flexTMS - A novel repetitive transcranial magnetic stimulation device with freely programmable stimulus currents

IEEE Transactions on Biomedical Engineering

Volumn 59, Issue 7, 2012, Pages 1962-1970

  Gattinger, Norbert ^a   Moessnang, Georg ^a   Gleich, Bernhard ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Biomedical engineering; insulated gate bipolar transistor (IGBT); power electronics; stimulation device; transcranial magnetic stimulation (TMS)

Indexed keywords

ARBITRARY WAVEFORM; BURST MODE; ENERGY STORAGE CAPACITOR; FULL-BRIDGE; INTER-STIMULUS INTERVALS; MAGNETIC FIELD PULSE; MAGNETIC PULSE; NEURONAL POPULATIONS; PHYSIOLOGICAL EFFECTS; PULSE PARAMETER; PULSE SHAPES; PULSEWIDTHS; REPETITION RATE; RESEARCH GROUPS; STEP SIZE; STIMULATION DEVICES; STIMULATION PULSE; TRANSCRANIAL MAGNETIC STIMULATION;

BIOMAGNETISM; BIOMEDICAL ENGINEERING; BIPOLAR TRANSISTORS; BRIDGE CIRCUITS; ELECTRIC NETWORK TOPOLOGY; FUNCTIONAL ELECTRIC STIMULATION; MAGNETIC FIELDS; MAGNETIC POLARITY; POWER ELECTRONICS; PULSE REPETITION RATE;

PULSE GENERATORS;

ADULT; ARTICLE; ELECTROMYOGRAPHY; ENERGY STORAGE CAPACITOR; EQUIPMENT DESIGN; EVOKED MUSCLE RESPONSE; FEMALE; HUMAN; HUMAN EXPERIMENT; INSULATED GATE BIPOLAR TRANSISTOR; MAGNETISM; MALE; MEDICAL DEVICE; NORMAL HUMAN; SEMICONDUCTOR; THETA RHYTHM; TRANSCRANIAL MAGNETIC STIMULATION; TRANSCRANIAL MAGNETIC STIMULATION DEVICE; WAVEFORM;

ADULT; BIOMEDICAL ENGINEERING; ELECTROMYOGRAPHY; ELECTRONICS, MEDICAL; EQUIPMENT DESIGN; FEMALE; HUMANS; MALE; MIDDLE AGED; SOFTWARE; TRANSCRANIAL MAGNETIC STIMULATION;

EID: 84862750558     PISSN: 00189294     EISSN: 15582531     Source Type: Journal    
DOI: 10.1109/TBME.2012.2195180     Document Type: Article

References (34)

