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Volumn 12, Issue 2, 2012, Pages 106-114

Molecular imaging of dementia

Author keywords

A ; Alzheimer's disease (AD); Amyloid; Dementia; Microglia; Positron emission tomography (PET)

Indexed keywords

PITTSBURGH COMPOUND B;

EID: 84862684117     PISSN: 13463500     EISSN: 14798301     Source Type: Journal    
DOI: 10.1111/j.1479-8301.2012.00409.x     Document Type: Review
Times cited : (27)

References (65)
  • 2
    • 0022414054 scopus 로고
    • Diagnosis of Alzheimer's disease
    • Khachaturian ZS. Diagnosis of Alzheimer's disease. Arch Neurol 1985; 42: 1097-1105.
    • (1985) Arch Neurol , vol.42 , pp. 1097-1105
    • Khachaturian, Z.S.1
  • 3
    • 0242363668 scopus 로고    scopus 로고
    • Looking backward to move forward: early detection of neurodegenerative disorders
    • DeKosky ST, Marek K. Looking backward to move forward: early detection of neurodegenerative disorders. Science 2003; 302: 830-834.
    • (2003) Science , vol.302 , pp. 830-834
    • DeKosky, S.T.1    Marek, K.2
  • 4
    • 33644697324 scopus 로고    scopus 로고
    • Prediction of individual clinical outcome in MCI by means of genetic assessment and (18)F-FDG PET
    • Drzezga A, Grimmer T, Riemenschneider M etal. Prediction of individual clinical outcome in MCI by means of genetic assessment and (18)F-FDG PET. J Nucl Med 2005; 46: 1625-1632.
    • (2005) J Nucl Med , vol.46 , pp. 1625-1632
    • Drzezga, A.1    Grimmer, T.2    Riemenschneider, M.3
  • 6
    • 0025863618 scopus 로고
    • Neuropathological staging of Alzheiner-related changes
    • Braak H, Braak E. Neuropathological staging of Alzheiner-related changes. Acta Neuropathol 1991; 82: 239-259.
    • (1991) Acta Neuropathol , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 7
    • 0032989712 scopus 로고    scopus 로고
    • Tangles and plaques in nondemented aging and 'preclinical' Alzheimer's disease
    • Price JL, Morris JC. Tangles and plaques in nondemented aging and 'preclinical' Alzheimer's disease. Ann Neurol 1999; 45: 358-368.
    • (1999) Ann Neurol , vol.45 , pp. 358-368
    • Price, J.L.1    Morris, J.C.2
  • 8
    • 0036685608 scopus 로고    scopus 로고
    • Transgenic mouse model of tauopathies with glial pathology and nervous system degeneration
    • Higuchi M, Ishihara T, Zhang B etal. Transgenic mouse model of tauopathies with glial pathology and nervous system degeneration. Neuron 2002; 35: 433-446.
    • (2002) Neuron , vol.35 , pp. 433-446
    • Higuchi, M.1    Ishihara, T.2    Zhang, B.3
  • 10
    • 33845707784 scopus 로고    scopus 로고
    • PET of brain amyloid and tau in mild cognitive impairment
    • Small GW, Kepe V, Ercoli LM etal. PET of brain amyloid and tau in mild cognitive impairment. N Engl J Med 2006; 355: 2652-2663.
    • (2006) N Engl J Med , vol.355 , pp. 2652-2663
    • Small, G.W.1    Kepe, V.2    Ercoli, L.M.3
  • 11
    • 10744232413 scopus 로고    scopus 로고
    • Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B
    • Klunk WE, Engler H, Nordberg A etal. Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B. Ann Neurol 2004; 55: 306-319.
    • (2004) Ann Neurol , vol.55 , pp. 306-319
    • Klunk, W.E.1    Engler, H.2    Nordberg, A.3
  • 12
    • 0038117796 scopus 로고    scopus 로고
    • Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline
    • Näslund J, Haroutunian V, Mohs R etal. Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline. JAMA 2000; 283: 1571-1577.
