Translational genetic approaches to substance use disorders: Bridging the gap between mice and humans

Human Genetics

Volumn 131, Issue 6, 2012, Pages 931-939

  Palmer, Abraham A ^a   De Wit, Harriet ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANAPLASTIC LYMPHOMA KINASE; CASEIN KINASE IEPSILON; CATECHOL METHYLTRANSFERASE; MU OPIATE RECEPTOR; NICOTINIC RECEPTOR; PDZ PROTEIN;

DNA POLYMORPHISM; DRUG RESPONSE; GENETIC ASSOCIATION; HEREDITY; HISTOPATHOLOGY; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PUNISHMENT; QUANTITATIVE TRAIT LOCUS; REVIEW; RNA TRANSLATION; SEIZURE; SINGLE NUCLEOTIDE POLYMORPHISM; SUBSTANCE ABUSE; WITHDRAWAL SYNDROME;

ANIMALS; CARRIER PROTEINS; CASEIN KINASE IEPSILON; CATECHOL O-METHYLTRANSFERASE; DISEASE MODELS, ANIMAL; GENETIC ASSOCIATION STUDIES; GENETIC VARIATION; HUMANS; MICE; PHENOTYPE; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, NICOTINIC; RECEPTORS, OPIOID, MU; SPECIES SPECIFICITY; SUBSTANCE-RELATED DISORDERS;

MUS;

EID: 84862683697     PISSN: 03406717     EISSN: 14321203     Source Type: Journal    
DOI: 10.1007/s00439-011-1123-5     Document Type: Review

References (58)

1. TJ Aitman C Boone GA Churchill MO Hengartner TF Mackay DL Stemple 2011 The future of model organisms in human disease research Nat Rev Genet 12 575 582 10.1038/nrg3047 21765459 10.1038/nrg3047 1:CAS:528:DC%2BC3MXovFyjtLw%3D
2. CI Amos X Wu P Broderick IP Gorlov J Gu T Eisen Q Dong Q Zhang X Gu J Vijayakrishnan K Sullivan A Matakidou Y Wang G Mills K Doheny YY Tsai WV Chen S Shete MR Spitz RS Houlston 2008 Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1 Nat Genet 40 616 622 10.1038/ng.109 18385676 10.1038/ng.109 1:CAS:528:DC%2BD1cXltFylurw%3D
3. A Arias R Feinn HR Kranzler 2006 Association of an Asn40Asp (A118G) polymorphism in the mu-opioid receptor gene with substance dependence: a meta-analysis Drug Alcohol Depend 83 262 268 10.1016/j.drugalcdep.2005.11.024 16387451 10.1016/j.drugalcdep.2005.11.024 1:CAS:528:DC%2BD28Xmt1Oqsrk%3D
4. L Bevilacqua S Doly J Kaprio Q Yuan R Tikkanen T Paunio Z Zhou J Wedenoja L Maroteaux S Diaz A Belmer CA Hodgkinson L Dell'osso J Suvisaari E Coccaro RJ Rose L Peltonen M Virkkunen D Goldman 2010 A population-specific HTR2B stop codon predisposes to severe impulsivity Nature 468 7327 1061 1066 21179162 10.1038/nature09629 1:CAS:528:DC%2BC3MXotlGmsQ%3D%3D
5. A Beyer T Koch H Schröder S Schulz V Höllt 2004 Effect of the A118G polymorphism on binding affinity, potency and agonist-mediated endocytosis, desensitization, and resensitization of the human mu-opioid receptor J Neurochem 89 3 553 560 15086512 10.1111/j.1471-4159.2004.02340.x 1:CAS:528:DC%2BD2cXjslWqurg%3D
6. CA Bousman SJ Glatt IP Everall MT Tsuang 2009 Genetic association studies of methamphetamine use disorders: a systematic review and synthesis Am J Med Genet B Neuropsychiatr Genet 150B 1025 1049 10.1002/ajmg.b.30936 19219857 10.1002/ajmg.b.30936 1:CAS:528:DC%2BC3cXitlClsA%3D%3D
