Vitamin A in prevention of bronchopulmonary dysplasia

Current Pharmaceutical Design

Volumn 18, Issue 21, 2012, Pages 3101-3113

  Guimarães, Hercília ^a,b   Guedes, Maria Beatriz ^a   Rocha, Gustavo ^a,b   Tomé, Teresa ^c   Albino Teixeira, António ^b,d  

^a HOSPITAL DE SÃO JOÃO   (Portugal)

^b University of Porto   (Portugal)

^c Maternidade Dr Alfredo da Costa ^*  (Portugal)

^d UNIVERSITY OF PORTO   (Portugal)

Author keywords

Bronchopulmonary dysplasia; Neonatal intensive care; Nutritional needs; Preterm; Prevention; Vitamin A

Indexed keywords

ANTIBIOTIC AGENT; ANTIOXIDANT; ASCORBIC ACID; BRONCHODILATING AGENT; CAFFEINE; CAROTENOID; CORTICOSTEROID; DEXAMETHASONE; ELASTIN; LUNG SURFACTANT; NITRIC OXIDE; RETINOIC ACID; RETINOL; RETINOL BINDING PROTEIN; RHODOPSIN; TOCOPHEROL;

ARTICLE; ARTIFICIAL VENTILATION; BIOAVAILABILITY; DIGESTION; DIURETIC THERAPY; DRUG SAFETY; FETUS GROWTH; GASTROINTESTINAL ABSORPTION; HUMAN; LACTATION; LIPID HYDROLYSIS; LUNG DYSPLASIA; LUNG FUNCTION; LUNG PROTECTION; MATERNAL CARE; NUTRITIONAL SUPPORT; OXYGENATION; PARENTERAL NUTRITION; PATENT DUCTUS ARTERIOSUS; PHOTOTHERAPY; PREGNANCY; PREMATURITY; PRIORITY JOURNAL; PROPHYLAXIS; RETINOL DEFICIENCY; RETROLENTAL FIBROPLASIA; VERY LOW BIRTH WEIGHT; VISION; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION;

EID: 84862611040     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/1381612811209023101     Document Type: Article

References (133)

