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Volumn 16, Issue 3, 2012, Pages

Clinical review: Clinical imaging of the sublingual microcirculation in the critically ill - where do we stand?

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ACTIVATED PROTEIN C; ADRENALIN; DOBUTAMINE; DOPAMINE; DOPEXAMINE; GLYCERYL TRINITRATE; HETASTARCH; NORADRENALIN; RINGER LACTATE SOLUTION; VASOCONSTRICTOR AGENT;

EID: 84862564353     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc11236     Document Type: Review
Times cited : (88)

References (58)
  • 2
    • 4444233598 scopus 로고    scopus 로고
    • Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock
    • 10.1097/01.CCM.0000138558.16257.3F, 15343008
    • Sakr Y, Dubois MJ, De Backer D, Creteur J, Vincent JL. Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock. Crit Care Med 2004, 32:1825-1831. 10.1097/01.CCM.0000138558.16257.3F, 15343008.
    • (2004) Crit Care Med , vol.32 , pp. 1825-1831
    • Sakr, Y.1    Dubois, M.J.2    De Backer, D.3    Creteur, J.4    Vincent, J.L.5
  • 3
    • 62749206780 scopus 로고    scopus 로고
    • Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis
    • 10.1007/s00134-008-1193-6, 2821162, 18594793, Microcirculatory Alterations in Resuscitation and Shock (MARS) investigators
    • Trzeciak S, McCoy JV, Phillip Dellinger R, Arnold RC, Rizzuto M, Abate NL, Shapiro NI, Parrillo JE, Hollenberg SM, . Microcirculatory Alterations in Resuscitation and Shock (MARS) investigators Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis. Intensive Care Med 2008, 34:2210-2217. 10.1007/s00134-008-1193-6, 2821162, 18594793, Microcirculatory Alterations in Resuscitation and Shock (MARS) investigators.
    • (2008) Intensive Care Med , vol.34 , pp. 2210-2217
    • Trzeciak, S.1    McCoy, J.V.2    Phillip Dellinger, R.3    Arnold, R.C.4    Rizzuto, M.5    Abate, N.L.6    Shapiro, N.I.7    Parrillo, J.E.8    Hollenberg, S.M.9
  • 4
    • 0035829842 scopus 로고    scopus 로고
    • Early goal-directed therapy in the treatment of severe sepsis and septic shock
    • 10.1056/NEJMoa010307, 11794169, Early Goal-Directed Therapy Collaborative Group
    • Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M, . Early Goal-Directed Therapy Collaborative Group Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001, 345:1368-1377. 10.1056/NEJMoa010307, 11794169, Early Goal-Directed Therapy Collaborative Group.
    • (2001) N Engl J Med , vol.345 , pp. 1368-1377
    • Rivers, E.1    Nguyen, B.2    Havstad, S.3    Ressler, J.4    Muzzin, A.5    Knoblich, B.6    Peterson, E.7    Tomlanovich, M.8
  • 5
    • 33751228986 scopus 로고    scopus 로고
    • A modified goal-directed protocol improves clinical outcomes in intensive care unit patients with septic shock: a randomized controlled trial
    • 10.1097/01.shk.0000232271.09440.8f, 17117128
    • Lin SM, Huang CD, Lin HC, Liu CY, Wang CH, Kuo HP. A modified goal-directed protocol improves clinical outcomes in intensive care unit patients with septic shock: a randomized controlled trial. Shock 2006, 26:551-557. 10.1097/01.shk.0000232271.09440.8f, 17117128.
    • (2006) Shock , vol.26 , pp. 551-557
    • Lin, S.M.1    Huang, C.D.2    Lin, H.C.3    Liu, C.Y.4    Wang, C.H.5    Kuo, H.P.6
  • 7
    • 27144553471 scopus 로고    scopus 로고
    • The microcirculation is the motor of sepsis
    • 10.1186/cc3753, 3226164, 16168069
    • Ince C. The microcirculation is the motor of sepsis. Crit Care 2005, 9(Suppl 4):S13-19. 10.1186/cc3753, 3226164, 16168069.
