663-668
    • (2006) Transplantation , vol.82 , pp. 663-668
    • Kowalski, R.J.1    Post, D.R.2    Mannon, R.B.3
  • 43
    • 33746865975 scopus 로고    scopus 로고
    • Assessing the risk of infection and rejection in Hispanic renal transplant recipients by means of an adenosine triphosphate release assay
    • Cadillo-Chavez R, de Echegaray S, Santiago-Delphin EA et al. Assessing the risk of infection and rejection in Hispanic renal transplant recipients by means of an adenosine triphosphate release assay. Transplant Proc 2006; 38: 918-920
    • (2006) Transplant Proc , vol.38 , pp. 918-920
    • Cadillo-Chavez, R.1    de Echegaray, S.2    Santiago-Delphin, E.A.3
  • 44
    • 0026643141 scopus 로고
    • Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation
    • Clipstone NA, Crabtree GR. Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation. Nature 1992; 357: 695-697
    • (1992) Nature , vol.357 , pp. 695-697
    • Clipstone, N.A.1    Crabtree, G.R.2
  • 45
    • 0033571210 scopus 로고    scopus 로고
    • The temporal profile of calcineurin inhibition by cyclosporine in vivo
    • Halloran PF, Helms LM, Kung L et al. The temporal profile of calcineurin inhibition by cyclosporine in vivo. Transplantation 1999; 68: 1356-1361
    • (1999) Transplantation , vol.68 , pp. 1356-1361
    • Halloran, P.F.1    Helms, L.M.2    Kung, L.3
  • 46
    • 0032846279 scopus 로고    scopus 로고
    • Inhibition of stimulated interleukin-2 production in whole blood: A practical measure of the cyclosporine effect
    • Stein CM, Murray JJ, Wood AJ. Inhibition of stimulated interleukin-2 production in whole blood: a practical measure of the cyclosporine effect. Clin Chem 1999; 45: 1477-1484
    • (1999) Clin Chem , vol.45 , pp. 1477-1484
    • Stein, C.M.1    Murray, J.J.2    Wood, A.J.3
  • 47
    • 0036893274 scopus 로고    scopus 로고
    • Delayed cytokine mRNA expression kinetics after T-lymphocyte co-stimulation: A quantitative measure of the efficacy of cyclosporine A-based immunosuppression
    • Hartel C, Fricke L, Schumacher N et al. Delayed cytokine mRNA expression kinetics after T-lymphocyte co-stimulation: a quantitative measure of the efficacy of cyclosporine A-based immunosuppression. Clin Chem 2002; 48: 2225-2231
    • (2002) Clin Chem , vol.48 , pp. 2225-2231
    • Hartel, C.1    Fricke, L.2    Schumacher, N.3
  • 48
    • 1642533461 scopus 로고    scopus 로고
    • Sensitivity of whole-blood T lymphocytes in individual patients to tacrolimus (FK 506): Impact of interleukin-2 mRNA expression as surrogate measure of immunosuppressive effect
    • Hartel C, Schumacher N, Fricke L et al. Sensitivity of whole-blood T lymphocytes in individual patients to tacrolimus (FK 506): impact of interleukin-2 mRNA expression as surrogate measure of immunosuppressive effect. Clin Chem 2004; 50: 141-151
    • (2004) Clin Chem , vol.50 , pp. 141-151
    • Hartel, C.1    Schumacher, N.2    Fricke, L.3
  • 49
    • 0026503434 scopus 로고
    • Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A
    • Fruman DA, Klee CB, Bierer BE et al. Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A. Proc Natl Acad Sci USA 1992; 89: 3686-3690
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 3686-3690
    • Fruman, D.A.1    Klee, C.B.2    Bierer, B.E.3
  • 50
    • 0029954497 scopus 로고    scopus 로고
    • Recovery of blood mononuclear cell calcineurin activity segregates two populations of renal transplant patients with different sensitivities to cyclosporine inhibition
    • Piccinini G, Gaspari F, Signorini O et al. Recovery of blood mononuclear cell calcineurin activity segregates two populations of renal transplant patients with different sensitivities to cyclosporine inhibition. Transplantation 1996; 61: 1526-1531