1. Northway WH Jr, Rosan RC, Porter DY. Pulmonary disease following respirator therapy of hyaline-membrane disease. bronchopulmonary dysplasia. N Engl J Med 1967; 276(7): 357-68.
2. Bhandari A, Bhandari V. Pitfalls, problems, and progress in bronchopulmonary dysplasia. Pediatrics 2009; 123(6): 1562-73.
3. Schmidt B, Roberts R, Millar D, Kirpalani H. Evidence-based neonatal drug therapy for prevention of bronchopulmonary dysplasia in very-low-birth-weight infants. Neonatology 2008; 93(4): 284-7.
4. Laughon MM, Smith PB, Bose C. Prevention of bronchopulmonary dysplasia. Semin Fetal Neonatal Med 2009; 14(6): 374-82. Epub 2009 Sep 6.
5. Amédé-Manesme O. Vitamin A. In: Ricour C, Ghisolfi J, Putet G, Goulet O, eds. Traité de Nutrition Pédiatrique. Paris: Maloine 1993: 228-41.
6. Kennedy KA. Epidemiology of acute and chronic lung injury. Semin Perinatol 1993; 17: 247-52.
7. Wald G. Carotenoids and the vitamin A cycle in vision. Nature 1934; 134: 65-9.
8. Goodman DW. Vitamin A and retinoids in health and disease. N Engl J Med 1984; 310: 1023-30.
9. Shenai J, Chytil F, Jhavery A, Stahlman MT. Plasma vitamin A and retinol binding protein in premature and term neonates. J Pediatr 1981; 99: 302-5.
10. Shenai J, Chytil F, Stahlman MT. Liver vitamin A reserves of very low birth weight neonates. Pediatr Res 1985; 19: 892-3.
11. Olson JA. Biochemistry of vitamin A and carotenoids. In: Sommer A, West KP, Eds. Vitamin A deficiency: health, survival, and vision. New York: Oxford University Press 1996: p. 226.
12. Amédé-Manesme O, De Maeyer E. Ledéficiten vitamine A. Ed Inserum-Orstom, Paris 1989.
13. th edition. Philadelphia, Lea and Febiger 1993: 287-307.
14. IIUPAC-IUB Joint Commission on Boichemical nomenclature. Eur J Biochem 1982; 129: 1-5.
15. nd ed. New York, Marcel Dekker 1992: 1-71.
16. nded. New York, Raven Press 1994: pp. 178-209.
17. nded. New York: Marcel Dekker 1990: pp. 1-57.
18. Ross AC. Overview of retinoid metabolism. J Nutr 1993; 123: 346-50.
19. nded. New York Raven Press 1994: 229-55.
20. Cowan SW, Newcomer ME, Jones TA. Crystallographic refinement of human serum retinol binding protein at 2A resolution. Proteins Struc Funct Genet 1990; 8: 44-61.
21. nded. New York Raven Press 1994: 257-81.
22. tH Ed Prentica-Hall International 1996.
23. Nagl B, Loui A, Raila J, et al Urinary vitamin A in very low birth wegh infants. Pediatr Nephrol2009; 24(1): 61-6.
24. Ambalavanan N, Kennedy K, Tyson J, Carlo WA. Survey of vitamin A supplementation for extremely-low birth weght infants is clinival practice consistent with evidence? J Pediatr 2004; 145(3): 304-7.
25. Mactier H, Weaver LT. Vitamin A and preterm infants: what we know, what we don't know, and what we need to know. Arch Dis Child Fetal Neonatal Ed 2005; 90(2): F103-8.
26. Vogelsang A, van Lingen RA, Slootstra J, et al. Antioxidant role of plasma carotenoids in bronchopulmonary dysplasia in preterm infants. Int J Vitam Nutr Res 2009; 79(5-6): 288-96.
27. Gilbert C, Foster A Childhood blindness in context of vision 2020, the right to sight. Bull World Health Organ 2001; 79(3): 227-32.
28. Gilbert, S. F.-Developmental biology, edit. Sunderland: Sinauer Associates Inc. 1994.
29. Marshall H, Morrison A, Studer M, Popperl H, Krumlauf R. Retinois and Hox genes. FASEB J 1996 (10): 969-78.
30. Morriss-Kay GM, Sokolova N. Embryonic development and pattern formation. FASEB J 1996(10): 961-8.
31. Wilson JG, Roth CB, Warkanay J. An analysis of the syndrome of malformations induced by maternal vitamin A deficiency. Effects of restoration of vitamin A at various times during gestation. Am J Anat 1953; 92: 189-217.
