Intramuscular ketorolac inhibits activation of rat peripheral NMDA receptors

Journal of Neurophysiology

Volumn 107, Issue 12, 2012, Pages 3308-3315

  Cairns, Brian E ^a   Dong, X D ^a   Wong, Hayes ^a   Svensson, Peter ^b,c  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b AARHUS UNIVERSITY   (Denmark)

^c AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Masseter muscle; N methyl D aspartate receptor; Pain; Trigeminal

Indexed keywords

KETOROLAC; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NAPROXEN; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; SEROTONIN;

ANALGESIC ACTIVITY; ANESTHESIA; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; FEMALE; IN VIVO STUDY; JAW MUSCLE; NOCICEPTIVE RECEPTOR; NOCICEPTIVE STIMULATION; NONHUMAN; PRIORITY JOURNAL; RAT;

ADENOSINE TRIPHOSPHATE; ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DICLOFENAC; DINOPROSTONE; EXCITATORY AMINO ACID AGONISTS; FEMALE; INJECTIONS, INTRAMUSCULAR; KETOROLAC; MALE; NAPROXEN; NOCICEPTORS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; SEROTONIN; TRIGEMINAL NERVE;

EID: 84862551514     PISSN: 00223077     EISSN: 15221598     Source Type: Journal    
DOI: 10.1152/jn.01118.2011     Document Type: Article

References (39)