1. A. T. Barker, R. Jalinous, and I. L. Freeston, "Non-invasive magnetic stimulation of human motor cortex," Lancet, vol. 1, pp. 1106-1107, 1985. (Pubitemid 15075547)
2. M. Hallett, "Transcranial magnetic stimulation: A primer," Neuron, vol. 55, pp. 187-199, 2007.
3. H. Rothkegel, M. Sommer, W. Paulus, and N. Lang, "Impact of pulse duration in single pulse TMS," Clin. Neurophysiol., vol. 121, pp. 1915-1921, 2010.
4. M. Sandrini, C. Umiltà, and E. Rusconi, "The use of transcranial magnetic stimulation in cognitive neuroscience: A new synthesis of methodological issues," Neurosci. Biobehav. Rev., vol. 35, pp. 516-536, 2011.
5. L. Cárdenas-Morales, D. A. Nowak, T. Kammer, R. C. Wolf, and C. Schönfeldt-Lecuona, "Mechanisms and applications of theta-burst rTMS on the human motor cortex," Brain Topogr., vol. 22, pp. 294-306, 2010.
6. U. Najib, S. Bashir, D. Edwards, A. Rotenberg, and A. Pascual-Leone, "Transcranial brain stimulation: Clinical applications and future directions,"Neurosurg. Clin. N. Amer., vol. 22, pp. 233-251, 2011.
7. T. Kammer, S. Beck, A. Thielscher, U. Laubis-Herrmann, and H. Topka, "Motor thresholds in humans: A transcranial magnetic stimulation study comparing different pulse waveforms, current directions and stimulator types," Clin. Neurophysiol., vol. 112, pp. 250-258, 2001. (Pubitemid 32126456)
8. A. T. Barker, C. W. Garnham, and I. L. Freeston, "Magnetic nerve stimulation: The effect of waveform on efficiency, determination of neural membrane time constants and the measurement of stimulator output, "Electroencephalogr. Clin. Neurophysiol. Suppl., vol. 43, pp. 227-237, 1991.
9. G. S. Pell, Y. Roth, and A. Zangen, "Modulation of cortical excitability induced by repetitive transcranial magnetic stimulation: Influence of timing and geometrical parameters and underlying mechanisms," Prog. Neurobiol., vol. 93, pp. 59-98, 2011.
10. A. V. Peterchev, T. J. Spellman, and S. H. Lisanby, "cTMS: A novel TMS device inducing near rectangular pulses with controllable pulse width,"Neuropsychopharmacology, vol. 31, no. S1, p. S130, 2006.
11. A. V. Peterchev, R. Jalinous, and S. H. Lisanby, "A transcranial magnetic stimulator inducing near-rectangular pulses with controllable pulse width (cTMS)," IEEE Trans. Biomed. Eng., vol. 55, no. 1, pp. 257-266, Jan. 2008. (Pubitemid 350308413)
12. A. V. Peterchev, D. L. Murphy, and S. H. Lisanby, "Repetitive transcranial magnetic stimulator with controllable pulse parameters," in Proc. IEEE Eng. Med. Biol. Soc., 2010, vol. 2010, pp. 2922-2926.
13. A. V. Peterchev, D. L. Murphy, and S. H. Lisanby, "Repetitive transcranial magnetic stimulator with controllable pulse parameters," J. Neural Eng., vol. 8, 036016, Jun. 2011.
14. A. Pechmann, I. Delvendahl, T. O. Bergmann, C. Ritter, G. Hartwigsen, B. Gleich, N. Gattinger, V. Mall, and H. R. Siebner, "The number of full-sine cycles per pulse influences the efficacy of multicycle transcranial magnetic stimulation," Brain Stimulat., 2011, [Epup ahead of print; doi: 10.1016/j.brs.2011.02.006].
15. G. Hartwigsen, C. J. Price, A. Baumgaertner, G. Geiss, M. Koehnke, S. Ulmer, and H. R. Siebner, "The right posterior inferior frontal gyrus contributes to phonological word decisions in the healthy brain: Evidence from dual-site TMS," Neuropsychologia, vol. 48, no. 10, pp. 3155-3163, 2010.
16. S. Rossi, M. Hallett, P. M. Rossini, and A. Pascual-Leone, "Safety, ethical considerations, and application guidelines for the use of transcranial magnetic stimulation in clinical practice and research," Clin. Neurophysiol., vol. 120, no. 12, pp. 2008-2039, 2009.
17. C. K. Loo, J. L. Taylor, S. C. Gandevia, P. B. Mitchell, and P. S. Sachdev, "Stimulus intensity in transcranial magnetic stimulation (TMS) studies,"J. ECT, vol. 17, pp. 294-295, 2001.
