Mechanisms involved in the antinociceptive effect in mice of the hydroalcoholic extract of Siphocampylus verticillatus

Journal of Pharmacy and Pharmacology

Volumn 49, Issue 5, 1997, Pages 567-572

  Trentin, Ana P ^a   Santos, Adair R S ^a   Miguel, Obdúlio G ^a   Pizzolatti, Moacir G ^a   Yunes, Rosendo A ^a   Calixto, João B ^a  

^a FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID; ARGININE; CAPSAICIN; FORMALDEHYDE; HORMONE; MORPHINE; N(G) NITROARGININE; NALOXONE; NITRIC OXIDE; OPIATE; PLANT EXTRACT; SIPHOCAMPYLUS VERTICILLATUS EXTRACT; UNCLASSIFIED DRUG;

ABDOMINAL WALL MUSCULATURE; ADRENALECTOMY; ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; DRUG POTENCY; HOT PLATE TEST; INFLAMMATION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOUSE; MUSCLE CONTRACTION; NOCICEPTION; NONHUMAN; ORAL DRUG ADMINISTRATION; PAIN; SUBCUTANEOUS DRUG ADMINISTRATION; TAIL FLICK TEST;

SIPHOCAMPYLUS VERTICILLATUS;

EID: 0031007721     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-7158.1997.tb06843.x     Document Type: Article

References (24)

1. Cechinel Filho, V., Santos, A. R. S., De Campos, R. O. P., Miguel, O. G., Yunes, R. A., Ferrari, F., Messana, I., Calixto, J. B. (1996) Chemical and pharmacological studies of Phyllanthus caroliniensis in mice. J. Pharm. Pharmacol. 48: 1231-1236
2. 2 kinin receptors in formalin-induced nociceptive response in the mouse. Br. J. Pharmacol. 110: 193-198
3. 2 bradykinin receptor antagonist NPC 18688 in mice. Br. J. Pharmacol. 117: 552-558
4. Corrol, R. A., Orazi, O. O., Pizzomo, M. T. (1970) Constituyentes de Siphocampylus foliosus Gris. Anales Asoc. Quim. Argentina (La Prata) 58: 285-290
5. D'Amour, F. E., Smith, D. L. (1941) A method for determining loss of pain sensation. J. Pharmacol. Exp. Ther. 72: 74-79
6. Eddy, N. B., Leimback, D. (1953) Synthetic analgesics II. Dithienylbutenyl and dithienylbutylamines. J. Pharmacol. Exp. Ther. 107: 385-393
7. Garello, F. (1950) Estudio del Siphocampylus foliosus Gris. Archivos de Farmácia y Bioquimica (Tucuman) 5: 5-46
8. Gorski, F., Corrêa, C. R., Cechinel Filho, V., Yunes, R. A., Calixto, J. B. (1993) Potent antinociceptive activity of the hydroalcoholic extract from Phyllanthus corcovadensis. J. Pharm. Pharmacol. 45: 1046-1049
9. Hunskaar, S., Hole, K. (1987) The formalin test in mice: dissociation between inflammatory and non-inflammatory pain. Pain 30: 103-114
10. Hunskaar, S., Fasmar, O. B., Hole, K. (1985) Formalin test in mice: a useful technique for evaluating mild analgesics. J. Neurosci. Methods. 14: 69-76
11. Hunskaar, S., Berge, O. G., Hole, K. (1986) Dissociation between antinociceptive and anti-inflammatory effects of acetylsalicylic acid and indomethacin in the formalin test. Pain 25: 125-132
12. Kawabata, A., Umeda, N., Takagi, H. (1993) L-Arginine exerts a dual role in nociceptive processing in the brain: involvement of the kyotorphinmet-enkephalin pathway and NO-cyclic GMP pathway. Br. J. Pharmacol. 109: 73-79
13. Miguel, O. G., Pizzolatti, M. G., Yunes, R. A., Vencato, I., Calixto, J. B., Santos, A. R. S., Contin, A., Moreira, E. A. (1996) cis-8,10-Di-n-propyllobelidiol hydrochloride dihydrate. Acta Crystallogr. C 52: 1223-1225
14. Moore, P. K., Babbedge, R. C., Wallace, P., Gaffen, Z. A., Hart, S. T. (1993) 7-Nitroindazole, an inhibitor of nitric oxide synthase, exhibits anti-nociceptive activity in the mouse without increasing blood pressure. Br. J. Pharmacol. 108: 296-297
15. Moreira, E. A., Santos, C. A. M., Leornat, R., Lamb, L. (1984) Investigação química preliminar de 2 espécies de Siphocampylus, Campanulaceae. Tribuna Farmacêutica 51: 26-31
16. Murray, C. W., Porreca, F., Cowan, A. (1988) Methodological refinements in the mouse paw formalin test-an animal model of tonic pain. J. Pharmacol. Methods. 20: 175-186
17. Przewlocka, B., Machelska, H., Przewlocki, R. (1994) Involvement of the nitric oxide pathway in nociceptive processes in the central nervous system in rats. Regl. Pept. (Suppl. 1): 75-76
18. Sakurada, T., Katsumata, K., Tan-No, K., Sakurada, S., Kisara, K. (1992) The capsaicin test in mice for evaluating tachykinin antagonists in the spinal cord. Neuropharmacology 31: 1279-1285
19. Santos, A. R. S., Cechinel Filho, V., Niero, R., Viana, A. M., Moreno, F. N., Campos, M. M., Yunes, R. A., Calixto, J. B. (1994) Analgesic effects of callus culture extracts from selected species of Phyllanthus. J. Pharm. Pharmacol. 46: 755-759
20. Santos, A. R. S., Cechinel Filho, V., Yunes, R. A., Calixto, J. B. (1995a) Further studies on the antinociceptive action of the hydroalcoholic extracts from plants of genus Phyllanthus. J. Pharm. Pharmacol. 47: 66-71
21. Santos, A. R. S., Cechinel Filho, V., Yunes, R. A., Calixto, J. B. (1995b) Analysis of the mechanisms underlying the antinociceptive effect of the extracts of plants from the genus Phyllanthus. Gen. Pharmacol. 26: 1499-1506
22. Vaz, Z. R., Cechinel Filho, V., Yunes, R. A., Calixto, J. B. (1996) Antinociceptive action of 2-(4-bromobenzoyl)-3-methyl-4,6-dimethoxybenzofuran, a novel xanthoxyline derivative on chemical and thermal models of nociception in mice. J. Pharmacol. Exp. Ther. 278: 304-312
23. Wimmer, E. F. (1968) Campanulaceae-Lobeliodeae, Suplementon et Campanulaceae-Cyphioideae. In: Enmgler, A.(ed.) Das Pflanzen reich 4
24. Zimmermann, M. (1983) Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16: 109-110