    • (2005) Crit Care , vol.9 , Issue.SUPPL. 4
    • Ince, C.1
  • 8
    • 27144452656 scopus 로고    scopus 로고
    • Microvascular resuscitation as a therapeutic goal in severe sepsis
    • 10.1186/cc3756, 3226165, 16168071
    • Bateman RM, Walley KR. Microvascular resuscitation as a therapeutic goal in severe sepsis. Crit Care 2005, 9(Suppl 4):S27-S32. 10.1186/cc3756, 3226165, 16168071.
    • (2005) Crit Care , vol.9 , Issue.SUPPL. 4
    • Bateman, R.M.1    Walley, K.R.2
  • 9
    • 44049093984 scopus 로고    scopus 로고
    • Resuscitating the microcirculation in sepsis: the central role of nitric oxide, emerging concepts for novel therapies, and challenges for clinical trials
    • 10.1111/j.1553-2712.2008.00109.x, 2727641, 18439194, Microcirculatory Alterations in Resuscitation and Shock (MARS) Investigators
    • Trzeciak S, Cinel I, Phillip Dellinger R, Shapiro NI, Arnold RC, Parrillo JE, Hollenberg SM, . Microcirculatory Alterations in Resuscitation and Shock (MARS) Investigators Resuscitating the microcirculation in sepsis: the central role of nitric oxide, emerging concepts for novel therapies, and challenges for clinical trials. Acad Emerg Med 2008, 15:399-413. 10.1111/j.1553-2712.2008.00109.x, 2727641, 18439194, Microcirculatory Alterations in Resuscitation and Shock (MARS) Investigators.
    • (2008) Acad Emerg Med , vol.15 , pp. 399-413
    • Trzeciak, S.1    Cinel, I.2    Phillip Dellinger, R.3    Shapiro, N.I.4    Arnold, R.C.5    Parrillo, J.E.6    Hollenberg, S.M.7
  • 10
    • 71449124779 scopus 로고    scopus 로고
    • The microcirculation as a diagnostic and therapeutic target in sepsis
    • 10.1007/s11739-009-0297-5, 19707845
    • Nencioni A, Trzeciak S, Shapiro NI. The microcirculation as a diagnostic and therapeutic target in sepsis. Intern Emerg Med 2009, 4:413-418. 10.1007/s11739-009-0297-5, 19707845.
    • (2009) Intern Emerg Med , vol.4 , pp. 413-418
    • Nencioni, A.1    Trzeciak, S.2    Shapiro, N.I.3
  • 11
    • 79955629732 scopus 로고    scopus 로고
    • Targeting the microcirculation in resuscitation of acutely unwell patients
    • 10.1097/MCC.0b013e3283466ba0, 21499095
    • Harrois A, Dupic L, Duranteau J. Targeting the microcirculation in resuscitation of acutely unwell patients. Curr Opin Crit Care 2011, 17:303-307. 10.1097/MCC.0b013e3283466ba0, 21499095.
    • (2011) Curr Opin Crit Care , vol.17 , pp. 303-307
    • Harrois, A.1    Dupic, L.2    Duranteau, J.3
  • 14
    • 80655122714 scopus 로고
    • A study of the pulmonary circulation by the transillumination method
    • Hall HL. A study of the pulmonary circulation by the transillumination method. Am J Physiol 1925, 72:446.
    • (1925) Am J Physiol , vol.72 , pp. 446
    • Hall, H.L.1
  • 15
    • 9244235235 scopus 로고
    • Microscopical observations of the pulmonary arterioles, capillaries, and venules of living guinea pigs and rabbits
    • 10.1002/ar.1091190309, 13197798
    • Irwin JW, Burrage WS, Aimar CE, Chesnut RW. Microscopical observations of the pulmonary arterioles, capillaries, and venules of living guinea pigs and rabbits. Anat Rec 1954, 119:391-407. 10.1002/ar.1091190309, 13197798.
    • (1954) Anat Rec , vol.119 , pp. 391-407
    • Irwin, J.W.1    Burrage, W.S.2    Aimar, C.E.3    Chesnut, R.W.4
  • 16
    • 84862542085 scopus 로고
    • Observations on the pulmonary alveolus and its capillary circulation in the living rabbit
    • Krahl VE. Observations on the pulmonary alveolus and its capillary circulation in the living rabbit. Anat Rec 1962, 142:350.
