-
1
-
-
3042822267
-
Cancer and the chemokine network
-
Balkwill F. (2004). Cancer and the chemokine network. Nat Rev Cancer 4: 540-550.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 540-550
-
-
Balkwill, F.1
-
2
-
-
0030826510
-
Transcriptional activation by p53 of the human type IV collagenase (gelatinase A or matrix metalloproteinase 2) promoter
-
Bian J, Sun Y. (1997). Transcriptional activation by p53 of the human type IV collagenase (gelatinase A or matrix metalloproteinase 2) promoter. Mol Cell Biol 17: 6330-6338.
-
(1997)
Mol Cell Biol
, vol.17
, pp. 6330-6338
-
-
Bian, J.1
Sun, Y.2
-
3
-
-
33846164111
-
Renal-cell carcinoma - Molecular pathways and therapies
-
Brugarolas J. (2007). Renal-cell carcinoma - molecular pathways and therapies. N Engl J Med 356: 185-187.
-
(2007)
N Engl J Med
, vol.356
, pp. 185-187
-
-
Brugarolas, J.1
-
4
-
-
77952115959
-
Von Hippel-Lindau syndrome: Molecular mechanisms of the disease
-
Calzada MJ. (2010). von Hippel-Lindau syndrome: molecular mechanisms of the disease. Clin Transl Oncol 12: 160-165.
-
(2010)
Clin Transl Oncol
, vol.12
, pp. 160-165
-
-
Calzada, M.J.1
-
5
-
-
0242691046
-
AP-1: A double-edged sword in tumorigenesis
-
Eferl R, Wagner EF. (2003). AP-1: a double-edged sword in tumorigenesis. Nat Rev Cancer 3: 859-868.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 859-868
-
-
Eferl, R.1
Wagner, E.F.2
-
6
-
-
48649098334
-
pVHL: A multipurpose adaptor protein
-
Frew IJ, Krek W. (2008). pVHL: a multipurpose adaptor protein. Sci Signal 1: pe30.
-
(2008)
Sci Signal
, vol.1
-
-
Frew, I.J.1
Krek, W.2
-
7
-
-
0344127560
-
Gene expression patterns in renal cell carcinoma assessed by complementary DNA microarray
-
Higgins JP, Shinghal R, Gill H, Reese JH, Terris M, Cohen RJ et al. (2003). Gene expression patterns in renal cell carcinoma assessed by complementary DNA microarray. Am J Pathol 162: 925-932.
-
(2003)
Am J Pathol
, vol.162
, pp. 925-932
-
-
Higgins, J.P.1
Shinghal, R.2
Gill, H.3
Reese, J.H.4
Terris, M.5
Cohen, R.J.6
-
8
-
-
54549113030
-
The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer
-
Kaelin Jr WG. (2008). The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer. Nat Rev Cancer 8: 865-873.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 865-873
-
-
Kaelin Jr., W.G.1
-
9
-
-
65949112237
-
Treatment of kidney cancer: Insights provided by the VHL tumor-suppressor protein
-
Kaelin Jr WG. (2009). Treatment of kidney cancer: insights provided by the VHL tumor-suppressor protein. Cancer 115: 2262-2272.
-
(2009)
Cancer
, vol.115
, pp. 2262-2272
-
-
Kaelin Jr., W.G.1
-
10
-
-
0034798212
-
Increased expression of matrix metalloproteinases 2 and 9 and tissue inhibitors of metalloproteinases 1 and 2 correlate with poor prognostic variables in renal cell carcinoma
-
Kallakury BV, Karikehalli S, Haholu A, Sheehan CE, Azumi N, Ross JS. (2001). Increased expression of matrix metalloproteinases 2 and 9 and tissue inhibitors of metalloproteinases 1 and 2 correlate with poor prognostic variables in renal cell carcinoma. Clin Cancer Res 7: 3113-3119.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 3113-3119
-
-
Kallakury, B.V.1
Karikehalli, S.2
Haholu, A.3
Sheehan, C.E.4
Azumi, N.5
Ross, J.S.6
-
12
-
-
2342597973
-
Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth
-
Kondo K, Kim WY, Lechpammer M, Kaelin Jr WG. (2003). Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth. PLoS Biol 1: E83.
-
(2003)
PLoS Biol
, vol.1
-
-
Kondo, K.1
Kim, W.Y.2
Lechpammer, M.3
Kaelin Jr., W.G.4
-
13
-
-
0036528246
-
Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein
-
Kondo K, Klco J, Nakamura E, Lechpammer M, Kaelin Jr WG. (2002). Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein. Cancer Cell 1: 237-246.
