A functional tonB gene is required for both virulence and competitive fitness in a chinchilla model of Haemophilus influenzae otitis media

BMC Research Notes

Volumn 5, Issue , 2012, Pages

  Morton, Daniel J ^a   Hempel, Randy J ^a   Seale, Thomas W ^a   Whitby, Paul W ^a   Stull, Terrence L ^a  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA (MICROORGANISMS); HAEMOPHILUS INFLUENZAE;

BACTERIAL PROTEIN; HEME; MEMBRANE PROTEIN; TONB PROTEIN, HAEMOPHILUS INFLUENZAE;

ANIMAL; ARTICLE; BACTERIAL GENE; CHINCHILLA; DISEASE MODEL; DRUG EFFECT; GENETICS; GROWTH, DEVELOPMENT AND AGING; HAEMOPHILUS INFECTION; HAEMOPHILUS INFLUENZAE; MICROBIOLOGY; MUTATION; OTITIS MEDIA; PATHOGENICITY; PATHOLOGY; REPRODUCTIVE FITNESS; SECRETORY OTITIS MEDIA; VIRULENCE;

ANIMALS; BACTERIAL PROTEINS; CHINCHILLA; DISEASE MODELS, ANIMAL; GENES, BACTERIAL; GENETIC FITNESS; HAEMOPHILUS INFECTIONS; HAEMOPHILUS INFLUENZAE; HEME; MEMBRANE PROTEINS; MUTATION; OTITIS MEDIA; OTITIS MEDIA WITH EFFUSION; VIRULENCE;

EID: 84862593886     PISSN: None     EISSN: 17560500     Source Type: Journal    
DOI: 10.1186/1756-0500-5-327     Document Type: Article

References (32)