7. Bryant CD, Parker CC, Zhou L, Olker C, Chandrasekaran RY, Wager TT, Bolivar VJ, Loudon AS, Vitaterna MH, Turek FW, Palmer AA (2011) Csnk1e is a genetic regulator of sensitivity to psychostimulants and opioids. Neuropsychopharmacology. doi: 10.1038/npp.2011.287
8. KJ Buck P Metten JK Belknap JC Crabbe 1997 Quantitative trait loci involved in genetic predisposition to acute alcohol withdrawal in mice J Neurosci 17 3946 3955 9133412 1:CAS:528:DyaK2sXjt1amt7o%3D
9. K Buck P Metten J Belknap J Crabbe 1999 Quantitative trait loci affecting risk for pentobarbital withdrawal map near alcohol withdrawal loci on mouse chromosomes 1, 4, and 11 Mamm Genome 10 431 437 10337613 10.1007/s003359901018 1:CAS:528:DyaK1MXkt1Olsbo%3D
10. JC Crabbe RA Harris GF Koob 2011 Preclinical studies of alcohol binge drinking Ann N Y Acad Sci 1216 24 40 10.1111/j.1749-6632.2010.05895.x 21272009 10.1111/j.1749-6632.2010.05895.x 1:CAS:528:DC%2BC3MXkt1alu7s%3D
11. C Fehr RL Shirley JK Belknap JC Crabbe KJ Buck 2002 Congenic mapping of alcohol and pentobarbital withdrawal liability loci to a < 1 centimorgan interval of murine chromosome 4: identification of Mpdz as a candidate gene J Neurosci 22 3730 3738 11978849 1:CAS:528:DC%2BD38Xjs1SlsrY%3D
12. CD Fowler Q Lu PM Johnson MJ Marks PJ Kenny 2011 Habenular alpha5 nicotinic receptor subunit signalling controls nicotine intake Nature 471 597 601 10.1038/nature09797 21278726 10.1038/nature09797 1:CAS:528: DC%2BC3MXht12msr0%3D
13. S Frahm MA Slimak L Ferrarese J Santos-Torres B Antolin-Fontes S Auer S Filkin S Pons JF Fontaine V Tsetlin U Maskos I Ibanez-Tallon 2011 Aversion to nicotine is regulated by the balanced activity of beta4 and alpha5 nicotinic receptor subunits in the medial habenula Neuron 70 522 535 10.1016/j.neuron. 2011.04.013 21555077 10.1016/j.neuron.2011.04.013 1:CAS:528:DC%2BC3MXlvVersro%3D
14. D Goldman F Ducci 2007 Deconstruction of vulnerability to complex diseases: enhanced effect sizes and power of intermediate phenotypes Sci World J 7 124 130 10.1100/tsw.2007.210 10.1100/tsw.2007.210 1:CAS:528: DC%2BD1cXjsFeku70%3D
15. II Gottesman TD Gould 2003 The endophenotype concept in psychiatry: etymology and strategic intentions Am J Psychiatry 160 636 645 12668349 10.1176/appi.ajp.160.4.636
16. TD Gould II Gottesman 2006 Psychiatric endophenotypes and the development of valid animal models Genes Brain Behav 5 113 119 10.1111/j.1601-183X.2005. 00186.x 16507002 10.1111/j.1601-183X.2005.00186.x 1:STN:280: DC%2BD287itVOqsg%3D%3D
17. RA Grucza EO Johnson RF Krueger N Breslau NL Saccone LS Chen J Derringer A Agrawal M Lynskey LJ Bierut 2010 Incorporating age at onset of smoking into genetic models for nicotine dependence: evidence for interaction with multiple genes Addict Biol 15 3 346 357 20624154 10.1111/j.1369-1600.2010.00220.x 1:CAS:528:DC%2BC3cXps1agsr0%3D