32. Burri P H. Posnatal development and growth. The Lung: Scientific Foundation, edit by R G Crystal, JB West, NY; Raven Press, 1991: 677-87.
33. Mcgowan SE, Harvey CS, Jackson SK. Retinois, retinoic acid receptors and cytoplasmic retinoid binding proteins in perinatal rat lung fibroblasts. Am J Physiol 1995; 269: L463-72.
34. Bruce MC. Developmental changes in tropoelastin mRNA levels in rat lung: evaluation by in situ hybridization. Am J Respir Cell Mol Biol 1991 (5): 344-50.
35. Bruce MC, Bruce EN, Janiga K, Chetty A. Hyperoxic exposure of developing rat lung decreases tropoelastine mRNA levels that rebound post exposure. Am J Physiol 1993; 265: L293-300.
36. Liu R, Harvey CS, Mcgowan SE. Retinoic acid increases elastin in neonatal rat lung fibroblast cultures. Am J Physiol 1993; 265: L430-7.
37. Lammer EL, Chen DT. Hoar RM, et al. Retinoic acid embryopathy. N Engl J Med 1985; 313: 837-41.
38. Rothman KJ, Moore LL, Singer MR, Nguyen DT, Mannino S, Milunsky A. Teratogenicity of high vitamin A intake. N Engl J Med 1995; 333: 1369-73.
39. Goulding EH, Pratt RM. Isoretinoin teratogenicity in mouse whole embryo culture. J Craniofac Genet Dev Biol 1986; 6: 99-112
40. Massaro GD, Massaro D. Postnatal treatment with retinoic acid increases the number of pulmonary alveoli in rats. Am J Physiol 1996; 270(2 Pt 1): L305-10
41. Dubreuil G, Locost A, Raymond R. Observation sur le development du poumon human. Bull Histol Appl Physiol 1936, 13: 235.
42. Ross AC, Gardner M. The function of vitamin A in cellular growth and differentiation and its roles during pregnancy and lactation. Adv Exp Med Biol 1994, 352: 187-200.
43. Northway WH. An introduction to bronchopulmonary dysplasia. Clin. Perinatol 1992; 19: 489-95.
44. Verma RP, McCulloch KM, Worrell L, Vidyasagar D. Vitamin A deficiency and severe bronchopulmonary dysplasia in very low birthweight infants. Am J Perinatol 1996; 13(7): 389-93.
45. Pierce RA, Albertine KH, Starcher BC, Bohnsack JF, Carlton DP, Bland RD. Chronic lung injury in preterm lambs: disordered pulmonary elastin deposition. Am J Physiol 1997; 272: L452-60.
46. Baptista MJ, Melo-Rocha G, Pedrosa C, et al. Antenatal vitamin A administration attenuates lung hypoplasia by interfering with early instead of late determinants of lung underdevelopment in congenital diaphragmatic hernia. Pediatr Surg 2005; 40(4): 658-65.
47. Stipanuk, M. H Vitamin A: Biochemical, Physiological, and Molecular Aspects of Human Nutrition. Philadelphia, PA: Elsevier Saunders 2006. ISBN141600209X.
48. Global prevalence of vitamin A deficiency in populations at risk 1995-2005. WHO Global Database on Vitamin A Deficiency.
49. Van den Broek N, Dou L, Othman M, Neilson JP, Gates S, Gülmezoglu AM. Vitamin A supplementation during pregnancy for maternal and newborn outcomes. The Cochrane Collaboration, 2010: 1-70.
50. Rothman KJ, Moore LL, Singer MRR, Nguyen U, Mannino S, Milunsky A. Teratogenicity of High Vitamin A Intake. N Engl J Med 1995; 333: 1369-73.
51. Mills JL, Simpson JL, Cunningham GC, Conley MR, Rhoads GG. Vitamin A and birth defects. Am J Obstet Gynecol 1997; 177: 31-6.
52. Miller RK. Periconceptional vitamin A use: How much is teratogenic? Reprod Toxicol 1998; 12: 75-88.
53. Wiysonge CS, Shey M, Kongnyuy EJ, Sterne JA, Brocklehurst P. Vitamin A. supplementation for reducing the risk of mother-tochild transmission of HIV infection 2011 Cochrane Database Syst Rev 2011; 1: CD003648.
54. Lohia N, UdipiS, Ghugre P, Deshpande K. serum retinol, alpha-tocopherol and lipid peroxide concentrations in low-income indian pregnant mothers. Int J Vitam Nutr Res 2009; 79(3): 142-51.
