Multi-compartmental modeling of SORLA's influence on amyloidogenic processing in Alzheimer's disease

BMC Systems Biology

Volumn 6, Issue , 2012, Pages

  Lao, Angelyn ^a   Schmidt, Vanessa ^b   Schmitz, Yvonne ^a   Willnow, Thomas E ^b   Wolkenhauer, Olaf ^a,c  

^a UNIVERSITY OF ROSTOCK   (Germany)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c STELLENBOSCH INSTITUTE FOR ADVANCED STUDY   (South Africa)

Author keywords

Amyloidogenic processing; Compartmental modeling; LR11; Secretases; SORL1; VPS10P domain receptors

Indexed keywords

AMYLOID PRECURSOR PROTEIN; CARRIER PROTEIN; SECRETASE;

ALZHEIMER DISEASE; ARTICLE; BIOLOGICAL MODEL; CHEMISTRY; GENE EXPRESSION REGULATION; METABOLISM; PROTEIN DEGRADATION; PROTEIN MULTIMERIZATION; PROTEIN SECONDARY STRUCTURE; RISK FACTOR; SOLUBILITY;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; GENE EXPRESSION REGULATION; MEMBRANE TRANSPORT PROTEINS; MODELS, BIOLOGICAL; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY; PROTEOLYSIS; RISK FACTORS; SOLUBILITY;

EID: 84862532640     PISSN: None     EISSN: 17520509     Source Type: Journal    
DOI: 10.1186/1752-0509-6-74     Document Type: Article

References (22)