    • (2000) JAMA , vol.283 , pp. 1571-1577
    • Näslund, J.1    Haroutunian, V.2    Mohs, R.3
  • 13
    • 33747048954 scopus 로고    scopus 로고
    • [11C]PIB in a nondemented population: potential antecedent marker of Alzheimer disease
    • Mintun MA, Larossa GN, Sheline YI etal. [11C]PIB in a nondemented population: potential antecedent marker of Alzheimer disease. Neurology 2006; 67: 446-452.
    • (2006) Neurology , vol.67 , pp. 446-452
    • Mintun, M.A.1    Larossa, G.N.2    Sheline, Y.I.3
  • 14
    • 33947198109 scopus 로고    scopus 로고
    • Molecular imaging with Pittsburgh Compound B confirmed at autopsy: a case report
    • Bacskai BJ, Frosch MP, Freeman SH etal. Molecular imaging with Pittsburgh Compound B confirmed at autopsy: a case report. Arch Neurol 2007; 64: 431-434.
    • (2007) Arch Neurol , vol.64 , pp. 431-434
    • Bacskai, B.J.1    Frosch, M.P.2    Freeman, S.H.3
  • 15
    • 59449097248 scopus 로고    scopus 로고
    • AZD2184: a radioligand for sensitive detection of beta-amyloid deposits
    • Johnson AE, Jeppsson F, Sandell J etal. AZD2184: a radioligand for sensitive detection of beta-amyloid deposits. J Neurochem 2009; 108: 1177-1186.
    • (2009) J Neurochem , vol.108 , pp. 1177-1186
    • Johnson, A.E.1    Jeppsson, F.2    Sandell, J.3
  • 16
    • 34248579112 scopus 로고    scopus 로고
    • 2-(2-[2-Dimethylaminothiazol-5-yl]ethenyl)-6-(2-[fluoro]ethoxy)benzoxazole: a novel PET agent for in vivo detection of dense amyloid plaques in Alzheimer's disease patients
    • Kudo Y, Okamura N, Furumoto S etal. 2-(2-[2-Dimethylaminothiazol-5-yl]ethenyl)-6-(2-[fluoro]ethoxy)benzoxazole: a novel PET agent for in vivo detection of dense amyloid plaques in Alzheimer's disease patients. J Nucl Med 2007; 48: 553-561.
    • (2007) J Nucl Med , vol.48 , pp. 553-561
    • Kudo, Y.1    Okamura, N.2    Furumoto, S.3
  • 17
    • 77956384880 scopus 로고    scopus 로고
    • 18F-flutemetamol amyloid imaging in Alzheimer disease and mild cognitive impairment: a phase 2 trial
    • Vandenberghe R, Van Laere K, Ivanoiu A etal. 18F-flutemetamol amyloid imaging in Alzheimer disease and mild cognitive impairment: a phase 2 trial. Ann Neurol 2010; 68: 319-329.
    • (2010) Ann Neurol , vol.68 , pp. 319-329
    • Vandenberghe, R.1    Van Laere, K.2    Ivanoiu, A.3
  • 18
    • 38149081191 scopus 로고    scopus 로고
    • Imaging of amyloid beta in Alzheimer's disease with 18F-BAY94-9172, a novel PET tracer: proof of mechanism
    • Rowe CC, Ackerman U, Browne W etal. Imaging of amyloid beta in Alzheimer's disease with 18F-BAY94-9172, a novel PET tracer: proof of mechanism. Lancet Neurol 2008; 7: 129-135.
    • (2008) Lancet Neurol , vol.7 , pp. 129-135
    • Rowe, C.C.1    Ackerman, U.2    Browne, W.3
  • 19
    • 70350716476 scopus 로고    scopus 로고
    • Preclinical properties of 18F-AV-45: a PET agent for Abeta plaques in the brain
    • Choi SR, Golding G, Zhuang Z etal. Preclinical properties of 18F-AV-45: a PET agent for Abeta plaques in the brain. J Nucl Med 2009; 50: 1887-1894.
