Identification of the cytochrome P450 and other enzymes involved in the in vitro oxidative metabolism of a novel antidepressant, Lu AA21004

Drug Metabolism and Disposition

Volumn 40, Issue 7, 2012, Pages 1357-1365

  Hvenegaard, Mette G ^a   Bang Andersen, Benny ^a   Pedersen, Henrik ^a   Jørgensen, Morten ^a   Püschl, Ask ^a   Dalgaard, Lars ^a  

^a H LUNDBECK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

1 [2 [2,4 DIMETHYL PHENYLSUFANYL] PHENYL] PIPERAZINE; 3 METHYL 4 [2 PIPERAZINE 1 YL PHENYLSULFANYL] BENZOIC ACID; 4 HYDROXYPHENYL; ALCOHOL DEHYDROGENASE; ALDEHYDE DEHYDROGENASE; ALDEHYDE OXIDASE; ALLOPURINOL; ANTIDEPRESSANT AGENT; BENZOIC ACID; BENZYL ALCOHOL; CYTOCHROME P450; CYTOCHROME P450 2A6; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; DISULFIRAM; DRUG METABOLITE; LU AA 21004; LU AA 34443; N HYDROXYLATED PIPERAZINE; RALOXIFENE; RECOMBINANT ENZYME; SULFOXIDE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; DRUG CLEARANCE; DRUG OXIDATION; ENZYME ANALYSIS; ENZYME KINETICS; HUMAN; HUMAN TISSUE; IN VITRO STUDY; LIVER MICROSOME; PRIORITY JOURNAL;

ANTIDEPRESSIVE AGENTS; CELL LINE; CYTOCHROME P-450 ENZYME SYSTEM; DEPRESSIVE DISORDER, MAJOR; HUMANS; HYDROXYLATION; ISOENZYMES; MICROSOMES, LIVER; OXIDATION-REDUCTION; PIPERAZINES; RECOMBINANT PROTEINS; SULFIDES;

EID: 84862698575     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.112.044610     Document Type: Article

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