-
(2002)
Cancer Cell
, vol.1
, pp. 237-246
-
-
Kondo, K.1
Klco, J.2
Nakamura, E.3
Lechpammer, M.4
Kaelin Jr., W.G.5
-
14
-
-
0032795938
-
The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells
-
Koochekpour S, Jeffers M, Wang PH, Gong C, Taylor GA, Roessler LM et al. (1999). The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells. Mol Cell Biol 19: 5902-5912.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 5902-5912
-
-
Koochekpour, S.1
Jeffers, M.2
Wang, P.H.3
Gong, C.4
Taylor, G.A.5
Roessler, L.M.6
-
15
-
-
38949161122
-
Collagen matrix assembly is driven by the interaction of von Hippel-Lindau tumor suppressor protein with hydroxylated collagen IV alpha 2
-
Kurban G, Duplan E, Ramlal N, Hudon V, Sado Y, Ninomiya Y et al. (2008). Collagen matrix assembly is driven by the interaction of von Hippel-Lindau tumor suppressor protein with hydroxylated collagen IV alpha 2. Oncogene 27: 1004-1012.
-
(2008)
Oncogene
, vol.27
, pp. 1004-1012
-
-
Kurban, G.1
Duplan, E.2
Ramlal, N.3
Hudon, V.4
Sado, Y.5
Ninomiya, Y.6
-
16
-
-
32944464205
-
Characterization of a von Hippel Lindau pathway involved in extracellular matrix remodeling, cell invasion, and angiogenesis
-
Kurban G, Hudon V, Duplan E, Ohh M, Pause A. (2006). Characterization of a von Hippel Lindau pathway involved in extracellular matrix remodeling, cell invasion, and angiogenesis. Cancer Res 66: 1313-1319.
-
(2006)
Cancer Res
, vol.66
, pp. 1313-1319
-
-
Kurban, G.1
Hudon, V.2
Duplan, E.3
Ohh, M.4
Pause, A.5
-
17
-
-
22344437713
-
Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors
-
Lee S, Jilani SM, Nikolova GV, Carpizo D, Iruela-Arispe ML. (2005a). Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors. J Cell Biol 169: 681-691.
-
(2005)
J Cell Biol
, vol.169
, pp. 681-691
-
-
Lee, S.1
Jilani, S.M.2
Nikolova, G.V.3
Carpizo, D.4
Iruela-Arispe, M.L.5
-
18
-
-
23644436667
-
Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: Developmental culling and cancer
-
Lee S, Nakamura E, Yang H, Wei W, Linggi MS, Sajan MP et al. (2005b). Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer. Cancer Cell 8: 155-167.
-
(2005)
Cancer Cell
, vol.8
, pp. 155-167
-
-
Lee, S.1
Nakamura, E.2
Yang, H.3
Wei, W.4
Linggi, M.S.5
Sajan, M.P.6
-
19
-
-
33846876103
-
Identification of the genes for kidney cancer: Opportunity for disease-specific targeted therapeutics
-
Linehan WM, Pinto PA, Srinivasan R, Merino M, Choyke P, Choyke L et al. (2007). Identification of the genes for kidney cancer: opportunity for disease-specific targeted therapeutics. Clin Cancer Res 13: 671s-679s.
-
(2007)
Clin Cancer Res
, vol.13
-
-
Linehan, W.M.1
Pinto, P.A.2
Srinivasan, R.3
Merino, M.4
Choyke, P.5
Choyke, L.6
-
20
-
-
4544299668
-
Focus on kidney cancer
-
Linehan WM, Zbar B. (2004). Focus on kidney cancer. Cancer Cell 6: 223-228.
-
(2004)
Cancer Cell
, vol.6
, pp. 223-228
-
-
Linehan, W.M.1
Zbar, B.2
-
21
-
-
70350381008
-
Chemokine (C-C motif) ligand 2 engages CCR2+ stromal cells of monocytic origin to promote breast cancer metastasis to lung and bone
-
Lu X, Kang Y. (2009). Chemokine (C-C motif) ligand 2 engages CCR2+ stromal cells of monocytic origin to promote breast cancer metastasis to lung and bone. J Biol Chem 284: 29087-29096.
-
(2009)
J Biol Chem
, vol.284
, pp. 29087-29096
-
-
Lu, X.1
Kang, Y.2
-
22
-
-
0030962525
-
Cytokine induction of monocyte chemoattractant protein-1 gene expression in human endothelial cells depends on the cooperative action of NF-kappa B and AP-1
-
Martin T, Cardarelli PM, Parry GC, Felts KA, Cobb RR. (1997). Cytokine induction of monocyte chemoattractant protein-1 gene expression in human endothelial cells depends on the cooperative action of NF-kappa B and AP-1. Eur J Immunol 27: 1091-1097.