18. RJ Hung JD McKay V Gaborieau P Boffetta M Hashibe D Zaridze A Mukeria N Szeszenia-Dabrowska J Lissowska P Rudnai E Fabianova D Mates V Bencko L Foretova V Janout C Chen G Goodman JK Field T Liloglou G Xinarianos A Cassidy J McLaughlin G Liu S Narod HE Krokan F Skorpen MB Elvestad K Hveem L Vatten J Linseisen F Clavel-Chapelon P Vineis HB Bueno-de-Mesquita E Lund C Martinez S Bingham T Rasmuson P Hainaut E Riboli W Ahrens S Benhamou P Lagiou D Trichopoulos I Holcatova F Merletti K Kjaerheim A Agudo G Macfarlane R Talamini L Simonato R Lowry DI Conway A Znaor C Healy D Zelenika A Boland M Delepine M Foglio D Lechner F Matsuda H Blanche I Gut S Heath M Lathrop P Brennan 2008 A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25 Nature 452 633 637 10.1038/nature06885 18385738 10.1038/nature06885 1:CAS:528:DC%2BD1cXktFCgtrs%3D
19. VM Karpyak JH Kim JM Biernacka ED Wieben DA Mrazek JL Black DS Choi 2009 Sequence variations of the human MPDZ gene and association with alcoholism in subjects with European ancestry Alcohol Clin Exp Res 33 712 721 10.1111/j.1530-0277.2008.00888.x 19175764 10.1111/j.1530-0277.2008.00888.x 1:CAS:528:DC%2BD1MXltVOiur4%3D
20. Karpyak VM, Geske JR, Colby CL, Mrazek DA, Biernacka JM (2011) Genetic variability in the NMDA-dependent AMPA trafficking cascade is associated with alcohol dependence. Addict Biol. doi: 10.1111/j.1369-1600.2011.00338.x
21. RL Kember C Fernandes EM Tunbridge L Liu JL Paya-Cano MJ Parsons LC Schalkwyk 2010 A B2 SINE insertion in the Comt1 gene (Comt1(B2i)) results in an overexpressing, behavior modifying allele present in classical inbred mouse strains Genes Brain Behav 9 925 932 10.1111/j.1601-183X.2010.00614.x 20618449 10.1111/j.1601-183X.2010.00614.x 1:CAS:528:DC%2BC3cXhs1WmsbfN
22. T Kroslak KS Laforge RJ Gianotti A Ho DA Nielsen MJ Kreek 2007 The single nucleotide polymorphism A118G alters functional properties of the human mu opioid receptor J Neurochem 103 77 87 10.1111/j.1471-4159.2007.04738.x 17877633 1:CAS:528:DC%2BD2sXhtF2qu7nJ
23. HM Lachman DF Papolos T Saito YM Yu CL Szumlanski RM Weinshilboum 1996 Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders Pharmacogenetics 6 243 250 8807664 10.1097/00008571-199606000-00007 1:CAS:528:DyaK28XksFemsLw%3D
24. AW Lasek F Giorgetti KH Berger S Tayor U Heberlein 2011 Lmo genes regulate behavioral responses to ethanol in Drosophila melanogaster and the mouse Alcohol Clin Exp Res 35 1600 1606 10.1111/j.1530-0277.2011.01506.x 21599714 1:CAS:528:DC%2BC3MXht1OisbrK
25. AW Lasek J Lim CL Kliethermes KH Berger G Joslyn G Brush L Xue M Robertson MS Moore K Vranizan SW Morris MA Schuckit RL White U Heberlein 2011 An evolutionary conserved role for anaplastic lymphoma kinase in behavioral responses to ethanol PLoS One 6 e22636 10.1371/journal.pone.0022636 21799923 10.1371/journal.pone.0022636 1:CAS:528:DC%2BC3MXhtVGqsrjL
26. O Levran D Londono K O'Hara DA Nielsen E Peles J Rotrosen P Casadonte S Linzy M Randesi J Ott M Adelson MJ Kreek 2008 Genetic susceptibility to heroin addiction: a candidate gene association study Genes Brain Behav 7 720 729 10.1111/j.1601-183X.2008.00410.x 18518925 10.1111/j.1601-183X.2008.00410.x 1:CAS:528:DC%2BD1cXhtlKru7bK
27. Z Li MK Mulligan X Wang MF Miles L Lu RW Williams 2010 A transposon in comt generates mRNA variants and causes widespread expression and behavioral differences among mice PLoS One 5 e12181 10.1371/journal.pone.0012181 20808911 10.1371/journal.pone.0012181
