Effect of multiple mutations in the hemoglobin- and hemoglobin- haptoglobin-binding proteins, HgpA, HgpB, and HgpC, of Haemophilus influenzae type b

Infection and Immunity

Volumn 67, Issue 6, 1999, Pages 2729-2739

  Morton, Daniel J ^a   Whitby, Paul W ^a   Jin, Hongfan ^a   Ren, Zhen ^a   Stull, Terrence L ^a,b  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b CHO 2308 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HAPTOGLOBIN; HEME; HEMOGLOBIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BACTERIAL GROWTH; BACTERIUM MUTANT; BINDING AFFINITY; GENE MUTATION; HAEMOPHILUS INFLUENZAE; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEQUENCE HOMOLOGY; STRAIN DIFFERENCE;

EID: 0033056281     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.67.6.2729-2739.1999     Document Type: Article

References (25)

1. Bezkorovainy, A. 1987. Iron proteins, p. 27-68. In J. J. Bullen and E. Griffiths (ed.), Iron and infection: molecular, physiological and clinical aspects. John Wiley & Sons, Inc., New York, N.Y.
2. Chen, C. J., C. Elkins, and P. F. Sparling. 1998. Phase variation of hemoglobin utilization in Neisseria gonorrhoeae. Infect. Immun. 66:987-993.
3. Evans, N. M., D. D. Smith, and A. J. Wicken. 1974. Haemin and nicotin-amide adenine dinucleotide requirements of Haemophilus influenzae and Haemophilus parainfluenzae. J. Med. Microbiol. 7:359-365.
4. Fleischmann, R. D., M. D. Adams, O. White, R. A. Clayton, E. F. Kirkness, A. R. Kerlavage, C. J. Bult, J. Tomb, B. A. Dougherty, J. M. Merrick, K. McKenney, G. Sutton, W. FitzHugh, C. Fields, J. D. Gocayne, J. Scott, R. Shirley, L. Liu, A. Glodek, J. M. Kelley, J. F. Weidman, C. A. Phillips, T. Spriggs, E. Hedblom, M. D. Cotton, R. C. Utterback, M. C. Hanna, D. T. Nguyen, D. M. Saudek, R. C. Brandon, L. D. Fine, J. L. Fritchman, J. L. Fuhrmann, N. S. M. Geoghagen, C. L. Gnehm, L. A. McDonald, K. V. Small, C. M. Fraser, H. O. Smith, and J. C. Venter. 1995. Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science 269:496-512.
5. Frangipane, M. E., D. J. Morton, J. A. Wooten, J. M. Pozsgay, and T. L. Stull. 1994. Binding of human hemoglobin by Haemophilus influenzae. FEMS Microbiol. Lett. 118:243-248.
6. High, N. J., M. P. Jennings, and E. R. Moxon. 1996. Tandem repeats of the tetramer 5′-CAAT-3′ present in lic2A are required for phase variation but not lipopolysaccharide biosynthesis in Haemophilus influenzae. Mol. Microbiol. 20:165-174.
7. Hood, D. W., M. E. Deadman, M. P. Jennings, M. Bisercic, R. D. Fleischmann, J. C. Venter, and E. R. Moxon. 1996. DNA repeals identify novel virulence genes in Haemophilus influenzae. Proc. Natl. Acad. Sci. USA 93: 11121-11125.
8. Jin, H., Z. Ren, J. M. Pozsgay, C. Elkins, P. W. Whitby, D. J. Morton, and T. L. Stull. 1996. Cloning of a DNA fragment encoding a heme-repressible hemoglobin-binding outer membrane protein from Haemophilus influenzae. Infect. Immun. 64:3134-3141.
9. Jin, H., Z. Ren, P. W. Whitby, D. J. Morton, and T. L. Stull. 1999. Characterization of hgpA, a gene encoding a haemoglobin/haemoglobin-haptoglobin binding protein of Haemophilus influenzae. Microbiology 145:905-914.
10. Klein, J. O. 1997. Role of nontypeable Haemophilia influenzae in pediatric respiratory tract infections. Pediatr. Infect. Dis. J. 16:S5-S8.
11. Lee, B. C. 1995. Quelling the red menace: haem capture by bacteria. Mol. Microbiol. 18:383-390.
12. Lundrigan, M. D., and R. J. Kadner. 1986. Nucleotide sequence of the gene for the ferrienterochelin receptor FepA in Escherichia coli. Homology among outer membrane receptors that interact with TonB. J. Biol. Chem. 261:10797-10801.
13. Maciver, I., J. L. Latimer, H. H. Liem, U. Muller-Eberhard, Z. Hrkal, and E. J. Hansen. 1996. Identification of an outer membrane protein involved in utilization of hemoglobin-haptoglobin complexes by nontypeable Haemophilus influenzae. Infect. Immun. 64:3703-3712.
14. Moeck, G. S., and J. W. Coulton. 1998. TonB-dependent iron acquisition: mechanisms of siderophore-mediated active transport. Mol. Microbiol. 28: 675-681.
15. Morton, D. J., and T. L. Stull. 1997. Haemophilus influenzae: species distribution of a family of genes containing CCAA nucleotide repeating units, abstr. B-224, p. 67. In Abstracts of the 97th General Meeting of the American Society for Microbiology 1997. American Society for Microbiology, Washington, D.C.
16. Morton, D. J., and P. Williams. 1990. Siderophore-independent acquisition of transferrin-bound iron by Haemophilus influenzae type b. J. Gen. Microbiol. 136:927-933.
17. Musser, J. M., S. J. Barenkamp, D. M. Granoff, and R. K. Selander. 1986. Genetic relationships of serologically nontypable and serotype b strains of Haemophilus influenzae. Infect. Immun. 52:183-191.
18. Ren, Z., H. Jin, D. J. Morton, and T. L. Stull. 1998. hgpB, a gene encoding a second Haemophilus influenzae hemoglobin- and hemoglobin-haptoglobin-binding protein. Infect. Immun. 66:4733-4741.
19. Sambrook, T., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
20. Sharetzsky, C., T. D. Edlind, J. J. LiPuma, and T. L. Stull. 1991. A novel approach to insertional mutagenesis of Haemophilus influenzae. J. Bacteriol. 173:1561-1564.
21. Spenser, H. T., and R. M. Herriott. 1965. Development of competence in Haemophilus influenzae. J. Bacteriol. 90:911-920.
22. Stull, T. L. 1987. Protein sources of heme for Haemophilus influenzae. Infect. Immun. 55:148-153.
23. Tartof, K. D., and C. A. Hobbs. 1988. New cloning vectors and techniques for easy and rapid restriction mapping. Gene 67:169-182.
24. Turk, D. C. 1984. The pathogenicity of Haemophilus influenzae. J. Med. Microbiol. 18:1-16.
25. Whitby, P. W., D. J. Morton, and T. L. Stull. 1998. Construction of antibiotic resistance cassettes with multiple paired restriction sites for insertional mutagenesis of Haemophilus influenzae. FEMS Microbiol. Lett. 158:57-60.