    • (2009) J Nucl Med , vol.50 , pp. 1887-1894
    • Choi, S.R.1    Golding, G.2    Zhuang, Z.3
  • 20
    • 77954338544 scopus 로고    scopus 로고
    • Characterization of AZD4694, a novel fluorinated Abeta plaque neuroimaging PET radioligand
    • Juréus A, Swahn BM, Sandell J etal. Characterization of AZD4694, a novel fluorinated Abeta plaque neuroimaging PET radioligand. J Neurochem 2010; 114: 784-794.
    • (2010) J Neurochem , vol.114 , pp. 784-794
    • Juréus, A.1    Swahn, B.M.2    Sandell, J.3
  • 21
    • 84862637129 scopus 로고    scopus 로고
    • Avid Radiopharmaceuticals, Inc. FDA Advisory Committee Meeting. October 23, 18F-AV-45: PET Amyloid Plaque Imaging Agent Summary of Development Program and Proposed Phase III Plan.
    • Avid Radiopharmaceuticals, Inc. FDA Advisory Committee Meeting. October 23, 2008. 18F-AV-45: PET Amyloid Plaque Imaging Agent Summary of Development Program and Proposed Phase III Plan.
    • (2008)
  • 22
    • 78751546481 scopus 로고    scopus 로고
    • Use of florbetapir-PET for imaging beta-amyloid pathology
    • Clark CM, Schneider JA, Bedell BJ etal. Use of florbetapir-PET for imaging beta-amyloid pathology. JAMA 2011; 305: 275-283.
    • (2011) JAMA , vol.305 , pp. 275-283
    • Clark, C.M.1    Schneider, J.A.2    Bedell, B.J.3
  • 23
    • 27944471285 scopus 로고    scopus 로고
    • Binding of the positron emission tomography tracer Pittsburgh compound-B reflects the amount of amyloid-beta in Alzheimer's disease brain but not in transgenic mouse brain
    • Klunk WE, Lopresti BJ, Ikonomovic MD etal. Binding of the positron emission tomography tracer Pittsburgh compound-B reflects the amount of amyloid-beta in Alzheimer's disease brain but not in transgenic mouse brain. J Neurosci 2005; 25: 10598-10606.
    • (2005) J Neurosci , vol.25 , pp. 10598-10606
    • Klunk, W.E.1    Lopresti, B.J.2    Ikonomovic, M.D.3
  • 24
    • 24044535149 scopus 로고    scopus 로고
    • PET imaging of brain with the beta-amyloid probe, [11C]6-OH-BTA-1, in a transgenic mouse model of Alzheimer's disease
    • Toyama H, Ye D, Ichise M etal. PET imaging of brain with the beta-amyloid probe, [11C]6-OH-BTA-1, in a transgenic mouse model of Alzheimer's disease. Eur J Nucl Med Mol Imaging 2005; 32: 593-600.
    • (2005) Eur J Nucl Med Mol Imaging , vol.32 , pp. 593-600
    • Toyama, H.1    Ye, D.2    Ichise, M.3
  • 25
    • 34250627649 scopus 로고    scopus 로고
    • Phase-dependent roles of reactive microglia and astrocytes in nervous system injury as delineated by imaging of peripheral benzodiazepine receptor
    • Maeda J, Higuchi M, Inaji M etal. Phase-dependent roles of reactive microglia and astrocytes in nervous system injury as delineated by imaging of peripheral benzodiazepine receptor. Brain Res 2007; 1157: 100-111.
    • (2007) Brain Res , vol.1157 , pp. 100-111
    • Maeda, J.1    Higuchi, M.2    Inaji, M.3
  • 26
    • 0028855851 scopus 로고
    • Dominant and differential deposition of distinct beta-amyloid peptide species, A beta N3(pE), in senile plaques
    • Saido TC, Iwatsubo T, Mann DM, Shimada H, Ihara Y, Kawashima S. Dominant and differential deposition of distinct beta-amyloid peptide species, A beta N3(pE), in senile plaques. Neuron 1995; 14: 457-466.