55. Van den Broek N, Kulier R, Gülmezoglu AM, Villar J. Safety of daily oral vitamin A supplementation during pregnancy. Cochrane Database Syst 2002. Rev 2007, Issue 4. Art. No.: CD001996. DOI: 10. 1002/14651858. CD001996.
56. Checkley W, West KP, Jr., Wise R, et al. Maternal Vitamin A Supplementation and Lung Function in Offspring. N Engl J Med 2010; 362: 1784-94.
57. Cristian P. Micronutrients, birth weight and survival. Annu Rev Nutr 2010; 30: 83-104.
58. Babu TA, Sharmila V. Vitamin A supplementation in late pregnancy can decrease the incidence of bronchopulmonary dysplasia in newborns. J Matern Fetal Neonatal Med 2010; 23(12): 1468-9
59. Aly H. Is there a strategy for preventing bronchopulmonary dysplasia? Absence of evidence is not evidence of absence. Pediatrics 2007; 119; 818-20.
60. Babu TA, Sharmila V. Vitamin A deficiency in pregnant women and respiratorymorbility in their infants-Is there a link? Med Hypotheses 2010,74: 1084-90.
61. Bessler H, Wyshelesky G, Osovsky M, Prober V, Sirota LA. comparison of the effect of vitamin A on cytokine secretion by mononuclear cells of preterm newborns and adults. Neonatology 2007; 91(3): 196-202.
62. Speer CP. Inflammation and Bronchopulmonary Dysplasia: A Continuing Story. Sem Fetal Neonat Med 2006; 11(5): 354-62.
63. Thomas W, Speer CP. Nonventilatory strategies for prevention and treatment of bronchopulmonary dysplasia-what is the evidence? Neonatology 2008; 94(3): 150-9.
64. Darlow BA, Graham PJ. Vitamin A supplementation to prevent mortality and short and long-term morbidity in very low birthweight infants. Cochrane Database Syst Rev 2007; (4): CD000501.
65. Greennough A. Emerging drugs for the prevention of Bronchopulmonary dysplasia. Expert Opin Emerg Drugs 2008; 13(3): 537-46
66. Adams J M, Stark AR. Prevention of bronchopulmonary dysplasia 2011 available at: www.uptodate.com.
67. Schulzke SM, Pillow JJ. The management of evolving bronchopulmonary dysplasia. Paediatr Respir Rev 2010; 11(3): 143-8.
68. Kaplan HC, Tabangin ME, McClendon D, Meinzen-Derr J, Margolis PA, Donovan EF. Understanding variation in vitamin A supplementation among NICUs. Pediatrics 2010; 126(2): e367-73.
69. Van Marter LJ. Epidemiology of bronchopulmonary dysplasia. Semin Fetal Neonatal Med 2009; 14(6): 358-66.
70. Ambalavanan N, Tyson JE, Kennedy KA, et al. National Institute of Child Health and Human Development Neonatal Research Network. Vitamin A supplementation for extremely low birth weight infants: outcome at 18 to 22 months. Pediatrics 2005; 115(3): e249-54.
71. Bancalari E, Abdenour GE, Feller R, Gannon J. Bronchopulmonary dysplasia: clinicalpresentation. J Pediatr 1979; 95(5 Pt 2): 819-23.
72. Jobe AJ. The new BPD: an arrest of lung development. Pediatr Res 1999; 46(6): 641-3.
73. Shennan AT, Dunn MS, Ohlsson A, Lennox K, Hoskins EM. Abnormal pulmonary outcomes in premature infants: prediction from oxygen requirement in the neonatal period. Pediatrics 1988; 82(4): 527-32.
74. Walsh MC, Yao Q, Gettner P, et al. National Institute of Child Health and Human Development Neonatal Research Network. Impact of a physiologic definition on bronchopulmonary dysplasia rates. Pediatrics 2004; 114(5): 1305-11.
75. Ehrenkranz RA, Walsh MC, Vohr BR, et al. National Institutes of Child Health and Human Development Neonatal Research Network. Validation of the National Institutes of Health consensus definition of bronchopulmonary dysplasia. Pediatrics 2005; 116(6): 1353-60.
76. Guimarães H, Rocha G, Vasconcellos G, et al. Risk factors for bronchopulmonary dysplasia in five Portuguese neonatal intensive care units. Rev Port Pneumol 2010; 16(3): 419-30.
77. Rocha G, Proença E, Quintas C, Rodrigues T, Guimarães H. Chorioamnionitis and lung damage in the extremely low birth weight infant. Rev Port Pneumol 2007; 13(5): 745-54.
