메뉴 건너뛰기




Volumn 42, Issue 6, 2012, Pages 2507-2512

The non-proteinogenic amino acids l-methionine sulfoximine and dl-phosphinothricin activate mTOR

Author keywords

Glutamine; Glutamine synthetase; Methionine sulfoximine; mTOR; Phosphinothricin

Indexed keywords

ESSENTIAL AMINO ACID; GLUTAMATE AMMONIA LIGASE; GLUTAMINE; MAMMALIAN TARGET OF RAPAMYCIN; METHIONINE SULFOXIMINE; PHOSPHINOTHRICIN; S6 KINASE;

EID: 84862758073     PISSN: 09394451     EISSN: 14382199     Source Type: Journal    
DOI: 10.1007/s00726-011-0981-4     Document Type: Article
Times cited : (7)

References (18)
  • 1
    • 50149112445 scopus 로고    scopus 로고
    • Inhibitors of glutamine synthetase and their potential application in medicine
    • 18691144 10.2174/138955708785132800 1:CAS:528:DC%2BD1cXovFWntLc%3D
    • L Berlicki 2008 Inhibitors of glutamine synthetase and their potential application in medicine Mini Rev Med Chem 8 869 878 18691144 10.2174/138955708785132800 1:CAS:528:DC%2BD1cXovFWntLc%3D
    • (2008) Mini Rev Med Chem , vol.8 , pp. 869-878
    • Berlicki, L.1
  • 2
    • 84860255359 scopus 로고    scopus 로고
    • Effects of essential amino acids or glutamine deprivation on intestinal permeability and protein synthesis in hct-8 cells: Involvement of gcn2 and mtor pathways
    • doi: 10.1007/s00726-010-0814-x
    • Boukhettala N, Claeyssens S, Bensifi M, Maurer B, Abed J, Lavoinne A, Dechelotte P, Coeffier M (2010) Effects of essential amino acids or glutamine deprivation on intestinal permeability and protein synthesis in hct-8 cells: involvement of gcn2 and mtor pathways. Amino Acids. doi: 10.1007/s00726-010- 0814-x
    • (2010) Amino Acids
    • Boukhettala, N.1    Claeyssens, S.2    Bensifi, M.3    Maurer, B.4    Abed, J.5    Lavoinne, A.6    Dechelotte, P.7    Coeffier, M.8
  • 3
    • 0026775030 scopus 로고
    • Transport system asc for neutral amino acids. An electroneutral sodium/amino acid cotransport sensitive to the membrane potential
    • 1569087 1:CAS:528:DyaK38Xitlarsrc%3D
    • O Bussolati PC Laris BM Rotoli V Dall'Asta GC Gazzola 1992 Transport system asc for neutral amino acids. An electroneutral sodium/amino acid cotransport sensitive to the membrane potential J Biol Chem 267 8330 8335 1569087 1:CAS:528:DyaK38Xitlarsrc%3D
    • (1992) J Biol Chem , vol.267 , pp. 8330-8335
    • Bussolati, O.1    Laris, P.C.2    Rotoli, B.M.3    Dall'Asta, V.4    Gazzola, G.C.5
  • 5
    • 0032929352 scopus 로고    scopus 로고
    • Amino acids are compatible osmolytes for volume recovery after hypertonic shrinkage in vascular endothelial cells
    • 10199817
    • V Dall'Asta O Bussolati R Sala A Parolari F Alamanni P Biglioli GC Gazzola 1999 Amino acids are compatible osmolytes for volume recovery after hypertonic shrinkage in vascular endothelial cells Am J Physiol 276 C865 C872 10199817
    • (1999) Am J Physiol , vol.276
    • Dall'Asta, V.1    Bussolati, O.2    Sala, R.3    Parolari, A.4    Alamanni, F.5    Biglioli, P.6    Gazzola, G.C.7
  • 6
    • 0034615560 scopus 로고    scopus 로고
    • Structure-function relationships of glutamine synthetases
    • 10708854 10.1016/S0167-4838(99)00270-8 1:CAS:528:DC%2BD3cXhsFGktLg%3D
    • D Eisenberg HS Gill GM Pfluegl SH Rotstein 2000 Structure-function relationships of glutamine synthetases Biochim Biophys Acta 1477 122 145 10708854 10.1016/S0167-4838(99)00270-8 1:CAS:528:DC%2BD3cXhsFGktLg%3D
    • (2000) Biochim Biophys Acta , vol.1477 , pp. 122-145
    • Eisenberg, D.1    Gill, H.S.2    Pfluegl, G.M.3    Rotstein, S.H.4
  • 7
    • 78650239404 scopus 로고    scopus 로고
    • Functions and regulation of the 70kda ribosomal s6 kinases
    • 20932932 10.1016/j.biocel.2010.09.018 1:CAS:528:DC%2BC3cXhsF2itrzN
    • TR Fenton IT Gout 2011 Functions and regulation of the 70kda ribosomal s6 kinases Int J Biochem Cell Biol 43 47 59 20932932 10.1016/j.biocel.2010.09.018 1:CAS:528:DC%2BC3cXhsF2itrzN
    • (2011) Int J Biochem Cell Biol , vol.43 , pp. 47-59
    • Fenton, T.R.1    Gout, I.T.2
  • 8
    • 23044474905 scopus 로고    scopus 로고
    • Amino acid transporters asct2 and lat1 in cancer: Partners in crime?
    • 15916903 10.1016/j.semcancer.2005.04.005 1:CAS:528:DC%2BD2MXmvVKntLY%3D