    • (1996) Transplantation , vol.61 , pp. 1526-1531
    • Piccinini, G.1    Gaspari, F.2    Signorini, O.3
  • 51
    • 0036487952 scopus 로고    scopus 로고
    • Blood tacrolimus levels and calcineurin phosphatase activity early after renal transplantation
    • Koefoed-Nielsen PB, Gesualdo MB, Poulsen JH et al. Blood tacrolimus levels and calcineurin phosphatase activity early after renal transplantation. Am J Transplant 2002; 2: 173-178
    • (2002) Am J Transplant , vol.2 , pp. 173-178
    • Koefoed-Nielsen, P.B.1    Gesualdo, M.B.2    Poulsen, J.H.3
  • 52
    • 0029028666 scopus 로고
    • Calcineurin activity is only partially inhibited in leukocytes of cyclosporine-treated patients
    • Batiuk TD, Pazderka F, Halloran P. Calcineurin activity is only partially inhibited in leukocytes of cyclosporine-treated patients. Transplantation 1995; 59: 1400-1404
    • (1995) Transplantation , vol.59 , pp. 1400-1404
    • Batiuk, T.D.1    Pazderka, F.2    Halloran, P.3
  • 53
    • 8644226828 scopus 로고    scopus 로고
    • Low-dose cyclosporine with mycophenolate mofetil induces similar calcineurin activity and cytokine inhibition as does standard-dose cyclosporine in stable renal allografts
    • Grinyo JM, Cruzado JM, Millan O et al. Low-dose cyclosporine with mycophenolate mofetil induces similar calcineurin activity and cytokine inhibition as does standard-dose cyclosporine in stable renal allografts. Transplantation 2004; 78: 1400-1403
    • (2004) Transplantation , vol.78 , pp. 1400-1403
    • Grinyo, J.M.1    Cruzado, J.M.2    Millan, O.3
  • 54
    • 0034870598 scopus 로고    scopus 로고
    • Whole-blood clacineurin activity is not predicted by cyclosporine blood concentration in renal transplant patients
    • Caruso R, Perico N, Cattaneo D et al. Whole-blood clacineurin activity is not predicted by cyclosporine blood concentration in renal transplant patients. Clin Chem 2001; 47: 1679-1687
    • (2001) Clin Chem , vol.47 , pp. 1679-1687
    • Caruso, R.1    Perico, N.2    Cattaneo, D.3
  • 55
    • 0037214522 scopus 로고    scopus 로고
    • Determination of serine/threonine protein phosphatase type 2B (PP2B) in lymphocytes by HPLC
    • Blanchet B, Hulin A, Duvoux C et al. Determination of serine/threonine protein phosphatase type 2B (PP2B) in lymphocytes by HPLC. Anal Biochem 2003; 312: 1-6
    • (2003) Anal Biochem , vol.312 , pp. 1-6
    • Blanchet, B.1    Hulin, A.2    Duvoux, C.3
  • 57
    • 33749429277 scopus 로고    scopus 로고
    • Spectrophotometric assay for calcineurin activity in leukocytes isolated from human blood
    • Sellar KJ, van Rossum HH, Romijn FPHT et al. Spectrophotometric assay for calcineurin activity in leukocytes isolated from human blood. Anal Biochem 2006; 358: 104-110
    • (2006) Anal Biochem , vol.358 , pp. 104-110
    • Sellar, K.J.1    van Rossum, H.H.2    Romijn, F.P.H.T.3
  • 58
    • 10744226204 scopus 로고    scopus 로고
    • Pharmacodynamic approach to immunosuppressive therapies using calcineurin inhibitors and mycophenolate mofetil
    • Millan O, Brunet M, Campistol JM et al. Pharmacodynamic approach to immunosuppressive therapies using calcineurin inhibitors and mycophenolate mofetil. Clin Chem 2003; 49: 1891-1899
    • (2003) Clin Chem , vol.49 , pp. 1891-1899
    • Millan, O.1    Brunet, M.2    Campistol, J.M.3
  • 59
    • 40449093233 scopus 로고    scopus 로고
    • Variation in leukocyte subset concentrations affects calcineurin activity measurement: Implications for pharmacodynamic monitoring strategies
    • van Rossum HH, Romijn FP, Sellar KJ et al. Variation in leukocyte subset concentrations affects calcineurin activity measurement: implications for pharmacodynamic monitoring strategies. Clin Chem 2008; 54: 517-524