28. JZ Liu F Tozzi DM Waterworth SG Pillai P Muglia L Middleton W Berrettini CW Knouff X Yuan G Waeber P Vollenweider M Preisig NJ Wareham JH Zhao RJ Loos I Barroso KT Khaw S Grundy P Barter R Mahley A Kesaniemi R McPherson JB Vincent J Strauss JL Kennedy A Farmer P McGuffin R Day K Matthews P Bakke A Gulsvik S Lucae M Ising T Brueckl S Horstmann HE Wichmann R Rawal N Dahmen C Lamina O Polasek L Zgaga J Huffman S Campbell J Kooner JC Chambers MS Burnett JM Devaney AD Pichard KM Kent L Satler JM Lindsay R Waksman S Epstein JF Wilson SH Wild H Campbell V Vitart MP Reilly M Li L Qu R Wilensky W Matthai HH Hakonarson DJ Rader A Franke M Wittig A Schafer M Uda A Terracciano X Xiao F Busonero P Scheet D Schlessinger D St Clair D Rujescu GR Abecasis HJ Grabe A Teumer H Volzke A Petersmann U John I Rudan C Hayward AF Wright I Kolcic BJ Wright JR Thompson AJ Balmforth AS Hall NJ Samani CA Anderson T Ahmad CG Mathew M Parkes J Satsangi M Caulfield PB Munroe M Farrall A Dominiczak J Worthington W Thomson S Eyre A Barton Wellcome Trust Case Control Consortium V Mooser C Francks J Marchini 2010 Meta-analysis and imputation refines the association of 15q25 with smoking quantity Nat Genet 42 436 440 10.1038/ng.572 20418889 10.1038/ng.572 1:CAS:528:DC%2BC3cXltFKlsro%3D
29. SD Mague JA Blendy 2010 OPRM1 SNP (A118G): involvement in disease development, treatment response, and animal models Drug Alcohol Depend 108 172 182 10.1016/j.drugalcdep.2009.12.016 20074870 10.1016/j.drugalcdep.2009.12.016 1:CAS:528:DC%2BC3cXlsFSns7c%3D
30. SD Mague C Isiegas P Huang LY Liu-Chen C Lerman JA Blendy 2009 Mouse model of OPRM1 (A118G) polymorphism has sex-specific effects on drug-mediated behavior Proc Natl Acad Sci USA 106 10847 10852 10.1073/pnas.0901800106 19528658 10.1073/pnas.0901800106 1:CAS:528:DC%2BD1MXosF2qsLY%3D
31. TA Manolio FS Collins NJ Cox DB Goldstein LA Hindorff DJ Hunter MI McCarthy EM Ramos LR Cardon A Chakravarti JH Cho AE Guttmacher A Kong L Kruglyak E Mardis CN Rotimi M Slatkin D Valle AS Whittemore M Boehnke AG Clark EE Eichler G Gibson JL Haines TFC Mackay SA McCarroll PM Visscher 2009 Finding the missing heritability of complex diseases Nature 461 747 753 10.1038/nature08494 19812666 10.1038/nature08494 1:CAS:528:DC%2BD1MXht1CisbrF
32. VS Mattay TE Goldberg F Fera AR Hariri A Tessitore MF Egan B Kolachana JH Callicott DR Weinberger 2003 Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine Proc Natl Acad Sci USA 100 6186 6191 10.1073/pnas.0931309100 12716966 10.1073/pnas.0931309100 1:CAS:528:DC%2BD3sXjvFOlurk%3D
33. MR Munafo J Flint 2011 Dissecting the genetic architecture of human personality Trends Cogn Sci 15 395 400 10.1016/j.tics.2011.07.007 21831694
34. Nikolova YS, Ferrell RE, Manuck SB, Hariri AR (2011) Multilocus genetic profile for dopamine signaling predicts ventral striatum reactivity. Neuropsychopharmacology 36(9):1940-1947. doi: 10.1038/npp.2011.82
