Adipose tissue macrophages: MR tracking to monitor obesity-associated inflammation

Radiology

Volumn 263, Issue 3, 2012, Pages 786-793

  Luciani, Alain ^a,b,c   Dechoux, Sophie ^a,b   Deveaux, Vanessa ^a,b   Poirier Quinot, Marie ^d   Luciani, Nathalie ^e   Levy, Michael ^e   Ballet, Sebastien ^f   Manin, Sylvie ^a,b   Pećhoux, Christine ^g   Autret, Gwennhael ^h   Cleḿent, Olivier ^h   Rahmouni, Alain ^c   Mallat, Ariane ^a,b,c   Wilhelm, Claire ^e   Lotersztajn, Sophie ^a,b,c   Gazeau, Florence ^e  

^a INSERM U955   (France)

^b FACULTÉ DE MÉDECINE   (France)

^c HENRI MONDOR HOSPITAL   (France)

^d UNIVERSITÉ PARIS SACLAY   (France)

^e UNIVERSITÉ PARIS DIDEROT   (France)

^f Laboratoire Guerbet   (France)

^g INRA Institut National de la Recherche Agronomique   (France)

^h HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN EMR1; TUMOR NECROSIS FACTOR ALPHA; ULTRASMALL SUPERPARAMAGNETIC IRON OXIDE; UNCLASSIFIED DRUG;

ADIPOSE TISSUE MACROPHAGE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ASSAY; CELL INFILTRATION; CONTROLLED STUDY; DISEASE ASSOCIATION; ELECTRON SPIN RESONANCE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MACROPHAGE; MACROPHAGE FUNCTION; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSMISSION ELECTRON MICROSCOPY;

ADIPOSE TISSUE; ANALYSIS OF VARIANCE; ANIMALS; ARTIFACTS; CONTRAST MEDIA; DEXTRANS; IMAGING, THREE-DIMENSIONAL; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MACROPHAGE ACTIVATION; MACROPHAGES; MAGNETIC RESONANCE IMAGING; MAGNETITE NANOPARTICLES; MICE; OBESITY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STATISTICS, NONPARAMETRIC;

EID: 84862503608     PISSN: 00338419     EISSN: 15271315     Source Type: Journal    
DOI: 10.1148/radiol.12111957     Document Type: Article

References (25)

1. Hotamisligil GS. Inflammation and metabolic disorders. Nature 2006;444(7121):860-867. (Pubitemid 46024993)
2. Hummasti S, Hotamisligil GS. Endoplasmic reticulum stress and inflammation in obesity and diabetes. Circ Res 2010;107(5):579-591.
3. Deveaux V, Cadoudal T, Ichigotani Y, et al. Cannabinoid CB2 receptor potentiates obesity-associated inflammation, insulin resistance and hepatic steatosis. PLoS ONE 2009;4(6):e5844.
4. Gutierrez DA, Puglisi MJ, Hasty AH. Impact of increased adipose tissue mass on inflammation, insulin resistance, and dyslipidemia. Curr Diab Rep 2009;9(1):26-32.
5. Cancello R, Clément K. Is obesity an inflammatory illness? role of low-grade inflammation and macrophage infiltration in human white adipose tissue. BJOG 2006;113(10):1141-1147. (Pubitemid 44401207)
6. Fransson EI, Batty GD, Tabák AG, et al. Association between change in body composition and change in inflammatory markers: an 11-year follow-up in the Whitehall II Study. J Clin Endocrinol Metab 2010;95(12):5370-5374.
7. Goldberg RB. Cytokine and cytokine-like inflammation markers, endothelial dysfunction, and imbalanced coagulation in development of diabetes and its complications. J Clin Endocrinol Metab 2009;94(9):3171-3182.
8. Furuhashi M, Fucho R, Görgün CZ, Tuncman G, Cao H, Hotamisligil GS. Adipocyte/macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice. J Clin Invest 2008;118(7):2640-2650. (Pubitemid 351949791)
9. Wellen KE, Hotamisligil GS. Obesity-induced inflammatory changes in adipose tissue. J Clin Invest 2003;112(12):1785-1788. (Pubitemid 38063699)
10. Popko K, Gorska E, Stelmaszczyk-Emmel A, et al. Proinflammatory cytokines Il-6 and TNF-a and the development of inflammation in obese subjects. Eur J Med Res 2010;15(suppl 2):120-122.
11. Morishige K, Kacher DF, Libby P, et al. High-resolution magnetic resonance imaging enhanced with superparamagnetic nanoparticles measures macrophage burden in atherosclerosis. Circulation 2010;122(17):1707-1715.
12. Truijers M, Fütterer JJ, Takahashi S, Heesakkers RA, Blankensteijn JD, Barentsz JO. In vivo imaging of the aneurysm wall with MRI and a macrophage-specific contrast agent. AJR Am J Roentgenol 2009;193(5):W437-W441.
13. Sigovan M, Boussel L, Sulaiman A, et al. Rapid-clearance iron nanoparticles for inflammation imaging of atherosclerotic plaque: initial experience in animal model. Radiology 2009;252(2):401-409.
14. Sigovan M, Bessaad A, Alsaid H, et al. Assessment of age modulated vascular inflammation in ApoE-/- mice by USPIO-enhanced magnetic resonance imaging. Invest Radiol 2010;45(11):702-707.
15. Pelleymounter MA, Cullen MJ, Baker MB, et al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 1995;269(5223):540-543.
16. Poirier-Quinot M, Frasca G, Wilhelm C, et al. High-resolution 1.5-Tesla magnetic resonance imaging for tissue-engineered constructs: a noninvasive tool to assess three-dimensional scaffold architecture and cell seeding. Tissue Eng Part C Methods 2010;16(2):185-200.
17. Levy M, Wilhelm C, Luciani N, et al. Nanomagnetism reveals the intracellular clustering of iron oxide nanoparticles in the organism. Nanoscale 2011;3(10):4402-4410.
18. Wilhelm C, Gazeau F, Bacri JC. Magnetophoresis and ferromagnetic resonance of magnetically labeled cells. Eur Biophys J 2002;31(2):118-125.
19. Levy M, Luciani N, Alloyeau D, et al. Long term in vivo biotransformation of iron oxide nanoparticles. Biomaterials 2011;32(16):3988-3999.
20. Cancello R, Henegar C, Viguerie N, et al. Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss. Diabetes 2005;54(8):2277-2286. (Pubitemid 41134253)
21. Trivedi RA, U-King-Im JM, Graves MJ, et al. In vivo detection of macrophages in human carotid atheroma: temporal dependence of ultrasmall superparamagnetic particles of iron oxide-enhanced MRI. Stroke 2004;35(7):1631-1635.
22. Asanuma T, Ono M, Kubota K, et al. Super paramagnetic iron oxide MRI shows defective Kupffer cell uptake function in non-alcoholic fatty liver disease. Gut 2010;59(2):258-266.
23. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2003;112(12):1796-1808. (Pubitemid 38063703)
24. Lindström P. The physiology of obese-hyperglycemic mice [ob/ob mice]. ScientificWorld-Journal 2007;7:666-685.
25. Farnaud S. The evolution of the Three Rs. Altern Lab Anim 2009;37(3):249-254.