    • (2008) Clin Chem , vol.54 , pp. 517-524
    • van Rossum, H.H.1    Romijn, F.P.2    Sellar, K.J.3
  • 60
    • 0032823696 scopus 로고    scopus 로고
    • Differences in Type 1 and Type 2 intracytoplasmic cytokines, detected by flow cytometry, according to immunosuppression (cyclosporine A vs. tacrolimus) in stable renal allograft recipients
    • Rostaing L, Puyoo O, Tkaczuk J et al. Differences in Type 1 and Type 2 intracytoplasmic cytokines, detected by flow cytometry, according to immunosuppression (cyclosporine A vs. tacrolimus) in stable renal allograft recipients. Clin Transplant 1999; 13: 400-409
    • (1999) Clin Transplant , vol.13 , pp. 400-409
    • Rostaing, L.1    Puyoo, O.2    Tkaczuk, J.3
  • 61
    • 33847167164 scopus 로고    scopus 로고
    • Validation of immunological biomarkers for the pharmacodynamic monitoring of immunosuppressive drugs in humans
    • Bohler T, Nolting J, Kamar N et al. Validation of immunological biomarkers for the pharmacodynamic monitoring of immunosuppressive drugs in humans. Ther Drug Monit 2007; 29: 77-86
    • (2007) Ther Drug Monit , vol.29 , pp. 77-86
    • Bohler, T.1    Nolting, J.2    Kamar, N.3
  • 62
    • 33846227941 scopus 로고    scopus 로고
    • Pharmacodynamics of T-cell function for monitoring immunosuppression
    • Barten MJ, Tarnok A, Garbade J et al. Pharmacodynamics of T-cell function for monitoring immunosuppression. Cell Prolif 2007; 40: 50-63
    • (2007) Cell Prolif , vol.40 , pp. 50-63
    • Barten, M.J.1    Tarnok, A.2    Garbade, J.3
  • 63
    • 0031936770 scopus 로고    scopus 로고
    • Independent regulation of cytokine genes in T cells
    • Fitzpatrick DR, Kelso A. Independent regulation of cytokine genes in T cells. Transplantation 1998; 65: 1-5
    • (1998) Transplantation , vol.65 , pp. 1-5
    • Fitzpatrick, D.R.1    Kelso, A.2
  • 64
    • 0031027528 scopus 로고    scopus 로고
    • Quantitative detection of immune activation transcripts as a diagnostic tool in kidney transplantation
    • Strehlau J, Pavlakis M, Lipman M et al. Quantitative detection of immune activation transcripts as a diagnostic tool in kidney transplantation. Proc Natl Acad Sci USA 1997; 94: 695-700
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 695-700
    • Strehlau, J.1    Pavlakis, M.2    Lipman, M.3
  • 65
    • 4344653892 scopus 로고    scopus 로고
    • Analysis of NFAT-regulated gene expression in vivo: A novel perspective for optimal individualized doses of calcineurin inhibitors
    • Giese T, Zeier M, Meuer S. Analysis of NFAT-regulated gene expression in vivo: a novel perspective for optimal individualized doses of calcineurin inhibitors. Nephrol Dial Transplant 2004; 19: S55-S60
    • (2004) Nephrol Dial Transplant , vol.19
    • Giese, T.1    Zeier, M.2    Meuer, S.3
  • 66
    • 1142310583 scopus 로고    scopus 로고
    • Monitoring of NFAT-regulated gene expression in the peripheral blood of allograft recipients: A novel perspective toward individually optimized drug doses of cyclosporine A
    • Giese T, Zeier M, Schemmer P et al. Monitoring of NFAT-regulated gene expression in the peripheral blood of allograft recipients: a novel perspective toward individually optimized drug doses of cyclosporine A. Transplantation 2004; 77: 339-344
    • (2004) Transplantation , vol.77 , pp. 339-344
    • Giese, T.1    Zeier, M.2    Schemmer, P.3
  • 67
    • 33751531164 scopus 로고    scopus 로고
    • Pharmacodynamic- monitoring of cyclosporine a in renal allograft recipients shows a quantitative relationship between immunosuppression and the occurrence of recurrent infections and malignancies
