First SIBEN clinical consensus: Diagnostic and therapeutic approach to patent ductus arteriosus in premature newborns;Primer consenso clínico de SIBEN: Enfoque diagnóstico y terapéutico del ductus arterioso permeable en recién nacidos pretérmino

Anales de Pediatria

Volumn 69, Issue 5, 2008, Pages 454-481

  Golombek, S G ^a,b   Sola, A ^a,c   Baquero, H ^a,d   Borbonet, D ^a,e   Cabanas F ^a,f   Fajardo, C ^a,g   Goldsmit, G ^a,h   Lemus, L ^a,i   Miura, E ^a,j   Pellicer, A ^a,f   Perez J M ^a,k   Rogido, M ^a,c   Zambosco, G ^a,l   Van Overmeire, B ^m  

^a Sociedad Iberoamericana de Neonatología ^*

^b NEW YORK MEDICAL COLLEGE   (United States)

^c University of Medicine and Dentistry   (United States)

^d UNIVERSIDAD DEL NORTE   (Colombia)

^e UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^f HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

^g UNIVERSITY OF ARIZONA   (United States)

^h Hospital de Pediatria SAMIC Prof Dr Juan P Garrahan   (Argentina)

ⁱ Hospital de Pediatría del C M N O   (Mexico)

^j HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

^k IT UTI Neonatal   (Brazil)

^l HOSPITAL ITALIANO DE BUENOS AIRES   (Argentina)

^m ANTWERP UNIVERSITY HOSPITAL   (Belgium)

more..

Author keywords

Ibuprofen; Indometacine; Patent ductus arteriosus; Premature newborns; SIBEN consensus

Indexed keywords

AMIKACIN; BICARBONATE; DIGOXIN; DIURETIC AGENT; DOBUTAMINE; DOPAMINE; FUROSEMIDE; GENTAMICIN; GLUCONATE CALCIUM; HYDROCORTISONE; IBUPROFEN; IBUPROFEN LYSINE; INDOMETACIN; INSULIN; NAPROXEN; OXYGEN; PLACEBO; POTASSIUM CHLORIDE; SULINDAC; SUPRAGESIC; TROMETAMOL; UNCLASSIFIED DRUG;

ARTIFICIAL VENTILATION; BIRTH WEIGHT; BRAIN CIRCULATION; BRAIN HEMORRHAGE; CLINICAL FEATURE; CLINICAL TRIAL; COMORBIDITY; CONSENSUS; CONSENSUS DEVELOPMENT; COST EFFECTIVENESS ANALYSIS; DIAGNOSTIC PROCEDURE; DISEASE ACTIVITY; DISEASE COURSE; DOPPLER ECHOCARDIOGRAPHY; DRUG ANTAGONISM; DRUG CONTRAINDICATION; DRUG DOSAGE FORM; DRUG EFFECT; DRUG EFFICACY; DRUG PREFERENCE; DRUG TREATMENT FAILURE; EARLY INTERVENTION; ECHOCARDIOGRAPHY; ELECTROLYTE BALANCE; ENTERIC FEEDING; EXPERIMENTAL MODEL; FLUID BALANCE; GESTATIONAL AGE; HEAD CIRCUMFERENCE; HEALTH CARE AVAILABILITY; HEALTH CARE COST; HEART HEMODYNAMICS; HEART LEFT RIGHT SHUNT; HEART MURMUR; HOSPITALIZATION; HUMAN; IBEROAMERICAN SOCIETY OF NEONATOLOGY CLINICAL CONSENSUS; INCIDENCE; INFECTION; INFLAMMATION; INFORMATION RETRIEVAL; INTERNATIONAL COOPERATION; INTESTINE PERFORATION; INTRAVENOUS FEEDING; MEDICAL SOCIETY; METABOLIC DISORDER; MORBIDITY; NECROTIZING ENTEROCOLITIS; NEWBORN; NEWBORN CARE; NEWBORN MORTALITY; NONHUMAN; NUTRITION; NUTRITIONAL DISORDER; OLIGURIA; OXYGEN CONSUMPTION; PARENTERAL NUTRITION; PATENT DUCTUS ARTERIOSUS; PATHOPHYSIOLOGY; PHARMACEUTICAL CARE; POSTNATAL GROWTH; POSTOPERATIVE COMPLICATION; PRACTICE GUIDELINE; PREMATURITY; PULMONARY HYPERTENSION; RECOMMENDED DRUG DOSE; REVIEW; SIDE EFFECT; SPAIN; THORACOSCOPY; THORACOTOMY; TREATMENT CONTRAINDICATION; TREATMENT DURATION; TREATMENT INDICATION; TREATMENT OUTCOME;

EID: 55949136964     PISSN: 16954033     EISSN: 16959531     Source Type: Journal    
DOI: 10.1157/13128003     Document Type: Review

References (290)