    • (1962) Anat Rec , vol.142 , pp. 350
    • Krahl, V.E.1
  • 17
    • 72049107146 scopus 로고
    • In vivo microscopy of the rabbit's lung
    • Krahl VE. In vivo microscopy of the rabbit's lung. Bibl Anat Fasc 1964, 4:400.
    • (1964) Bibl Anat Fasc , vol.4 , pp. 400
    • Krahl, V.E.1
  • 18
    • 0015061110 scopus 로고
    • Incident dark-field illumination: a new method for microcirculatory study
    • 10.1177/000331977102200507, 5089888
    • Sherman H, Klausner S, Cook WA. Incident dark-field illumination: a new method for microcirculatory study. Angiology 1971, 22:295-303. 10.1177/000331977102200507, 5089888.
    • (1971) Angiology , vol.22 , pp. 295-303
    • Sherman, H.1    Klausner, S.2    Cook, W.A.3
  • 19
    • 0004810613 scopus 로고
    • Clinical observations on the capillary circulation
    • Freedlander SO, Lenhart CH. Clinical observations on the capillary circulation. Arch Intern Med 1922, 29:12-32.
    • (1922) Arch Intern Med , vol.29 , pp. 12-32
    • Freedlander, S.O.1    Lenhart, C.H.2
  • 21
    • 0032828956 scopus 로고    scopus 로고
    • Orthogonal polarization spectral imaging: a new method for study of the microcirculation
    • 10.1038/13529, 10502828
    • Groner W, Winkelman JW, Harris AG, Ince C, Bouma GJ, Messmer K, Nadeau RG. Orthogonal polarization spectral imaging: a new method for study of the microcirculation. Nat Med 1999, 5:1209-1212. 10.1038/13529, 10502828.
    • (1999) Nat Med , vol.5 , pp. 1209-1212
    • Groner, W.1    Winkelman, J.W.2    Harris, A.G.3    Ince, C.4    Bouma, G.J.5    Messmer, K.6    Nadeau, R.G.7
  • 22
    • 0036375463 scopus 로고    scopus 로고
    • OPS imaging of human microcirculation: a short technical report
    • 10.1159/000065549, 12187127
    • Lindert J, Werner J, Redlin M, Kuppe H, Habazettl H, Pries AR. OPS imaging of human microcirculation: a short technical report. J Vasc Res 2002, 39:368-372. 10.1159/000065549, 12187127.
    • (2002) J Vasc Res , vol.39 , pp. 368-372
    • Lindert, J.1    Werner, J.2    Redlin, M.3    Kuppe, H.4    Habazettl, H.5    Pries, A.R.6
  • 23
    • 34247859196 scopus 로고    scopus 로고
    • Orthogonal polarization spectral imaging
    • Cerný V, Turek Z, Parízková R. Orthogonal polarization spectral imaging. Physiol Res 2007, 56:141-147.
    • (2007) Physiol Res , vol.56 , pp. 141-147
    • Cerný, V.1    Turek, Z.2    Parízková, R.3
  • 24
    • 36248992450 scopus 로고    scopus 로고
    • Sidestream Dark Field (SDF) imaging: a novel stroboscopic LED ring-based imaging modality for clinical assessment of the microcirculation
    • 10.1364/OE.15.015101, 19550794
    • Goedhart PT, Khalilzada M, Bezemer R, Merza J, Ince C. Sidestream Dark Field (SDF) imaging: a novel stroboscopic LED ring-based imaging modality for clinical assessment of the microcirculation. Opt Express 2007, 15:15101-15114. 10.1364/OE.15.015101, 19550794.
    • (2007) Opt Express , vol.15 , pp. 15101-15114
    • Goedhart, P.T.1    Khalilzada, M.2    Bezemer, R.3    Merza, J.4    Ince, C.5
  • 25
    • 0037010370 scopus 로고    scopus 로고
    • Nitroglycerin in septic shock after intravascular volume resuscitation
    • 10.1016/S0140-6736(02)11393-6, 12423989
    • Spronk PE, Ince C, Gardien MJ, Mathura KR, Oudemans-van Straaten HM, Zandstra DF. Nitroglycerin in septic shock after intravascular volume resuscitation. Lancet 2002, 360:1395-1396. 10.1016/S0140-6736(02)11393-6, 12423989.