-
(1997)
Eur J Immunol
, vol.27
, pp. 1091-1097
-
-
Martin, T.1
Cardarelli, P.M.2
Parry, G.C.3
Felts, K.A.4
Cobb, R.R.5
-
23
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, Cockman ME et al. (1999). The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399: 271-275.
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang, G.W.3
Clifford, S.C.4
Vaux, E.C.5
Cockman, M.E.6
-
24
-
-
77950859659
-
Identification of candidate tumour suppressor genes frequently methylated in renal cell carcinoma
-
Morris MR, Ricketts C, Gentle D, Abdulrahman M, Clarke N, BrownM et al. (2010). Identification of candidate tumour suppressor genes frequently methylated in renal cell carcinoma. Oncogene 29: 2104-2117.
-
(2010)
Oncogene
, vol.29
, pp. 2104-2117
-
-
Morris, M.R.1
Ricketts, C.2
Gentle, D.3
Abdulrahman, M.4
Clarke, N.5
Brown, M.6
-
25
-
-
33144486527
-
Clusterin is a secreted marker for a hypoxia-inducible factor-independent function of the von Hippel-Lindau tumor suppressor protein
-
Nakamura E, Abreu-e-Lima P, Awakura Y, Inoue T, Kamoto T, Ogawa O et al. (2006). Clusterin is a secreted marker for a hypoxia-inducible factor-independent function of the von Hippel-Lindau tumor suppressor protein. Am J Pathol 168: 574-584.
-
(2006)
Am J Pathol
, vol.168
, pp. 574-584
-
-
Nakamura, E.1
Abreu-e-Lima, P.2
Awakura, Y.3
Inoue, T.4
Kamoto, T.5
Ogawa, O.6
-
26
-
-
33845684375
-
Recent insights into the molecular pathogenesis of pheochromocytoma and paraganglioma
-
Nakamura E, Kaelin Jr WG. (2006). Recent insights into the molecular pathogenesis of pheochromocytoma and paraganglioma. Endocr Pathol 17: 97-106.
-
(2006)
Endocr Pathol
, vol.17
, pp. 97-106
-
-
Nakamura, E.1
Kaelin Jr., W.G.2
-
27
-
-
0032085240
-
The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix
-
Ohh M, Yauch RL, Lonergan KM, Whaley JM, Stemmer-Rachamimov AO, Louis DN et al. (1998). The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix. Mol Cell 1: 959-968.
-
(1998)
Mol Cell
, vol.1
, pp. 959-968
-
-
Ohh, M.1
Yauch, R.L.2
Lonergan, K.M.3
Whaley, J.M.4
Stemmer-Rachamimov, A.O.5
Louis, D.N.6
-
28
-
-
33846048058
-
Transcription factors control invasion: AP-1 the first among equals
-
Ozanne BW, Spence HJ, McGarry LC, Hennigan RF. (2007). Transcription factors control invasion: AP-1 the first among equals. Oncogene 26: 1-10.
-
(2007)
Oncogene
, vol.26
, pp. 1-10
-
-
Ozanne, B.W.1
Spence, H.J.2
McGarry, L.C.3
Hennigan, R.F.4
-
29
-
-
0036463679
-
JunB can substitute for Jun in mouse development and cell proliferation
-
Passegue E, Jochum W, Behrens A, Ricci R, Wagner EF. (2002). JunB can substitute for Jun in mouse development and cell proliferation. Nat Genet 30: 158-166.
-
(2002)
Nat Genet
, vol.30
, pp. 158-166
-
-
Passegue, E.1
Jochum, W.2
Behrens, A.3
Ricci, R.4
Wagner, E.F.5
-
30
-
-
70649112122
-
Identification of TNF-alpha and MMP-9 as potential baseline predictive serum markers of sunitinib activity in patients with renal cell carcinoma using a human cytokine array
-
Perez-Gracia JL, Prior C, Guillen-Grima F, Segura V, Gonzalez A, Panizo A et al. (2009). Identification of TNF-alpha and MMP-9 as potential baseline predictive serum markers of sunitinib activity in patients with renal cell carcinoma using a human cytokine array. Br J Cancer 101: 1876-1883.
-
(2009)
Br J Cancer
, vol.101
, pp. 1876-1883
-
-
Perez-Gracia, J.L.1
Prior, C.2
Guillen-Grima, F.3
Segura, V.4
Gonzalez, A.5
Panizo, A.6
-
31
-
-
53849118121
-
Regulation and function of JunB in cell proliferation
-
Piechaczyk M, Farras R. (2008). Regulation and function of JunB in cell proliferation. Biochem Soc Trans 36: 864-867.