    • (1995) Neuron , vol.14 , pp. 457-466
    • Saido, T.C.1    Iwatsubo, T.2    Mann, D.M.3    Shimada, H.4    Ihara, Y.5    Kawashima, S.6
  • 27
    • 33749617597 scopus 로고    scopus 로고
    • On the seeding and oligomerization of pGlu-amyloid peptides (in vitro)
    • Schilling S, Lauber T, Schaupp M etal. On the seeding and oligomerization of pGlu-amyloid peptides (in vitro). Biochemistry 2006; 45: 12393-12399.
    • (2006) Biochemistry , vol.45 , pp. 12393-12399
    • Schilling, S.1    Lauber, T.2    Schaupp, M.3
  • 28
    • 34548553576 scopus 로고    scopus 로고
    • Age-dependent axonal degeneration in an Alzheimer mouse model
    • Wirths O, Weis J, Kayed R, Saido TC, Bayer TA. Age-dependent axonal degeneration in an Alzheimer mouse model. Neurobiol Aging 2007; 28: 1689-1699.
    • (2007) Neurobiol Aging , vol.28 , pp. 1689-1699
    • Wirths, O.1    Weis, J.2    Kayed, R.3    Saido, T.C.4    Bayer, T.A.5
  • 29
    • 0035863055 scopus 로고    scopus 로고
    • Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease
    • Kawarabayashi T, Younkin LH, Saido TC, Shoji M, Ashe KH, Younkin SG. Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease. J Neurosci 2001; 21: 372-381.
    • (2001) J Neurosci , vol.21 , pp. 372-381
    • Kawarabayashi, T.1    Younkin, L.H.2    Saido, T.C.3    Shoji, M.4    Ashe, K.H.5    Younkin, S.G.6
  • 30
    • 0029610011 scopus 로고
    • The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases
    • McGeer PL, McGeer EG. The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases. Brain Res Brain Res Rev 1995; 21: 195-218.
    • (1995) Brain Res Brain Res Rev , vol.21 , pp. 195-218
    • McGeer, P.L.1    McGeer, E.G.2
  • 31
    • 34548146119 scopus 로고    scopus 로고
    • Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements
    • Asuni AA, Boutajangout A, Quartermain D, Sigurdsson EM. Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements. J Neurosci 2007; 27: 9115-9129.
    • (2007) J Neurosci , vol.27 , pp. 9115-9129
    • Asuni, A.A.1    Boutajangout, A.2    Quartermain, D.3    Sigurdsson, E.M.4
  • 32
    • 33846538660 scopus 로고    scopus 로고
    • Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model
    • Yoshiyama Y, Higuchi M, Zhang B etal. Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron 2007; 53: 337-351.
    • (2007) Neuron , vol.53 , pp. 337-351
    • Yoshiyama, Y.1    Higuchi, M.2    Zhang, B.3
  • 34
    • 67650075027 scopus 로고    scopus 로고
    • Quantitative analysis of peripheral benzodiazepine receptor in the human brain using PET with (11)C-AC-5216
    • Miyoshi M, Ito H, Arakawa R etal. Quantitative analysis of peripheral benzodiazepine receptor in the human brain using PET with (11)C-AC-5216. J Nucl Med 2009; 50: 1095-1101.
    • (2009) J Nucl Med , vol.50 , pp. 1095-1101
    • Miyoshi, M.1    Ito, H.2    Arakawa, R.3
  • 35
    • 0035845283 scopus 로고    scopus 로고
    • In-vivo measurement of activated microglia in dementia
    • Cagnin A, Brooks DJ, Kennedy AM etal. In-vivo measurement of activated microglia in dementia. Lancet 2001; 358: 461-467.
    • (2001) Lancet , vol.358 , pp. 461-467
    • Cagnin, A.1    Brooks, D.J.2    Kennedy, A.M.3
  • 36
    • 2342540487 scopus 로고    scopus 로고
    • Novel peripheral benzodiazepine receptor ligand [11C]DAA1106 for PET: an imaging tool for glial cells in the brain
    • Maeda J, Suhara T, Zhang MR etal. Novel peripheral benzodiazepine receptor ligand [11C]DAA1106 for PET: an imaging tool for glial cells in the brain. Synapse 2004; 52: 283-291.