18. J. L. Taylor and C. K. Loo, "Stimulus waveform influences the efficacy of repetitive transcranial magnetic stimulation," J. Affect Disord., vol. 97, pp. 271-276, 2007.
19. F. Awiszus, "Chapter 2 TMS and threshold hunting," in Transcranial Magnetic Stimulation and Transcranial Direct Current Stimulation, proceeding of the 2nd International Transcranial Magnetic stimulation (TMS) and Transcranial Direct Stimulation (tDCS) Symulation (Supplements to Clinical Neurophysiology), vol. 56, pp. 13-23, New York: Elsevier, 2003, ISBN: 978-0-444-51438-7.
20. F. Awiszus, "Fast estimation of transcranial magnetic stimulation motor threshold: Is it safe?" Brain Stimulat., vol. 4, no. 1, pp. 58-59, 2011.
21. F. Awiszus and F. Feistner, "Rapid on-line estimation of responses to transcranial magnetic and peripheral nerve electrical stimulation in single human motoneurons," J. Neurosci. Methods, vol. 61, no. 1-2, pp. 91-97, 1995.
22. M. C. Ridding and J. C. Rothwell, "Stimulus/response curves as a method of measuring motor cortical excitability in man," Electroencephalogr. Clin. Neurophysiol., vol. 105, no. 5, pp. 340-344, 1997.
23. A. Thielscher and T. Kammer, "Linking physics with physiology in TMS: A sphere field model to determine the cortical stimulation site in TMS,"Neuroimage, vol. 17, pp. 1117-1130, 2002. (Pubitemid 35333835)
24. T. Kammer, S. Beck, K. Puls, C. Roether, and A. Thielscher, "Motor and phosphene thresholds: Consequences of cortical anisotropy," Suppl. Clin. Neurophysiol., vol. 56, pp. 198-203, 2003.
25. N. Lang, J. Harms, T. Weyh, R. N. Lemon, W. Paulus, J. C. Rothwell, and H. R. Siebner, "Stimulus intensity and coil characteristics influence the efficacy of rTMS to suppress cortical excitability," Clin. Neurophysiol., vol. 117, pp. 2292-2301, 2006. (Pubitemid 44333265)
26. S. Tringali, X. Perrot, L. Collet, and A. Moulin, "Repetitive transcranial magnetic stimulation: Hearing safety considerations," Brain Stimulat., 2011, [Epup ahead of print; doi: 10.1016/j.brs.2011.06.005].
27. S. A. Counter, E. Borg, and L. Lofqvist, "Acoustic trauma in extracranial magnetic brain stimulation," Electroencephalogr. Clin. Neurophysiol., vol. 78, pp. 173-184, 1991.
28. S. A. Counter and E. Borg, "Analysis of the coil generated impulse noise in extracranial magnetic stimulation," Electroencephalogr. Clin. Neurophysiol., vol. 85, pp. 280-288, 1992.
29. V. Nikouline, J. Ruohonen, and R. J. Ilmoniemi, "The role of the coil click in TMS assessed with simultaneous EEG," Clin. Neurophysiol., vol. 110, pp. 1325-1328, 1999. (Pubitemid 29333867)
30. Y. Z. Huang, M. Sommer, G. Thickbroom, M. Hamada, A. Pascual-Leonne, W. Paulus, J. Classen, A. V. Peterchev, A. Zangen, and Y. Ugawa, "Consensus: New methodologies for brain stimulation," Brain Stimulat., vol. 2, pp. 2-13, 2009.
31. M. S. George, Z. Nahas, F. A. Kozel, X. Li, S. Denslow, K. Yamanaka, A. Mishory, M. J. Foust, and D. E. Bohning, "Mechanisms and state of the art of transcranial magnetic stimulation," J. ECT, vol. 18, pp. 170-181, 2002. (Pubitemid 35471056)
32. N. Arai, S. Okabe, T. Furubayashi, Y. Terao, K. Yuasa, and Y. Ugawa, "Comparison between short train, monophasic and biphasic repetitive transcranial magnetic stimulation (rTMS) of the human motor cortex,"Clin. Neurophysiol., vol. 116, pp. 605-613, 2005. (Pubitemid 40249828)
33. E. R. Kandel and W. A. Spencer, "Electrophysiology of hippocampal neurons: II. After-potentials and repetitive firing," J. Neurophysiol., vol. 24, pp. 243-259, 1961.
34. E. Corthout, A. T. Barker, and A. Cowey, "Transcranial magnetic stimulation. Which part of the current waveform causes the stimulation?" Exp Brain Res., vol. 141, pp. 128-132, 2001. (Pubitemid 32947226)