-
(2008)
Biochem Soc Trans
, vol.36
, pp. 864-867
-
-
Piechaczyk, M.1
Farras, R.2
-
32
-
-
70349385645
-
Resistance to targeted therapy in renalcell carcinoma
-
Rini BI, Atkins MB. (2009). Resistance to targeted therapy in renalcell carcinoma. Lancet Oncol 10: 992-1000.
-
(2009)
Lancet Oncol
, vol.10
, pp. 992-1000
-
-
Rini, B.I.1
Atkins, M.B.2
-
34
-
-
36549044524
-
Beyond the hypoxia-inducible factor-centric tumour suppressor model of von Hippel-Lindau
-
Roberts AM, Ohh M. (2008). Beyond the hypoxia-inducible factor-centric tumour suppressor model of von Hippel-Lindau. Curr Opin Oncol 20: 83-89.
-
(2008)
Curr Opin Oncol
, vol.20
, pp. 83-89
-
-
Roberts, A.M.1
Ohh, M.2
-
35
-
-
70449732503
-
Matrix metalloproteinases as novel biomarkers and potential therapeutic targets in human cancer
-
Roy R, Yang J, Moses MA. (2009). Matrix metalloproteinases as novel biomarkers and potential therapeutic targets in human cancer. J Clin Oncol 27: 5287-5297.
-
(2009)
J Clin Oncol
, vol.27
, pp. 5287-5297
-
-
Roy, R.1
Yang, J.2
Moses, M.A.3
-
36
-
-
0034234623
-
Human endothelial cells express CCR2 and respond to MCP-1: Direct role of MCP-1 in angiogenesis and tumor progression
-
Salcedo R, Ponce ML, Young HA, Wasserman K, Ward JM, Kleinman HK et al. (2000). Human endothelial cells express CCR2 and respond to MCP-1: direct role of MCP-1 in angiogenesis and tumor progression. Blood 96: 34-40.
-
(2000)
Blood
, vol.96
, pp. 34-40
-
-
Salcedo, R.1
Ponce, M.L.2
Young, H.A.3
Wasserman, K.4
Ward, J.M.5
Kleinman, H.K.6
-
37
-
-
33846995958
-
Critical role for NF-kappaB-induced JunB in VEGF regulation and tumor angiogenesis
-
Schmidt D, Textor B, Pein OT, Licht AH, Andrecht S, Sator-Schmitt Met al. (2007). Critical role for NF-kappaB-induced JunB in VEGF regulation and tumor angiogenesis. EMBO J 26: 710-719.
-
(2007)
EMBO J
, vol.26
, pp. 710-719
-
-
Schmidt, D.1
Textor, B.2
Pein, O.T.3
Licht, A.H.4
Andrecht, S.5
Sator-Schmitt, M.6
-
38
-
-
77949916262
-
AP-1-the Jun proteins: Oncogenes or tumor suppressors in disguise?
-
Shaulian E. (2010). AP-1-the Jun proteins: oncogenes or tumor suppressors in disguise? Cell Signal 22: 894-899.
-
(2010)
Cell Signal
, vol.22
, pp. 894-899
-
-
Shaulian, E.1
-
39
-
-
33751270700
-
Activating transcription factor 2 mediates matrix metalloproteinase-2 transcriptional activation induced by p38 in breast epithelial cells
-
Song H, Ki SH, Kim SG, Moon A. (2006). Activating transcription factor 2 mediates matrix metalloproteinase-2 transcriptional activation induced by p38 in breast epithelial cells. Cancer Res 66: 10487-10496.
-
(2006)
Cancer Res
, vol.66
, pp. 10487-10496
-
-
Song, H.1
Ki, S.H.2
Kim, S.G.3
Moon, A.4
-
40
-
-
36148943924
-
The oncoprotein NPM-ALK of anaplastic large-cell lymphoma induces JUNB transcription via ERK1/2 and JunB translation via mTOR signaling
-
Staber PB, Vesely P, Haq N, Ott RG, Funato K, Bambach I et al. (2007). The oncoprotein NPM-ALK of anaplastic large-cell lymphoma induces JUNB transcription via ERK1/2 and JunB translation via mTOR signaling. Blood 110: 3374-3383.