    • (2004) Synapse , vol.52 , pp. 283-291
    • Maeda, J.1    Suhara, T.2    Zhang, M.R.3
  • 37
    • 11144353899 scopus 로고    scopus 로고
    • Development of a new radioligand, N-(5-fluoro-2-phenoxyphenyl)-N-(2-[18F]fluoroethyl-5-methoxybenzyl)acetamide, for pet imaging of peripheral benzodiazepine receptor in primate brain
    • Zhang MR, Maeda J, Ogawa M etal. Development of a new radioligand, N-(5-fluoro-2-phenoxyphenyl)-N-(2-[18F]fluoroethyl-5-methoxybenzyl)acetamide, for pet imaging of peripheral benzodiazepine receptor in primate brain. J Med Chem 2004; 47: 2228-2235.
    • (2004) J Med Chem , vol.47 , pp. 2228-2235
    • Zhang, M.R.1    Maeda, J.2    Ogawa, M.3
  • 38
    • 54149105539 scopus 로고    scopus 로고
    • Increased binding of peripheral benzodiazepine receptor in Alzheimer's disease measured by positron emission tomography with [11C]DAA1106
    • Yasuno F, Ota M, Kosaka J etal. Increased binding of peripheral benzodiazepine receptor in Alzheimer's disease measured by positron emission tomography with [11C]DAA1106. Biol Psychiatry 2008; 64: 835-841.
    • (2008) Biol Psychiatry , vol.64 , pp. 835-841
    • Yasuno, F.1    Ota, M.2    Kosaka, J.3
  • 39
    • 35348821915 scopus 로고    scopus 로고
    • Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography
    • Maeda J, Ji B, Irie T etal. Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography. J Neurosci 2007; 27: 10957-10968.
    • (2007) J Neurosci , vol.27 , pp. 10957-10968
    • Maeda, J.1    Ji, B.2    Irie, T.3
  • 40
    • 34548260271 scopus 로고    scopus 로고
    • A comparison of the high-affinity peripheral benzodiazepine receptor ligands DAA1106 and (R)-PK11195 in rat models of neuroinflammation: implications for PET imaging of microglial activation
    • Venneti S, Lopresti BJ, Wang G etal. A comparison of the high-affinity peripheral benzodiazepine receptor ligands DAA1106 and (R)-PK11195 in rat models of neuroinflammation: implications for PET imaging of microglial activation. J Neurochem 2007; 102: 2118-2131.
    • (2007) J Neurochem , vol.102 , pp. 2118-2131
    • Venneti, S.1    Lopresti, B.J.2    Wang, G.3
  • 41
    • 58149391968 scopus 로고    scopus 로고
    • Imaging of peripheral benzodiazepine receptor expression as biomarkers of detrimental versus beneficial glial responses in mouse models of Alzheimer's and other CNS pathologies
    • Ji B, Maeda J, Sawada M etal. Imaging of peripheral benzodiazepine receptor expression as biomarkers of detrimental versus beneficial glial responses in mouse models of Alzheimer's and other CNS pathologies. J Neurosci 2008; 28: 12255-12267.
    • (2008) J Neurosci , vol.28 , pp. 12255-12267
    • Ji, B.1    Maeda, J.2    Sawada, M.3
  • 42
    • 59049090545 scopus 로고    scopus 로고
    • A comparative autoradiography study in post mortem whole hemisphere human brain slices taken from Alzheimer patients and age-matched controls using two radiolabelled DAA1106 analogues with high affinity to the peripheral benzodiazepine receptor (PBR) system
    • Gulyás B, Makkai B, Kása P etal. A comparative autoradiography study in post mortem whole hemisphere human brain slices taken from Alzheimer patients and age-matched controls using two radiolabelled DAA1106 analogues with high affinity to the peripheral benzodiazepine receptor (PBR) system. Neurochem Int 2009; 54: 28-36.