    • (2002) Lancet , vol.360 , pp. 1395-1396
    • Spronk, P.E.1    Ince, C.2    Gardien, M.J.3    Mathura, K.R.4    Oudemans-van Straaten, H.M.5    Zandstra, D.F.6
  • 26
    • 27144483559 scopus 로고    scopus 로고
    • Microvascular dysfunction as a cause of organ dysfunction in severe sepsis
    • 10.1186/cc3748, 3226162, 16168075
    • Vincent JL, De Backer D. Microvascular dysfunction as a cause of organ dysfunction in severe sepsis. Crit Care 2005, 9(Suppl 4):S9-S12. 10.1186/cc3748, 3226162, 16168075.
    • (2005) Crit Care , vol.9 , Issue.SUPPL. 4
    • Vincent, J.L.1    De Backer, D.2
  • 27
    • 33845872563 scopus 로고    scopus 로고
    • Early microcirculatory perfusion derangements in patients with severe sepsis and septic shock: relationship to hemodynamics, oxygen transport, and survival
    • 10.1016/j.annemergmed.2006.08.021, 17095120, Microcirculatory Alterations in Resuscitation and Shock Investigators
    • Trzeciak S, Dellinger RP, Parrillo JE, Guglielmi M, Bajaj J, Abate NL, Arnold RC, Colilla S, Zanotti S, Hollenberg SM, . Microcirculatory Alterations in Resuscitation and Shock Investigators Early microcirculatory perfusion derangements in patients with severe sepsis and septic shock: relationship to hemodynamics, oxygen transport, and survival. Ann Emerg Med 2007, 49:88-98. 10.1016/j.annemergmed.2006.08.021, 17095120, Microcirculatory Alterations in Resuscitation and Shock Investigators.
    • (2007) Ann Emerg Med , vol.49 , pp. 88-98
    • Trzeciak, S.1    Dellinger, R.P.2    Parrillo, J.E.3    Guglielmi, M.4    Bajaj, J.5    Abate, N.L.6    Arnold, R.C.7    Colilla, S.8    Zanotti, S.9    Hollenberg, S.M.10
  • 28
    • 0347416931 scopus 로고    scopus 로고
    • Microvascular alterations in patients with acute severe heart failure and cardiogenic shock
    • 10.1016/j.ahj.2003.07.006, 14691425
    • De Backer D, Creteur J, Dubois MJ, Sakr Y, Vincent JL. Microvascular alterations in patients with acute severe heart failure and cardiogenic shock. Am Heart J 2004, 147:91-99. 10.1016/j.ahj.2003.07.006, 14691425.
    • (2004) Am Heart J , vol.147 , pp. 91-99
    • De Backer, D.1    Creteur, J.2    Dubois, M.J.3    Sakr, Y.4    Vincent, J.L.5
  • 29
    • 62949220827 scopus 로고    scopus 로고
    • Microvascular flow and tissue oxygenation after major abdominal surgery: association with postoperative complications
    • 10.1007/s00134-008-1325-z, 18936911
    • Jhanji S, Lee C, Watson D, Hinds C, Pearse RM. Microvascular flow and tissue oxygenation after major abdominal surgery: association with postoperative complications. Intensive Care Med 2009, 35:671-677. 10.1007/s00134-008-1325-z, 18936911.
    • (2009) Intensive Care Med , vol.35 , pp. 671-677
    • Jhanji, S.1    Lee, C.2    Watson, D.3    Hinds, C.4    Pearse, R.M.5
  • 30
    • 45749149531 scopus 로고    scopus 로고
    • A positive fluid balance is associated with a worse outcome in patients with acute renal failure
    • 10.1186/cc6916, 2481469, 18533029, Sepsis Occurrence in Acutely Ill Patients (SOAP) Investigators
    • Payen D, de Pont AC, Sakr Y, Spies C, Reinhart K, Vincent JL, . Sepsis Occurrence in Acutely Ill Patients (SOAP) Investigators A positive fluid balance is associated with a worse outcome in patients with acute renal failure. Crit Care 2008, 12:R74. 10.1186/cc6916, 2481469, 18533029, Sepsis Occurrence in Acutely Ill Patients (SOAP) Investigators.
