SiRNA knockdown of ADAM-10, but not ADAM-17, significantly reduces fractalkine shedding following pro-inflammatory cytokine treatment in a human adult brain endothelial cell line

Neuroscience Letters

Volumn 521, Issue 1, 2012, Pages 52-56

  Hurst, Louise A ^a   Bunning, Rowena A D ^a   Sharrack, Basil ^b   Woodroofe, M Nicola ^a  

^a SHEFFIELD HALLAM UNIVERSITY   (United Kingdom)

^b ROYAL HALLAMSHIRE HOSPITAL   (United Kingdom)

Author keywords

ADAM 10; ADAM 17; Endothelial cells; Fractalkine; HCMEC D3; SiRNA

Indexed keywords

ADAM10 ENDOPEPTIDASE; FRACTALKINE; MESSENGER RNA; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME;

ARTICLE; BRAIN CELL; CELL MEMBRANE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE SILENCING; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADAM PROTEINS; ADULT; AMYLOID PRECURSOR PROTEIN SECRETASES; BRAIN; CELL LINE; CHEMOKINE CX3CL1; ENDOTHELIAL CELLS; GENE KNOCKDOWN TECHNIQUES; GENE SILENCING; HUMANS; INFLAMMATION; MEMBRANE PROTEINS; RNA, SMALL INTERFERING; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84862602961     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2012.05.057     Document Type: Article

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