1. Haass C, Selkoe DJ. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat Rev Mol Cell Biol 2007, 8:101-112. 10.1038/nrm2101, 17245412.
2. Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 2002, 297:353-356. 10.1126/science.1072994, 12130773.
3. Hung LW, Ciccotosto GD, Giannakis E, Tew DJ, Perez K, Masters CL, Cappai R, Wade JD, Barnham KJ. Amyloid-{beta} Peptide (A{beta}) Neurotoxicity Is Modulated by the Rate of Peptide Aggregation: A{beta} Dimers and Trimers Correlate with Neurotoxicity. J Neurosci 2008, 28:11950-11958. 10.1523/JNEUROSCI.3916-08.2008, 19005060.
4. Kins S, Lauther N, Szodorai A, Beyreuther K. Subcellular trafficking of the amyloid precursor protein gene family and its pathogenic role in Alzheimer's disease. Neurodegener Dis 2006, 3:218-226. 10.1159/000095259, 17047360.
5. Thinakaran G, Koo EH. Amyloid precursor protein trafficking, processing, and function. J Biol Chem 2008, 283:29615-29619. 10.1074/jbc.R800019200, 2573065, 18650430.
6. Jacobsen L, Madsen P, Moestrup SK, Lund AH, Tommerup N, Nykjær A, Sottrup-Jensen L, Gliemann J, Petersen CM. Molecular Characterization of a Novel Human Hybrid-type Receptor That Binds the α2-Macroglobulin Receptor-associated Protein. J Biol Chem 1996, 271:31379-31383. 10.1074/jbc.271.49.31379, 8940146.
7. Yamazaki H, Bujo H, Kusunoki J, Seimiya K, Kanaki T, Morisaki N, Schneider WJ, Saito Y. Elements of Neural Adhesion Molecules and a Yeast Vacuolar Protein Sorting Receptor Are Present in a Novel Mammalian Low Density Lipoprotein Receptor Family Member. J Biol Chem 1996, 271:24761-24768. 10.1074/jbc.271.40.24761, 8798746.
8. Marcusson EG, Horazdovsky BF, Cereghino JL, Gharakhanian E, Emr SD. The sorting receptor for yeast vacuolar carboxypeptidase Y is encoded by the VPS10 gene. Cell 1994, 77:579-586. 10.1016/0092-8674(94)90219-4, 8187177.
9. Andersen OM, Reiche J, Schmidt V, Gotthardt M, Spoelgen R, Behlke J, von Arnim CAF, Breiderhoff T, Jansen P, Wu X, Bales KR, Cappai R, Masters CL, Gliemann J, Mufson EJ, Hyman BT, Paul SM, Nykjær A, Willnow TE. Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein. Proc Natl Acad Sci U S A 2005, 102:13461-13466. 10.1073/pnas.0503689102, 1224625, 16174740.
10. Offe K, Dodson SE, Shoemaker JT, Fritz JJ, Gearing M, Levey AI, Lah JJ. The lipoprotein receptor LR11 regulates amyloid beta production and amyloid precursor protein traffic in endosomal compartments. J Neurosci 2006, 26:1596-1603. 10.1523/JNEUROSCI.4946-05.2006, 2638122, 16452683.
11. Schmidt V, Sporbert A, Rohe M, Reimer T, Rehm A, Andersen OM, Willnow TE. SorLA/LR11 Regulates Processing of Amyloid Precursor Protein via Interaction with Adaptors GGA and PACS-1. J Biol Chem 2007, 282:32956-32964. 10.1074/jbc.M705073200, 17855360.
12. Scherzer CR, Offe K, Gearing M, Rees HD, Fang G, Heilman CJ, Schaller C, Bujo H, Levey AI, Lah JJ. Loss of apolipoprotein E receptor LR11 in Alzheimer disease. Arch Neurol 2004, 61:1200-1205. 10.1001/archneur.61.8.1200, 15313836.
13. Rogaeva E, Meng Y, Lee JH, Gu Y, Kawarai T, Zou F, Katayama T, Baldwin CT, Cheng R, Hasegawa H, Chen F, Shibata N, Lunetta KL, Pardossi-Piquard R, Bohm C, Wakutani Y, Cupples LA, Cuenco KT, Green RC, Pinessi L, Rainero I, Sorbi S, Bruni A, Duara R, Friedland RP, Inzelberg R, Hampe W, Bujo H, Song Y-Q, Andersen OM, Willnow TE, Graff-Radford N, Petersen RC, Dickson D, Der SD, Fraser PE, Schmitt-Ulms G, Younkin S, Mayeux R, Farrer LA, St George-Hyslop P. The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. Nat Genet 2007, 39:168-177. 10.1038/ng1943, 2657343, 17220890.
14. Schmidt V, Baum K, Lao A, Rateitschak K, Schmitz Y, Teichmann A, Wiesner B, Petersen CM, Nykjaer A, Wolf J, Wolkenhauer O, Willnow TE. Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease. EMBO J 2012, 31:187-200.
15. Spoelgen R, von Arnim CAF, Thomas AV, Peltan ID, Koker M, Deng A, Irizarry MC, Andersen OM, Willnow TE, Hyman BT. Interaction of the Cytosolic Domains of sorLA/LR11 with the Amyloid Precursor Protein (APP) and beta-Secretase beta-Site APP-Cleaving Enzyme. J Neurosci 2006, 26:418-428. 10.1523/JNEUROSCI.3882-05.2006, 16407538.
16. Andersen OM, Schmidt V, Spoelgen R, Gliemann J, Behlke J, Galatis D, McKinstry WJ, Parker MW, Masters CL, Hyman BT, Cappai R, Willnow TE. Molecular Dissection of the Interaction between Amyloid Precursor Protein and Its Neuronal Trafficking Receptor SorLA/LR11†. Biochemistry 2006, 45:2618-2628. 10.1021/bi052120v, 16489755.
17. Dodson SE, Andersen OM, Karmali V, Fritz JJ, Cheng D, Peng J, Levey AI, Willnow TE, Lah JJ. Loss of LR11/SORLA enhances early pathology in a mouse model of amyloidosis: evidence for a proximal role in Alzheimer's disease. J Neurosci 2008, 28:12877-12886. 10.1523/JNEUROSCI.4582-08.2008, 2669320, 19036982.
18. Kitano H, Funahashi A, Matsuoka Y, Oda K. Using process diagrams for the graphical representation of biological networks. Nat Biotech 2005, 23:961-966.
19. Cell Designer 2008, The Systems Biology Institute, Tokyo, Japan, Cell Designer.
20. Willnow TE, Petersen CM, Nykjaer A. VPS10P-domain receptors - regulators of neuronal viability and function. Nat Rev Neurosci 2008, 9:899-909. 10.1038/nrg2454, 19002190.
21. Andersen OM, Willnow TE. Lipoprotein receptors in Alzheimer's disease. Trends Neurosci 2006, 29:687-694. 10.1016/j.tins.2006.09.002, 17000013.
22. MATLAB 2009, Natick, Massachusetts: Math Works Inc, MATLAB.