Novel polypyridyl chelators deplete cellular zinc and destabilize the X-linked inhibitor of apoptosis protein (XIAP) prior to induction of apoptosis in human prostate and breast cancer cells

Journal of Cellular Biochemistry

Volumn 113, Issue 8, 2012, Pages 2567-2575

  Zuo, Jian ^a,b   Schmitt, Sara M ^a   Zhang, Zhen ^a,b   Prakash, Jai ^a   Fan, Yuhua ^b   Bi, Caifeng ^b   Kodanko, Jeremy J ^a   Dou, Q Ping ^a  

^a WAYNE STATE UNIVERSITY   (United States)

^b OCEAN UNIVERSITY OF CHINA   (China)

Author keywords

Apoptosis; Breast cancer; Polypyridyl chelator; Prostate cancer; XIAP; Zinc

Indexed keywords

ACETYLCYSTEINE; BNTPEN; CASPASE 3; CHELATING AGENT; DPA; IRON; N4PY; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; POLYPYRIDYL CHELATOR DERIVATIVE; REACTIVE OXYGEN METABOLITE; TPA; TPEN; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS; ZINC;

APOPTOSIS; ARTICLE; BINDING AFFINITY; BREAST CANCER; CANCER CELL; CELL DEATH; CELL STRUCTURE; CELL VIABILITY; CHEMICAL STRUCTURE; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION;

APOPTOSIS; BREAST NEOPLASMS; CELL LINE, TUMOR; CHELATING AGENTS; FEMALE; HUMANS; MALE; PROSTATIC NEOPLASMS; PROTEIN STABILITY; PYRIDINES; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN; ZINC;

EID: 84862550426     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.24132     Document Type: Article

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