Biological and pharmacological properties of Terminalia chebula Retz. (haritaki)- an overview

International Journal of Pharmacy and Pharmaceutical Sciences

Volumn 4, Issue SUPPL.3, 2012, Pages 62-68

  Gupta, Prakash Chandra ^a  

^a KN Government PG College   (India)

Author keywords

Anti diabetic; Chebulic acid; Haritaki; Phytoconstituents; Terminalia chebula; Triphala

Indexed keywords

TERMINALIA CHEBULA EXTRACT;

ADAPTOGENIC ACTIVITY; ANTHELMINTIC ACTIVITY; ANTIAGING ACTIVITY; ANTIAMOEBIC ACTIVITY; ANTIANAPHYLACTIC ACTIVITY; ANTIARTHRITIC ACTIVITY; ANTIBACTERIAL ACTIVITY; ANTIDIABETIC ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIMALARIAL ACTIVITY; ANTIMUTAGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTINOCICEPTION; ANTIOXIDANT ACTIVITY; ANTISPERMATOGENIC ACTIVITY; ANTIVIRAL ACTIVITY; BIOLOGICAL ACTIVITY; CELL PROTECTION; CHEMOMOPREVENTIVE ACTIVITY; DRUG SAFETY; FRUIT; HEART PROTECTION; HUMAN; HYPOCHOLESTEROLEMIC ACTIVITY; HYPOLIPIDEMIC ACTIVITY; IMMUNOMODULATION; LIVER PROTECTION; MOLLUSCICIDAL ACTIVITY; NONHUMAN; PHYTOCHEMISTRY; PLANT SEED; PLANT TAXONOMY; RADIATION PROTECTION; RENAL PROTECTION; REVIEW; TERMINALIA CHEBULA; VARIETAS; WOUND HEALING;

EID: 84862630444     PISSN: None     EISSN: 09751491     Source Type: Journal    
DOI: None     Document Type: Review

References (77)

