Efficacy of EGFR inhibition is modulated by model, sex, genetic background and diet: Implications for preclinical cancer prevention and therapy trials

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Rinella, Erica S ^a   Threadgill, David W ^a,b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; APC PROTEIN; AZOXYMETHANE; EPIDERMAL GROWTH FACTOR RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CANCER MODEL; CANCER PREVENTION; COLORECTAL CANCER; CONTROLLED STUDY; DIETARY INTAKE; FEMALE; GENETIC MODEL; MALE; MOUSE; NONHUMAN; PREDICTIVE VALUE; PROTEIN PHOSPHORYLATION; SEX DIFFERENCE;

ANIMALS; ANTINEOPLASTIC AGENTS; AZOXYMETHANE; COLORECTAL NEOPLASMS; DIET; DISEASE MODELS, ANIMAL; FEMALE; MALE; MICE; MICE, INBRED C57BL; PHOSPHORYLATION; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; SEX FACTORS; TYRPHOSTINS;

EID: 84862651055     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0039552     Document Type: Article

References (24)

1. Roberts TG Jr, Goulart BH, Squitieri L, Stallings SC, Halpern EF, et al. (2004) Trends in the risks and benefits to patients with cancer participating in phase 1 clinical trials. JAMA 292: 2130-2140.
2. Langreth R, (2002) Conquering Cancer. Forbes 10: 118-123.
3. Harari PM, Allen GW, Bonner JA, (2007) Biology of interactions: antiepidermal growth factor receptor agents. J Clin Oncol 25: 4057-4065.
4. Steele VE, Moon RC, Lubet RA, Grubbs CJ, Reddy BS, et al. (1994) Preclinical efficacy evaluation of potential chemopreventive agents in animal carcinogenesis models: methods and results from the NCI Chemoprevention Drug Development Program. J Cell Biochem pp. 32-54.
5. Druckrey H, (1970) Colonic Carcinomas by 1,2-Dialkylhydrazines and Azoxyalkanes. Springfield, IL: Charles C Thomas.
6. Su LK, Kinzler KW, Vogelstein B, Preisinger AC, Moser AR, et al. (1992) Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science 256: 668-670.
7. Lipkin M, (1997) New rodent models for studies of chemopreventive agents. J Cell Biochem pp. 144-147.
8. Roberts RB, Min L, Washington MK, Olsen SJ, Settle SH, et al. (2002) Importance of epidermal growth factor receptor signaling in establishment of adenomas and maintenance of carcinomas during intestinal tumorigenesis. Proc Natl Acad Sci U S A 99: 1521-1526.
9. Torrance CJ, Jackson PE, Montgomery E, Kinzler KW, Vogelstein B, et al. (2000) Combinatorial chemoprevention of intestinal neoplasia. Nat Med 6: 1024-1028.
10. Moran AE, Hunt DH, Javid SH, Redston M, Carothers AM, et al. (2004) Apc deficiency is associated with increased Egfr activity in the intestinal enterocytes and adenomas of C57BL/6J-Min/+ mice. J Biol Chem 279: 43261-43272.
11. Malecka-Panas E, Fligiel SE, Relan NK, Dutta S, Majumdar AP, (1996) Azoxymethane enhances ligand-induced activation of EGF receptor tyrosine kinase in the colonic mucosa of rats. Carcinogenesis 17: 233-237.
12. Fichera A, Little N, Jagadeeswaran S, Dougherty U, Sehdev A, et al. (2007) Epidermal growth factor receptor signaling is required for microadenoma formation in the mouse azoxymethane model of colonic carcinogenesis. Cancer Research 67: 827-835.
13. Xue L, Lipkin M, Newmark H, Wang J, (1999) Influence of dietary calcium and vitamin D on diet-induced epithelial cell hyperproliferation in mice. J Natl Cancer Inst 91: 176-181.
14. Newmark HL, Yang K, Lipkin M, Kopelovich L, Liu Y, et al. (2001) A Western-style diet induces benign and malignant neoplasms in the colon of normal C57Bl/6 mice. Carcinogenesis 22: 1871-1875.
15. Yang K, Kurihara N, Fan K, Newmark H, Rigas B, et al. (2008) Dietary induction of colonic tumors in a mouse model of sporadic colon cancer. Cancer Research 68: 7803-7810.
16. Bissahoyo A, Pearsall RS, Hanlon K, Amann V, Hicks D, et al. (2005) Azoxymethane is a genetic background-dependent colorectal tumor initiator and promoter in mice: effects of dose, route, and diet. Toxicol Sci 88: 340-345.
17. Nambiar PR, Girnun G, Lillo NA, Guda K, Whiteley HE, et al. (2003) Preliminary analysis of azoxymethane induced colon tumors in inbred mice commonly used as transgenic/knockout progenitors. Int J Oncol 22: 145-150.
18. Papanikolaou A, Wang QS, Delker DA, Rosenberg DW, (1998) Azoxymethane-induced colon tumors and aberrant crypt foci in mice of different genetic susceptibility. Cancer Lett 130: 29-34.
19. Kwong LN, Shedlovsky A, Biehl BS, Clipson L, Pasch CA, et al. (2007) Identification of Mom7, a novel modifier of Apc(Min/+) on mouse chromosome 18. Genetics 176: 1237-1244.
20. Steffensen IL, Alexander J, (2006) Impact of genetic background on spontaneous or 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced intestinal tumorigenesis in Min/+ mice. Cancer Lett 240: 289-296.
21. Ruff SJ, Chen K, Cohen S, (1997) Peroxovanadate induces tyrosine phosphorylation of multiple signaling proteins in mouse liver and kidney. J Biol Chem 272: 1263-1267.
22. Aggarwal BB, Shishodia S, (2006) Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol 71: 1397-1421.
23. Vacaresse N, Lajoie-Mazenc I, Auge N, Suc I, Frisach MF, et al. (1999) Activation of epithelial growth factor receptor pathway by unsaturated fatty acids. Circ Res 85: 892-899.
24. Moral R, Solanas M, Garcia G, Colomer R, Escrich E, (2003) Modulation of EGFR and neu expression by n-6 and n-9 high-fat diets in experimental mammary adenocarcinomas. Oncol Rep 10: 1417-1424.