Harmonease Chewable Tablets reduces noise-induced fear and anxiety in a laboratory canine thunderstorm simulation: A blinded and placebo-controlled study

Journal of Veterinary Behavior: Clinical Applications and Research

Volumn 7, Issue 4, 2012, Pages 225-232

  DePorter, Theresa L ^a   Landsberg, Gary M ^b   Araujo, Joseph A ^c,d   Ethier, Jennifer L ^d   Bledsoe, David L ^e  

^a Oakland Veterinary Referral Services   (United States)

^b North Toronto Animal Clinic   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d CanCog Technologies Incorporated   (Canada)

^e Veterinary Products Laboratories   (United States)

Author keywords

Anxiety; Fear; Honokiol; Laboratory model; Magnolia officinalis and Phellodendron amurense; Thunderstorm

Indexed keywords

CANIS FAMILIARIS; MAGNOLIA OFFICINALIS; MAGNOLIACEAE; PHELLODENDRON AMURENSE;

EID: 84862741284     PISSN: 15587878     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jveb.2011.05.024     Document Type: Article

References (27)

1. Araujo, J., Milgram, B., de Rivera, C., Landsberg, G., 2009. The development of laboratory models for the objective evaluation of anxiolytics in dogs. Proceedings of the Joint ACVB/AVSAB Scientific Meeting, 10 July 2009, Seattle, WA.
2. Araujo J.A., de Rivera C., Landsberg G.M., Milgram N.W. Development and validation of a novel laboratory model of sound-induced fear and anxiety in Beagle dogs. J. Vet. Behav. Clin: Appl. Res. 2012, Manuscript in review.
3. Chen J.K., Chen T.T. Heat-clearing herbs. Chinese medical herbology and pharmacology 2004, Art of Medicine Press, City of Industry, CA, pp. 145-146.
4. Chen J.K., Chen T.T. Aromatic damp-dissolving herbs. Chinese medical herbology and pharmacology 2004, Art of Medicine Press, City of Industry, CA, pp. 365-367.
5. Crowell-Davis S.L., Murray T. Veterinary psychopharmacology (Introduction) 2006, Blackwell Publishing, Ames, IA, pp. 16-18.
6. Dreschel N.A., Granger D.A. Physiological and behavioral reactivity to stress in thunderstorm-phobic dogs and their caregivers. Appl. Anim. Behav. Sci. 2005, 95:153-168.
7. Green S.B., Byar D.P. Using observational data from registries to compare treatments: the fallacy of omnimetrics. Stat. Med. 1984, 3:361-370.
8. Kalman D., Feldman S., Feldman R., Schwartz H., Krieger D., Garrison R. Effect of proprietary Magnolia and Phellodendron extract on stress levels in healthy women: a pilot, double-blind, placebo-controlled clinical trial. Nutr. J. 2008, 7:11.
9. Kuribara H., Stavinoha W.B., Maruyuma Y. Behavioral pharmacological characteristics of honokiol, an anxiolytic agent present in extracts of Magnolia bark, evaluated by an elevated plus-maze test in mice. J. Pharm. Pharmacol. 1998, 50:819-826.
10. Kuribara H., Stavinoha W.B., Maruyuma Y. Honokiol, a putative anxiolytic agent extracted from Magnolia bark has no diazepam-like side effects in mice. J. Pharm. Pharmacol. 1999, 51:97-103.
11. Landsberg G., Hunthausen W., Ackerman L. Complimentary and alternative therapy for behavior problems. Handbook of behavior problems of the dog and cat 2003, Saunders, London, UK, pp. 153-165. 2nd Ed.
12. Landsberg G., Hunthausen W., Ackerman L. Fears and phobias. Handbook of behavior problems of the dog and cat 2003, Saunders, London, UK, pp. 251-256. 2nd Ed.
13. Levine E.D., Mills D.S. Long term follow-up of the efficacy of a behavioural treatment programme for dogs with firework fears. Vet. Rec. 2008, 162:657-659.
14. Levine E.D., Ramos D., Mills D.S. A prospective study of two self help CD based desensitization and counter-conditioning programmes with the use of Dog Appeasing Pheromone for the treatment of firework fears in dogs (Canis familiaris). Appl. Anim. Behav. Sci. 2007, 105:311-329.
15. Maruyama Y., Kuribara H. Overview of the pharmacological features of honokiol. CNS Drug Rev. 2000, 6:35-44.
16. Maruyama Y., Kuribara H., Morita M., Mitutoshi Y., Weintraub S. Identification of magnolol and honokiol as anxiolytic agents in extracts of saiboku-to, an oriental herbal medicine. J. Nat. Prod. 1998, 61:135-138.
17. Mills D., Cracknell N. A double blind placebo controlled study into the efficacy of a homeopathic remedy for fear of firework noises in the dog (Canis familiaris). Vet. J. 2008, 177:80-88.
18. Overall K.L. Clinical behavioural medicine for small animals. Fears, anxieties and stereotypes 1997, Mosby, St Louis, MO, pp. 212-215.
19. Overall K.L. Pharmacological treatment in behavioural medicine: the importance of neurochemistry, molecular biology and mechanistic hypotheses (Review). Vet. J. 2001, 162:9-23.
20. Overall K.L., Dunham A.E. Homeopathy and the curse of the scientific method. Vet. J. 2009, 180:141-148.
21. Patocka J., Jakl J., Strunecka A. Expectations of biologically active compounds of the genus Magnolia in biomedicine. J. Appl. Biomed. 2006, 4:171-178.
22. Peng W., Wu C., Chen C., Chen C., Leu Z., Hsieh M. Anxiolytic effect of berberine on exploratory activity of the mouse in two experimental anxiety models: Interaction with drugs acting at 5-HT receptors. Life Sci. 2004, 75:2451-2462.
23. Scott S. Complementary, alternative and integrated therapies. BSAVA Manual of Canine and Feline Behavioural Health 2002, BSAVA, Gloucester, England, pp. 249-257. D. Horwitz, D. Mills, S. Heath (Eds.).
24. Sheppard G., Mills D.S. Evaluation of dog-appeasing pheromone as a potential treatment for dogs fearful of fireworks. Vet. Rec. 2003, 152:432-436.
25. Sherman B.L., Mills D.S. Canine anxieties and phobias: an update on separation anxiety and noise aversions. Vet. Clin. North Am. Small Anim.Pract. 2008, 38:1081-1106.
26. Sufka K.J., Roach J.T., Champbliss W.G., Broom S.L., Feltstein M.W., Wyandt C.M., Zeng L. Anxiolytic properties of botanical extracts in the chick social separation-stress procedure. Psychopharmacology (Berl) 2001, 153:219-224.
27. Xu Q., Yi L., Ying P., Wang X., Li Y., Li J., Wang C., Kong L. Antidepressant-like effects of the mixture of honokiol and magnolol from the barks of Magnolia officinalis in stressed rodents. Prog. Neuropsychopharmacol. Biol. Psychiatry 2008, 32:715-720.