    • (2008) Crit Care , vol.12
    • Payen, D.1    de Pont, A.C.2    Sakr, Y.3    Spies, C.4    Reinhart, K.5    Vincent, J.L.6
  • 31
    • 33644584325 scopus 로고    scopus 로고
    • Does dopamine administration in shock influence outcome? Results of the Sepsis Occurrence in Acutely Ill Patients (SOAP) Study
    • 10.1097/01.CCM.0000201896.45809.E3, 16505643
    • Sakr Y, Reinhart K, Vincent JL, Sprung CL, Moreno R, Ranieri VM, De Backer D, Payen D. Does dopamine administration in shock influence outcome? Results of the Sepsis Occurrence in Acutely Ill Patients (SOAP) Study. Crit Care Med 2006, 34:589-597. 10.1097/01.CCM.0000201896.45809.E3, 16505643.
    • (2006) Crit Care Med , vol.34 , pp. 589-597
    • Sakr, Y.1    Reinhart, K.2    Vincent, J.L.3    Sprung, C.L.4    Moreno, R.5    Ranieri, V.M.6    De Backer, D.7    Payen, D.8
  • 33
    • 37549025798 scopus 로고    scopus 로고
    • Are blood transfusions associated with greater mortality rates? Results of the Sepsis Occurrence in Acutely Ill Patients study
    • 10.1097/01.anes.0000296070.75956.40, 18156879, Sepsis Occurrence in Acutely Ill Patients (SOAP) Investigators
    • Vincent JL, Sakr Y, Sprung C, Harboe S, Damas P, . Sepsis Occurrence in Acutely Ill Patients (SOAP) Investigators Are blood transfusions associated with greater mortality rates? Results of the Sepsis Occurrence in Acutely Ill Patients study. Anesthesiology 2008, 108:31-39. 10.1097/01.anes.0000296070.75956.40, 18156879, Sepsis Occurrence in Acutely Ill Patients (SOAP) Investigators.
    • (2008) Anesthesiology , vol.108 , pp. 31-39
    • Vincent, J.L.1    Sakr, Y.2    Sprung, C.3    Harboe, S.4    Damas, P.5
  • 34
    • 78650417770 scopus 로고    scopus 로고
    • Both passive leg raising and intravascular volume expansion improve sublingual microcirculatory perfusion in severe sepsis and septic shock patients
    • 10.1007/s00134-010-1966-6, 20725823
    • Pottecher J, Deruddre S, Teboul JL, Georger JF, Laplace C, Benhamou D, Vicaut E, Duranteau J. Both passive leg raising and intravascular volume expansion improve sublingual microcirculatory perfusion in severe sepsis and septic shock patients. Intensive Care Med 2010, 36:1867-1874. 10.1007/s00134-010-1966-6, 20725823.
    • (2010) Intensive Care Med , vol.36 , pp. 1867-1874
    • Pottecher, J.1    Deruddre, S.2    Teboul, J.L.3    Georger, J.F.4    Laplace, C.5    Benhamou, D.6    Vicaut, E.7    Duranteau, J.8
  • 36
    • 77955301640 scopus 로고    scopus 로고
    • Haemodynamic optimisation improves tissue microvascular flow and oxygenation after major surgery: a randomised controlled trial
    • 10.1186/cc9220, 2945135, 20698956
    • Jhanji S, Vivian-Smith A, Lucena-Amaro S, Watson D, Hinds CJ, Pearse RM. Haemodynamic optimisation improves tissue microvascular flow and oxygenation after major surgery: a randomised controlled trial. Crit Care 2010, 14:R151. 10.1186/cc9220, 2945135, 20698956.
    • (2010) Crit Care , vol.14
    • Jhanji, S.1    Vivian-Smith, A.2    Lucena-Amaro, S.3    Watson, D.4    Hinds, C.J.5    Pearse, R.M.6
  • 39
    • 79955672176 scopus 로고    scopus 로고
    • Blood transfusions recruit the microcirculation during cardiac surgery
    • 10.1111/j.1537-2995.2010.02971.x, 21133930
    • Yuruk K, Almac E, Bezemer R, Goedhart P, de Mol B, Ince C. Blood transfusions recruit the microcirculation during cardiac surgery. Transfusion 2011, 51:961-967. 10.1111/j.1537-2995.2010.02971.x, 21133930.