1. Sarasa D, Sridhar S, Prabakaran E. Effect of an antidiabetic extract of Trigonella foenum-graecum on normal and alloxan induced diabetic mice. Int J Pharmacy Pharmaceutical Sci 2012;4(1):63-65.
2. Agarwal M, Sharma P, Kushwaha S. Antifertility efficacy of 50% ethanolic extract of Calendula officinalis in male rats. Int J Pharmacy Pharmaceutical Sci 2011;3(5):192-196.
3. Gupta PC. Withania coagulans Dunal-An Overview. Int J Pharmaceutical Sci Review Research 2012;12(2):68-71.
4. World Health Organization. Summary of WHO guidelines for the assessment of herbal medicines. Herbal Gram 1993;28:13-14.
5. Naik GH, Priyadarsini KI, Naik DB, Gangabhagirathi R, Mohan H. Studies on the aqueous extract of Terminalia chebula as a potent antioxidant and a probable radioprotector. Phytomedicine 2004;11:530-38.
6. Ayyanara M, Ignacimuthu S. Ethnobotanical survey of medicinal plants commonly used by Kani tribals in Tirunelveli hills of Western Ghats in India. J Ethnopharmacol 2011;134:851-64.
7. Aneja KR, Joshi R. Evaluation of antimicrobial properties of fruit extracts of Terminalia chebula against dental caries pathogens. Jundishapur J Microbiol 2009;2(3):105-11.
8. Pulliah T. Encyclopedia of world medicinal plants. New Delhi, India: Regency Pub Vol 4, pp1931-1934.
9. Kumar KJ. Effect of geographical variation on contents of tannic acid, gallic acid, chebulinic acid and ethyl gallate in Terminalia chebula. Natural Products 2006;2(3-4):170-75.
10. Juang LJ, Sheu SJ, Lin TC. Determination of hydrolyzable tannins in the fruit of Terminalia chebula Retz. by high-performance liquid chromatography and capillary electrophoresis. J Sep Sci 2004;27(9):718-24.
11. Srivastava A, Chandra A, Singh M, Jamal F, Rastogi P, Rajendran SM, Bansode FW, Lakshmi V. Inhibition of hyaluronidase activity of human and rat spermatozoa in vitro and antispermatogenic activity in rats in vivo by Terminalia chebula, a flavonoid rich plant. Reproductive Toxicol 2010;29:214-24.
12. Kundu AP, Mahato SB. Triterpenoids and their glycosides from Terminalia chebula. Phytochemistry1993;32(4):999-1002.
13. Saleem A, Husheem M, Harkonen P, Pihlaja K. Inhibition of cancer cell growth by crude extract and the phenolics of Terminalia chebula Retz. Fruit. J Ethnopharmacol 2002;81:327-36.
14. Panunto W, Jaijoy K, Lerdvuthisopon N, Lertprasertsuke N, Jiruntanat N, Soonthornchareonnon N, Sireeratawong S. Acute and chronic toxicity studies of the water extract from dried fruits of Terminalia chebula Rezt. in rats. Int J Applied Research in Natural Products 2011;3(4):36-43.
15. Prasad L, Khan TH, Jahangir T, Sultana S. Chemomodulatory effects of Terminalia chebula against nickel chloride induced oxidative stress and tumor promotion response in male Wistar rats. J Trace Elements in Medicine and Biology 2006;20:233-39.
16. Kaur S, Michael H, Arora S, Harkonen PL, Kumar S. The in vitro cytotoxic and apoptotic activity of Triphala-an Indian herbal drug. J Ethnopharmacol 2005;97:15-20.
17. Usha C, Satyanarayanan R and Velmurugan A. Use of an aqueous extract of Terminalia chebula as an anticaries agent: A clinical study. Indian J Dent Res 2007;18(4):152-56.
18. nd eds, Allahabad, India: Lolit Mohan Basu Pub 1935.p. 1020-23.
19. Kim JH, Koo YC, Hong CO, Yang SY, Jun W, Lee KW. Mutagenicity and oral toxicity studies of Terminalia chebula. Phytotherapy Res 2011 May 2 [Epub ahead of print].
20. Sato Y, Oketani H, Singyouchi K, Ohtsubo T, Kihara M, Shibata H and Higuti T. Extraction and purification of effective antimicrobial constituents of Terminalia chebula Retz. against methicillin-resistant Staphylococcus aureus. Bio Pharm Bull 1997;20(4): 401-04.
