TGF-β and IL-23 gene expression in unstimulated PBMCs of patients with diabetes

Endocrine

Volumn 41, Issue 3, 2012, Pages 430-434

  Abbasi, Farzaneh ^a   Amiri, Parvin ^a   Sayahpour, Forough A ^a   Pirmoradi, Saeed ^b   Abolhalaj, Milad ^b   Larijani, Bagher ^a   Bazzaz, Javad Tavakkoly ^c   Amoli, Mahsa M ^a  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b ISLAMIC AZAD UNIVERSITY   (Iran)

^c TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Diabetes; Expression; Gene; Th17 cytokine

Indexed keywords

CYTOKINE; INTERLEUKIN 23; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; AUTOIMMUNE DISEASE; CYTOKINE PRODUCTION; DIABETIC PATIENT; DIABETOGENESIS; DOWN REGULATION; GENE CONTROL; GENE EXPRESSION; HUMAN; HUMAN CELL; INSULIN DEPENDENT DIABETES MELLITUS; LYMPHOCYTE DIFFERENTIATION; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; ONSET AGE; PATHOGENESIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; TH17 CELL;

EID: 84862686498     PISSN: 1355008X     EISSN: 15590100     Source Type: Journal    
DOI: 10.1007/s12020-011-9578-7     Document Type: Article

References (20)

1. W.A. Border, N.A. Noble, Targeting TGF-beta for treatment of disease. Nat. Med. 1, 1000-1001 (1995)
2. D. Fujii, J.E. Brissenden, R. Derynck, U. Francke, Transforming growth factor beta gene maps to human chromosome 19 long arm and to mouse chromosome 7. Somat. Cell Mol. Genet. 12, 281-288 (1986) (Pubitemid 16040676)
3. C.A. Piccirillo, Y. Chang, G.J. Prud'homme, TGF-beta1 somatic gene therapy prevents autoimmune disease in nonobese diabetic mice. J. Immunol. 161, 3950-3956 (1998) (Pubitemid 28468971)
4. C. King, J. Davies, R. Mueller, M.S. Lee, T. Krahl, B. Yeung, E. O'Connor, N. Sarvetnick, TGF-beta1 alters APC preference, polarizing islet antigen responses toward a Th2 phenotype. Immunity 8, 601-613 (1998) (Pubitemid 28264751)
5. M. Moritani, K. Yoshimoto, S.F. Wong, C. Tanaka, T. Yamaoka, T. Sano, Y. Komagata, J. Miyazaki, H. Kikutani, M. Itakura, Abrogation of autoimmune diabetes in nonobese diabetic mice and protection against effector lymphocytes by transgenic paracrine TGF-beta1. J. Clin. Invest. 102, 499-506 (1998) (Pubitemid 28376152)
6. H.S. Han, H.S. Jun, T. Utsugi, J.W. Yoon, A new type of CD4? suppressor T cell completely prevents spontaneous autoimmune diabetes and recurrent diabetes in syngeneic islet-transplanted NOD mice. J. Autoimmun. 9, 331-339 (1996) (Pubitemid 26226592)
7. S. You, M. Alyanakian, B. Segovia, D. Damotte, J. Bluestone, J. Bach, L. Chatenoud, Immunoregulatory pathways controlling progression of autoimmunity in NOD mice. Ann. N. Y. Acad. Sci. 1150, 300-310 (2008)
8. P.Y. Mantel, C.B. Schmidt-Weber, Transforming growth factorbeta: recent advances on its role in immune tolerance. Methods Mol. Biol. 677, 303-338 (2011)
9. W. Łuczyński, A. Stasiak-Barmuta, A. Juchniewicz, N. Wawrusiewicz-Kurylonek, E. Iłendo, J. Kos, A. Kretowski, M. Górska, L. Chyczewski, A. Bossowski, The mRNA expression of pro- and anti-inflammatory cytokines in T regulatory cells in children with type 1 diabetes. Folia Histochem. Cytobiol. 1(48), 93-100 (2010)
10. M. Halminen, O. Simell, M. Knip, J. Ilonen, Cytokine expression in unstimulated PBMC of children with type 1 diabetes and subjects positive for diabetes-associated autoantibodies. Scand. J. Immunol. 53, 510-513 (2001) (Pubitemid 32382276)
11. M. Kunz, S.M. Ibrahim, Cytokines and cytokine profiles in human autoimmune diseases and animal models of autoimmunity. Mediat. Inflamm. 97, 92-98 (2009)
12. X. Gao, G. Ding, Z. Wang, H. Fu, Z. Ni, J. Ma, S. Song, F. Liu, Z. Fu, Adjuvant treatment suppresses IL-17 production by T cellindependent myeloid sources in nonobese diabetic mice. Mol. Immunol. 47(14), 2397-2404 (2010)
13. V.S. Costa, T.C. Mattana, M.E. da Silva, Unregulated IL-23/IL-17 immune response in autoimmune diseases. Diabetes Res. Clin. Pract. 88, 222-226 (2010)
14. B. Ciric, M. El-behi, R. Cabrera, G.X. Zhang, A. Rostami, IL-23 drives pathogenic IL-17-producing CD8? T cells. J. Immunol. 182(9), 5296-5305 (2009)
15. S.M. Wahl, Transforming growth factor beta: the good, the bad, and the ugly. J. Exp. Med. 180, 1587-1590 (1994) (Pubitemid 24328550)
16. C.M. Filippi, A.E. Juedes, J.E. Oldham, E. Ling, L. Togher, Y. Peng, R.A. Flavell, M.G. von Herrath, Transforming growth factor-beta suppresses the activation of CD8? T-cells when naive but promotes their survival and function once antigen experienced: a two-faced impact on autoimmunity. Diabetes 57(10), 2684-2692 (2008)
17. R.C. Padmos, N.C. Schloot, H. Beyan, C. Ruwhof, F.J. Staal, D. de Ridder, H.J. Aanstoot, W.K. Lam-Tse, H. de Wit, C. de Herder, R.C. Drexhage, B. Menart, R.D. Leslie, H.A. Drexhage, LADA Consortium, Distinct monocyte gene-expression profiles in autoimmune diabetes. Diabetes 57, 2768-2773 (2008)
18. J.C. Pickup, Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. Diabetes Care 27, 813-823 (2004) (Pubitemid 38280558)
19. R.D. Leslie, M. Delli Castelli, Age-dependent influences on the origins of autoimmune diabetes: evidence and implications. Diabetes 53, 3033-3040 (2004) (Pubitemid 39571713)
20. E. Korpinen, P.H. Groop, J.A. Fagerudd, A.M. Teppo, H.K. Akerblom, O. Vaarala, Increased secretion of TGF-beta1 by peripheral blood mononuclear cells from patients with Type 1 diabetes mellitus with diabetic nephropathy. Diabet. Med. 18(2), 121-125 (2001) (Pubitemid 32238957)