1. Sola A, Soliz A. Ibero-American Society of Neonatology. Collaborative group for the improvement of clinical practice and research in neonatology. An Pediatr (Barc). 2004;61:390-2.
2. Hermes-DeSantis ER, Clyman RI. Patent ductus arteriosus: pathophysiology and management. J Perinatol. 2006;26 Suppl 1:S14-8; discussion S22-3.
3. Schneider DJ, Moore JW. Patent ductus arteriosus. Circulation. 2006;114:1873-82.
4. Dice JE BJ. Patent Ductus Arteriosus: An overview. J Pediat Pharmacol Ther. 2007;12:138-46.
5. Clyman RI. Mechanisms regulating the ductus arteriosus. Biol Neonate. 2006;89:330-5.
6. Very-low-birth-weight infant outcomes in 11 South American NICUs. J Perinatol. 2002;22:2-7.
7. Van Overmeire B, Smets K, Lecoutere D, Van de Broek H, Weyler J, Degroote K, et al. A comparison of ibuprofen and indomethacin for closure of patent ductus arteriosus. N Engl J Med. 2000;343:674-81.
8. Cordero L, Nankervis CA, Gardner D, Giannone PJ. The effects of indomethacin tocolysis on the postnatal response of the ductus arteriosus to indomethacin in extremely low birth weight infants. J Perinatol. 2007;27:22-7.
9. Lee HC, Silverman N, Hintz SR. Diagnosis of patent ductus arteriosus by a neonatologist with a compact, portable ultrasound machine. J Perinatol. 2007;27:291-6.
10. Hammoud MS, Elsori HA, Hanafi EA, Shalabi AA, Fouda IA, Devarajan LV. Incidence and risk factors associated with the patency of ductus arteriosus in preterm infants with respiratory distress syndrome in Kuwait. Saudi Med J. 2003;24:982-5.
11. Costeloe K, Hennessy E, Gibson AT, Marlow N, Wilkinson AR. The EPICure study: Outcomes to discharge from hospital for infants born at the threshold of viability. Pediatrics. 2000;106:659-71.
12. DiMenna L, Laabs C, McCoskey L, Seals A. Management of the neonate with patent ductus arteriosus. J Perinat Neonatal Nurs. 2006;20:333-40; quiz 341-2.
13. Kesiak M, Nowiczewski M, Gulczynska E, Kasprzak E, Binikowska J, Gadzinowski J. Can we expect decreasing the incidence of patent ductus arteriosus (PDA) in the population of premature neonates who had received antenatal steroid therapy? Ginekol Pol. 2005;76:812-8.
14. Del moral T, González-Quintero VH, Claure N, Vanbuskirk S, Bancalari E. Antenatal exposure to magnesium sulfate and the incidence of patent ductus arteriosus in extremely low birth weight infants. J Perinatol. 2007;27:154-7.
15. Travadi J, Simmer K, Ramsay J, Doherty D, Hagan R. Patent ductus arteriosus in extremely preterm infants receiving phototherapy: Does shielding the chest make a difference? A randomized, controlled trial. Acta Paediatr. 2006;95:1418-23.
16. Reller MD, Lorenz JM, Kotagal UR, Meyer RA, Kaplan S. Hemodynamically significant PDA: An echocardiographic and clinical assessment of incidence, natural history, and outcome in very low birth weight infants maintained in negative fluid balance. Pediatr Cardiol. 1985;6:17-23.
17. Evans N. Diagnosis of patent ductus arteriosus in the preterm newborn. Arch Dis Child. 1993;68:58-61.
18. Kluckow M, Evans N. Ductal shunting, high pulmonary blood flow, and pulmonary hemorrhage. J Pediatr. 2000;137:68-72.
19. Koch J, Hensley G, Roy L, Brown S, Ramaciotti C, Rosenfeld CR. Prevalence of spontaneous closure of the ductus arteriosus in neonates at a birth weight of 1000 grams or less. Pediatrics. 2006;117:1113-21.
20. Kluckow M, Evans N. Early echocardiographic prediction of symptomatic patent ductus arteriosus in preterm infants undergoing mechanical ventilation. J Pediatr. 1995;127:774-9.
21. Evans N MG, Osborn D, Kluckow M. Diagnosis of patent ductus arteriosus in preterm infants. Neoreviews. 2004;5:86-97.
22. Evans N, Iyer P. Change in blood pressure after treatment of patent ductus arteriosus with indomethacin. Arch Dis Child. 1993;68:584-7.
23. Evans N, Iyer P. Longitudinal changes in the diameter of the ductus arteriosus in ventilated preterm infants: Correlation with respiratory outcomes. Arch Dis Child Fetal Neonatal Ed. 1995;72:F156-61.
24. Skelton R, Evans N, Smythe J. A blinded comparison of clinical and echocardiographic evaluation of the preterm infant for patent ductus arteriosus. J Paediatr Child Health. 1994;30:406-11.
25. Ratner I, Perelmuter B, Toews W, Whitfield J. Association of low systolic and diastolic blood pressure with significant patent ductus arteriosus in the very low birth weight infant. Crit Care Med. 1985;13:497-500.
26. Laughon MM, Simmons MA, Bose CL. Patency of the ductus arteriosus in the premature infant: Is it pathologic? Should it be treated? Curr Opin Pediatr. 2004;16:146-51.
27. Boo NY, Mohd-Amin I, Bilkis AA, Yong-Junina F. Predictors of failed closure of patent ductus arteriosus with indomethacin. Singapore Med J. 2006;47:763-8.
28. Pezzati M, Vangi V, Biagiotti R, Bertini G, Cianciulli D, Rubaltelli FF. Effects of indomethacin and ibuprofen on mesenteric and renal blood flow in preterm infants with patent ductus arteriosus. J Pediatr. 1999;135:733-8.
29. Patole S, Muller R. Enteral feeding of preterm neonates: A survey of Australian neonatologists. J Matern Fetal Neonatal Med. 2004;16:309-14.
30. Patole SK, Kumaran V, Travadi JN, Brooks JM, Doherty DA. Does patent ductus arteriosus affect feed tolerance in preterm neonates? Arch Dis Child Fetal Neonatal Ed. 2007;92:F53-5.
31. Patole S, McGlone L, Muller R. Virtual elimination of necrotising enterocolitis for 5 years - reasons? Med Hypotheses. 2003;61:617-22.
32. Chorne N, Leonard C, Piecuch R, Clyman RI. Patent ductus arteriosus and its treatment as risk factors for neonatal and neurodevelopmental morbidity. Pediatrics. 2007;119:1165-74.
33. Cherif A, Jabnoun S, Khrouf N. Oral ibuprofen in early curative closure of patent ductus arteriosus in very premature infants. Am J Perinatol. 2007;24:339-45.
34. Sola A, Goldsmith G, Fariña D, Valdés M, Lee B, Menonna A, et al. Persistencia prolongada del ductus arterioso permeable: potencial producción de anomalías prolongadas en recién nacidos pequeños. An Pediatr (Barc). 2007;67 Supl 1:39.
35. Jaillard S, Larrue B, Rakza T, Magnenant E, Warembourg H, Storme L. Consequences of delayed surgical closure of patent ductus arteriosus in very premature infants. Ann Thorac Surg. 2006;81:231-4.
36. Raval MV, Laughon MM, Bose CL, Phillips JD. Patent ductus arteriosus ligation in premature infants: Who really benefits, and at what cost? J Pediatr Surg. 2007;42:69-75; discussion 75.
37. Thomas RL, Parker GC, Van Overmeire B, Aranda JV. A meta-analysis of ibuprofen versus indomethacin for closure of patent ductus arteriosus. Eur J Pediatr. 2005;164:135-40.
38. Dudell GG, Gersony WM. Patent ductus arteriosus in neonates with severe respiratory disease. J Pediatr. 1984;104:915-20.
39. Cotton RB, Stahlman MT, Bender HW, Graham TP, Catterton WZ, Kovar I. Randomized trial of early closure of symptomatic patent ductus arteriosus in small preterm infants. J Pediatr. 1978;93:647-51.
40. Kitterman JA, Edmunds LH, Jr., Gregory GA, Heymann MA, Tooley WH, Rudolph AM. Patent ducts arteriosus in premature infants. Incidence, relation to pulmonary disease and management. N Engl J Med. 1972;287:473-7.
41. Neal WA, Bessinger FB, Jr., Hunt CE, Lucas RV, Jr. Patent ductus arteriosus complicating respiratory distress syndrome. J Pediatr. 1975;86:127-32.
42. Jacob J, Gluck L, DiSessa T, Edwards D, Kulovich M, Kurlinski J, et al. The contribution of PDA in the neonate with severe RDS. J Pediatr. 1980;96:79-87.
43. Jones RW, Pickering D. Persistent ductus arteriosus complicating the respiratory distress syndrome. Arch Dis Child. 1977;52:274-81.
44. Stefano JL, Abbasi S, Pearlman SA, Spear ML, Esterly KL, Bhutani VK. Closure of the ductus arteriosus with indomethacin in ventilated neonates with respiratory distress syndrome. Effects of pulmonary compliance and ventilation. Am Rev Respir Dis. 1991;143:236-9.