    • (2009) Neurochem Int , vol.54 , pp. 28-36
    • Gulyás, B.1    Makkai, B.2    Kása, P.3
  • 43
    • 36049035022 scopus 로고    scopus 로고
    • 11C-AC-5216: a novel PET ligand for peripheral benzodiazepine receptors in the primate brain
    • Zhang MR, Kumata K, Maeda J etal. 11C-AC-5216: a novel PET ligand for peripheral benzodiazepine receptors in the primate brain. J Nucl Med 2007; 48: 853-861.
    • (2007) J Nucl Med , vol.48 , pp. 853-861
    • Zhang, M.R.1    Kumata, K.2    Maeda, J.3
  • 44
    • 61349126690 scopus 로고    scopus 로고
    • [18F]FEAC and [18F]FEDAC: two novel positron emission tomography ligands for peripheral-type benzodiazepine receptor in the brain
    • Yanamoto K, Kumata K, Yamasaki T etal. [18F]FEAC and [18F]FEDAC: two novel positron emission tomography ligands for peripheral-type benzodiazepine receptor in the brain. Bioorg Med Chem Lett 2009; 19: 1707-1710.
    • (2009) Bioorg Med Chem Lett , vol.19 , pp. 1707-1710
    • Yanamoto, K.1    Kumata, K.2    Yamasaki, T.3
  • 45
    • 70349283883 scopus 로고    scopus 로고
    • Evaluation of N-benzyl-N-[11C]methyl-2-(7-methyl-8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetamide ([11C]DAC) as a novel translocator protein (18 kDa) radioligand in kainic acid-lesioned rat
    • Yanamoto K, Yamasaki T, Kumata K etal. Evaluation of N-benzyl-N-[11C]methyl-2-(7-methyl-8-oxo-2-phenyl-7, 8-dihydro-9H-purin-9-yl)acetamide ([11C]DAC) as a novel translocator protein (18 kDa) radioligand in kainic acid-lesioned rat. Synapse 2009; 63: 961-971.
    • (2009) Synapse , vol.63 , pp. 961-971
    • Yanamoto, K.1    Yamasaki, T.2    Kumata, K.3
  • 46
    • 79953004994 scopus 로고    scopus 로고
    • In vivo positron emission tomographic imaging of glial responses to amyloid-beta and tau pathologies in mouse models of Alzheimer's disease and related disorders
    • Maeda J, Zhang MR, Okauchi T etal. In vivo positron emission tomographic imaging of glial responses to amyloid-beta and tau pathologies in mouse models of Alzheimer's disease and related disorders. J Neurosci 2011; 31: 4720-4730.
    • (2011) J Neurosci , vol.31 , pp. 4720-4730
    • Maeda, J.1    Zhang, M.R.2    Okauchi, T.3
  • 47
    • 77953614566 scopus 로고    scopus 로고
    • In vivo detection of neuropathologic changes in presymptomatic MAPT mutation carriers: a PET and MRI study
    • Miyoshi M, Shinotoh H, Wszolek ZK etal. In vivo detection of neuropathologic changes in presymptomatic MAPT mutation carriers: a PET and MRI study. Parkinsonism Relat Disord 2010; 16: 404-408.
    • (2010) Parkinsonism Relat Disord , vol.16 , pp. 404-408
    • Miyoshi, M.1    Shinotoh, H.2    Wszolek, Z.K.3
  • 49
    • 76749104184 scopus 로고    scopus 로고
    • In-vivo visualization of key molecular processes involved in Alzheimer's disease pathogenesis: insights from neuroimaging research in humans and rodent models
    • Higuchi M, Maeda J, Ji B etal. In-vivo visualization of key molecular processes involved in Alzheimer's disease pathogenesis: insights from neuroimaging research in humans and rodent models. Biochim Biophys Acta 2010; 1802: 373-388.