78. Kinsella JP, Greenough A, Abman SH. Bronchopulmonary dysplasia. Lancet 2006; 367(9520): 1421-31.
79. Rocha G, Ribeiro O, Guimarães H. Fluid and electrolyte balance during the first week of life and risk of bronchopulmonary dysplasia in the preterm neonate. Clinics 2010; 65 (7): 663-74.
80. Guimarães H, Rocha G, Vasconcellos G, et al. Bronchopulmonary dysplasia: Clinical practices in five Portuguese neonatal intensive care units. Rev Port Pneumol 2010; 16(2): 273-86.
81. Gortner L, Misselwitz B, Milligan D, et al. members of the MOSAIC Research Group. Rates of bronchopulmonary dysplasia in very preterm neonates in Europe: results from the MOSAIC cohort. Neonatology 2011; 99(2): 112-7.
82. Stevens TP, Harrington EW, Blennow M, Soll RF. Early surfactant administration with brief ventilation vs. selective surfactant and continued mechanical ventilation for preterm infants with or at risk for respiratory distress syndrome. Cochrane Database Syst Rev 2007; (4): CD003063.
83. Castoldi F, Daniele I, Fontana P, Cavigioli F, Lupo E, Lista G. Lung. Recruitment Maneuver during Volume Guarantee Ventilation of Preterm Infants with Acute Respiratory Distress Syndrome. Am J Perinatol 2011; 28: 521-8.
84. Cerny L, Torday JS, Rehan VK. Prevention and treatment of bronchopulmonary dysplasia: contemporary status and future outlook. Lung 2008; 186(2): 75-89.
85. Lai NM, Rajadurai SV, Tan KH. Increased energy intake for preterm infants with (or developing) bronchopulmonary dysplasia/ chronic lung disease. Cochrane Database Syst Rev 2006; 3: CD005093.
86. Shenai JP, Chytil F, Stahlman MT. Vitamin A status of neonates with bronchopulmonary dysplasia. Pediatr Res 1985; 19(2): 185-8.
87. Hustead VA, Gutcher GR, Anderson SA, Zachman RD. Relationship of vitamin A (retinol) status to lung disease in the preterm infant. J Pediatr 1984; 105(4): 610-5.
88. Greene HL, Hambidge KM, Schanler R, Tsang RC. Guidelines for the use of vitamins, trace elements, calcium, magnesium, and phosphorus in infants and children receiving total parenteral nutrition: report of the Subcommittee on Pediatric Parenteral Nutrient Requirements from the Committee on Clinical Practice Issues of the American Society for Clinical Nutrition. Am J Clin Nutr 1988; 48(5): 1324-42. Erratum in: Am J Clin Nutr 1989 Jun; 49(6): 1332. Am J Clin Nutr 1989; 50(3): 560.
89. Bell EF, Acarregui MJ. Restricted versus liberal water intake for preventing morbidity and mortality in preterm infants. Cochrane Database Syst Rev 2008; (1): CD000503.
90. Golombek SG, Sola A, Baquero H, et al. Primer Grupo de Consenso Clínico SIBEN. First SIBEN clinical consensus: diagnostic and therapeutic approach to patent ductusarteriosus in premature newborns. An Pediatr (Barc) 2008; 69(5): 454-81.
91. Doyle LW, Ehrenkranz RA, Halliday HL. Dexamethasone treatment after the first week of life for bronchopulmonary dysplasia in preterm infants: a systematic review. Neonatology 2010; 98(4): 289-96. Epub 2010 May 4.
92. Doyle LW, Ehrenkranz RA, Halliday HL. Dexamethasone treatment in the first week of life for preventing bronchopulmonary dysplasia in preterm infants: a systematic review. Neonatology 2010; 98(3): 217-24.
93. Denjean A, Paris-Llado J, Zupan V, et al. Inhaled salbutamol and beclomethasone for preventing broncho-pulmonary dysplasia: a randomised double-blind study. Eur J Pediatr 1998; 157(11): 926-31.
94. Lister P, Iles R, Shaw BN, Ducharme FM. WITHDRAWN. Inhaled steroids for neonatal chronic lung disease. Cochrane Database Syst Rev 2010; (1): CD002311.
