Imaging amyloid plaque in Alzheimer's disease brain with a biotinylated Aβ peptide radiopharmaceutical conjugated to an IgG-avidin fusion protein

Bioconjugate Chemistry

Volumn 23, Issue 6, 2012, Pages 1318-1321

  Sumbria, Rachita K ^a   Boado, Ruben J ^a,b   Pardridge, William M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b ArmaGen Technologies Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COENZYMES; GLYCOPROTEINS; INSULIN; MAMMALS; MOLECULES; MONOCLONAL ANTIBODIES; NEURODEGENERATIVE DISEASES; RADIOGRAPHY;

ALZHEIMERS DISEASE; AMYLOID PEPTIDES; AMYLOID PLAQUES; AVIDIN-BIOTIN TECHNOLOGY; BLOOD-BRAIN BARRIER; FUSION PROTEINS; HOST CELLS; HUMAN INSULINS; INSULIN RECEPTORS; MAMMALIAN HOSTS;

PEPTIDES;

AMYLOID BETA PROTEIN[1-40]; BIOTIN; HUMAN INSULIN RECEPTOR MONOCLONAL ANTIBODY AVIDIN FUSION PROTEIN; HYBRID PROTEIN; INSULIN RECEPTOR; IODINE 125; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMYLOID PLAQUE; ARTICLE; AUTOPSY; AUTORADIOGRAPHY; BINDING AFFINITY; BIOTINYLATION; BLOOD BRAIN BARRIER; BRAIN; CLINICAL EVALUATION; CONJUGATION; FROZEN SECTION; GENETIC ENGINEERING; HUMAN; HUMAN TISSUE; ISOTOPE LABELING; MAMMAL CELL; NEUROIMAGING; PROTEIN BINDING; PROTEIN DOMAIN; TISSUE SECTION;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AUTORADIOGRAPHY; AVIDIN; BIOTINYLATION; BRAIN; HUMANS; IMMUNOGLOBULIN G; IODINE RADIOISOTOPES; MODELS, MOLECULAR; PEPTIDE FRAGMENTS; PLAQUE, AMYLOID; RADIOPHARMACEUTICALS; RECOMBINANT FUSION PROTEINS;

EID: 84862679517     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc3001744     Document Type: Article

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