Using electron induced dissociation (EID) on an LC time-scale to characterize a mixture of analogous small organic molecules

Journal of the American Society for Mass Spectrometry

Volumn 23, Issue 5, 2012, Pages 850-857

  Prakash, Aruna S ^a   Smith, Michael J P ^a   Kaabia, Zied ^a   Hurst, Glenn ^a   Yan, Ci ^a   Sims, Martin ^b   Bristow, Anthony W T ^b   Stokes, Peter ^a   Parker, David ^a   Mosely, Jackie A ^a  

^a DURHAM UNIVERSITY   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

LC MS MS for low abundant compounds; Structural characterization of pharmaceuticals; Tandem mass spectrometry by electron induced dissociation

Indexed keywords

ANALYTICAL PROBLEMS; COLLISION INDUCED DISSOCIATION; CONCENTRATION RANGES; DUTY CYCLES; ELECTRON INDUCED DISSOCIATIONS; ESI-FTICR; ION CURRENTS; LC-MS/MS; LOW LEVEL; PEAK INTENSITY; PROTONATED MOLECULES; PYRROLIDINE RINGS; SMALL ORGANIC MOLECULES; STRUCTURAL CHARACTERIZATION; SYNTHETIC COMPOUNDS; TANDEM MASS SPECTROMETRY; TARGET MOLECULE; TIME-SCALES; TRACE IMPURITIES; TRADITIONAL METHODOLOGIES;

CHROMATOGRAPHY; DISSOCIATION; MASS SPECTROMETRY; MOLECULES;

IONS;

CEDIRANIB;

ACCURACY; ARTICLE; CONCENTRATION (PARAMETERS); DISSOCIATION; DRUG IDENTIFICATION; DRUG STRUCTURE; ELECTRON INDUCED DISSOCIATION; ELECTROSPRAY MASS SPECTROMETRY; FLOW RATE; FRAGMENTATION REACTION; ION CURRENT; LIQUID CHROMATOGRAPHY; TANDEM MASS SPECTROMETRY;

CHEMISTRY, ORGANIC; CHROMATOGRAPHY, LIQUID; MODELS, CHEMICAL; PHARMACEUTICAL PREPARATIONS; SIGNAL-TO-NOISE RATIO; TANDEM MASS SPECTROMETRY;

EID: 84862580818     PISSN: 10440305     EISSN: 18791123     Source Type: Journal    
DOI: 10.1007/s13361-012-0338-6     Document Type: Article

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