21. Ahmad I, Mehmood Z, Mohammad F. Screening of some Indian medicinal plants for their antimicrobial properties. J Ethnopharmacol 1998;62:183-93.
22. Malekzadeh F, Ehsanifar H, Shahamat M, Levin M, Colwell RR. Antibacterial activity of black myrobalan (Terminalia chebula Retz) against Helicobacter pylori. J Antimicrobial Agents 2001;18:85-88.
23. Kim HG, Cho JH, Jeong EY, Lim JH, Lee SH, Lee HS. Growth-inhibiting activity of active component isolated from Terminalia chebula fruits against intestinal bacteria. J Food Prot 2006;69(9):2205-9.
24. Kannan P, Ramadevi SR, Hopper W. Antibacterial activity of Terminalia chebula fruit extract. African J Microbiol Res 2009;3(4):180-84.
25. Dutta BK, Rahman I, Das TK. Antifungal activity of Indian plant extracts. Mycoses 1998;41(11-12):535-36.
26. Mehmood Z, Ahmad I, Mohammad F, Ahmad S. Indian medicinal plants: A potential source for anticandidal drugs. Pharmaceutical Biology 1999;37(3):237-42.
27. Vonshak O, Barazani P, Sathiyomoorthy R, Shalev D, Vardy A Golan-goldhirsh. Screening of South-Indian medicinal plants for antifungal activity. Phytotherapy Res 2003;17(9):1123-25.
28. Shinde SL, More SM, Junne SB, Wadje SS, The antifungal activity of five Terminalia species checked by paper disk method. Int J Pharma Res and Develop 2011;3(2).
29. Sohni YR, Kaimal P, Bhatt RM. The antiamoebic effect of a crude drug formulation of herbal extracts against Entamoeba histolytica in vitro and in vivo. J Ethnopharmacol 1995;45(1):43-52.
30. Sohni YR, Bhatt RM. Activity of a crude extract formulation in experimental hepatic amoebiasis and in immunomodulation studies. J Ethnopharmacol 1996;54(2-3):119-24.
31. Pinmai K, Hiriote W, Soonthornchareonnon N, Jongsakul K, Sireeratawong S, Tor-Udom S. In vitro and in vivo antiplasmodial activity and cytotoxicity of water extracts of Phyllanthus emblica, Terminalia chebula, and Terminalia bellerica. J Med Assoc Thai. 2010;93(7):120-26.
32. Bagavan A, Rahuman AA, Kamaraj C, Kaushik NK, Mohanakrishnan D, Sahal D. Antiplasmodial activity of botanical extracts against Plasmodium falciparum. Parasitol Res 2011;108:1099-109.
33. Upadhyay A, Singh DK. Molluscicidal activity of Sapindus mukorossi and Terminalia chebula against the freshwater snail Lymnaea acuminate. Chemosphere. 2011;83(4):468-74.
34. Kamaraj C, Rahuman AA. Efficacy of anthelmintic properties of medicinal plant extracts against Haemonchus contortus. Res Vet Sci. 2011;91(3):400-4.
35. Mekkaway SE, Meselhy MR, Kusumoto IT, Kadota S, Hattori M, Namba T. Inhibitory Effects of Egyptian Folk Medicines oh Human Immunodeficiency Virus (HIV) Reverse Transcriptase. Chemical & Pharmaceutical Bulletin 1995;43(4):641-48.
36. Yukawa TA, Kurokawa M, Sato H, Yoshida Y, Kageyama S, Hasegawa T, Namba T, Imakita M, Hozumi T, Shiraki K. Prophylactic treatment of cytomegalovirus infection with traditional herbs. Antiviral Res 1996; 32(2):63-70.
37. Badmaev V, Nowakowski M. Protection of epithelial cells against influenza A virus by a plant derived biological response modifier Ledretan-96. Phytotherapy Res 2000;14(4): 245-49.
38. Ahn MJ, Kim CY, Lee JS, Kim TG, Kim SH, Lee CK, Lee BB, Shin CG, Huh H, Kim J. Inhibition of HIV-1 integrase by galloyl glucoses from Terminalia chebula and flavonol glycoside gallates from Euphorbia pekinensis. Planta Med 2002;68(5):457-59.
39. Vermani K, Garg S. Herbal medicines for sexually transmitted diseases and AIDS. J Ethnopharmacol 2002;80(1):49-66.
40. Ma H, Diao Y, Zhao D, Li K, Kang T. A new alternative to treat swine influenza A virus infection: extracts from Terminalia chebula Retz. African J Microbiol 2010;4(6):497-99.