    • (2010) Biochim Biophys Acta , vol.1802 , pp. 373-388
    • Higuchi, M.1    Maeda, J.2    Ji, B.3
  • 50
    • 35348939603 scopus 로고    scopus 로고
    • Clinical diagnostic criteria for dementia associated with Parkinson's disease
    • Emre M, Aarsland D, Brown R etal. Clinical diagnostic criteria for dementia associated with Parkinson's disease. Mov Disord 2007; 22: 1689-1707.
    • (2007) Mov Disord , vol.22 , pp. 1689-1707
    • Emre, M.1    Aarsland, D.2    Brown, R.3
  • 51
    • 0019972810 scopus 로고
    • The cholinergic hypothesis of geriatric memory dysfunction
    • Bartus RT, Dean RL 3rd, Beer B, Lippa AS. The cholinergic hypothesis of geriatric memory dysfunction. Science 1982; 217: 408-414.
    • (1982) Science , vol.217 , pp. 408-414
    • Bartus, R.T.1    Dean 3rd, R.L.2    Beer, B.3    Lippa, A.S.4
  • 52
    • 0029010288 scopus 로고
    • Hypersensitivity of cortical muscarinic receptors in Parkinson's disease demonstrated by PET
    • Asahina M, Shinotoh H, Hirayama K etal. Hypersensitivity of cortical muscarinic receptors in Parkinson's disease demonstrated by PET. Acta Neurol Scand 1995; 91: 437-443.
    • (1995) Acta Neurol Scand , vol.91 , pp. 437-443
    • Asahina, M.1    Shinotoh, H.2    Hirayama, K.3
  • 53
    • 0032998728 scopus 로고    scopus 로고
    • Human cerebral acetylcholinesterase activity measured with positron emission tomography: procedure, normal values and effect of age
    • Namba H, Iyo M, Fukushi K etal. Human cerebral acetylcholinesterase activity measured with positron emission tomography: procedure, normal values and effect of age. Eur J Nucl Med 1999; 26: 135-143.
    • (1999) Eur J Nucl Med , vol.26 , pp. 135-143
    • Namba, H.1    Iyo, M.2    Fukushi, K.3
  • 54
    • 0030910311 scopus 로고    scopus 로고
    • Measurement of acetylcholinesterase by positron emission tomography in the brains of healthy controls and patients with Alzheimer's disease
    • Iyo M, Namba H, Fukushi K etal. Measurement of acetylcholinesterase by positron emission tomography in the brains of healthy controls and patients with Alzheimer's disease. Lancet 1997; 349: 1805-1809.
    • (1997) Lancet , vol.349 , pp. 1805-1809
    • Iyo, M.1    Namba, H.2    Fukushi, K.3
  • 55
    • 0033541026 scopus 로고    scopus 로고
    • In vivo mapping of cerebral acetylcholinesterase activity in aging and Alzheimer's disease
    • Kuhl DE, Koeppe RA, Minoshima S etal. In vivo mapping of cerebral acetylcholinesterase activity in aging and Alzheimer's disease. Neurology 1999; 52: 691-699.
    • (1999) Neurology , vol.52 , pp. 691-699
    • Kuhl, D.E.1    Koeppe, R.A.2    Minoshima, S.3
  • 56
    • 0033010467 scopus 로고    scopus 로고
    • Positron emission tomographic measurement of acetylcholinesterase activity reveals differential loss of ascending cholinergic systems in Parkinson's disease and progressive supranuclear palsy
    • Shinotoh H, Namba H, Yamaguchi M etal. Positron emission tomographic measurement of acetylcholinesterase activity reveals differential loss of ascending cholinergic systems in Parkinson's disease and progressive supranuclear palsy. Ann Neurol 1999; 46: 62-69.
    • (1999) Ann Neurol , vol.46 , pp. 62-69
    • Shinotoh, H.1    Namba, H.2    Yamaguchi, M.3
  • 57
    • 0347385143 scopus 로고    scopus 로고
    • Cortical cholinergic function is more severely affected in parkinsonian dementia than in Alzheimer disease: an in vivo positron emission tomographic study
    • Bohnen NI, Kaufer DI, Ivanco LS etal. Cortical cholinergic function is more severely affected in parkinsonian dementia than in Alzheimer disease: an in vivo positron emission tomographic study. Arch Neurol 2003; 60: 1745-1748.