    • (2011) Transfusion , vol.51 , pp. 961-967
    • Yuruk, K.1    Almac, E.2    Bezemer, R.3    Goedhart, P.4    de Mol, B.5    Ince, C.6
  • 40
    • 84862536563 scopus 로고    scopus 로고
    • Blood transfusions recruit the microcirculation in on-pump cardiac surgery patients, but not in septic patients
    • Ayhan B, Yuruk K, Bakker J, de Mol BAJM, Ince C. Blood transfusions recruit the microcirculation in on-pump cardiac surgery patients, but not in septic patients. Intensive Care Med 2010, 36(Suppl S208):0489.
    • (2010) Intensive Care Med , vol.36 , Issue.SUPPL. S208 , pp. 0489
    • Ayhan, B.1    Yuruk, K.2    Bakker, J.3    de Mol, B.A.J.M.4    Ince, C.5
  • 41
    • 78649327189 scopus 로고    scopus 로고
    • The role of vasoactive agents in the resuscitation of microvascular perfusion and tissue oxygenation in critically ill patients
    • 10.1007/s00134-010-1970-x, 2981743, 20811874
    • Boerma EC, Ince C. The role of vasoactive agents in the resuscitation of microvascular perfusion and tissue oxygenation in critically ill patients. Intensive Care Med 2010, 36:2004-2018. 10.1007/s00134-010-1970-x, 2981743, 20811874.
    • (2010) Intensive Care Med , vol.36 , pp. 2004-2018
    • Boerma, E.C.1    Ince, C.2
  • 42
    • 66449113461 scopus 로고    scopus 로고
    • The effect of increasing doses of norepinephrine on tissue oxygenation and microvascular flow in patients with septic shock
    • 10.1097/CCM.0b013e3181a00a1c, 19384212
    • Jhanji S, Stirling S, Patel N, Hinds CJ, Pearse RM. The effect of increasing doses of norepinephrine on tissue oxygenation and microvascular flow in patients with septic shock. Crit Care Med 2009, 37:1961-1966. 10.1097/CCM.0b013e3181a00a1c, 19384212.
    • (2009) Crit Care Med , vol.37 , pp. 1961-1966
    • Jhanji, S.1    Stirling, S.2    Patel, N.3    Hinds, C.J.4    Pearse, R.M.5
  • 44
    • 31344453457 scopus 로고    scopus 로고
    • The effects of dobutamine on microcirculatory alterations in patients with septic shock are independent of its systemic effects
    • 10.1097/01.CCM.0000198107.61493.5A, 16424721
    • De Backer D, Creteur J, Dubois MJ, Sakr Y, Koch M, Verdant C, Vincent JL. The effects of dobutamine on microcirculatory alterations in patients with septic shock are independent of its systemic effects. Crit Care Med 2006, 34:403-408. 10.1097/01.CCM.0000198107.61493.5A, 16424721.
    • (2006) Crit Care Med , vol.34 , pp. 403-408
    • De Backer, D.1    Creteur, J.2    Dubois, M.J.3    Sakr, Y.4    Koch, M.5    Verdant, C.6    Vincent, J.L.7
  • 45
    • 74049118733 scopus 로고    scopus 로고
    • Effects of nitroglycerin on sublingual microcirculatory blood flow in patients with severe sepsis/septic shock after a strict resuscitation protocol: a double-blind randomized placebo controlled trial
    • 10.1097/CCM.0b013e3181b02fc1, 19730258
    • Boerma EC, Koopmans M, Konijn A, Kaiferova K, Bakker AJ, van Roon EN, Buter H, Bruins N, Egbers PH, Gerritsen RT, Koetsier PM, Kingma WP, Kuiper MA, Ince C. Effects of nitroglycerin on sublingual microcirculatory blood flow in patients with severe sepsis/septic shock after a strict resuscitation protocol: a double-blind randomized placebo controlled trial. Crit Care Med 2010, 38:93-100. 10.1097/CCM.0b013e3181b02fc1, 19730258.