-
(2007)
Blood
, vol.110
, pp. 3374-3383
-
-
Staber, P.B.1
Vesely, P.2
Haq, N.3
Ott, R.G.4
Funato, K.5
Bambach, I.6
-
41
-
-
40349089893
-
pVHL coordinately regulates CXCR4/CXCL12 and MMP2/MMP9 expression in human clear-cell renal cell carcinoma
-
Struckmann K, Mertz K, Steu S, Storz M, Staller P, Krek W et al. (2008). pVHL coordinately regulates CXCR4/CXCL12 and MMP2/MMP9 expression in human clear-cell renal cell carcinoma. J Pathol 214: 464-471.
-
(2008)
J Pathol
, vol.214
, pp. 464-471
-
-
Struckmann, K.1
Mertz, K.2
Steu, S.3
Storz, M.4
Staller, P.5
Krek, W.6
-
42
-
-
0036434760
-
Prognostic significance of matrix metalloproteinases-2 activation ratio in renal cell carcinoma
-
Takahashi M, Oka N, Naroda T, Nishitani MA, Kanda K, Kanayama HO et al. (2002). Prognostic significance of matrix metalloproteinases-2 activation ratio in renal cell carcinoma. Int J Urol 9: 531-538.
-
(2002)
Int J Urol
, vol.9
, pp. 531-538
-
-
Takahashi, M.1
Oka, N.2
Naroda, T.3
Nishitani, M.A.4
Kanda, K.5
Kanayama, H.O.6
-
43
-
-
76749127520
-
Identification of EP4 as a potential target for the treatment of castration-resistant prostate cancer using a novel xenograft model
-
Terada N, Shimizu Y, Kamba T, Inoue T, Maeno A, Kobayashi T et al. (2010). Identification of EP4 as a potential target for the treatment of castration-resistant prostate cancer using a novel xenograft model. Cancer Res 70: 1606-1615.
-
(2010)
Cancer Res
, vol.70
, pp. 1606-1615
-
-
Terada, N.1
Shimizu, Y.2
Kamba, T.3
Inoue, T.4
Maeno, A.5
Kobayashi, T.6
-
44
-
-
24744470529
-
JunB induced by constitutive CD30-extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase signaling activates the CD30 promoter in anaplastic large cell lymphoma and Reed-Sternberg cells of Hodgkin lymphoma
-
Watanabe M, Sasaki M, Itoh K, Higashihara M, Umezawa K, Kadin ME et al. (2005). JunB induced by constitutive CD30-extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase signaling activates the CD30 promoter in anaplastic large cell lymphoma and Reed-Sternberg cells of Hodgkin lymphoma. Cancer Res 65: 7628-7634.
-
(2005)
Cancer Res
, vol.65
, pp. 7628-7634
-
-
Watanabe, M.1
Sasaki, M.2
Itoh, K.3
Higashihara, M.4
Umezawa, K.5
Kadin, M.E.6
-
45
-
-
0029328266
-
Intratumor microvessel density as a prognostic factor in cancer
-
Weidner N. (1995). Intratumor microvessel density as a prognostic factor in cancer. Am J Pathol 147: 9-19.
-
(1995)
Am J Pathol
, vol.147
, pp. 9-19
-
-
Weidner, N.1
-
46
-
-
33745109564
-
Von Hippel-Lindau disease and endocrine tumour susceptibility
-
Woodward ER, Maher ER. (2006). von Hippel-Lindau disease and endocrine tumour susceptibility. Endocr Relat Cancer 13: 415-425.
-
(2006)
Endocr Relat Cancer
, vol.13
, pp. 415-425
-
-
Woodward, E.R.1
Maher, E.R.2
-
47
-
-
34948883495
-
pVHL acts as an adaptor to promote the inhibitory phosphorylation of the NF-kappaB agonist Card9 by CK2
-
Yang H, Minamishima YA, Yan Q, Schlisio S, Ebert BL, Zhang X et al. (2007). pVHL acts as an adaptor to promote the inhibitory phosphorylation of the NF-kappaB agonist Card9 by CK2. Mol Cell 28: 15-27.
-
(2007)
Mol Cell
, vol.28
, pp. 15-27
-
-
Yang, H.1
Minamishima, Y.A.2
Yan, Q.3
Schlisio, S.4
Ebert, B.L.5
Zhang, X.6
-
48
-
-
73349089306
-
Analysis of VHL gene alterations and their relationship to clinical parameters in sporadic conventional renal cell carcinoma
-
Young AC, Craven RA, Cohen D, Taylor C, Booth C, Harnden P et al. (2009). Analysis of VHL gene alterations and their relationship to clinical parameters in sporadic conventional renal cell carcinoma. Clin Cancer Res 15: 7582-7592.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 7582-7592
-
-
Young, A.C.1
Craven, R.A.2
Cohen, D.3
Taylor, C.4
Booth, C.5
Harnden, P.6
|