45. Horsley BL, Lerberg DB, Allen AC, Zuberbuhler JR, Bahnson HT. Respiratory distress from patent ductus arteriosus in the premature newborn. Ann Surg. 1973;177:806-10.
46. Siassi B, Blanco C, Cabal LA, Coran AG. Incidence and clinical features of patent ductus arteriosus in low-birthweight infants: A prospective analysis of 150 consecutively born infants. Pediatrics. 1976;57:347-51.
47. Halliday HL, Hirata T, Brady JP. Echocardiographic findings of large patent ductus arteriosus in the very low birthweight infant before and after treatment with indomethacin. Arch Dis Child. 1979;54:744-9.
48. Lee J, Rajadurai VS, Tan KW, Wong KY, Wong EH, Leong JY. Randomized trial of prolonged low-dose versus conventional-dose indomethacin for treating patent ductus arteriosus in very low birth weight infants. Pediatrics. 2003;112:345-50.
49. Shimada S, Kasai T, Hoshi A, Murata A, Chida S. Cardiocirculatory effects of patent ductus arteriosus in extremely low-birth-weight infants with respiratory distress syndrome. Pediatr Int. 2003;45:255-62.
50. Noori S, Friedlich P, Seri I, Wong P. Changes in myocardial function and hemodynamics after ligation of the ductus arteriosus in preterm infants. J Pediatr. 2007;150:597-602.
51. Kabra NS, Schmidt B, Roberts RS, Doyle LW, Papile L, Fanaroff A. Neurosensory impairment after surgical closure of patent ductus arteriosus in extremely low birth weight infants: Results from the Trial of Indomethacin Prophylaxis in Preterms. J Pediatr. 2007;150:229-34, 234 e1.
52. Sperandio M, Beedgen B, Feneberg R, Huppertz C, Brussau J, Poschl J, et al. Effectiveness and side effects of an escalating, stepwise approach to indomethacin treatment for symptomatic patent ductus arteriosus in premature infants below 33 weeks of gestation. Pediatrics. 2005;116:1361-6.
53. Raval D, Yeh TF, Mora A, Cuevas D, Pyati S, Pildes RS. Chest physiotherapy in preterm infants with RDS in the first 24 hours of life. J Perinatol. 1987;7:301-4.
54. McCurnin DC, Yoder BA, Coalson J, Grubb P, Kerecman J, Kupferschmid J, et al. Effect of ductus ligation on cardiopulmonary function in premature baboons. Am J Respir Crit Care Med. 2005;172:1569-74.
55. Lee LC, Tillett A, Tulloh R, Yates R, Kelsall W. Outcome following patent ductus arteriosus ligation in premature infants: A retrospective cohort analysis. BMC Pediatr. 2006;6:15.
56. Carboni MP, Ringel RE. Ductus arteriosus in premature infants beyond the second week of life. Pediatr Cardiol. 1997;18:372-5.
57. Ivey KN, Srivastava D. The paradoxical patent ductus arteriosus. J Clin Invest. 2006;116:2863-5.
58. Gonzalez A, Sosenko IR, Chandar J, Hummler H, Claure N, Bancalari E. Influence of infection on patent ductus arteriosus and chronic lung disease in premature infants weighing 1000 grams or less. J Pediatr. 1996;128:470-8.
59. Bancalari E, Claure N, Gonzalez A. Patent ductus arteriosus and respiratory outcome in premature infants. Biol Neonate. 2005;88:192-201.
60. Watterberg KL, Scott SM, Backstrom C, Gifford KL, Cook KL. Links between early adrenal function and respiratory outcome in preterm infants: Airway inflammation and patent ductus arteriosus. Pediatrics. 2000;105:320-4.
61. Eronen MKA, Pesonen E, Hallman M. The effect of antenatal dexamethasone administration on the fetal and neonatal ductus arteriosus. A randomized double-blind study. Am J Dis Child. 1993;147:187-92.
62. Clyman RI, Roman C, Heymann MA, Ballard PL, Rudolph AM, Payne B. Effects of antenatal glucocorticoid administration on ductus arteriosus of preterm lambs. Am J Physiol. 1981;241:H415-20.
63. Oh W. Fluid and electrolyte therapy and parenteral nutrition in low birth weight infants. Clin Perinatol. 1982;9:637-43.
64. Bell EF, Oh W. Fluid and electrolyte balance in very low birth weight infants. Clin Perinatol. 1979;6:139-50.
65. Shaffer SG, Weismann DN. Fluid requirements in the preterm infant. Clin Perinatol. 1992;19:233-50.
66. Lorenz JM, Kleinman LI, Kotagal UR, Reller MD. Water balance in very low-birth-weight infants: Relationship to water and sodium intake and effect on outcome. J Pediatr. 1982;101:423-32.
67. Tammela OK, Lanning FP, Koivisto ME. The relationship of fluid restriction during the 1st month of life to the occurrence and severity of bronchopulmonary dysplasia in low birth weight infants: A 1-year radiological follow up. Eur J Pediatr. 1992;151:367-71.
68. Von Stockhausen HB, Struve M. Effects of highly varying parenteral fluid intakes in premature and newborn infants during the first three days of life (author's transl). Klin Padiatr. 1980;192:539-46.
69. Stevenson JG. Fluid administration in the association of patent ductus arteriosus complicating respiratory distress syndrome. J Pediatr. 1977;90:257-61.
70. Brown ER, Stark A, Sosenko I, Lawson EE, Avery ME. Bronchopulmonary dysplasia: Possible relationship to pulmonary edema. J Pediatr. 1978;92:982-4.
71. Bell EF, Warburton D, Stonestreet BS, Oh W. Effect of fluid administration on the development of symptomatic patent ductus arteriosus and congestive heart failure in premature infants. N Engl J Med. 1980;302:598-604.
72. Brion LP, Campbell DE. Furosemide for symptomatic patent ductus arteriosus in indomethacin-treated infants. Cochrane Database Syst Rev. 2001;(3):CD001148.
73. Bell EF, Acarregui MJ. Restricted versus liberal water intake for preventing morbidity and mortality in preterm infants. Cochrane Database Syst Rev. 2008;(1):CD000503.
74. Green TP, Thompson TR, Johnson D, Lock JE. Furosemide use in premature infants and appearance of patent ductus arteriosus. Am J Dis Child. 1981;135:239-43.
75. Brion LP, Campbell DE. Furosemide in indomethacin-treated infants. Systematic review and meta-analysis. Pediatr Nephrol. 1999;13:212-8.
76. Rais-Bahrami K, Majd M, Veszelovszky E, Short BL. Use of furosemide and hearing loss in neonatal intensive care survivors. Am J Perinatol. 2004;21:329-32.
77. Christmann V, Liem KD, Semmekrot BA, Van de Bor M. Changes in cerebral, renal and mesenteric blood flow velocity during continuous and bolus infusion of indomethacin. Acta Paediatr. 2002;91:440-6.
78. Gimeno Navarro A, Modesto Alapont V, Morcillo Sopena F, Fernández Gilino C, Izquierdo Macián I, Gutiérrez Laso A. Ibuprofen versus indomethacin in the preterm persistent patent ductus arteriosus therapy: Review and meta-analysis. An Pediatr (Barc). 2007;67:309-18.
79. Coombs RC, Morgan ME, Durbin GM, Booth IW, McNeish AS. Gut blood flow velocities in the newborn: Effects of patent ductus arteriosus and parenteral indomethacin. Arch Dis Child. 1990;65:1067-71.
80. Coombs RC, Morgan ME, Durbin GM, Booth IW, McNeish AS. Gut blood flow velocities in the newborn: Effects of patent ductus arteriosus and parenteral indomethacin. Arch Dis Child. 1991;66:1261.
81. Gimeno Navarro A, Cano Sánchez A, Fernández Gilino C, Carrasco Moreno JI, Izquierdo Macián I, Gutiérrez Laso A, et al. Ibuprofen versus indomethacin in the treatment of patent ductus arteriosus in preterm infants. An Pediatr (Barc). 2005;63:212-8.
82. Lago P, Bettiol T, Salvadori S, Pitassi I, Vianello A, Chiandetti L, et al. Safety and efficacy of ibuprofen versus indomethacin in preterm infants treated for patent ductus arteriosus: A randomised controlled trial. Eur J Pediatr. 2002;161:202-7.
83. Su BH, Lin HC, Chiu HY, Hsieh HY, Chen HH. Comparison of ibuprofen and indomethacin for early-targeted treatment of patent ductus arteriosus in extremely premature infants: A randomized controlled trial. Arch Dis Child Fetal Neonatal Ed. 2008;93:F94-F99.