1. Ambalavanar R, Moritani M, Dessem D. Trigeminal P2X3 receptor expression differs from dorsal root ganglion and is modulated by deep tissue inflammation. Pain 117: 280-291, 2005.
2. Bendixen KH, Baad-Hansen L, Cairns BE, Svensson P. Effects of low-dose intramuscular ketorolac on experimental pain in the masseter muscle of healthy women. J Orofac Pain 24: 398-407, 2010.
3. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254, 1976.
4. Brodin P, Skoglund LA. Effects of salicylates and paracetamol compared to lidocaine on nerve conduction in vitro. Neuropharmacology 26: 1441-1444, 1987.
5. Cairns BE. Pathophysiology of TMD pain-basic mechanisms and their implications for pharmacotherapy. J Oral Rehabil 37: 391-410, 2010.
6. Cairns BE, Dong X, Mann MK, Svensson P, Sessle BJ, Arendt-Nielsen L, McErlane KM. Systemic administration of monosodium glutamate elevates intramuscular glutamate levels and sensitizes rat masseter muscle afferent fibers. Pain 132: 33-41, 2007.
7. Cairns BE, Dong XD. The role of peripheral glutamate and glutamate receptors in muscle pain. J Musculoskelet Pain 16: 85-91, 2008.
8. Cairns BE, Gambarota G, Svensson P, Arendt-Nielsen L, Berde CB. Glutamate-induced sensitization of rat masseter muscle fibers. Neuroscience 109: 389-399, 2002.
9. Cairns BE, Mann MK, Mok E, Dong XD, Svensson P. Diclofenac exerts local anesthetic-like actions on rat masseter muscle afferent fibers. Brain Res 1194: 56-64, 2008.
10. Cairns BE, Svensson P, Wang K, Castrillon E, Hupfeld S, Sessle BJ, Arendt-Nielsen L. Ketamine attenuates glutamate-induced mechanical sensitization of the masseter muscle in human males. Exp Brain Res 169: 467-472, 2006.
11. Cairns BE, Svensson P, Wang K, Hupfeld S, Graven-Nielsen T, Sessle BJ, Berde CB, Arendt-Nielsen L. Activation of peripheral NMDA receptors contributes to human pain and rat afferent discharges evoked by injection of glutamate into the masseter muscle. J Neurophysiol 90: 2098-2105, 2003.
12. Castrillon EE, Cairns BE, Ernberg M, Wang K, Sessle BJ, Arendt-Nielsen L, Svensson P. Glutamate-evoked jaw muscle pain as a model of persistent myofascial TMD pain? Arch Oral Biol 53: 666-676, 2008.
13. Castrillon EE, Ernberg M, Cairns BE, Wang K, Sessle BJ, Arendt-Nielsen L, Svensson P. Interstitial glutamate concentration is elevated in the masseter muscle of myofascial temporomandibular disorder patients. J Orofac Pain 24: 350-360, 2010.
14. Compton P, Charuvastra VC, Ling W. Effect of oral ketorolac and gender on human cold pressor pain tolerance. Clin Exp Pharmacol Physiol 30: 759-763, 2003.
15. Dessem D, Ambalavanar R, Evancho M, Moutanni A, Yallampalli C, Bai G. Eccentric muscle contraction and stretching evoke mechanical hyperalgesia and modulate CGRP and P2X3 expression in a functionally relevant manner. Pain 149: 284-295, 2010.
16. Dong XD, Svensson P, Cairns BE. The analgesic action of topical diclofenac may be mediated through peripheral NMDA receptor antagonism. Pain 147: 36-45, 2009.
17. Dong XD, Mann MK, Kumar U, Svensson P, Arendt-Nielsen L, Hu JW, Sessle BJ, Cairns BE. Sex-related differences in NMDA-evoked rat masseter muscle afferent discharge result from estrogen-mediated modulation of peripheral NMDA receptor activity. Neuroscience 146: 822-832, 2007.
18. Gazerani P, Au S, Dong XD, Kumar U, Arendt-Nielsen L, Cairns BE. Botulinum neurotoxin type A (BoNTA) decreases the mechanical sensitivity of nociceptors and inhibits neurogenic vasodilation in a craniofacial muscle targeted for migraine prophylaxis. Pain 151: 606-616, 2010.
19. Jett MF, Ramesha CS, Brown CD, Chiu S, Emmett C, Voronin T, Sun T, O'Yang C, Hunter JC, Eglen RM, Johnson RM. Characterization of the analgesic and anti-inflammatory activities of ketorolac and its enantiomers in the rat. J Pharmacol Exp Ther 288: 1288-1297, 1999.
20. Kuo CC, Huang RC, Lou BS. Inhibition of Na+ current by diphenhydramine and other diphenyl compounds: molecular determinants of selective binding to the inactivated channels. Mol Pharmacol 57: 135-143, 2000.
21. Lee HM, Kim HI, Shin YK, Lee CS, Park M, Song JH. Diclofenac inhibition of sodium currents in rat dorsal root ganglion neurons. Brain Res 992: 120-127, 2003.
22. LeResche L. Epidemiology of temporomandibular disorders: implications for the investigation of etiologic factors. Crit Rev Oral Biol Med 8: 291-305, 1997.
23. LeResche L, Mancl LA, Drangsholt MT, Huang G, Von Korff M. Predictors of onset of facial pain and temporomandibular disorders in early adolescence. Pain 129: 269-278, 2007.
24. McRoberts JA, Li JE, HS, Mayer EA. Sex-dependent differences in the activity and modulation of N-methyl-D-aspartic acid receptors in rat dorsal root ganglia neurons. Neuroscience 148: 1015-1020, 2007.
25. Mense S. Sensitization of group IV muscle receptors to bradykinin by 5-hydroxytryptamine and prostaglandin E2. Brain Res 225: 95-105, 1981.
26. Miyatake S, Ichiyama H, Kondo E, Yasuda K. Randomized clinical comparisons of diclofenac concentration in the soft tissues and blood plasma between topical and oral applications. Br J Clin Pharmacol 67: 125-129, 2009.
27. Mok E, Mann MK, Dong XD, Cairns BE. Local anaesthetic-like effects of diclofenac on muscle nociceptors. Pain Res Manag 10: 95, 2005.
28. Nilsson IM, Drangsholt M, List T. Impact of temporomandibular disorder pain in adolescents: differences by age and gender. J Orofac Pain 23: 115-122, 2009.
29. Oliveira MC, Parada CA, Veiga MC, Rodrigues LR, Barros SP, Tambeli CH. Evidence for the involvement of endogenous ATP and P2X receptors in TMJ pain. Eur J Pain 9: 87-93, 2005.
30. Petersen B, Rovati S. Diclofenac epolamine (Flector) patch: evidence for topical activity. Clin Drug Investig 29: 1-9, 2009.
31. Riccioppo Neto F. Further studies on the actions of salicylates on nerve membranes. Eur J Pharmacol 68: 155-162, 1980.
32. Sahara Y, Noro N, Iida Y, Soma K, Nakamura Y. Glutamate receptor subunits GluR5 and KA-2 are co-expressed in rat trigeminal ganglion neurons. J Neurosci 17: 6611-6625, 1997.
33. Shinoda M, Ozaki N, Sugiura Y. Involvement of ATP and its receptors on nociception in rat model of masseter muscle pain. Pain 134: 148-157, 2008.
34. Sotgiu ML, Biella G, Formaglio F, Marchettini P. Central effect of ketorolac involving NMDA receptors activity. Brain Res 813: 223-226, 1998.
35. Sung D, Dong X, Ernberg M, Kumar U, Cairns BE. Serotonin (5-HT) excites rat masticatory muscle afferent fibers through activation of peripheral 5-HT3 receptors. Pain 134: 41-50, 2008.
36. Svensson P, Cairns BE, Wang K, Hu JW, Graven-Nielsen T, Arendt-Nielsen L, Sessle BJ. Glutamate-evoked pain and mechanical allodynia in the human masseter muscle. Pain 101: 221-227, 2003.
37. Tashiro A, Okamoto K, Milam SB, Bereiter DA. Differential effects of estradiol on encoding properties of TMJ units in laminae I and V at the spinomedullary junction in female rats. J Neurophysiol 98: 3242-3253, 2007.
38. Teixeira JM, Oliveira MC, Nociti FH Jr, Clemente-Napimoga JT, Pelegrini-da-Silva A, Parada CA, Tambeli CH. Involvement of temporomandibular joint P2X3 and P2X2/3 receptors in carrageenan-induced inflammatory hyperalgesia in rats. Eur J Pharmacol 645: 79-85, 2010.
39. Zacher J, Altman R, Bellamy N, Brühlmann P, Da Silva J, Huskisson E, Taylor RS. Topical diclofenac and its role in pain and inflammation: an evidence-based review. Curr Med Res Opin 24: 925-950, 2008.