The apicoplast: A red alga in human parasites

Essays in Biochemistry

Volumn 51, Issue 1, 2011, Pages 111-125

  Striepen, Boris ^a  

^a UNIVERSITY OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALGAE; ANIMALIA; APICOMPLEXA; BACILLARIOPHYTA; LAMINARIALES; RHODOPHYTA;

ANIMAL; APICOMPLEXA; CELL ORGANELLE; CHLOROPLAST; CYTOLOGY; EVOLUTION; HUMAN; METABOLISM; PARASITOLOGY; PATHOGENICITY; PHOTOSYNTHESIS; PHYSIOLOGY; PROTOZOAL INFECTION; RED ALGA; REVIEW;

ANIMALS; APICOMPLEXA; BIOLOGICAL EVOLUTION; CHLOROPLASTS; HUMANS; ORGANELLES; PHOTOSYNTHESIS; PROTOZOAN INFECTIONS; RHODOPHYTA;

EID: 84862636540     PISSN: 00711365     EISSN: None     Source Type: Journal    
DOI: 10.1042/BSE0510111     Document Type: Article

References (35)

1. Wilson, R.J., Gardner, M.J., Feagin, J.E. and Williamson, D.H. (1991) Have malaria parasites three genomes? Parasitol. Today 7, 134-136
2. Kohler, S., Delwiche, C.F., Denny, P.W., Tilney, L.G., Webster, P., Wilson, R.J., Palmer, J.D. and Roos, D.S. (1997) A plastid of probable green algal origin in apicomplexan parasites. Science 275, 1485-1489
3. McFadden, G.I., Reith, M.E., Munholland, J. and Lang-Unnasch, N. (1996) Plastid in human parasites. Nature 381, 482
4. Gould, S.B., Waller, R.F. and McFadden, G.I. (2008) Plastid evolution. Annu. Rev. Plant Biol. 59, 491-517
5. Moore, R.B., Obornik, M., Janouskovec, J., Chrudimsky, T., Vancova, M., Green, D.H., Wright, S.W., Davies, N.W., Bolch, C.J., Heimann, K. et al. (2008) A photosynthetic alveolate closely related to apicomplexan parasites. Nature 451, 959-963
6. Fichera, M.E. and Roos, D.S. (1997) A plastid organelle as a drug target in apicomplexan parasites. Nature 390, 407-409
7. He, C.Y., Shaw, M.K., Pletcher, C.H., Striepen, B., Tilney, L.G. and Roos, D.S. (2001) A plastid segregation defect in the protozoan parasite Toxoplasma gondii. EMBO J. 20, 330-339
8. van Dooren, G.G., Reiff, S.B., Tomova, C., Meissner, M., Humbel, B.M. and Striepen, B. (2009) A novel dynamin-related protein has been recruited for apicoplast fission in Toxoplasma gondii. Curr. Biol. 19, 267-276
9. Ralph, S.A., van Dooren, G.G., Waller, R.F., Crawford, M.J., Fraunholz, M.J., Foth, B.J., Tonkin, C.J., Roos, D.S. and McFadden, G.I. (2004) Tropical infectious diseases: metabolic maps and functions of the Plasmodium falciparum apicoplast. Nat. Rev. Microbiol. 2, 203-216
10. Gardner, M.J., Hall, N., Fung, E., White, O., Berriman, M., Hyman, R.W., Carlton, J.M., Pain, A., Nelson, K.E., Bowman, S. et al. (2002) Genome sequence of the human malaria parasite Plasmodium falciparum. Nature 419, 498-511
11. Waller, R.F., Keeling, P.J., Donald, R.G., Striepen, B., Handman, E., Lang-Unnasch, N., Cowman, A.F., Besra, G.S., Roos, D.S. and McFadden, G.I. (1998) Nuclear-encoded proteins target to the plastid in Toxoplasma gondii and Plasmodium falciparum. Proc. Natl. Acad. Sci. U.S.A. 95, 12352-12357
12. Jomaa, H., Wiesner, J., Sanderbrand, S., Altincicek, B., Weidemeyer, C., Hintz, M., Turbachova, I., Eberl, M., Zeidler, J., Lichtenthaler, H.K. et al. (1999) Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs. Science 285, 1573-1576
13. Foth, B.J., Ralph, S.A., Tonkin, C.J., Struck, N.S., Fraunholz, M., Roos, D.S., Cowman, A.F. and McFadden, G.I. (2003) Dissecting apicoplast targeting in the malaria parasite Plasmodium falciparum. Science 299, 705-708
14. Seeber, F. and Soldati-Favre, D. (2010) Metabolic pathways in the apicoplast of apicomplexa. Int. Rev. Cell Mol. Biol. 281, 161-228
15. Mazumdar, J., Wilson, E.H., Masek, K., Hunter, C.A. and Striepen, B. (2006) Apicoplast fatty acid synthesis is essential for organelle biogenesis and parasite survival in Toxoplasma gondii. Proc. Natl. Acad. Sci. U.S.A. 103, 13192-13197
16. Yu, M., Kumar, T.R., Nkrumah, L.J., Coppi, A., Retzlaff, S., Li, C.D., Kelly, B.J., Moura, P.A., Lakshmanan, V., Freundlich, J.S. et al. (2008) The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites. Cell Host Microbe 4, 567-578