84. Su PH, Chen JY, Su CM, Huang TC, Lee HS. Comparison of ibuprofen and indomethacin therapy for patent ductus arteriosus in preterm infants. Pediatr Int. 2003;45:665-70.
85. Van Overmeire B, Follens I, Hartmann S, Creten WL, Van Acker KJ. Treatment of patent ductus arteriosus with ibuprofen. Arch Dis Child Fetal Neonatal Ed. 1997;76:F179-84.
86. Boo NY, Goon HK. Epidemiology of necrotising enterocolitis in Malaysian neonates. Singapore Med J. 1989;30:444-8.
87. Milner AD. Surfactant and respiratory distress syndrome. Turk J Pediatr. 1996;38:37-43.
88. O'Donovan DJ, Baetiong A, Adams K, Chen A, Smith EO, Adams JM, et al. Necrotizing enterocolitis and gastrointestinal complications after indomethacin therapy and surgical ligation in premature infants with patent ductus arteriosus. J Perinatol. 2003;23:286-90.
89. Ohlsson A, Walia R, Shah S. Ibuprofen for the treatment of patent ductus arteriosus in preterm and/or low birth weight infants. Cochrane Database Syst Rev. 2005;(4):CD003481.
90. De Carolis MP, Romagnoli C, Polimeni V, Piersigilli F, Zecca E, Papacci P, et al. Prophylactic ibuprofen therapy of patent ductus arteriosus in preterm infants. Eur J Pediatr. 2000;159:364-8.
91. Ohlsson A, Walia R, Shah S. Ibuprofen for the treatment of patent ductus arteriosus in preterm and/or low birth weight infants. Cochrane Database Syst Rev. 2008;(1):CD003481.
92. Bellander M, Ley D, Polberger S, Hellstrom-Westas L. Tolerance to early human milk feeding is not compromised by indomethacin in preterm infants with persistent ductus arteriosus. Acta Paediatr. 2003;92:1074-8.
93. Alpan G, Scheerer R, Bland R, Clyman R. Patent ductus arteriosus increases lung fluid filtration in preterm lambs. Pediatr Res. 1991;30:616-21.
94. Nelin LD, Wearden ME, Welty SE, Hansen TN. The effect of blood flow and left atrial pressure on the DLCO in lambs and sheep. Respir Physiol. 1992;88:333-42.
95. Gerhardt T, Bancalari E. Lung compliance in newborns with patent ductus arteriosus before and after surgical ligation. Biol Neonate. 1980;38:96-105.
96. Schmidt DP, Moddemann D, Ohlsson A, Roberts RS, Saigal S, Solimano A, et al, and the TIPP investigators. Long-term effects of indomethacin prophylaxis in extremely-low-birthweight infants N Engl J Med. 2001;344:1966-72.
97. Shimada S, Kasai T, Konishi M, Fujiwara T. Effects of patent ductus arteriosus on left ventricular output and organ blood flows in preterm infants with respiratory distress syndrome treated with surfactant. J Pediatr. 1994;125:270-7.
98. Volpe JJ. Brain injury caused by intraventricular hemorrhage: Is indomethacin the silver bullet for prevention? Pediatrics. 1994;93:673-7.
99. Mosca BM, Lattnazio M, Fumagalli M, Toscetto C. Comparative evaluation of the effect of indomethacin and ibuprofen on cerebral perfusion and oxygenation in preterm infants with patent ductus arteriosus. J Pediatr. 1997;131:549-54.
100. Patel J, Marks KA, Roberts I, Azzopardi D, Edwards AD. Ibuprofen treatment of patent ductus arteriosus. Lancet. 1995;346:255.
101. Patel RI, Azzopardi D, Hamilton P, Edwards AD. Randomised double blind controlled trial comparing the effects of ibuprofen with indomethacin on cerebral hemodynamics in preterm infants with patent ductus arteriosus. Pediatr Res. 2000;47:36-42.
102. Knight DB. The treatment of patent ductus arteriosus in preterm infants. A review and overview of randomized trials. Semin Neonatol. 2001;6:63-73.
103. Adamska E, Helwich E, Rutkowska M, Zacharska E, Piotrowska A. Comparison of the efficacy of ibuprofen and indomethacin in the treatment of patent ductus arteriosus in prematurely born infants. Med Wieku Rozwoj. 2005;9:335-54.
104. Plavka SP, Borek I, Biolek J, Kostirova M, Liska K. Ibuprofen vs. indomethacin in the treatment of patent ductus arteriosus (PDA) in very premature neonates. Pediatric Res. 2001;49:375A.
105. Hammerman C, Aramburo MJ. Prolonged indomethacin therapy for the prevention of recurrences of patent ductus arteriosus. J Pediatr. 1990;117:771-6.
106. Hammerman C. Patent ductus arteriosus. Clinical relevance of prostaglandins and prostaglandin inhibitors in PDA pathophysiology and treatment. Clin Perinatol. 1995;22:457-79.
107. Hammerman C, Glaser J, Schimmel MS, Ferber B, Kaplan M, Eidelman AI. Continuous versus multiple rapid infusions of indomethacin: Effects on cerebral blood flow velocity. Pediatrics. 1995;95:244-8.
108. Hammerman C, Kaplan M. Patent ductus arteriousus in the premature neonate: Current concepts in pharmacological management. Paediatr Drugs. 1999;1:81-92.
109. Desfrere L, Zohar S, Morville P, Brunhes A, Chevret S, Pons G, et al. Dose-finding study of ibuprofen in patent ductus arteriosus using the continual reassessment method. J Clin Pharm Ther. 2005;30:121-32.
110. Narayanan M, Cooper B, Weiss H, Clyman RI. Prophylactic indomethacin: Factors determining permanent ductus arteriosus closure. J Pediatr. 2000;136:330-7.
111. Van Overmeire B, Touw D, Schepens PJ, Kearns GL, Van den Anker JN. Ibuprofen pharmacokinetics in preterm infants with patent ductus arteriosus. Clin Pharmacol Ther. 2001;70:336-43.
112. Herrera C, Holberton J, Davis P. Prolonged versus short course of indomethacin for the treatment of patent ductus arteriosus in preterm infants. Cochrane Database Syst Rev. 2007;(2):CD003480.
113. Simko A. Effects on cerebral blood flow velocities of slow and rapid infusion of indomethacin. J Perinatol. 1994;14:29-35.
114. Finch MB, Johnston GD, Kelly JG, McDevitt DG. Pharmacokinetics of digoxin alone and in the presence of indomethacin therapy. Br J Clin Pharmacol. 1984;17:353-5.
115. Haig GM, Brookfield EG. Increase in serum digoxin concentrations after indomethacin therapy in a full-term neonate. Pharmacotherapy. 1992;12:334-6.
116. Jorgensen HS, Christensen HR, Kampmann JP. Interaction between digoxin and indomethacin or ibuprofen. Br J Clin Pharmacol. 1991;31:108-10.
117. Koren G, Zarfin Y, Perlman M, MacLeod SM. Effects of indomethacin on digoxin pharmacokinetics in preterm infants. Pediatr Pharmacol (New York). 1984;4:25-30.
118. Marcus FI. Pharmacokinetic interactions between digoxin and other drugs. J Am Coll Cardiol. 1985;5 Suppl 5A:82A-90A.
119. Smyth JM, Collier PS, Darwish M, Millership JS, Halliday HL, Petersen S, et al. Intravenous indometacin in preterm infants with symptomatic patent ductus arteriosus. A population pharmacokinetic study. Br J Clin Pharmacol. 2004;58:249-58.
120. Zarfin Y, Koren G, Perlman M. Digoxin and indomethacin in preterm infants with PDA. J Pediatr. 1984;105:678-9.
121. Zarfin Y, Koren G, Maresky D, Perlman M, MacLeod S. Possible indomethacin-aminoglycoside interaction in preterm infants. J Pediatr. 1985;106:511-3.
122. Allegaert K, Rayyan M, Anderson BJ. Impact of ibuprofen administration on renal drug clearance in the first weeks of life. Methods Find Exp Clin Pharmacol. 2006;28:519-22.
123. Ishisaka DY, Van Vleet J, Marquardt E. Visual compatibility of indomethacin sodium trihydrate with drugs given to neonates by continuous infusion. Am J Hosp Pharm. 1991;48:2442-3.
124. Goldsmith SG. Indometacina: dosis administrada versus dosis indicada. Arch Arg Pediatr. 2006;104:10-4.
125. Satar M, Yapicioglu H, Narli N, Ozbarlas N, Kucukosmanoglu O, Tutak E. Is oral indomethacin effective in treatment of preterm infants with patent ductus arteriosus? Turk J Pediatr. 2004;46:137-41.
126. Fakhraee SH, Badiee Z, Mojtahedzadeh S, Kazemian M, Kelishadi R. Comparison of oral ibuprofen and indomethacin therapy for patent ductus arteriosus in preterm infants. Zhongguo Dang Dai Er Ke Za Zhi. 2007;9:399-403.
127. Lai TH, Soong WJ, Hwang B. Indomethacin for the prevention of symptomatic patent ductus arteriosus in very low birth weight infants. Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi. 1990;31:17-23.