    • (2003) Arch Neurol , vol.60 , pp. 1745-1748
    • Bohnen, N.I.1    Kaufer, D.I.2    Ivanco, L.S.3
  • 58
    • 68249119247 scopus 로고    scopus 로고
    • Mapping of brain acetylcholinesterase alterations in Lewy body disease by PET
    • Shimada H, Hirano S, Shinotoh H etal. Mapping of brain acetylcholinesterase alterations in Lewy body disease by PET. Neurology 2009; 73: 273-278.
    • (2009) Neurology , vol.73 , pp. 273-278
    • Shimada, H.1    Hirano, S.2    Shinotoh, H.3
  • 59
    • 77954380422 scopus 로고    scopus 로고
    • Cholinergic imaging in corticobasal syndrome, progressive supranuclear palsy and frontotemporal dementia
    • Hirano S, Shinotoh H, Shimada H etal. Cholinergic imaging in corticobasal syndrome, progressive supranuclear palsy and frontotemporal dementia. Brain 2010; 133: 2058-2068.
    • (2010) Brain , vol.133 , pp. 2058-2068
    • Hirano, S.1    Shinotoh, H.2    Shimada, H.3
  • 60
    • 72849134835 scopus 로고    scopus 로고
    • Metabolic networks for assessment of therapy and diagnosis in Parkinson's disease
    • Hirano S, Eckert T, Flanagan T, Eidelberg D. Metabolic networks for assessment of therapy and diagnosis in Parkinson's disease. Mov Disord 2009; 24: 725-731.
    • (2009) Mov Disord , vol.24 , pp. 725-731
    • Hirano, S.1    Eckert, T.2    Flanagan, T.3    Eidelberg, D.4
  • 61
    • 77951026072 scopus 로고    scopus 로고
    • Estimation of plasma IC50 of donepezil for cerebral acetylcholinesterase inhibition in patients with Alzheimer disease using positron emission tomography
    • Ota T, Shinotoh H, Fukushi K etal. Estimation of plasma IC50 of donepezil for cerebral acetylcholinesterase inhibition in patients with Alzheimer disease using positron emission tomography. Clin Neuropharmacol 2010; 33: 74-78.
    • (2010) Clin Neuropharmacol , vol.33 , pp. 74-78
    • Ota, T.1    Shinotoh, H.2    Fukushi, K.3
  • 62
    • 66549127860 scopus 로고    scopus 로고
    • Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects
    • Mormino EC, Kluth JT, Madison CM etal. Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects. Brain 2009; 132: 1310-1323.
    • (2009) Brain , vol.132 , pp. 1310-1323
    • Mormino, E.C.1    Kluth, J.T.2    Madison, C.M.3
  • 63
    • 66549106850 scopus 로고    scopus 로고
    • Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease
    • Jack CR Jr, Lowe VJ, Weigand SD etal. Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease. Brain 2009; 132: 1355-1365.
    • (2009) Brain , vol.132 , pp. 1355-1365
    • Jack Jr., C.R.1    Lowe, V.J.2    Weigand, S.D.3
  • 64
    • 72049130805 scopus 로고    scopus 로고
    • Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade
    • Jack CR Jr, Knopman DS, Jagust WJ etal. Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade. Lancet Neurol 2010; 9: 119-128.
    • (2010) Lancet Neurol , vol.9 , pp. 119-128
    • Jack Jr., C.R.1    Knopman, D.S.2    Jagust, W.J.3
  • 65
    • 79956098248 scopus 로고    scopus 로고
    • Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
    • Sperling RA, Aisen PS, Beckett LA etal. Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 2011; 7: 280-292.
    • (2011) Alzheimers Dement , vol.7 , pp. 280-292
    • Sperling, R.A.1    Aisen, P.S.2    Beckett, L.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.