    • BC Fuchs BP Bode 2005 Amino acid transporters asct2 and lat1 in cancer: partners in crime? Semin Cancer Biol 15 254 266 15916903 10.1016/j.semcancer. 2005.04.005 1:CAS:528:DC%2BD2MXmvVKntLY%3D
    • (2005) Semin Cancer Biol , vol.15 , pp. 254-266
    • Fuchs, B.C.1    Bode, B.P.2
  • 9
    • 0017804058 scopus 로고
    • Differential inhibition of glutamine and gamma-glutamylcysteine synthetases by alpha-alkyl analogs of methionine sulfoximine that induce convulsions
    • 24637 1:CAS:528:DyaE1cXltVSqs7g%3D
    • OW Griffith A Meister 1978 Differential inhibition of glutamine and gamma-glutamylcysteine synthetases by alpha-alkyl analogs of methionine sulfoximine that induce convulsions J Biol Chem 253 2333 2338 24637 1:CAS:528:DyaE1cXltVSqs7g%3D
    • (1978) J Biol Chem , vol.253 , pp. 2333-2338
    • Griffith, O.W.1    Meister, A.2
  • 10
    • 1242317710 scopus 로고    scopus 로고
    • The glutamate/neutral amino acid transporter family slc1: Molecular, physiological and pharmacological aspects
    • 14530974 10.1007/s00424-003-1146-4 1:CAS:528:DC%2BD2cXhtVygtrc%3D
    • Y Kanai MA Hediger 2004 The glutamate/neutral amino acid transporter family slc1: molecular, physiological and pharmacological aspects Pflugers Arch 447 469 479 14530974 10.1007/s00424-003-1146-4 1:CAS:528:DC%2BD2cXhtVygtrc%3D
    • (2004) Pflugers Arch , vol.447 , pp. 469-479
    • Kanai, Y.1    Hediger, M.A.2
  • 11
    • 0034073638 scopus 로고    scopus 로고
    • Regulation of amino acid-sensitive tor signaling by leucine analogues in adipocytes
    • 10723090 10.1002/(SICI)1097-4644(20000501)77:2<234::AID-JCB7>3.0. CO;2-I 1:CAS:528:DC%2BD3cXit1Gktb0%3D
    • CJ Lynch HL Fox TC Vary LS Jefferson SR Kimball 2000 Regulation of amino acid-sensitive tor signaling by leucine analogues in adipocytes J Cell Biochem 77 234 251 10723090 10.1002/(SICI)1097-4644(20000501)77:2<234::AID-JCB7>3. 0.CO;2-I 1:CAS:528:DC%2BD3cXit1Gktb0%3D
    • (2000) J Cell Biochem , vol.77 , pp. 234-251
    • Lynch, C.J.1    Fox, H.L.2    Vary, T.C.3    Jefferson, L.S.4    Kimball, S.R.5
  • 12
    • 0036786523 scopus 로고    scopus 로고
    • Tissue-specific effects of chronic dietary leucine and norleucine supplementation on protein synthesis in rats
    • 12217901 1:CAS:528:DC%2BD38XotV2qsrk%3D
    • CJ Lynch SM Hutson BJ Patson A Vaval TC Vary 2002 Tissue-specific effects of chronic dietary leucine and norleucine supplementation on protein synthesis in rats Am J Physiol Endocrinol Metab 283 E824 E835 12217901 1:CAS:528:DC%2BD38XotV2qsrk%3D
    • (2002) Am J Physiol Endocrinol Metab , vol.283
    • Lynch, C.J.1    Hutson, S.M.2    Patson, B.J.3    Vaval, A.4    Vary, T.C.5
  • 13
    • 1242317638 scopus 로고    scopus 로고
    • Sodium-coupled neutral amino acid (system n/a) transporters of the slc38 gene family
    • 12845534 10.1007/s00424-003-1117-9 1:CAS:528:DC%2BD2cXhtVygtr4%3D
    • B Mackenzie JD Erickson 2004 Sodium-coupled neutral amino acid (system n/a) transporters of the slc38 gene family Pflugers Arch 447 784 795 12845534 10.1007/s00424-003-1117-9 1:CAS:528:DC%2BD2cXhtVygtr4%3D
    • (2004) Pflugers Arch , vol.447 , pp. 784-795
    • MacKenzie, B.1    Erickson, J.D.2
  • 17
    • 1342281232 scopus 로고    scopus 로고
    • Cats and hats: The slc7 family of amino acid transporters
    • 14770310 10.1007/s00424-003-1086-z 1:CAS:528:DC%2BD2cXhtVygt7k%3D
    • F Verrey EI Closs CA Wagner M Palacin H Endou Y Kanai 2004 Cats and hats: the slc7 family of amino acid transporters Pflugers Arch 447 532 542 14770310 10.1007/s00424-003-1086-z 1:CAS:528:DC%2BD2cXhtVygt7k%3D
    • (2004) Pflugers Arch , vol.447 , pp. 532-542
    • Verrey, F.1    Closs, E.I.2    Wagner, C.A.3    Palacin, M.4    Endou, H.5    Kanai, Y.6
  • 18
    • 78650510609 scopus 로고    scopus 로고
    • MTOR: From growth signal integration to cancer, diabetes and ageing
    • 21157483 10.1038/nrm3025 1:CAS:528:DC%2BC3cXhsFGqsbnK
    • R Zoncu A Efeyan DM Sabatini 2011 mTOR: from growth signal integration to cancer, diabetes and ageing Nat Rev Mol Cell Biol 12 21 35 21157483 10.1038/nrm3025 1:CAS:528:DC%2BC3cXhsFGqsbnK
    • (2011) Nat Rev Mol Cell Biol , vol.12 , pp. 21-35
    • Zoncu, R.1    Efeyan, A.2    Sabatini, D.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.