128. So LY, Fok TF, Sung RY, Ho JK. Preterm infants with patent ductus arteriosus: Treatment with an enteral preparation of indomethacin. Ann Trop Paediatr. 1992;12:403-8.
129. Sharma PK, Garg SK, Narang A. A preliminary study on pharmacokinetics of oral indomethacin in premature infants in north India. Indian J Med Res. 2003;117:164-9.
130. Gournay V, Savagner C, Thiriez G, Kuster A, Roze JC. Pulmonary hypertension after ibuprofen prophylaxis in very preterm infants. Lancet. 2002;359:1486-8.
131. Bellini C, Campone F, Serra G. Pulmonary hypertension following L-lysine ibuprofen therapy in a preterm infant with patent ductus arteriosus. CMAJ. 2006;174:1843-4.
132. Aly H, Lotfy W, Badrawi N, Ghawas M, Abdel-Meguid IE, Hammad TA. Oral Ibuprofen and ductus arteriosus in premature infants: A randomized pilot study. Am J Perinatol. 2007;24:267-70.
133. Chotigeat U, Jirapapa K, Layangkool T. A comparison of oral ibuprofen and intravenous indomethacin for closure of patent ductus arteriosus in preterm infants. J Med Assoc Thai. 2003;86 Suppl 3:S563-9.
134. Heyman E, Morag I, Batash D, Keidar R, Baram S, Berkovitch M. Closure of patent ductus arteriosus with oral ibuprofen suspension in premature newborns: A pilot study. Pediatrics. 2003;112:e354.
135. Hariprasad P, Sundarrajan V, Srimathy G, Suthagar B, Ramadevi BS. Oral ibuprofen for closure of hemodynamically significant PDA in premature neonates. Indian Pediatr. 2002;39:99-100.
136. Tatli MM, Kumral A, Duman N, Demir K, Gurcu O, Ozkan H. Spontaneous intestinal perforation after oral ibuprofen treatment of patent ductus arteriosus in two very-low-birthweight infants. Acta Paediatr. 2004;93:999-1001.
137. Aranda JV, Thomas R. Systematic review: Intravenous Ibuprofen in preterm newborns. Semin Perinatol. 2006;30:114-20.
138. Fowlie PW, Davis PG. Prophylactic intravenous indomethacin for preventing mortality and morbidity in preterm infants. Cochrane Database Syst Rev. 2002;(3):CD000174.
139. Ng PC, So KW, Fok TF, Yam MC, Wong MY, Wong W. Comparing sulindac with indomethacin for closure of ductus arteriosus in preterm infants. J Paediatr Child Health. 1997;33:324-8.
140. Wilkinson AR, Aynsley-Green A, Mitchell MD. Persistent pulmonary hypertension and abnormal prostaglandin E levels in preterm infants after maternal treatment with naproxen. Arch Dis Child. 1979;54:942-5.
141. Burdan F, Sykut J, Przybylski P. Developmental toxicity of naproxen. Pol Merkur Lekarski. 2007;23:155-8.
142. Talati AJ, Salim MA, Korones SB. Persistent pulmonary hypertension after maternal naproxen ingestion in a term newborn: A case report. Am J Perinatol. 2000;17:69-71.
143. Colditz P, Murphy D, Rolfe P, Wilkinson AR. Effect of infusion rate of indomethacin on cerebrovascular responses in preterm neonates. Arch Dis Child. 1989;64:8-12.
144. Edwards WJ, Richardson C, Potter A, CopeM, Delpy DT, Reynolds EO. Effects of indomethacin on cerebral hemodynamics in very preterm infants. Lancet. 1990;335:1491-5.
145. Osborn DA, Evans N, Kluckow M. Effect of early targeted indomethacin on the ductus arteriosus and blood flow to the upper body and brain in the preterm infant. Arch Dis Child Fetal Neonatal Ed. 2003;88:F477-82.
146. Su BH, Peng CT, Tsai CH. Echocardiographic flow pattern of patent ductus arteriosus: A guide to indomethacin treatment in premature infants. Arch Dis Child Fetal Neonatal Ed. 1999;81:F197-200.
147. Dumas de la Roque BF, Demarquez JL, Pedespan L. Minimal effective dose of indomethacin for the treatment of patent ductus arteriosus in preterm infants. Biol Neonate. 2002;81:91-4.
148. Evans N. Patent ductus arteriosus in the neonate. Curr Paediatr. 2005;15:381-9.
149. Ment LR, Ehrenkranz RA, Kleinman CS, Pitt BR, Taylor KJ, Scott DT, et al. Randomized indomethacin trial for prevention of intraventricular hemorrhage in very low birth weight infants. J Pediatr. 1985;107:937-43.
150. Ment LR, Ehrenkranz RA, Kleinman CS, Taylor KJ, Scott DT, Gettner P, et al. Randomized low-dose indomethacin trial for prevention of intraventricular hemorrhage in very low birth weight neonates. J Pediatr. 1988;112: 948-55.
151. Ment LR, Ehrenkranz RA, Phillip AGS. Low-dose indomethacin therapy and extension of intraventricular hemorrhage: A multicenter randomized trial. J Pediatr. 1994;124:951-5.
152. Ment LR, Ehrenkranz RA, Phillip AGS, Vohr B, Allan W, Duncan CC, et al. Low-dose indomethacin and prevention of intraventricular hemorrhage: A multicenter randomized trial. Pediatrics. 1994;93:543-50.
153. Schmidt B, Roberts RS, Fanaroff A, Davis P, Kirpalani HM, Nwaesei C, et al. Indomethacin prophylaxis, patent ductus arteriosus, and the risk of bronchopulmonary dysplasia: Further analyses from the Trial of Indomethacin Prophylaxis in Preterms (TIPP). J Pediatr. 2006;148:730-4.
154. Bose CL, Laughon MM. Patent ductus arteriosus: Lack of evidence for common treatments. Arch Dis Child Fetal Neonatal Ed. 2007;92:F498-502.
155. Van Overmeire B, Van de Broek H, Van Laer P, Weyler J, Vanhaesebrouck P. Early versus late indomethacin treatment for patent ductus arteriosus in premature infants with respiratory distress syndrome. J Pediatr. 2001;138:205-11.
156. Hammerman C, Kaplan M. Comparative tolerability of pharmacological treatments for patent ductus arteriosus. Drug Saf. 2001;24:537-51.
157. Mikhail M, Lee W, Toews W, Synhorst DP, Hawes CR, Hernandez J, et al. Surgical and medical experience with 734 premature infants with patient ductus arteriosus. J Thorac Cardiovasc Surg. 1982;83:349-57.
158. Weiss H, Cooper B, Brook M, Schlueter M, Clyman R. Factors determining reopening of the ductus arteriosus after successful clinical closure with indomethacin. J Pediatr. 1995;127:466-71.
159. Clyman RI, Chorne N. Patent ductus arteriosus: Evidence for and against treatment. J Pediatr. 2007;150:216-9.
160. Shah SS, Ohlsson A. Ibuprofen for the prevention of patent ductus arteriosus in preterm and/or low birth weight infants. Cochrane Database Syst Rev. 2006;(1):CD004213.
161. Brandt B, Marvin WJ, Ehrenhaft JL, Heintz S, Doty DB. Ligation of patent ductus arteriosus in premature infants. Ann Thorac Surg. 1981;32:166-72.
162. Gersony WM, Peckham GJ, Ellison RC, Miettinen OS, Nadas AS. Effects of indomethacin in premature infants with patent ductus arteriosus: Results of a national collaborative study. J Pediatr. 1983;102:895-906.
163. Ghosh PK, Lubliner J, Mogilner M, Yakirevich V, Vidne BA. Patent ductus arteriosus in premature infants. Tex Heart Inst J. 1986;13:163-8.
164. Gournay RJ, Kuster A, Daoud P, Cambonie G, Hascoet JM, Chamboux C, et al. Prophylactic ibuprofen versus placebo in very premature infants: A randomised, double-blind, placebo-controlled trial. Lancet. 2004;364:1939-44.
165. Koehne PS, Bein G, Alexi-Meskhishvili V, Weng Y, Buhrer C, Obladen M. Patent ductus arteriosus in very low birthweight infants: Complications of pharmacological and surgical treatment. J Perinat Med. 2001;29:327-34.
166. Palder SB, Schwartz MZ, Tyson KR, Marr CC. Management of patent ductus arteriosus: A comparison of operative v pharmacologic treatment. J Pediatr Surg. 1987;22:1171-4.
167. Archer N. Drug induced closure of patent ductus arteriosus. Heart. 1996;76:384-5.
168. Brooks JM, Travadi JN, Patole SK, Doherty DA, Simmer K. Is surgical ligation of patent ductus arteriosus necessary? The Western Australian experience of conservative management. Arch Dis Child Fetal Neonatal Ed. 2005;90:F235-9.
169. Dani C, Bertini G, Reali MF, Murru P, Fabris C, Vangi V, et al. Prophylaxis of patent ductus arteriosus with ibuprofen in preterm infants. Acta Paediatr. 2000;89:1369-74.
