The polyphenolic ellagitannin vescalagin acts as a preferential catalytic inhibitor of the α isoform of human DNA topoisomerase II

Molecular Pharmacology

Volumn 82, Issue 1, 2012, Pages 134-141

  Auzanneau, Céline ^a   Montaudon, Danièle ^a   Jacquet, Rémi ^a   Puyo, Stéphane ^a   Pouységu, Laurent ^a   Deffieux, Denis ^a   Elkaoukabi Chaibi, Assia ^b   De Giorgi, Francesca ^b   Ichas, François ^b   Quideau, Stéphane ^a   Pourquier, Philippe ^a  

^a UNIVERSITÉ DE BORDEAUX   (France)

^b FLUOFARMA   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE 2 ALPHA; DNA TOPOISOMERASE 2 BETA; DOUBLE STRANDED DNA; ELLAGITANNIN; ETOPOSIDE; ISOPROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DNA STRAND BREAKAGE; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION;

ANTIGENS, NEOPLASM; ANTINEOPLASTIC AGENTS; CATALYSIS; CELL PROLIFERATION; DNA BREAKS, DOUBLE-STRANDED; DNA TOPOISOMERASES, TYPE II; DNA, KINETOPLAST; DNA-BINDING PROTEINS; DOWN-REGULATION; ETOPOSIDE; HUMANS; HYDROLYZABLE TANNINS; OXIDATION-REDUCTION; PROTEIN ISOFORMS; TUMOR CELLS, CULTURED;

EID: 84862538123     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.111.077537     Document Type: Article

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