35. AA Palmer SC Dulawa 2010 Murine warriors or worriers: the saga of Comt1, B2 SINE elements, and the future of translational genetics Front Neurosci 4 177 10.3389/fnins.2010.00177 20976038 10.3389/fnins.2010.00177
36. AA Palmer M Verbitsky R Suresh HM Kamens CL Reed N Li S Burkhart-Kasch CS McKinnon JK Belknap TC Gilliam TJ Phillips 2005 Gene expression differences in mice divergently selected for methamphetamine sensitivity Mamm Genome 16 291 305 16104378 10.1007/s00335-004-2451-8 1:CAS:528:DC%2BD2MXmtleksrw%3D
37. F Papaleo JN Crawley J Song BK Lipska J Pickel DR Weinberger J Chen 2008 Genetic dissection of the role of catechol-O-methyltransferase in cognition and stress reactivity in mice J Neurosci 28 8709 8723 10.1523/JNEUROSCI.2077-08.2008 18753372 10.1523/JNEUROSCI.2077-08.2008 1:CAS:528:DC%2BD1cXhtVyksLzI
38. TJ Phillips HM Kamens JM Wheeler 2008 Behavioral genetic contributions to the study of addiction-related amphetamine effects Neurosci Biobehav Rev 32 707 759 10.1016/j.neubiorev.2007.10.008 18207241 10.1016/j.neubiorev.2007.10.008 1:CAS:528:DC%2BD1cXjtVegt7o%3D
39. VA Ramchandani J Umhau FJ Pavon V Ruiz-Velasco W Margas H Sun R Damadzic R Eskay M Schoor A Thorsell ML Schwandt WH Sommer DT George LH Parsons P Herscovitch D Hommer M Heilig 2011 A genetic determinant of the striatal dopamine response to alcohol in men Mol Psychiatry 16 809 817 10.1038/mp.2010.56 20479755 10.1038/mp.2010.56 1:CAS:528:DC%2BC3MXpt1ahtbk%3D
40. Ray LA, Barr CS, Blendy JA, Oslin D, Goldman D, Anton RF (2011) The role of the Asn40Asp polymorphism of the mu opioid receptor gene (OPRM1) on alcoholism etiology and treatment: a critical review. Alcohol Clin Exp Res. doi: 10.1111/j.1530-0277.2011.01633.x
41. SF Saccone AL Hinrichs NL Saccone GA Chase K Konvicka PA Madden N Breslau EO Johnson D Hatsukami O Pomerleau GE Swan AM Goate J Rutter S Bertelsen L Fox D Fugman NG Martin GW Montgomery JC Wang DG Ballinger JP Rice LJ Bierut 2007 Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs Hum Mol Genet 16 36 49 10.1093/hmg/ddl438 17135278 10.1093/hmg/ddl438 1:CAS:528: DC%2BD2sXotVWktw%3D%3D
42. NL Saccone RC Culverhouse TH Schwantes-An DS Cannon X Chen S Cichon I Giegling S Han Y Han K Keskitalo-Vuokko X Kong MT Landi JZ Ma SE Short SH Stephens VL Stevens L Sun Y Wang AS Wenzlaff SH Aggen N Breslau P Broderick N Chatterjee J Chen AC Heath M Heliovaara NR Hoft DJ Hunter MK Jensen NG Martin GW Montgomery T Niu TJ Payne L Peltonen ML Pergadia JP Rice R Sherva MR Spitz J Sun JC Wang RB Weiss W Wheeler SH Witt BZ Yang NE Caporaso MA Ehringer T Eisen SM Gapstur J Gelernter R Houlston J Kaprio KS Kendler P Kraft MF Leppert MD Li PA Madden MM Nothen S Pillai M Rietschel D Rujescu A Schwartz CI Amos LJ Bierut 2010 Multiple independent loci at chromosome 15q25 1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD PLoS Genet 6 e1001053 10.1371/journal.pgen.1001053 20700436 10.1371/journal.pgen.1001053