170. Fanos V, Benini D, Verlato G, Errico G, Cuzzolin L. Efficacy and renal tolerability of ibuprofen vs. indomethacin in preterm infants with patent ductus arteriosus. Fundam Clin Pharmacol. 2005;19:187-93.
171. Malviya M, Ohlsson A, Shah S. Surgical versus medical treatment with cyclooxygenase inhibitors for symptomatic patent ductus arteriosus in preterm infants. Cochrane Database Syst Rev. 2003;(3):CD003951.
172. Perez CA, Bustorff-Silva JM, Villasenor E, Fonkalsrud EW, Atkinson JB. Surgical ligation of patent ductus arteriosus in very low birth weight infants: Is it safe? Am Surg. 1998;64:1007-9.
173. Trus T, Winthrop AL, Pipe S, Shah J, Langer JC, Lau GY. Optimal management of patent ductus arteriosus in the neonate weighing less than 800 g. J Pediatr Surg. 1993;28:1137-9.
174. Wyllie J. Treatment of patent ductus arteriosus. Semin Neonatol. 2003;8:425-32.
175. Mahony CR, Girod DA, Hurwitz RA, Jansen RD, Lemons JA, Schreiner RL. Indomethacin therapy on the first day of life in infants with very low birth weight. J Pediatr. 1985;106:801-5.
176. Van Overmeire AK, Allegaert K, Casaer A, Debauche C, Decaluwe W, Jespers A, et al. Prophylactic ibuprofen in premature infants: A multicentre, randomised, double-blind, placebo-controlled trial. Lancet. 2004;364:1945-9.
177. Merritt TA, DiSessa TG, Feldman BH, Kirkpatrick SE, Gluck L, Friedman WF. Closure of the patent ductus arteriosus with ligation and indomethacin: A consecutive experience. J Pediatr. 1978;93:639-46.
178. Finer WB, Hayashi A, Hayes B. Neonatal surgery. Intensive care unit versus operating room. J Pediatr Surg. 1993;28:645-9.
179. Gavilanes AW, Heineman E, Herpers MJ, Blanco CE. Use of neonatal intensive care unit as a safe place for neonatal surgery. Arch Dis Child Fetal Neonatal Ed. 1997;76:F51-3.
180. Gould DS, Montenegro LM, Gaynor JW, Lacy SP, Ittenbach R, Stephens P, et al. A comparison of on-site and off-site patent ductus arteriosus ligation in premature infants. Pediatrics. 2003;112:1298-301.
181. Kuster A, Jouvet P, Bonnet D, Flandin C, Lenclein R, Hubert P, et al. Feasibility of surgery for patent ductus arteriosus of premature babies in a neonatal intensive care unit. Eur J Pediatr Surg. 2003;13:294-7.
182. Robie DK, Waltrip T, García-Prats JA, Pokorny WJ, Jaksic T. Is surgical ligation of a patent ductus arteriosus the preferred initial approach for the neonate with extremely low birth weight? J Pediatr Surg. 1996;31:1134-7.
183. Taylor GF, Harman PK, Escobedo MK, Ramamurthy RS, Trinkle JK. Operative closure of patent ductus arteriosus in premature infants in the neonatal intensive care unit. Am J Surg. 1986;152:704-8.
184. Mavroudis C, Cook LN, Fleischaker JW, Nagaraj HS, Shott RJ, Howe WR, et al. Management of patent ductus arteriosus in the premature infant: Indomethacin versus ligation. Ann Thorac Surg. 1983;36:561-6.
185. Galal MO, Von Sinner W, Al-Fadley F, Solymar L, Bulbul Z, Boecker J, et al. Radiographic characteristics of Cook detachable and Gianturco coils as well as clinical results of transcatheter closure of the patent ductus arteriosus. Z Kardiol. 1999;88:1006-14.
186. Little DC, Pratt TC, Blalock SE, Krauss DR, Cooney DR, Custer MD. Patent ductus arteriosus in micropreemies and full-term infants: The relative merits of surgical ligation versus indomethacin treatment. J Pediatr Surg. 2003;38:492-6.
187. Villa E, Vanden Eynden F, Le Bret E, Folliguet T, Laborde F. Paediatric video-assisted thoracoscopic clipping of patent ductus arteriosus: Experience in more than 700 cases. Eur J Cardiothorac Surg. 2004;25:387-93.
188. Adzick HM, DeLorimier AA. Surgical clip ligation of patent ductus arteriosus in premature infants. J Pediatr Surg. 1986;21:158.
189. Mandhan PL, Samarakkody U, Brown S, Kukkady A, Maoate K, Blakelock R, et al. Comparison of suture ligation and clip application for the treatment of patent ductus arteriosus in preterm neonates. J Thorac Cardiovasc Surg. 2006;132:672-4.
190. Traugott WR, Schuchmann GF, Treasure RL. A simplified method of ligation of patent ductus arteriosus in premature infants. Ann Thorac Surg. 1980;29:263.
191. Burke RP, Jacobs JP, Cheng W, Trento A, Fontana GP. Video-assisted thoracoscopic surgery for patent ductus arteriosus in low birth weight neonates and infants. Pediatrics. 1999;104:227-30.
192. Mortier E, Ongenae M, Vermassen F, Van Aken J, De Roose J, Van Haesebrouck P, et al. Operative closure of patent ductus arteriosus in the neonatal intensive care unit. Acta Chir Belg. 1996;96:266-8.
193. Iwase J, Tajima K, Io A, Katoh W, Tanaka K, Toki S, et al. Less invasive surgical closure of patent ductus arteriosus in extremely low birth weight infants. Jpn J Thorac Cardiovasc Surg. 2003;51:651-5.
194. Hines MH, Raines KH, Payne RM, Covitz W, Cnota JF, Smith TE, et al. Video-assisted ductal ligation in premature infants. Ann Thorac Surg. 2003;76:1417-20; discussion 1420.
195. Forster R. Thoracoscopic clipping of patent ductus arteriosus in premature infants. Ann Thorac Surg. 1993;56:1418-20.
196. Prieto LR, DeCamillo DM, Konrad DJ, Scalet-Longworth L, Latson LA. Comparison of cost and clinical outcome between transcatheter coil occlusion and surgical closure of isolated patent ductus arteriosus. Pediatrics. 1998;101:1020-4.
197. Rothenberg CJ, Toews WH, Washington RL. Thoracoscopic closure of patent ductus arteriosus: A less traumatic and more cost-effective technique. J Pediatr Surg. 1995;30:1057-60.
198. Wagner HR, Ellison RC, Zierler S, Lang P, Purohit DM, Behrendt D, et al. Surgical closure of patent ductus arteriosus in 268 preterm infants. J Thorac Cardiovasc Surg. 1984;87: 870-5.
199. Pokorny AJ, Mcgill CW. Ligation of patent ductus arteriosus in the neonatal intensive care unit. Pediatrics. 1985;23:133-42.
200. Daniels O, Hopman JC, Busch HJ, Stoelinga GB. Contribution of PDA to RDS. J Pediatr. 1980;97:514-5.
201. Daniels RM, Kaplan S. Recurrence of patency of the ductus arteriosus after surgical ligation in premature infants. Pediatrics. 1984;73:56-8.
202. Coster DD, Gorton ME, Grooters RK, Thieman KC, Schneider RF, Soltanzadeh H. Surgical closure of the patent ductus arteriosus in the neonatal intensive care unit. Ann Thorac Surg. 1989;48:386-9.
203. Davis JT, Baciewicz FA, Suriyapa S, Vauthy P, Polamreddy R, Barnett B. Vocal cord paralysis in premature infants undergoing ductal closure. Ann Thorac Surg. 1988;46:214-5.
204. Eggert LD, Jung AJ, Ruttenberg HD. Surgical treatment of patent ductus arteriosus in preterm infants. Four-year experience with ligation in the newborn intensive care unit. Pediatr Cardiol. 1982;2:15-8.
205. Fan LL, Campbell DN, Clarke DR, Washington RL, Fix EJ, White CW. Paralyzed left vocal cord associated with ligation of patent ductus arteriosus. J Thorac Cardiovasc Surg. 1989;98:611-3.
206. Taylor AF, Morrow WR, Lally KP, Kinsella JP, Gerstmann DR, DeLemos RA. Left ventricular dysfunction following ligation of the ductus arteriosus in the preterm baboon. J Surg Res. 1990;48:590-6.
207. Mosalli R, Alfaleh K. Prophylactic surgical ligation of patent ductus arteriosus for prevention of mortality and morbidity in extremely low birth weight infants. Cochrane Database Syst Rev. 2008;(1):CD006181.
208. Dollberg S, Lusky A, Reichman B. Patent ductus arteriosus, indomethacin and necrotizing enterocolitis in very low birth weight infants: A population-based study. J Pediatr Gastroenterol Nutr. 2005;40:184-8.
209. Lubetzky R, Mandel D, Mimouni FB, Diamant S, Birger A, Barak M, et al. Indomethacin-induced early patent ductus arteriosus closure cannot be predicted by a decrease in pulse pressure. Am J Perinatol. 2004;21:257-61.
210. Narayanan M, Clyman R. Pharmacologic closure of patent ductus arteriosus in the neonate. Pharmacol Rev. 2003;4(8).
