Oxysophoridine through intrathecal injection induces antinociception and increases the expression of the GABAA α 1 Receptor in the spinal cord of mice

Planta Medica

Volumn 78, Issue 9, 2012, Pages 874-880

  Yang, Guang ^a   Gao, Jinxian ^b   Jia, Yuexia ^a   Yan, Lin ^a   Yu, Jianqiang ^a   Jiang, Yuanxu ^a  

^a NINGXIA MEDICAL UNIVERSITY   (China)

^b GANSU PROVINCIAL HOSPITAL   (China)

Author keywords

antinociceptive; Campanulaceae; GABAA receptor; intrathecal injection; oxysophoridine; Siphocampylus verticillatus; spinal cord

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR ALPHA1; ALKALOID DERIVATIVE; BICUCULLINE; FORMALDEHYDE; MESSENGER RNA; OXYSOPHORIDINE; PICROTOXIN; SIPHOCAMPYLUS VERTICILLATUS EXTRACT; UNCLASSIFIED DRUG;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; MOUSE; NEUROTRANSMISSION; NONHUMAN; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SPINAL CORD; TAIL FLICK TEST; THERMAL STIMULATION; WESTERN BLOTTING;

ALKALOIDS; ANALGESICS; ANIMALS; BICUCULLINE; DRUG EVALUATION, PRECLINICAL; DRUG INTERACTIONS; GABA-A RECEPTOR AGONISTS; GABA-A RECEPTOR ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; INJECTIONS, SPINAL; MICE; MICE, INBRED ICR; MUSCIMOL; PAIN MEASUREMENT; PICROTOXIN; RECEPTORS, GABA-A; SPINAL CORD;

CAMPANULACEAE; MUS; RATTUS; SIPHOCAMPYLUS VERTICILLATUS;

EID: 84862528260     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0031-1298471     Document Type: Article

References (34)