43. SK Segall AG Nackley L Diatchenko WR Lariviere X Lu JS Marron L Grabowski-Boase JR Walker G Slade J Gauthier JS Bailey BM Steffy TM Maynard LM Tarantino T Wiltshire 2010 Comt1 genotype and expression predicts anxiety and nociceptive sensitivity in inbred strains of mice Genes Brain Behav 9 933 946 10.1111/j.1601-183X.2010.00633.x 20659173 10.1111/j.1601-183X.2010.00633.x 1:CAS:528:DC%2BC3cXhs1WmsbfP
44. J Shi JK Wittke-Thompson JA Badner E Hattori JB Potash VL Willour FJ McMahon ES Gershon C Liu 2008 Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm Am J Med Genet B Neuropsychiatr Genet 147B 1047 1055 10.1002/ajmg.b.30714 18228528 10.1002/ajmg.b.30714 1:CAS:528:DC%2BD1cXht12ru7rP
45. RL Shirley NA Walter MT Reilly C Fehr KJ Buck 2004 Mpdz is a quantitative trait gene for drug withdrawal seizures Nat Neurosci 7 699 700 10.1038/nn1271 15208631 10.1038/nn1271 1:CAS:528:DC%2BD2cXltF2htb0%3D
46. WC Skarnes B Rosen AP West M Koutsourakis W Bushell V Iyer AO Mujica M Thomas J Harrow T Cox D Jackson J Severin P Biggs J Fu M Nefedov PJ de Jong AF Stewart A Bradley 2011 A conditional knockout resource for the genome-wide study of mouse gene function Nature 474 337 342 10.1038/nature10163 21677750 10.1038/nature10163 1:CAS:528:DC%2BC3MXnsFOqsrs%3D
47. Stephens DN, Crombag HS, Duka T (2011) The challenge of studying parallel behaviors in humans and animal models. Curr Top Behav Neurosci. doi: 10.1007/7854-2011-133
48. TE Thorgeirsson F Geller P Sulem T Rafnar A Wiste KP Magnusson A Manolescu G Thorleifsson H Stefansson A Ingason SN Stacey JT Bergthorsson S Thorlacius J Gudmundsson T Jonsson M Jakobsdottir J Saemundsdottir O Olafsdottir LJ Gudmundsson G Bjornsdottir K Kristjansson H Skuladottir HJ Isaksson T Gudbjartsson GT Jones T Mueller A Gottsater A Flex KK Aben F de Vegt PF Mulders D Isla MJ Vidal L Asin B Saez L Murillo T Blondal H Kolbeinsson JG Stefansson I Hansdottir V Runarsdottir R Pola B Lindblad AM van Rij B Dieplinger M Haltmayer JI Mayordomo LA Kiemeney SE Matthiasson H Oskarsson T Tyrfingsson DF Gudbjartsson JR Gulcher S Jonsson U Thorsteinsdottir A Kong K Stefansson 2008 A variant associated with nicotine dependence, lung cancer and peripheral arterial disease Nature 452 638 642 10.1038/nature06846 18385739 10.1038/nature06846 1:CAS:528:DC%2BD1cXktFCgsbg%3D
49. TE Thorgeirsson DF Gudbjartsson I Surakka JM Vink N Amin F Geller P Sulem T Rafnar T Esko S Walter C Gieger R Rawal M Mangino I Prokopenko R Magi K Keskitalo IH Gudjonsdottir S Gretarsdottir H Stefansson JR Thompson YS Aulchenko M Nelis KK Aben M den Heijer A Dirksen H Ashraf N Soranzo AM Valdes C Steves AG Uitterlinden A Hofman A Tonjes P Kovacs JJ Hottenga G Willemsen N Vogelzangs A Doring N Dahmen B Nitz ML Pergadia B Saez V De Diego V Lezcano MD Garcia-Prats S Ripatti M Perola J Kettunen AL Hartikainen A Pouta J Laitinen M Isohanni S Huei-Yi M Allen M Krestyaninova AS Hall GT Jones AM van Rij T Mueller B Dieplinger M Haltmayer S Jonsson SE Matthiasson H Oskarsson T Tyrfingsson LA Kiemeney JI Mayordomo JS Lindholt JH Pedersen WA Franklin H Wolf GW Montgomery AC Heath NG Martin PA Madden I Giegling D Rujescu MR Jarvelin V Salomaa M Stumvoll TD Spector HE Wichmann A Metspalu NJ Samani BW Penninx BA Oostra DI Boomsma H Tiemeier CM van Duijn J Kaprio JR Gulcher ENGAGE Consortium MI McCarthy L Peltonen U Thorsteinsdottir K Stefansson 2010 Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior Nat Genet 42 448 453 10.1038/ng.573 20418888 10.1038/ng.573 1:CAS:528:DC%2BC3cXltFKltr4%3D