211. Fujii AM, Brown E, Mirochnick M, O'Brien S, Kaufman G. Neonatal necrotizing enterocolitis with intestinal perforation in extremely premature infants receiving early indomethacin treatment for patent ductus arteriosus. J Perinatol. 2002;22:535-40.
212. Laughon M, Bose C, Clark R. Treatment strategies to prevent or close a patent ductus arteriosus in preterm infants and outcomes. J Perinatol. 2007;27:164-70.
213. Ohlsson A, Walia R, Shah S. Ibuprofen for the treatment of a patent ductus arteriosus in preterm and/or low birth weight infants. Cochrane Database Syst Rev. 2003;(2):CD003481.
214. Martin CG, Snider AR, Katz SM, Peabody JL, Brady JP. Abnormal cerebral blood flow patterns in preterm infants with a large patent ductus arteriosus. J Pediatr. 1982;101:587-93.
215. Evans N, Kluckow M. Early ductal shunting and intraventricular haemorrhage in ventilated preterm infants. Arch Dis Child Fetal Neonatal Ed. 1996;75:F183-6.
216. Szymonowicz W, Yu VY. Periventricular haemorrhage: Association with patent ductus arteriosus and its treatment with indomethacin or surgery. Aust Paediatr J. 1987;23:21-5.
217. Shortland DB, Gibson NA, Levene MI, Archer LN, Evans DH, Shaw DE. Patent ductus arteriosus and cerebral circulation in preterm infants. Dev Med Child Neurol. 1990;32:386-93.
218. Limperopoulos C, Benson CB, Bassan H, Disalvo DN, Kinnamon DD, Moore M, et al. Cerebellar hemorrhage in the preterm infant: Ultrasonographic findings and risk factors. Pediatrics. 2005;116:717-24.
219. Chung MY, Fang PC, Chung CH, Huang CB, Ou Yang MH, Chen CC. Risk factors for hemodynamically-unrelated cystic periventricular leukomalacia in very low birth weight premature infants. J Formos Med Assoc. 2005;104:571-7.
220. Cooke L, Steer P, Woodgate P. Indomethacin for asymptomatic patent ductus arteriosus in preterm infants. Cochrane Database Syst Rev. 2003;(2):CD003745.
221. Kluckow M, Evans N. Low superior vena cava flow and intraventricular haemorrhage in preterm infants. Arch Dis Child Fetal Neonatal Ed. 2000;82:F188-F194.
222. Pladys BA, Wodey E, Treguier C, Lassel L, Betremieux P. Patent ductus arteriosus and cystic periventricular leukomalacia in preterm infants. Acta Paediatr. 2001;90:309-15.
223. Hunt RW, Evans N, Rieger I, Kluckow M. Low superior vena cava flow and neurodevelopment at 3 years in very preterm infants. J Pediatr. 2004;145:588-92.
224. Ichihashi K, Shiraishi H, Endou H, Kuramatsu T, Yano S, Yanagisawa M. Cerebral and abdominal arterial hemodynamics in preterm infants with patent ductus arteriosus. Acta Paediatr Jpn. 1990;32:349-56.
225. Weir FJ, Ohlsson A, Myhr TL, Fong K, Ryan ML. A patent ductus arteriosus is associated with reduced middle cerebral artery blood flow velocity. Eur J Pediatr. 1999;158:484-7.
226. Perlman JM, Hill A, Volpe JJ. The effect of patent ductus arteriosus on flow velocity in the anterior cerebral arteries: Ductal steal in the premature newborn infant. J Pediatr. 1981;99:767-71.
227. Wilcox WD, Carrigan TA, Dooley KJ, Giddens DP, Dykes FD, Lazzara A, et al. Range-gated pulsed Doppler ultrasonographic evaluation of carotid arterial blood flow in small preterm infants with patent ductus arteriosus. J Pediatr. 1983;102:294-8.
228. Kurtis RT, Zalneraitis EL. Cerebral blood flow and EEG changes in preterm infants with patent ductus arteriosus. Pediatr Neurol. 1995;12:114-9.
229. Austin N. Regional cerebral blood flow velocity changes after indomethacin infusion in preterm infants. Arch Dis Child. 1992;67:851-4.
230. Coldittz P. Effect of infusion rate of indomethacin on cerebrovascular responses in preterm neonates. Arch Dis Child. 1989;64:8-12.
231. Evans LM, Archer LN. The effect of indomethacin on cerebral-blood flor velocity in premature infants. Dev Med Child Neurol. 1987;29:776-82.
232. Laugdignon CS, Bard H, Aranda JV. Effect of indomethacin on cerebral blood flow velocity of premature newborns. Biol Neonate. 1988;54:254-62.
233. Levene SD, Gibson N, Evans DH. Carbon dioxide reactivity of the cerebral circulation in extremely premature infants: Effects of postnatal age and indomethacin. Pediatr Res. 1988;24:175-9.
234. Van Bel F, Van de Bor M, Stijnen T, Baan J, Ruys JH. Cerebral blood flow velocity changes in preterm infants after a single dose of indomethacin: Duration of its effect. Pediatrics. 1989;84:802-7.
235. Van Bel F, Houdkamp E, Berger HM. Is there a relationship between indomethacin-induced reduction in neonatal cerebral blood flor velocity and prostaglandin production. Dev Pharmacol Ther. 1993;20:45-53.
236. Ohlsson BJ, Govan J, Ryan ML, Fong K, Myhr T. Effect of indomethacin on cerebral blood flor velocities in very low birth weight neonates with a patent ductus arteriosus. Dev Pharmacol Ther. 1993;20:100-6.
237. Benders DC, Van de Bor M, Van Bel F. Acute effects of indomethacin on cerebral hemodynamics and oxygenation. Biol Neonate. 1995;68:91-9.
238. Liem HJC, Kollee LA, Oeseburg B. Effects of repeated indomethacin administration on cerebral oxygenation and hemodynamics in preterm infants: Combined near-infrared spectrophotometry and Doppler ultrasound study. Eur J Pediatr. 1994;153:504-9.
239. Mc Cormick EA, Brown GC, Wyatt JS, Potter A, Cope M, Delpy DT, Reynolds EO. Effect of Indomethacin on cerebral oxydized cytochrome oxydase in preterm infants. Pediatr Res. 1993;33:603-8.
240. Brown HJ, Lee TY. Near-infrared spectroscopy measurement of oxygen extraction fraction and cerebral metabolic rateo of oxygen in newborn piglets. Pediatr Res. 2003;54:861-7.
241. Brown LD, Kumaran VS, Lee TY. Age-dependent cerebral hemodynamic effects of indomethacin in the newborn piglet. J Appl Physiol. 2004;97:1880-7.
242. Gork A, Ehrenkranz R, Bracken M. Continuous infusion versus intermittent bolus doses of indomethacin for patent ductus arteriosus closure in symptomatic preterm infants. Cochrane Database Syst Rev. 2008;(1):CD006071.
243. Parrilla TRK, Cohen LS, Clark E. Lack of effect of antenatal indomethacin on fetal cerebral blood flow. Am J Obstet Gynecol. 1997;176:1166-71.
244. Skarsgard ED. Vanderwall MJA, Roman C, Heymann MA, Harrison MR. Effects of nitroglycerin and ondomethacin on fetal-maternal circulation ando n fetal cerebral blood flor and metabolism in sheep. Am J Obstet Gynecol. 1999;181:440-5.
245. Biestro RA, Soca AE, Cancela M, Puppo CB, Borovich B. Use of indomethacin in brain-injured patients with cerebral perfusion pressure impairment: Preliminary report. J Neurosurg. 1995;83:627-30.
246. Imberti RF, Bellinzona G, Pagani M, Langer M. The use of indomethacin to treat acute rises of intracraneal pressure and improve global cerebral perfusion in a child with head trauma. Acta Anaesthesiol Scand. 1997;41:536-40.
247. Chung C, Gottstein J, Blei AT. Indomethacin prevents the development of experimental ammonia-induced brain edema in rats after portacaval anastomosis. Hepatology. 2001;34:249-54.
248. Clemmesen H, Larsen FS. Indomethacin normalizes intracraneal pressure in acute liver failure: A twenty-three year-old woman treated with indomethacin. Hepatology. 1997;26: 1423-5.
249. Chemtob S, Barna T, Varma DR, Aranda JV. Prostanoids determine the range of cerebral blood flow autoregulation of newborn piglets. Stroke. 1990;21:777-84.
250. Chemtob S, Abran D, Fernandez H, Varma DR. Prevention of post asphyxial increase in lipid peroxides and retinal function and deterioration in the newborn pig by inhibition of cyclooxygenase activity and free radical generation. Pediatr Res. 1993;33:336-40.
251. Pellicer A, Cabanas F, Valverde E, Quero J, Stiris TA. Effect of the cyclo-oxygenase blocker ibuprofen on cerebral blood volume and cerebral blood flow during normocarbia and hypercarbia in newborn piglets. Acta Paediatr. 1999;88:82-8.