    • (2010) Crit Care Med , vol.38 , pp. 93-100
    • Boerma, E.C.1    Koopmans, M.2    Konijn, A.3    Kaiferova, K.4    Bakker, A.J.5    van Roon, E.N.6    Buter, H.7    Bruins, N.8    Egbers, P.H.9    Gerritsen, R.T.10    Koetsier, P.M.11    Kingma, W.P.12    Kuiper, M.A.13    Ince, C.14
  • 48
    • 0031057343 scopus 로고    scopus 로고
    • The cytokine-mediated imbalance between coagulant and anticoagulant mechanisms in sepsis and endotoxaemia
    • Levi M, van der Poll T, ten Cate H, van Deventer SJ. The cytokine-mediated imbalance between coagulant and anticoagulant mechanisms in sepsis and endotoxaemia. Eur J Clin Invest 1997, 27:3-9.
    • (1997) Eur J Clin Invest , vol.27 , pp. 3-9
    • Levi, M.1    van der Poll, T.2    ten Cate, H.3    van Deventer, S.J.4
  • 49
    • 2942738936 scopus 로고    scopus 로고
    • Leukocyte and endothelial cell interactions in sepsis: relevance of the protein C pathway
    • Joyce DE, Nelson DR, Grinnell BW. Leukocyte and endothelial cell interactions in sepsis: relevance of the protein C pathway. Crit Care Med 2004, 32(5 Suppl):S280-S286.
    • (2004) Crit Care Med , vol.32 , Issue.5 SUPPL
    • Joyce, D.E.1    Nelson, D.R.2    Grinnell, B.W.3
  • 50
    • 0035826096 scopus 로고    scopus 로고
    • Efficacy and safety of recombinant human activated protein C for severe sepsis
    • 10.1056/NEJM200103083441001, 11236773, Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group
    • Bernard GR, Vincent JL, Laterre PF, LaRosa SP, Dhainaut JF, Lopez-Rodriguez A, Steingrub JS, Garber GE, Helterbrand JD, Ely EW, Fisher CJ, . Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001, 344:699-709. 10.1056/NEJM200103083441001, 11236773, Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group.
    • (2001) N Engl J Med , vol.344 , pp. 699-709
    • Bernard, G.R.1    Vincent, J.L.2    Laterre, P.F.3    LaRosa, S.P.4    Dhainaut, J.F.5    Lopez-Rodriguez, A.6    Steingrub, J.S.7    Garber, G.E.8    Helterbrand, J.D.9    Ely, E.W.10    Fisher, C.J.11
  • 51
    • 77955980902 scopus 로고    scopus 로고
    • Colombari F. Prowess-shock trial: a protocol overview and perspectives
    • 10.1097/SHK.0b013e3181e7e97b, 20523271
    • Silva E, de Figueiredo LF, Colombari F. Colombari F. Prowess-shock trial: a protocol overview and perspectives. Shock 2010, 34(Suppl 1):48-53. 10.1097/SHK.0b013e3181e7e97b, 20523271.
    • (2010) Shock , vol.34 , Issue.SUPPL. 1 , pp. 48-53
    • Silva, E.1    de Figueiredo, L.F.2    Colombari, F.3
  • 52
    • 33745603201 scopus 로고    scopus 로고
    • Effects of drotrecogin alfa activated on microcirculatory alterations in patients with severe sepsis
    • 10.1097/01.CCM.0000220498.48773.3C, 16715034
    • De Backer D, Verdant C, Chierego M, Koch M, Gullo A, Vincent JL. Effects of drotrecogin alfa activated on microcirculatory alterations in patients with severe sepsis. Crit Care Med 2006, 34:1918-1924. 10.1097/01.CCM.0000220498.48773.3C, 16715034.
    • (2006) Crit Care Med , vol.34 , pp. 1918-1924
    • De Backer, D.1    Verdant, C.2    Chierego, M.3    Koch, M.4    Gullo, A.5    Vincent, J.L.6
  • 55
    • 45849113262 scopus 로고    scopus 로고
    • Measurement of functional microcirculatory geometry and velocity distributions using automated image analysis
    • 10.1007/s11517-008-0349-4, 2441502, 18427850
    • Dobbe JG, Streekstra GJ, Atasever B, van Zijderveld R, Ince C. Measurement of functional microcirculatory geometry and velocity distributions using automated image analysis. Med Biol Eng Comput 2008, 46:659-670. 10.1007/s11517-008-0349-4, 2441502, 18427850.
    • (2008) Med Biol Eng Comput , vol.46 , pp. 659-670
    • Dobbe, J.G.1    Streekstra, G.J.2    Atasever, B.3    van Zijderveld, R.4    Ince, C.5


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