95. Denjean A, Guimarães H, Migdal M, Miramand JL, Dehan M, Gaultier C. Dose-related bronchodilator response to aerosolized salbutamol (albuterol) in ventilator-dependent premature infants. J Pediatr 1992; 120(6): 974-9.
96. Donohue PK, Gilmore MM, Cristofalo E, et al. Inhaled nitric oxide in preterm infants: a systematic review. Pediatrics 2011; 127(2): e414-22.
97. McMenamy KR, Zachman RD. Effect of gestational age and retinol (vitamin A) deficiency on fetal rat lung nuclear retinoic acid receptors. Pediatr Res 1993; 33(3): 251-5.
98. Biniwale MA, Ehrenkranz RA. The role of nutrition in the prevention and management of bronchopulmonary dysplasia. Semin Perinatol 2006; 30(4): 200-8.
99. Blomhoff R, Green MH, Norum KR. Vitamin A: physiological and biochemical processing. Annu Rev Nutr 1992; 12: 37-57.
100. Roth-Kleiner M, Post M. Similarities and dissimilarities of branching and septation during lung development. Pediatr Pulmonol 2005; 40(2): 113-34.
101. Spears K, Cheney C, ZerzanJ. Low plasma retinol concentrations increase the risk of developing bronchopulmonary dysplasia and long-term respiratory disability in very-low-birth-weight infants. Am J Clin Nutr 2004; 80(6): 1589-94.
102. Bry K, LappalainenU. Pathogenesis of bronchopulmonary dysplasia: the role of interleukin 1beta in the regulation of inflammationmediated pulmonary retinoic acid pathways in transgenic mice. Semin Perinatol 2006; 30 (3): 121-8.
103. McGowan S, Jackson SK, Jenkins-Moore M, Dai HH, Chambon P, Snyder JM. Mice bearing deletions of retinoic acid receptors demonstrate reduced lung elastin and alveolar numbers. Am J Respir Cell Mol Biol 2000; 23(2): 162-7.
104. Bland RD, Albertine KH, Pierce RA, Starcher BC, Carlton DP. Impaired alveolar development and abnormal lung elastin in preterm lambs with chronic lung injury: potential benefits of retinol treatment. Biol Neonate 2003; 84(1): 101-2.
105. Ozer EA, Kumral A, Ozer E, et al. Effect of retinoic acid on oxygen-induced lung injury in the newborn rat. Pediatr Pulmonol 2005; 39(1): 35-40.
106. Hind M, Maden M. Retinoic acid induces alveolar regeneration in the adult mouse lung. Eur Respir J 2004; 23(1): 20-7.
107. Pierce RA, Joyce B, Officer S, et al. Retinoids increase lung elastin expression but fail to alter morphology or angiogenesis genes in premature ventilated baboons. Pediatr Res 2007; 61(6): 703-9.
108. Nadeau K, Montermini L, Mandeville I, et al. Modulation of Lgl1 by steroid, retinoic acid, and vitamin D models complex transcriptional regulation during alveolarization. Pediatr Res 2010; 67(4): 375-81.
109. Cho SJ, George CL, Snyder JM, Acarregui MJ. Retinoic acid and erythropoietin maintain alveolar development in mice treated with an angiogenesis inhibitor. Am J Respir Cell Mol Biol 2005; 33(6): 622-8.
110. Couroucli XI, Liang YW, Jiang W, Barrios R, Moorthy B. Attenuation of oxygen-induced abnormal lung maturation in rats by retinoic acid: possible role of cytochrome P4501A enzymes. J Pharmacol Exp Ther 2006; 317(3): 946-54.
111. Sharma A, Lewandoski JR, Zimmerman JJ. Retinol inhibition of in vitro human neutrophil superoxide anion release. Pediatr Res 1990; 27(6): 574-9.
112. Albertine KH, Dahl MJ, Gonzales LW, et al. Chronic lung disease in preterm lambs: effect of daily vitamin A treatment on alveolarization. Am J Physiol Lung Cell Mol Physiol 2010; 299(1): L59-72.
113. Atkinson SA. Special nutritional needs of infants for prevention of and recovery from bronchopulmonary dysplasia. J Nutr 2001; 131(3): 942S-6S.
114. Inder TE, Graham PJ, Winterbourn CC, Austin NC, Darlow BA. Plasma vitamin A levels in the very low birthweight infant--relationship to respiratory outcome. Early Hum Dev 1998; 52(2): 155-68.