41. Lin LT, Chen TY, Chung CY, Noyce RS, Grindley TB, McCormick C, Lin TC, Wang GH, Lin CC, Richardson CD. Hydrolyzable tannins (chebulagic acid and punicalagin) target viral glycoprotein-glycosaminoglycan interactions to inhibit herpes simplex virus 1 entry and cell-to-cell spread. J Virol. 2011;85(9):4386-98.
42. Arora S, Kaur K, Kaur S. Indian medicinal plants as a reservoir of protective phytochemicals. Teratogenesis, Carcinogenesis, and Mutagenesis 2003;23(S1): 295-300.
43. Reddy DB, Reddy TCM, Jyotsna G, Sharan S, Priya N, Lakshmipathi V, Reddann P. Chebulagic acid, a COX-LOX dual inhibitor isolated from the fruits of Terminalia chebula Retz., induces apoptosis in C0L0-205 cell line. J Ethnopharmacol 2009;124(3):506-12.
44. Ponnusankar S, Pandit S, Babu R, Bandyopadhyay A, Mukherjee PK. Cytochrome P450 inhibitory potential of Triphala-A Rasayana from Ayurveda. J Ethnopharmacol 2011;133(1):120-25.
45. Cheng HW, Lin TC, Yu KH, Yang CM, Lin CC. Antioxidant and free radical Scavenging activities of Terminalia chebula. Biol Pharm Bull 2003;26(9):1331-35.
46. Suchalatha S, Srinivasalu C, Devi S. Antioxidant activity of ethanolic extracts of Terminalia chebula fruit against isoproterenol-induced oxidative stress in rats. Indian J Biochem and Biophys 2005;42:246-49.
47. Lee HS, Won NH, Kim KH, Lee H, Jun W, Lee KW. Antioxidant effects of aqueous extract of Terminalia chebula in vivo and in vitro. Biol Pharm Bull 2005;28(9);1639-44.
48. Lee HS, Jung SH, Yun BS, Lee KW. Isolation of chebulic acid from Terminalia chebula Retz. and its antioxidant effect in isolated rat hepatocytes. Arch Toxicol. 2007 Mar;81(3):211-8. Epub 2006 Aug 24.
49. Chen X, Sun F, Ma L, Wang J, Qin H, Du G. In vitro evaluation on the antioxidant capacity of triethylchebulate, an aglycone from Terminalia chebula Retz fruit. Indian J Pharmacol 2011;43(3):320-23.
50. Sabu MC, Kuttan R. Anti-diabetic activity of medicinal plants and its relationship with their antioxidant property. J Ethnopharmacol 2002;81:155-60.
51. Rao NK, Nammi S. Antidiabetic and renoprotective effects of the chloroform extract of Terminalia chebula Retz. seeds in streptozotocin-induced diabetic rats. BMC Complementary and Alternative Medicine 2006;6:17.
52. Kumar GPS, Arulselvan P, Kumar DS, Subramanian SP. Antidiabetic activity of fruits of Terminalia chebula on streptozotocin induced diabetic rats. J Health Sci 2006;52(3):283-91.
53. Murali YK, Anand P, Tandon V, Singh R, Chandra R, Murthy PS. Long-term effects of Terminalia chebula Retz. on hyperglycemia and associated hyperlipidemia, tissue glycogen content and in vitro release of insulin in streptozotocin induced diabetic rats. Exp Clin Endocrinol Diabetes. 2007;115(10):641-46.
54. Rege NN, Thatte UM, Dahanukar SA. Adaptogenic properties of six rasayana herbs used in Ayurvedic medicine. Phytotherapy Res 1999;13(4) 275-91.
55. Shin TY, Jeong HJ, Kim DK, Kim SH, Lee JK, Kim DK, Chae BS, Kim JH, Kang HW, Lee CM, Lee KC, Park ST, Lee EJ, Lim JP, Kim HM, Leen YM. Inhibitory action of water soluble fraction of Terminalia chebula on systemic and local anaphylaxis. J Ethnopharmacol 2001;74:133-40.
56. Kaur S, Jaggi RK. Antinociceptive activity of chronic administration of different extracts of Terminalia bellerica Roxb. and Terminalia chebula Retz. fruits. Indian J Exp Biol. 2010;48(9):925-30.
57. Sharma P, Prakash T, Kotresha D, Ansari MA, Sahrm UR, Kumar B, Debnath J, Goli D. Antiulcerogenic activity of Terminalia chebula fruit in experimentally induced ulcer in rats. Pharm Biol. 2011;49(3):262-68.