1. Millan MJ. Descending control of pain. Neurobiology: 2002; 66 355 474 (Pubitemid 34606906)
2. Malcangio M, Bowery NG. GABA and its receptors in the spinal cord. TIPS: 1996; 17 457 462 (Pubitemid 27028478)
3. Reis G, Pacheco D, Francischi J, Castro M, Perez A, Duarte I. Involvement of GABAA receptor-associated chloride channels in the peripheral antinociceptive effect induced by GABAA receptor agonist muscimol. Eur J Pharmacol: 2007; 564 112 115 (Pubitemid 46946858)
4. Michels G, Moss SJ. GABAA receptors: properties and trafficking. Crit Rev Biochem Mol Biol: 2007; 42 3 14 (Pubitemid 46391137)
5. Nadeson R, Guo Z, Porter V, Gent JP, Goodchild CS. Gamma-aminobutyric acid A receptors and spinally mediated antinociception in rats. Pharmacol Exp Ther: 1996; 278 620 626
6. Zhong R. Research and application of sophora. Yinchuan Ningxia Peoples Publishing House Press: 1985; 10 20
7. Rodrigues AL, da Silva GL, Mateussi AS, Fernandes ES, Miguel OG, Yunes RA, Calixto JB, Santos AR. Involvement of monoaminergic system in the antidepressant-like effect of the hydroalcoholic extract of Siphocampylus verticillatus. Life Sci: 2002; 70 1347 1358 (Pubitemid 34159092)
8. Trentin AP, Santos AR, Miguel OG, Pizzolatti MG, Yunes RA, Calixto JB. Mechanisms involved in the antinociceptive effect in mice of the hydroalcoholic extract of Siphocampylus verticillatus. J Pharm Pharmacol: 1997; 49 567 572 (Pubitemid 27229484)
9. Gao J, Tao L, Yu J, Jin S, Yang G, Yonghui XU, Jiang Y. The antinociceptive action of oxysophoridine and its effect on the expression of PKCγ in central nervous system of mice. Chin Pharmacol Bull: 2009; 11 1453 1456
10. Yao W, Zhou J, Yan L, Jin S, Jiang Y. Antinociceptive effect of oxysophoridine and its mechanism. Chin Tradit Herb Drugs: 2008; 4 569 571
11. Yan L, Jiang Y, Yao W. Experimental study of the analgesia actions of oxysophoridine. Chin Tradit Herb Drugs: 2006; 7 1061 1062
12. Yu J, Jiang Y. Effects of oxysophoridine on Glu and GABA immuno-reaction positive neurons in cortex and hippocampus of rats. China J Chin Mater Med: 2006; 10 1611 1614
13. Zhou J, Jiang YX, Jin S, Tao L, Liu L. Studies on analgesic effects and sites of oxymatrine carbenoxolone sodium complex. China J Chi Mater Med: 2008; 33 822 824
14. Zhou J, Yang G, Jin S, Tao L, Yu J, Jiang Y. Oxymatrine-carbenoxolone sodium inclusion compound induces anti-nociception and increases the expression of GABAAα1 receptors in mice. Eur J Pharmacol: 2010; 626 244 249
15. Hylden JL, Wilcox GL. Intrathecal morphine in mice: a new technique. Eur J Pharmacol: 1980; 67 313 316 (Pubitemid 10007057)
16. Bannon AW, Malmberg AB. Models of nociception: hot-plate, tail-flick, and formalin tests in rodents. Curr Protoc Neurosci: 2007; 41 891 896
17. Le Bars D, Gozariu M, Cadden SW. Animal models of nociception. Pharmacol Rev: 2001; 53 597 652 (Pubitemid 33136239)
18. Enna SJ, McCarson KE. The role of GABA in the mediation and perception of pain. Adv Pharmacol: 2006; 54 1 27
19. Pirker S, Schwarzer C, Wieselthaler A, Sieghart W, Sperk G. GABA (A) receptors: immunocytochemical distribution of 13 subunits in the adult rat brain. Neuroscience: 2000; 101 815 850
20. Bormann J. The ABC of GABA receptors. Trends Pharmacol Sci: 2000; 21 16 19
21. Hammond DL. J. J. Bonica Lecture-2001: role of spinal GABA in acute and persistent nociception. Reg Anesth Pain Med: 2001; 26 551 557 (Pubitemid 33065133)
22. Munro G, Ahring PK, Mirza NR. Developing antinociceptives by enhancing spinal inhibition after injury: GABAA receptor subtypes as novel targets. Trends Pharmacol Sci: 2009; 30 453 459
23. Sieghart W. Structure, pharmacology, and function of GABAA receptor subtypes. Adv Pharmacol: 2006; 54 231 263
24. Suh HW, Song DK, Huh SO, Lee KC, Kim YH. Differential potentiative effects of GABA receptor agonists in the production of antinociception induced by morphine and p-endorphin administered intrathecally in the mouse. Life Sci: 2000; 66 61 69
25. Natsu K, Fumihiko H, Toshikatsu Y. Does intravenous administration of GABAA receptor antagonists induce both descending antinociception and touch-evoked allodynia? Pain: 1998; 76 327 336
26. Knabl J, Witschi R, Hösl K, Reinold H, Zeilhofer UB, Ahmadi S, Brockhaus J, Sergejeva M, Hess A, Brune K, Fritschy JM, Rudolph U, Möhler H, Zeilhofer HU. Reversal of pathological pain through specific spinal GABAA receptor subtypes. Nature: 2008; 451 330 334
27. Raschid MH, Ueda H. Neuropathy-specific analgesic action of intrathecal nicotinic agonists and its spinal GABA-mediated mechanism. Brain Res: 2002; 953 53 62 (Pubitemid 35217807)
28. Edwards M, Serrao JM, Gent JP, Goodchild CS. On the mechanism by which midazolam causes spinally mediated analgesia. Anesthesiology: 1990; 73 273 277 (Pubitemid 20295288)
29. Wang Y, Deng X, You X, Liu S, Zhao Z. Involvement of GABA and opioid peptide receptors in sevoflurane-induced antinociception in rat spinal cord. Acta Pharmacol Sin: 2005; 26 1045 1048 (Pubitemid 41296942)
30. Whiting PJ, Bonnert TP, McKernan RM, Farrar S, Le Bourdellès B, Heavens RP, Smith DW, Hewson L, Rigby MR, Sirinathsinghji DJ, Thompson SA, Wafford KA. Molecular and functional diversity of the expanding GABA-A receptor gene family. Ann NY Acad Sci: 1999; 30 645 653 (Pubitemid 29281180)
31. Nutt D. GABAA receptors: subtypes, regional distribution, and function. J Clin Sleep Med: 2006; 2 S7 S11
32. Barnard EA, Skolnick P, Olsen RW, Mohler H, Sieghart W, Biggio G, Braestrup C, Bateson AN, Langer SZ. International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor function. Pharmacol Rev: 1998; 50 291 313 (Pubitemid 28304030)
33. Yi Z, Yang G, Yan L, Jia Y, Jiang Y. Effect of oxysophoridine on amino acid content in spinal cord of rats with formalin-induced pain. Chin Pharm J: 2011; 46 826 829
34. Gao J, Yi Z, Yang G, Yan L, Tao L, Gao S, Pan Q, Jiang Y. Effect of the down-regulation of GAT-1 on analgesic action of oxysophoridine. China J Chin Mater Med: 2011; 36 32 36