50. Tobacco and Genetics Consortium 2010 Genome-wide meta-analyses identify multiple loci associated with smoking behavior Nat Genet 42 441 447 10.1038/ng.571 10.1038/ng.571
51. T Truong RJ Hung CI Amos X Wu H Bickeboller A Rosenberger W Sauter T Illig HE Wichmann A Risch H Dienemann R Kaaks P Yang R Jiang JK Wiencke M Wrensch H Hansen KT Kelsey K Matsuo K Tajima AG Schwartz A Wenzlaff A Seow C Ying A Staratschek-Jox P Nurnberg E Stoelben J Wolf P Lazarus JE Muscat CJ Gallagher S Zienolddiny A Haugen HF van der Heijden LA Kiemeney D Isla JI Mayordomo T Rafnar K Stefansson ZF Zhang SC Chang JH Kim YC Hong EJ Duell AS Andrew F Lejbkowicz G Rennert H Muller H Brenner L Le Marchand S Benhamou C Bouchardy MD Teare X Xue J McLaughlin G Liu JD McKay P Brennan MR Spitz 2010 Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21: a pooled analysis from the International Lung Cancer Consortium J Natl Cancer Inst 102 959 971 10.1093/jnci/djq178 20548021 10.1093/jnci/djq178 1:CAS:528:DC%2BC3cXptlegsL8%3D
52. EM Tunbridge 2010 The catechol-O-methyltransferase gene: its regulation and polymorphisms Int Rev Neurobiol 95 7 27 10.1016/B978-0-12-381326-8.00002-8 21095457 10.1016/B978-0-12-381326-8.00002-8 1:CAS:528:DC%2BC3MXovFSnuw%3D%3D
53. J Veenstra-VanderWeele A Qaadir AA Palmer EH Cook Jr. H de Wit 2006 Association between the casein kinase 1 epsilon gene region and subjective response to d-amphetamine Neuropsychopharmacology 31 1056 1063 10.1038/sj.npp.1300936 16237383 10.1038/sj.npp.1300936 1:CAS:528: DC%2BD28XjsFahur8%3D
54. SI Walaas HC Hemmings Jr. P Greengard AC Nairn 2011 Beyond the dopamine receptor: regulation and roles of serine/threonine protein phosphatases Front Neuroanat 5 50 10.3389/fnana.2011.00050 21904525 10.3389/fnana.2011.00050 1:CAS:528:DC%2BC38XjvV2msQ%3D%3D
55. C Walter J Lotsch 2009 Meta-analysis of the relevance of the OPRM1 118A>G genetic variant for pain treatment Pain 146 270 275 10.1016/j.pain.2009.07.013 19683391 10.1016/j.pain.2009.07.013 1:CAS:528:DC%2BD1MXhtlygs7fM
56. RA Wise MA Bozarth 1987 A psychomotor stimulant theory of addiction Psychol Rev 94 469 492 3317472 10.1037/0033-295X.94.4.469 1:STN:280: DyaL1c%2FmvFShtg%3D%3D
57. V Yuferov O Levran D Proudnikov DA Nielsen MJ Kreek 2010 Search for genetic markers and functional variants involved in the development of opiate and cocaine addiction and treatment Ann N Y Acad Sci 1187 184 207 10.1111/j.1749-6632.2009.05275.x 20201854 10.1111/j.1749-6632.2009.05275.x 1:CAS:528:DC%2BC3cXks1Smsr0%3D
58. Y Zhang D Wang AD Johnson AC Papp W Sadée 2005 Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G J Biol Chem 280 38 32618 32624 16046395 10.1074/jbc.M504942200 1:CAS:528: DC%2BD2MXhtVWiur7I