17. Vaughan, A.M., O'Neill, M.T., Tarun, A.S., Camargo, N., Phuong, T.M., Aly, A.S., Cowman, A.F. and Kappe, S.H. (2009) Type II fatty acid synthesis is essential only for malaria parasite late liver stage development. Cell. Microbiol. 11, 506-520
18. Nair, S.C., Brooks, C.F., Goodman, C.D., Strurm, A., McFadden, G.I., Sundriyal, S., Anglin, J.L., Song, Y., Moreno, S.N. and Striepen, B. (2011) Apicoplast isoprenoid precursor synthesis and the molecular basis of fosmidomycin resistance in Toxoplasma gondii. J. Exp. Med. 208, 1547-1559
19. Oyakhirome, S., Issifou, S., Pongratz, P., Barondi, F., Ramharter, M., Kun, J.F., Missinou, M.A., Lell, B. and Kremsner, P.G. (2007) Randomized controlled trial of fosmidomycin-clindamycin versus sulfadoxine-pyrimethamine in the treatment of Plasmodium falciparum malaria. Antimicrob. Agents Chemother. 51, 1869-1871
20. Shanmugam, D., Wu, B., Ramirez, U., Jaffe, E.K. and Roos, D.S. (2010) Plastid-associated porphobilinogen synthase from Toxoplasma gondii: kinetic and structural properties validate therapeutic potential. J. Biol. Chem. 285, 22122-22131
21. Mullin, K.A., Lim, L., Ralph, S.A., Spurck, T.P., Handman, E. and McFadden, G.I. (2006) Membrane transporters in the relict plastid of malaria parasites. Proc. Natl. Acad. Sci. U.S.A. 103, 9572-9577
22. Brooks, C.F., Johnsen, H., van Dooren, G.G., Muthalagi, M., Lin, S.S., Bohne, W., Fischer, K. and Striepen, B. (2010) The toxoplasma apicoplast phosphate translocator links cytosolic and apicoplast metabolism and is essential for parasite survival. Cell Host Microbe 7, 62-73
23. Lim, L., Linka, M., Mullin, K.A., Weber, A.P. and McFadden, G.I. (2010) The carbon and energy sources of the non-photosynthetic plastid in the malaria parasite. FEBS Lett. 584, 549-554
24. Dahl, E.L. and Rosenthal, P.J. (2008) Apicoplast translation, transcription and genome replication: targets for antimalarial antibiotics. Trends Parasitol. 24, 279-284
25. Sommer, M.S., Gould, S.B., Lehmann, P., Gruber, A., Przyborski, J.M. and Maier, U.G. (2007) Der1-mediated preprotein import into the periplastid compartment of chromalveolates? Mol. Biol. Evol. 24, 918-928
26. Bolte, K., Bullmann, L., Hempel, F., Bozarth, A., Zauner, S. and Maier, U.G. (2009) Protein targeting into secondary plastids. J. Eukaryot. Microbiol. 56, 9-15
27. DeRocher, A., Gilbert, B., Feagin, J.E. and Parsons, M. (2005) Dissection of brefeldin A-sensitive and -insensitive steps in apicoplast protein targeting. J. Cell Sci. 118, 565-574
28. Agrawal, S., van Dooren, G.G., Beatty, W.L. and Striepen, B. (2009) Genetic evidence that an endosymbiont-derived endoplasmic reticulum-associated protein degradation (ERAD) system functions in import of apicoplast proteins. J. Biol. Chem. 284, 33683-33691
29. Hempel, F., Bullmann, L., Lau, J., Zauner, S. and Maier, U.G. (2009) ERAD-derived preprotein transport across the second outermost plastid membrane of diatoms. Mol. Biol. Evol. 26, 1781-1790
30. Spork, S., Hiss, J.A., Mandel, K., Sommer, M., Kooij, T.W., Chu, T., Schneider, G., Maier, U.G. and Przyborski, J.M. (2009) An unusual ERAD-like complex is targeted to the apicoplast of Plasmodium falciparum. Eukaryot. Cell 8, 1134-1145
31. Hempel, F., Felsner, G. and Maier, U.G. (2010) New mechanistic insights into pre-protein transport across the second outermost plastid membrane of diatoms. Mol. Microbiol. 76, 793-801
32. Jarvis, P. (2008) Targeting of nucleus-encoded proteins to chloroplasts in plants. New Phytol. 179, 257-285
33. Bullmann, L., Haarmann, R., Mirus, O., Bredemeier, R., Hempel, F., Maier, U.G. and Schleiff, E. (2010) Filling the gap, evolutionary conserved Omp85 in plastids of chromalveolates. J. Biol. Chem. 285, 6848-6856
34. van Dooren, G.G., Tomova, C., Agrawal, S., Humbel, B.M. and Striepen, B. (2008) Toxoplasma gondii Tic20 is essential for apicoplast protein import. Proc. Natl. Acad. Sci. U.S.A. 105, 13574-13579
35. Keeling, P.J., Burger, G., Durnford, D.G., Lang, B.F., Lee, R.W., Pearlman, R.E., Roger, A.J. and Gray, M.W. (2005) The tree of eukaryotes. Trends Ecol. Evol. 20, 670-676