58. Nair V, Singh S, Gupta YK. Anti-arthritic and disease modifying activity of Terminalia chebula Retz. in experimental models. J Pharm Pharmacol. 2010;62(12):1801-06.
59. Sugun L, Sing S, Sivakuma P, Sampat P, Chandrakasa G. Influence of Terminalia chebula on dermal wound healing in rats. Phytotherapy Res 2002;16(3):227-31.
60. Bhattacharya S, Chaudhuri SR, Chattopadhyay S, Bandyopadhyay SK. Healing properties of some Indian medicinal plants against indomethacin-induced gastric ulceration of rats. J Clin Biochem and Nutrition 2007;41(2):106-14.
61. Singh MP, Sharma CS. Wound healing activity of Terminalia chebula in experimentally induced diabetic rats. Int J Pharma Tech Res 2009;1(4):1267-70.
62. Li K, Diao Y, Zhang H, Wang S, Zhang Z, Yu B, Huang S, Yang H. Tannin extracts from immature fruits of Terminalia chebula Fructus Retz. promote cutaneous wound healing in rats. BMC Complementary and Alternative Med 2011;11:8.
63. Choudhary GP. Wound healing activity of ethanolic extract of Terminalia chebula Retz. Int J Pharma and Bio Sci 2011;2(1):48-52.
64. Hamada S, Kataoka T, Woo JT, Yamada A, Yoshida T, Nishimura T, Otake N, Nagai K. Immunosuppressive effects of gallic acid and chebulagic acid on CTL-mediated cytotoxicity. Biological & Pharmaceutical Bulletin 1997;20(9):1017-19.
65. Na MK, Bae KH, Kang SS, Min BS, Yoo JK, Kamiryo Y, Senoo YI, Yokoo S, Miwa N. Cytoprotective effect on oxidative stress and inhibitory effect on cellular aging of Terminalia chebula fruit. Phytotherapy Res 2004;18(9) 737-41.
66. Manosroi A, Jantrawut P, Akihisa T, Manosroi W, Manosroi J. In vitro anti-aging activities of Terminalia chebula gall extract. Pharm Biol. 2010;48(4):469-81.
67. Jagetia GC, Baliga MS, Malagi KJ, Sethukumar Kamath M. The evaluation of the radioprotective effect of Triphala (an ayurvedic rejuvenating drug) in the mice exposed to g-radiation. Phytomedicine 2002;9:99-108.
68. Gandhi NM, Nair CKK. Radiation protection by Terminalia chebula: Some mechanistic aspects. Mol Cell Biochem 2005;277:43-48.
69. Suchalatha S, Shyamala Devi CS. Protective effect of Terminalia chebula against experimental myocardial injury induced by isoproterenol. Indian J Exp Biol 2004;42(2):174-78.
70. Suchalatha S, Shyamala Devi CS. Protective effect of Terminalia chebula against lysosomal enzyme alterations in isoproterenolinduced cardiac damage in rats. Exp Clin Cardiol 2005;10(2):91-95.
71. Suchalatha S, Srinivasan P, Shyamala Devi CS. Effect of T. chebula on mitochondrial alterations in experimental myocardial injury. Chemico-Biological Interactions 2007;169:145-53.
72. Tasduq SA, Singh K, Satti NK, Gupta DK, Suri KA. Terminalia chebula (fruit) prevents liver toxicity caused by sub-chronic administration of rifampicin, isoniazid and pyrazinamide in combination. Hum Exp Toxicol 2006;25:111-18.
73. Prasad L, Khan TH, Jahangir T, Sultana S. Chemomodulatory effects of Terminalia chebula against nickel chloride induced oxidative stress and tumor promotion response in male Wistar rats. J Trace Elements in Med and Biol 2006;20(4)233-39.
74. Thakur CP, Thakur B, Singh S, Sinha PK, Sinha SK. The Ayurvedic medicines Haritaki, Amla and Bahira reduce cholesterol-induced atherosclerosis in rabbits. Int J Cardiol 1988;21(2):167-75.
75. Shaila HP, Udupa SL, Udupa AL. Hypolipidemic activity of three indigenous drugs in experimentally induced atherosclerosis. Int J Cardiol 1998;67(2):119-24.
76. Saravanan S, Shrikumar R, Manikandan S, Jayaparthasarathy N, Sheela Devi R. Hypolipidemic effect of Triphala in experimentally induced hypercholesteremic rats. Yakugaku Zasshi 2007;127:2385-388.
77. th Annual Meeting of the Indian Society for the Study of Reproduction & Fertility Feb 8-10, 2010:40.