    • Sommerer C, Konstandin M, Dengler T et al. Pharmacodynamic- monitoring of cyclosporine a in renal allograft recipients shows a quantitative relationship between immunosuppression and the occurrence of recurrent infections and malignancies. Transplantation 2006; 82: 1280-1285
    • (2006) Transplantation , vol.82 , pp. 1280-1285
    • Sommerer, C.1    Konstandin, M.2    Dengler, T.3
  • 68
    • 0037323992 scopus 로고    scopus 로고
    • Calcineurin phosphatase activity and immunosuppression. A review on the role of calcineurin phosphatase activity and the immunosuppressive effect of cyclosporin A and tacrolimus
    • Jorgensen KA, Koefoed-Nielsen PB, Karamperis N. Calcineurin phosphatase activity and immunosuppression. A review on the role of calcineurin phosphatase activity and the immunosuppressive effect of cyclosporin A and tacrolimus. Scand J Immunol 2003; 57: 93-98
    • (2003) Scand J Immunol , vol.57 , pp. 93-98
    • Jorgensen, K.A.1    Koefoed-Nielsen, P.B.2    Karamperis, N.3
  • 69
    • 0027985339 scopus 로고
    • Inhibition of calcineurin phosphatase activity in adult bone marrow transplant patients treated with cyclosporine A
    • Pai SY, Fruman DA, Leong T et al. Inhibition of calcineurin phosphatase activity in adult bone marrow transplant patients treated with cyclosporine A. Blood 1994; 84: 3974-3979
    • (1994) Blood , vol.84 , pp. 3974-3979
    • Pai, S.Y.1    Fruman, D.A.2    Leong, T.3
  • 70
    • 1842472956 scopus 로고    scopus 로고
    • Calcineurin activity as a functional index of immunosuppression after allogeneic stem-cell transplantation
    • Sanquer S, Schwarzinger M, Maury S et al. Calcineurin activity as a functional index of immunosuppression after allogeneic stem-cell transplantation. Transplantation 2004; 77: 854-858
    • (2004) Transplantation , vol.77 , pp. 854-858
    • Sanquer, S.1    Schwarzinger, M.2    Maury, S.3
  • 71
    • 23444460244 scopus 로고    scopus 로고
    • Pharmacodynamic analysis of tacrolimus and cyclosporine in living-donor liver transplant patients
    • Fukudo M, Yano I, Masuda S et al. Pharmacodynamic analysis of tacrolimus and cyclosporine in living-donor liver transplant patients. Clin Pharmacol Ther 2005; 78: 168-181
    • (2005) Clin Pharmacol Ther , vol.78 , pp. 168-181
    • Fukudo, M.1    Yano, I.2    Masuda, S.3
  • 72
    • 35748980556 scopus 로고    scopus 로고
    • Pharmacodynamic cyclosporine A monitoring: Relation of gene expression in lymphocytes to cyclosporine blood levels in cardiac allograft recipients
    • Konstandin MH, Sommerer C, Doesch A, et al. Pharmacodynamic cyclosporine A monitoring: relation of gene expression in lymphocytes to cyclosporine blood levels in cardiac allograft recipients. Transpl Int 2007; 20: 1036-1043
    • (2007) Transpl Int , vol.20 , pp. 1036-1043
    • Konstandin, M.H.1    Sommerer, C.2    Doesch, A.3
  • 73
    • 52649095428 scopus 로고    scopus 로고
    • Pharmacodynamic immune monitoring of NFAT-regulated genes predicts skin cancer in elderly long-term renal transplant recipients
    • Sommerer C, Hartschuh W, Enk A et al. Pharmacodynamic immune monitoring of NFAT-regulated genes predicts skin cancer in elderly long-term renal transplant recipients. Clin Transplant 2008; 22: 549-554
    • (2008) Clin Transplant , vol.22 , pp. 549-554
    • Sommerer, C.1    Hartschuh, W.2    Enk, A.3
  • 74
    • 38149059079 scopus 로고    scopus 로고
    • Ciclosporin A tapering monitored by NFAT-regulated gene expression: A new concept of individual immunosuppression
    • Sommerer C, Giese T, Schmidt J et al. Ciclosporin A tapering monitored by NFAT-regulated gene expression: a new concept of individual immunosuppression. Transplantation 2008; 85: 15-21
    • (2008) Transplantation , vol.85 , pp. 15-21
    • Sommerer, C.1    Giese, T.2    Schmidt, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.