252. Naulaers GD, Allegaert K, Debeer A, Cossey V, Vanhole C, Casaer P, et al. Ibuprofen and cerebral oxygenation and circulation. Arch Dis Child Fetal Neonatal Ed. 2005;90:F75-F76.
253. Speziale A, Henderson CR, Barrington KJ, Finer NN. Effects of ibuprofen and indomethacin on the regional circulation in newborn piglets. Biol Neonate. 1999;76:242-52.
254. Dani C, Bertini G, Pezzati M, Poggi C, Guerrini P, Martano C, et al. Prophylactic ibuprofen for the prevention of intraventricular hemorrhage among preterm infants: A multicenter, randomized study. Pediatrics. 2005;115:1529-35.
255. Ment S, Duncan CC, Scott DT, Lambrecht R. Beagle puppy model of intraventricular hemorrhage. Effect of indomethacin on cerebral blood flow. J Neurosurg. 1983;58:857-62.
256. Bada GR, Pourcyrous M. Indomethacin reduces the risks of severe intraventricular hemorrhage. J Pediatr. 1989;115:631-7.
257. Bandstra MB, Goldberg RN, Ferrer PL, Flynn J, Gregorios JB, Bancalari E. Prophylactic indomethacin for prevention of intraventricular hemorrhage in premature infants. Pediatrics. 1988;82:533-42.
258. Couser HR, Ferrara B, Wright GB, Cabalka AK, Connet JE. Neurodevelopmental follow-up at 36 months' corrected age of preterm infants treated with prophylactic indomethacin. Arch Pediatr Adolesc Med. 2000;154:598-602.
259. Hanigan KG, Roemisch F, Anderson R, Cusack T, Powers W. Administration of indomethacin for the prevention of periventricular haemorrhage in high-risk neonates. J Pediatr. 1988;112:914-7.
260. Krueger MM, Bratton D, Cotton R. Prevention of symptomatic patent ductus arteriosus with a single dose of indomethacin. J Pediatr. 1987;111:749-54.
261. Morales-Suárez S, Lemus-Varela L, Udaeta-Mora E, Cardiel-Marmolejo L, Rodríguez-Balderrama I, Liz-Cedillo RE. Estudio comparativo de dosis baja de indometacina profiláctica para hemorragia subependimaria/ intraventricular en neonatos pretérmino con ventilación mecánica. Bol Med Hosp Infant Mex. 1994;51:389-94.
262. Rennie DJ, Cooke RWI. Early administration of indomethacin to preterm infants. Arch Dis Child. 1986;61:233-8.
263. Supapannachart S, Khowsathit P, Patchakapati B. Indomethacin prophylaxis for patent ductus arteriosus (PDA) in infants with a birth weight of less than 1250 grams. J Med Assoc Thai. 1999;82 Suppl 1:S87-92.
264. Vincer AA, Evans J, Nwaesei C, Stinson D, Rees E, Fraser A. Early intravenous indomethacin prolongs respiratory support in very low birth weight infants. Acta Paediatr Scand. 1985;76:894-7.
265. Yaseen UK, Ali H, Rustum M, Darwich M, Al-Faraidy A. Effects of early indomethacin administration on oxygenation and surfactant requirement in low birth weight infants. J Trop Pediatr. 1997;43:42-6.
266. Ment VB, Allan W, Westerveld M, Sparrow S, Schneider K, Katz K, et al. Outcome of children in the indomethacin intraventricular hemorrhage prevention trial. Pediatrics. 2000;105:485-91.
267. Ment VB, Oh W, Scott DT, Allen WC, Westerveld M, Duncan CC, et al. Neurodevelopmental outcome at 36 months corrected age of preterm infants in the multicenter indomethacin intraventricular hemorrhage prevention trial. Pediatrics. 1996;98:714-8.
268. Vohr AW, Westerveld M, Schneider KC, Katz KH, Makuch RW, Ment LR. School-age outcomes of very low birth weight infants in the indomethacin intraventricular hemorrhage prevention trial. Pediatrics. 2003;111:e340-6.
269. Couser FT, Wright GB, Cabalka AK, Schilling CG, Hoekstra RE, Payne NR. Prophylactic indomethacin therapy in the first 24 hours of life for the prevention of patent ductus arteriosus in preterm infants treated prophylactically with surfactant in the delivery room. J Pediatr. 1996;128:631-7.
270. Hammerman C, Strates E, Komar K, Bui K. Failure of prophylactic indomethacin to improve the outcome of the very low birth weight infant. Dev Pharmacol Ther. 1987;10:393-404.
271. Mahony CV, Brett C, Heymann M, Clyman R. Prophylactic indomethacin therapy for patent ductus arteriosus in very-low-birthweight infants. N Engl J Med. 1982;306:506-10.
272. Weesner DR, Boyle R, Block S. Prophlactic treatment of asymptomatic patent ductus arteriosus in premature infants with respiratory distress syndrome. South Med J. 1987;80:706-8.
273. Antezana C, Alkayed NJ, Murphy SJ, Anderson LG, Frazier J, Hurn PD, et al. High-dose ibuprofen for reduction of striatal infarcts during middle cerebral artery occlusion in rats. J Neurosurg. 2003;98:860-6.
274. Armstead L, Busija DW, Beasley DG, Mirro R. Adrenergic and prostanoid mechanisms in control of cerebral blood flow in hypotensive newborn pigs. Am J Physiol. 1988;254:H671-7.
275. Armstead L, Busija DW, Mirro R. Vasopressin and prostanoid mechanisms in control of cerebral blood flow in hypotensive newborn pigs. Am J Physiol. 1990;258:H408-13.
276. Armstead L, Busija DW, Leffler CW. Opioids and the prostanoid system in the control of cerebral blood flow in hypotensive piglets. J Cereb Blood Flow Metab. 1992;67:851-4.
277. Chemtob B, Barna T, Varma DR, Aranda JV. Differences in the effects in the newborn piglet of various non-steroidal anti-inflammatory drugs on cerebral blood flow but not on cerebrovascular prostaglandins. Pediatr Res. 1991;30:106-11.
278. Louis Y, Del Toro J, Michael LH, Contant CF, Goddard-Finegold J. Brain blood flor responses to indomethacin during hemorrhagic hypotension in newborn piglets. Biol Neonate. 1994;66:359-66.
279. Miyamoto OT, Kasai H, Hirakawa H, Hayashida Y, Konishi R, Itano T. Supression of hyperemia and DNA oxidation by indomethacin in cerebral ischemia. Eur J Pharmacol. 2003;459:179-86.
280. Vanhaesebrouck S, Zonnenberg I, Vandervoort P, Bruneel E, Van Hoestenberghe MR, Theyskens C. Conservative treatment for patent ductus arteriosus in the preterm. Arch Dis Child Fetal Neonatal Ed. 2007;92:F244-7.
281. Evans N. Echocardiography on neonatal intensive care units in Australia and New Zealand. J Paediatr Child Health. 2000;36:169-71.
282. Katumba-Lunyenya JL. Neonatal/infant echocardiography by the non-cardiologist: A personal practice, past, present, and future. Arch Dis Child Fetal Neonatal Ed. 2002;86:F55-7.
283. Randolph GR, Hagler DJ, Khandheria BK, Lunn ER, Cook WJ, Seward JB, et al. Remote telemedical interpretation of neonatal echocardiograms: Impact on clinical management in a primary care setting. J Am Coll Cardiol. 1999;34:241-5.
284. Skinner JR. Echocardiography on the neonatal unit: A job for the neonatologist or the cardiologist? Arch Dis Child. 1998;78:401-2.
285. Fowlie P. Managing the baby with a patent ductus arteriosus. More questions than answers? Arch Dis Child Fetal Neonatal Ed. 2005;90:F190.
286. Cassady CD, Kirklin JW. A randomized, controlled trial of very early prophylactic ligation of the ductus arteriosus in babies who weighed 1000 g or less at birth. N Engl J Med. 1989;320:1511-6.
287. Patel J, Roberts I, Azzopardi D, Hamilton P, Edwards AD. Randomized double-blind controlled trial comparing the effects of ibuprofen with indomethacin on cerebral hemodynamics in preterm infants with patent ductus arteriosus. Pediatr Res. 2000;47:36-42.
288. Moin F, Kennedy KA, Moya FR. Risk factors predicting vasopressor use after patent ductus arteriosus ligation. Am J Perinatol. 2003;20:313-20.
289. Zbar RI, Chen AH, Behrendt DM, Bell EF, Smith RJ. Incidence of vocal fold paralysis in infants undergoing ligation of patent ductus arteriosus. Ann Thorac Surg. 1996;61:814-6.
290. Su BH, Lin HC, Chiu HY, Hsieh HY, Chen HH, Tsai YC. Comparison of ibuprofen and indometacin for early-targeted treatment of patent ductus arteriosus in extremely premature infants: A randomised controlled trial. Arch Dis Child Fetal Neonatal Ed. 2008;93:F94-9.