Freeze-dried xanthan/guar gum nasal inserts for the delivery of metoclopramide hydrochloride

Iranian Journal of Pharmaceutical Research

Volumn 11, Issue 2, 2012, Pages 513-521

  Dehghan, Mohamed Hassan ^a   Girase, Mohan ^a  

^a Y B CHAVAN COLLEGE OF PHARMACY   (India)

Author keywords

Bioadhesion; Guar gum; In vitro drug release; Metoclopramide hydrochloride; Nasal inserts; Xanthan gum

Indexed keywords

GUAR GUM; METOCLOPRAMIDE; POLYMER; XANTHAN;

ARTICLE; CHEMICAL INTERACTION; CONTROLLED STUDY; CRYSTALLIZATION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; DRUG RELEASE; FLOW KINETICS; FREEZE DRYING; GEL; IN VITRO STUDY; MUCOADHESION; MUCOCILIARY CLEARANCE; NASAL INSERT; VISCOSITY; WATER TRANSPORT; X RAY POWDER DIFFRACTION;

EID: 84862745633     PISSN: 17350328     EISSN: 17266890     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Costantino HR, Illum L, Brandt G, Johnson P, Quay SC. Intranasal delivery: physicochemical and therapeutic aspects. Int. J. Pharm. (2007) 337: 1-24.
2. Wolfe TR and Bernstone T. Intranasal drug delivery: an alternative to intravenous administration in selected emergency cases. J. Emergency Nursing (2004) 30: 141-147.
3. Merkus FW, Merkus FW, Verhoef JC, Schipper NG and Marttin E. Nasal mucociliary clearance as a factor in nasal drug delivery. Adv. Drug Deliv. Rev. (1998) 29: 13-38.
4. Verbeke N, Agu RU, Verbeke N and Kinget R. Nasal mucoadhesive drug delivery: background, applications, trends and future perspectives. Adv. Drug Deliv. Rev. (2005) 57: 1640-1665.
5. Bertram U and Bodmeier R. Parameters affecting the drug release from in-situ gelling nasal inserts. Eur. J. Pharm. Biopharm. (2006) 63: 310-319.
6. Zaki NM, Mortada ND, Awad GAS and Abd ElHady SS. Rapid onset intranasal delivery of metoclopramide hydrochloride. Part-1, Infuence of formulation variables on drug absorption in anesthetized rats. Int. J. Pharm. (2006) 327: 89-96.
7. nd edn. Churchill Livingstone. B57-B59.
8. Amundarain JL, Castro LJ, Rojas MR, Siquier S, Ramírez N, Müller AJ and Sáez AE. Solutions of xanthan gum/guar gum mixtures: shear rheology, porous media flow, and solids transport in annular flow. Rheol. Acta (2009) 48: 491-498.
9. Krishnaiah YSR, Karthikeyan RS, Gouri Sankar V and Satyanarayana V. Three-layer guar gum matrix tablet formulations for oral controlled delivery of highly soluble trimetazidinedihydrochloride. J. Control. Rel. (2002) 81: 45-56.
10. Patel VF and Patel NM. Statistical evaluation of influence of xanthan gum and guar gum blends on dipyridamole release from floating matrix tablets. Drug Dev. Ind. Pharm. (2007) 33: 327-334.
11. Bresolin TMB, Milas M, Rinaudo M and Ganter J. Xanthan and galactomannan (from M. scabrella) matrix tablets for oral controlled delivery of theophylline. Int. J. Pharm. (2005) 296: 1-11.
12. Mundargi RC and Patil SA. Development of polysaccharide based colon targeted drug delivery systems for the treatment of amoebiasis. Drug Dev. Ind. Pharm. (2007) 33: 255-264.
13. Phaechamud T and Ritthidej GC. Sustained-release from layered matrix system comprising chitosan and xanthan gum. Drug Dev. Ind. Pharm. (2007) 33: 595-605.
14. Kar R, Mohapatraa S, Bhanjaa S, Das D and Barik B. Formulation and in-vitro characterization of xanthan gum-based sustained release matrix tables of isosorbide-5- mononitrate. Iranian J. Pharm. Res. (2010) 9: 13-19.
15. Madsen F, Eberth K and Smart JD. A rheological examination of the mucoadhesive/mucus interaction: the effect of mucoadhesive type and concentration. J. Control. Rel. (1998) 50: 167-178.