1. The pathogenicity ofHaemophilus influenzae. Turk DC, J Med Microbiol 1984 18 1 16 10.1099/00222615-18-1-1 6146721
2. NontypeableHaemophilus influenzaeas a pathogen in children. Murphy TF, Faden H, Bakaletz LO, Kyd JM, Forsgren A, Campos J, Virji M, Pelton SI, Pediatr Infect Dis J 2009 28 43 48 10.1097/INF.0b013e318184dba2 19057458
3. A whole genome view of prokaryotic haem biosynthesis. Panek H, O'Brian MR, Microbiology 2002 148 2273 2282 12177321
4. Hemin biosynthesis inHaemophilus. White DC, Granick S, J Bacteriol 1963 85 842 850 14044953
5. Haemophilus. Morton DJ, Stull TL, Iron Transport in Bacteria American Society for Microbiology, Washington, DC, Crosa JH, Mey AR, Payne SM, 2004 273 292
6. Effect of multiple mutations in the hemoglobin- and hemoglobin- haptoglobin-binding proteins, HgpA, HgpB, and HgpC ofHaemophilus influenzaetype b. Morton DJ, Whitby PW, Jin H, Ren Z, Stull TL, Infect Immun 1999 67 2729 2739 10338475
7. Identification of a haem-utilization protein (Hup) inHaemophilus influenzae. Morton DJ, Smith A, Ren Z, Madore LL, VanWagoner TM, Seale TW, Whitby PW, Stull TL, Microbiology 2004 150 3923 3933 10.1099/mic.0.27238-0 15583146 (Pubitemid 40045323)
8. The haem-haemopexin utilization gene cluster (hxuCBA) as a virulence factor ofHaemophilus influenzae. Morton DJ, Seale TW, Madore LL, VanWagoner TM, Whitby PW, Stull TL, Microbiology 2007 153 215 224 10.1099/mic.0.2006/000190-0 17185550 (Pubitemid 46111836)
9. Siderophore-independent acquisition of transferrin-bound iron byHaemophilus influenzaetype b. Morton DJ, Williams P, J Gen Microbiol 1990 136 927 933 10.1099/00221287-136-5-927 2143216 (Pubitemid 20165337)
10. New substrates for TonB-dependent transport: do we only see the 'tip of the iceberg'? Schauer K, Rodionov DA, de RH, Trends Biochem Sci 2008 33 330 338 10.1016/j.tibs.2008.04.012 18539464
11. Molecular basis of bacterial outer membrane permeability revisited. Nikaido H, Microbiol Mol Biol Rev 2003 67 593 656 10.1128/MMBR.67.4.593-656.2003 14665678 (Pubitemid 37549772)
12. Reduced severity of middle ear infection caused by nontypeableHaemophilus influenzaelacking the hemoglobin/hemoglobin-haptoglobin binding proteins (Hgp) in a chinchilla model of otitis media. Morton DJ, Bakaletz LO, Jurcisek JA, VanWagoner TM, Seale TW, Whitby PW, Stull TL, Microb Pathog 2004 36 25 33 10.1016/j.micpath.2003.08.007 14643637 (Pubitemid 37476187)
13. Complex role of hemoglobin and hemoglobin-haptoglobin binding proteins inHaemophilus influenzaevirulence in the infant rat model of invasive infection. Seale TW, Morton DJ, Whitby PW, Wolf R, Kosanke SD, VanWagoner TM, Stull TL, Infect Immun 2006 74 6213 6225 10.1128/IAI.00744-06 16966415 (Pubitemid 44657401)
14. Lipoproteine(P4) ofHaemophilus influenzae: Role in heme utilization and pathogenesis. Morton DJ, Smith A, VanWagoner TM, Seale TW, Whitby PW, Stull TL, Microbes Infect 2007 9 932 939 10.1016/j.micinf.2007.03.013 17548224 (Pubitemid 46921015)
15. The heme-binding protein (HbpA) ofHaemophilus influenzaeas a virulence determinant. Morton DJ, Seale TW, Bakaletz LO, Jurcisek JA, Smith A, VanWagoner TM, Whitby PW, Stull TL, Int J Med Microbiol 2009 299 479 488 10.1016/j.ijmm.2009.03.004 19451029
16. Characterization of theHaemophilus influenzae tehBgene and its role in virulence. Whitby PW, Seale TW, Morton DJ, VanWagoner TM, Stull TL, Microbiology 2010 156 1188 1200 10.1099/mic.0.036400-0 20075041
17. A functionaltonBgene is required for both utilization of heme and virulence expression byHaemophilus influenzaetype b. Jarosik GP, Sanders JD, Cope LD, Muller-Eberhard U, Hansen EJ, Infect Immun 1994 62 2470 2477 8188372 (Pubitemid 24157078)
18. Utilization of transferrin-bound iron byHaemophilus influenzaerequires an intacttonBgene. Jarosik GP, Maciver I, Hansen EJ, Infect Immun 1995 63 710 713 7822047
19. Protection against development of otitis media induced by nontypeableHaemophilus influenzaeby both active and passive immunization in a chinchilla model of virus-bacterium superinfection. Bakaletz LO, Kennedy B-J, Novotnoy LA, Duquesne G, Cohen J, Lobet Y, Infect Immun 1999 67 2746 2762 10338477 (Pubitemid 29244686)
20. Passive transfer of antiserum specific for immunogens derived from a nontypeableHaemophilus influenzaeadhesin and lipoprotein D prevents otitis media after heterologous challenge. Kennedy BJ, Novotnoy LA, Jurcisek JA, Lobet Y, Bakaletz LO, Infect Immun 2000 68 2756 2765 10.1128/IAI.68.5.2756-2765.2000 10768970 (Pubitemid 30253853)
21. Synergistic effect of adenovirus type 1 and nontypeableHaemophilus influenzaein a chinchilla model of experimental otitis media. Suzuki K, Bakaletz LO, Infect Immun 1994 62 1710 1718 8168932 (Pubitemid 24136968)
22. General methods for culturingHaemophilus influenzae. Poje G, Redfield RJ, Methods Mol Med 2003 71 51 56 12374030
23. Genomic sequence of an otitis media isolate of nontypeableHaemophilus influenzae: comparative study withH. influenzaeserotype d, strain KW20. Harrison A, Dyer DW, Gillaspy A, Ray WC, Mungur R, Carson MB, Zhong H, Gipson J, Gipson M, Johnson LS, Lewis L, Bakaletz LO, Munson RS, J Bacteriol 2005 187 4627 4636 10.1128/JB.187.13.4627-4636.2005 15968074 (Pubitemid 40880975)
24. The heme-binding lipoprotein (HbpA) ofHaemophilus influenzae: role in heme utilization. Morton DJ, Madore LL, Smith A, VanWagoner TM, Seale TW, Whitby PW, Stull TL, FEMS Microbiol Lett 2005 253 193 199 10.1016/j.femsle.2005.09.016 16289530 (Pubitemid 41674515)
25. Differential utilization byHaemophilus influenzaeof hemoglobin complexed to the three human haptoglobin phenotypes. Morton DJ, VanWagoner TM, Seale TW, Whitby PW, Stull TL, FEMS Immunol Med Microbiol 2006 46 426 432 10.1111/j.1574-695X.2006.00052.x 16553817
26. Chinchilla and murine models of upper respiratory tract infections with respiratory syncytial virus. Gitiban N, Jurcisek JA, Harris RH, Mertz SE, Durbin RK, Bakaletz LO, Durbin JE, J Virol 2005 79 6035 6042 10.1128/JVI.79.10.6035- 6042.2005 15857989 (Pubitemid 40617209)
27. Simplified agar plate method for quantifying viable bacteria. Jett BD, Hatter KL, Huycke MM, Gilmore MS, Biotechniques 1997 23 648 650 9343684 (Pubitemid 27450920)
28. Relative immunogenicity and efficacy of two synthetic chimeric peptides of fimbrin as vaccinogens against nasopharyngeal colonization by nontypeableHaemophilus influenzaein the chinchilla. Bakaletz LO, Leake ER, Billy JM, Kaumaya PTP, Vaccine 1997 15 955 961 10.1016/S0264-410X(96)00298-8 9261941 (Pubitemid 27308570)
29. Use of the riboflavin synthase gene (ribC) as a model for development of an essential gene disruption and complementation system forHaemophilus influenzae. Saeed-Kothe A, Yang W, Mills SD, Appl Environ Microbiol 2004 70 4136 4143 10.1128/AEM.70.7.4136-4143.2004 15240293 (Pubitemid 38969758)
30. A gene cluster involved in the utilization of both free heme and heme:hemopexin byHaemophilus influenzaetype b. Cope LD, Yogev R, Muller-Eberhard U, Hansen EJ, J Bacteriol 1995 177 2644 2653 7751272
31. Phosphorylcholine decreases early inflammation and promotes the establishment of stable biofilm communities of nontypeableHaemophilus influenzaestrain 86-028NP in a chinchilla model of otitis media. Hong W, Mason K, Jurcisek J, Novotny L, Bakaletz LO, Swords WE, Infect Immun 2007 75 958 965 10.1128/IAI.01691-06 17130253 (Pubitemid 46203461)
32. Survival of bacterial biofilms within neutrophil extracellular traps promotes nontypeableHaemophilus influenzaepersistence in the chinchilla model for otitis media. Hong W, Juneau RA, Pang B, Swords WE, J Innate Immun 2009 1 215 224 10.1159/000205937 20375579