115. Shenai JP, Kennedy KA, Chytil F, Stahlman MT. Clinical trial of vitamin A supplementation in infants susceptible to bronchopulmonary dysplasia. J Pediatr 1987; 111(2): 269-77.
116. Pearson E, Bose C, Snidow T, et al. Trial of vitamin A supplementation in very low birth weight infants at risk for bronchopulmonary dysplasia. J Pediatr 1992; 121(3): 420-7.
117. Italian Collaborative Group on Preterm Delivery (ICGPD). Supplementation and plasma levels of vitamin A in premature newborns at risk for chronic lung disease. Dev Pharmacol Ther 1993; 20(3-4): 144-51.
118. Italian Collaborative Group on Preterm Delivery (ICGPD). Vitamin A supplementation in premature neonates with postnatal lung injury. Italian Int J Clin Pharmacol Ther 1996; 34(8): 362-5.
119. Baptista MJ, Correia-Pinto J, Areias JC, Guimarães H. Patent ductusarteriosus in neonatal intensive care. Rev Port Cardiol 1999; 18(12): 1095-100.
120. Robbins ST, Fletcher AB. Early vs delayed vitamin A supplementation in very-low-birth-weight infants. JPEN J Parenter Enteral Nutr 1993; 17(3): 220-5.
121. Werkman SH, Peeples JM, Cooke RJ, Tolley EA, Carlson SE. Effect of vitamin A supplementation of intravenous lipids on early vitamin A intake and status of premature infants. Am J ClinNutr 1994; 59(3): 586-92.
122. Kennedy KA, Stoll BJ, Ehrenkranz RA, et al. Vitamin A to prevent bronchopulmonary dysplasia in very-low-birth-weight infants: has the dose been too low? The NICHD Neonatal Research Network. Early Hum Dev 1997; 49(1): 19-31.
123. Tyson JE, Wright LL, Oh W, et al. Vitamin A supplementation for extremely-low-birth-weight infants. National Institute of Child Health and Human Development Neonatal Research Network. N Engl J Med 1999; 340(25): 1962-8.
124. Ambalavanan N, Wu TJ, Tyson JE, Kennedy KA, Roane C, Carlo WA. A comparison of three vitamin A dosing regimens in extremely-low-birth-weight infants. J Pediatr 2003; 142(6): 656-61.
125. Wardle SP, Hughes A, Chen S, Shaw NJ. Randomised controlled trial of oral vitamin A supplementation in preterm infants to prevent chronic lung disease. Arch Dis Child Fetal Neonatal Ed 2001; 84(1): F9-F13.
126. Salle BL, Delvin E, Claris O, Hascoet JM, Levy E. Is it justifiable to administrate vitamin A, E and D for 6 months in the premature infants. Arch Pediatr 2007; 14(12): 1408-12.
127. Agostoni C, Buonocore G, Carnielli VP, et al. ESPGHAN Committee on Nutrition. Enteral nutrient supply for preterm infants: commentary from the European Society of Paediatric Gastroenterology, Hepatology and Nutrition Committee on Nutrition. J Pediatr Gastroenterol Nutr 2010; 50(1): 85-91.
128. Landman J, Sive A, Heese HD, Van der Elst C, Sacks R. Comparison of enteral and intramuscular vitamin A supplementation in preterm infants. Early Hum Dev 1992; 30(2): 163-70.
129. Humphrey JH, Agoestina T, Wu L, et al. Impact of neonatal vitamin A supplementation on infant morbidity and mortality. J Pediatr 1996; 128(4): 489-96.
130. Ambalavanan N, Kennedy K, Tyson J, Carlo WA. Survey of vitamin A supplementation for extremely-low-birth-weight infants: is clinical practice consistent with the evidence? Pediatr 2004; 145(3): 304-7.
131. Skouroliakou M, Konstantinou D, Koutri K, et al. A double-blind, randomized clinical trial of the effect of omega-3 fatty acids on the oxidative stress of preterm neonates fed through parenteral nutrition. Eur J Clin Nutr 2010; 64(9): 940-7.
132. Shenai JP, Mellen BG, Chytil F. Vitamin A status and postnatal dexamethasone treatment in bronchopulmonary dysplasia. Pediatrics 2000; 106(3): 547-53.
133. Mactier H, Mokaya MM, Farrell L, Edwards CA. Vitamin A provision for preterm infants: are we meeting current guidelines? Arch Dis Child Fetal Neonatal Ed 2011 Jan 17.