Cellular impact and selectivity of half-sandwich organorhodium(III) anticancer complexes and their organoiridium(III) and trichloridorhodium(III) counterparts

Journal of Biological Inorganic Chemistry

Volumn 17, Issue 4, 2012, Pages 631-646

  Geldmacher, Yvonne ^a   Splith, Katrin ^b   Kitanovic, Igor ^c   Alborzinia, Hamed ^c   Can, Suzan ^c   Rubbiani, Riccardo ^d   Nazif, M Ali ^a   Wefelmeier, Pascal ^e   Prokop, Aram ^e   Ott, Ingo ^d   Wölfl, Stefan ^c   Neundorf, Ines ^b   Sheldrick, William S ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

^e UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

Author keywords

Antileukemic activity Cell penetrating peptides; Apoptosis; Iridium; Rhodium

Indexed keywords

ANTINEOPLASTIC AGENT; CYTOCHROME C; MEMBRANE PROTEIN; ORGANOIRIDIUM COMPLEX; ORGANOMETALLIC COMPOUND; ORGANORHODIUM COMPLEX; TRICHLORIDORHODIUM COMPLEX; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL ADHESION; CELL DEATH; CELL IMMORTALIZATION; CELL PROLIFERATION; CELL RESPIRATION; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; EMBRYO; ENZYME RELEASE; EX VIVO STUDY; GLYCOLYSIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LEUKOCYTE; LYMPHOMA CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS; CATTLE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CYTOCHROMES C; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HEK293 CELLS; HUMANS; IRIDIUM; MICE; MICE, INBRED C57BL; MITOCHONDRIA, LIVER; ORGANOMETALLIC COMPOUNDS; OXYGEN; REACTIVE OXYGEN SPECIES; RHODIUM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84862522363     PISSN: 09498257     EISSN: 14321327     Source Type: Journal    
DOI: 10.1007/s00775-012-0883-2     Document Type: Article

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