"Inactivating" PF4: A new approach to HIT treatment?

Blood

Volumn 119, Issue 25, 2012, Pages 5951-5952

  Aster, Richard H ^a  

^a BLOOD RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT AGENT; ANTIVITAMIN K; FC RECEPTOR IIA; GLYCOSAMINOGLYCAN; HEPARIN; HEPARIN PLATELET FACTOR 4 ANTIBODY; IMMUNOGLOBULIN G; PROCOAGULANT; TETRAMER; THROMBIN INHIBITOR;

BLEEDING; CONCENTRATION (PARAMETERS); CONFORMATIONAL TRANSITION; HEPARIN INDUCED THROMBOCYTOPENIA; HUMAN; MORBIDITY; NOTE; PATHOGENESIS; PRIORITY JOURNAL; THROMBOCYTE COUNT; THROMBOSIS;

EID: 84862729236     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2012-04-422535     Document Type: Note

References (10)

1. Sachais BS, Rux AH, Cines DB, et al. Rational design and characterization of platelet factor 4 antagonists for the study of heparin-induced thrombocytopenia. Blood. 2012;119(25):5955-5962.
2. Arepally GM, Ortel TL. Clinical practice. Heparin-induced thrombocytopenia.NEngl J Med. 2006;355(8): 809-817.
3. Davoren A, Aster RH. Heparin-induced thrombocytopenia and thrombosis. Am J Hematol. 2006;81(1):36-44. (Pubitemid 43077211)
4. Warkentin TE. How I diagnose and manage HIT. Hematology Am Soc Hematol Educ Program. 2011;2011:143-149.
5. Aster RH. Heparin-independent activation of platelets by HIT antibodies: a clue to the etiology of delayed thrombocytopenia/ thrombosis in patients given heparin? J Thromb Haemost. 2005;3(10):2166-2167. (Pubitemid 41727192)
6. Rauova L, Hirsch JD, Greene TK, et al. Monocytebound PF4 in the pathogenesis of heparin-induced thrombocytopenia. Blood. 2010;116(23):5021-5031.
7. Chen MJ, Mayo KH. Human platelet factor 4 subunit association/ dissociation thermodynamics and kinetics. Biochemistry. 1991;30(26):6402-6411.
8. Rauova L, Poncz M, McKenzie SE, et al. Ultralarge complexes of PF4 and heparin are central to the pathogenesis of heparin-induced thrombocytopenia. Blood. 2005;105(1):131-138. (Pubitemid 40053074)
9. Rauova L, Zhai L, Kowalska MA, Arepally GM, Cines DB, Poncz M. Role of platelet surface PF4 antigenic complexes in heparin-induced thrombocytopenia pathogenesis: diagnostic and therapeutic implications. Blood. 2006;107(6):2346-2353. (Pubitemid 43345554)
10. Reilly MP, Taylor SM, Franklin C, et al. Prothrombotic factors enhance heparin-induced thrombocytopenia and thrombosis in vivo in a mouse model. J Thromb Haemost. 2006;4(12):2687-2694. (Pubitemid 44741566)