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Volumn 73, Issue 4, 2012, Pages 304-313

Is metformin indicated as primary ovulation induction agent in women with PCOS? A systematic review and meta-analysis

Author keywords

Clomiphene citrate; Metformin; Ovulation induction; Polycystic ovarian syndrome; Randomized controlled trials

Indexed keywords

CLOMIFENE CITRATE; METFORMIN;

EID: 84862488675     PISSN: 03787346     EISSN: 1423002X     Source Type: Journal    
DOI: 10.1159/000335253     Document Type: Article
Times cited : (40)

References (46)
  • 1
    • 0023879442 scopus 로고    scopus 로고
    • Polycystic ovaries - A common finding in normal women
    • Polson DW, Adams J, Wadsworth J, Franks S: Polycystic ovaries - a common finding in normal women. Lancet 1998; 1: 870-872.
    • (1998) Lancet , vol.1 , pp. 870-872
    • Polson, D.W.1    Adams, J.2    Wadsworth, J.3    Franks, S.4
  • 2
    • 0346186090 scopus 로고    scopus 로고
    • Revised 2003 consensus on diagnostic criteria and long-term health risk related to polycystic ovary syndrome
    • The Rotterdam ESHRE/ASRM sponsored PCOS consensus group
    • The Rotterdam ESHRE/ASRM sponsored PCOS consensus group: Revised 2003 consensus on diagnostic criteria and long-term health risk related to polycystic ovary syndrome. Hum Reprod 2004; 19: 41-47.
    • (2004) Hum Reprod , vol.19 , pp. 41-47
  • 4
    • 0031456016 scopus 로고    scopus 로고
    • Insulin resistance and the polycystic ovarian syndrome: Mechanism and implications for pathogenesis
    • Dunaif A: Insulin resistance and the polycystic ovarian syndrome: mechanism and implications for pathogenesis. Endocrinol Rev 1997; 18: 774-800.
    • (1997) Endocrinol Rev , vol.18 , pp. 774-800
    • Dunaif, A.1
  • 5
    • 0018906734 scopus 로고
    • Correlation of hyperandrogenism with hyperinsulinemia in polycystic ovarian disease
    • Burghen GA, Givens JR, Kitabchi AE: Correlation of hyperandrogenism with hyperinsulinemia in polycystic ovarian disease. J Clin Endocrinol Metab 1980; 50: 113-115.
    • (1980) J Clin Endocrinol Metab , vol.50 , pp. 113-115
    • Burghen, G.A.1    Givens, J.R.2    Kitabchi, A.E.3
  • 6
    • 0028315971 scopus 로고
    • Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia, and systolic blood pressure, while facilitating normal menses and pregnancy
    • DOI 10.1016/0026-0495(94)90209-7
    • Velazquez EM, Mendoza SG, Hamer T, Sosa F, Glueck CJ: Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenaemia and systolic blood pressure, while facilitating normal menses and pregnancy. Metabolism 1994; 43: 647-654. (Pubitemid 24145474)
    • (1994) Metabolism: Clinical and Experimental , vol.43 , Issue.5 , pp. 647-654
    • Velazquez, E.M.1    Mendoza, S.2    Hamer, T.3    Sosa, F.4    Glueck, C.J.5
  • 7
    • 8344289055 scopus 로고    scopus 로고
    • Insulin-sensitizing agents as primary therapy for patients with polycystic ovarian syndrome
    • DOI 10.1093/humrep/deh440
    • Kashyap S, Wells GA, Rosenwaks Z: Insulin-sensitizing agents as primary therapy for patients with polycystic ovarian syndrome. Hum Reprod 2004; 19: 2474-2483. (Pubitemid 39481270)
    • (2004) Human Reproduction , vol.19 , Issue.11 , pp. 2474-2483
    • Kashyap, S.1    Wells, G.A.2    Rosenwaks, Z.3
  • 9
    • 0030783316 scopus 로고    scopus 로고
    • Lean women with polycystic ovary syndrome respond to insulin reduction with decreases in ovarian P450c17α activity and serum androgens
    • Nestler JE, Jakubowicz D: Lean women with polycystic ovary syndrome respond to insulin reduction with decreases in ovarian P450c17 α activity and serum androgens. J Clin Endocrinol Metab 1997; 82: 4075-4079. (Pubitemid 27525516)
    • (1997) Journal of Clinical Endocrinology and Metabolism , vol.82 , Issue.12 , pp. 4075-4079
    • Nestler, J.E.1    Jakubowicz, D.J.2
  • 10
    • 0032565971 scopus 로고    scopus 로고
    • Effects of metformin on spontaneous and clomiphene-induced ovulation in the polycystic ovary syndrome
    • DOI 10.1056/NEJM199806253382603
    • Nestler JE, Jakubowicz DJ, Evans WS, Pasquali R: Effects of metformin on spontaneous and clomiphene-induced ovulation in the polycystic ovary syndrome. N Engl J Med 1998; 338: 1876-1880. (Pubitemid 28287859)
    • (1998) New England Journal of Medicine , vol.338 , Issue.26 I , pp. 1876-1880
    • Nestler, J.E.1    Jakubowicz, D.J.2    Evans, W.S.3    Pasquali, R.4
  • 11
    • 55449136083 scopus 로고    scopus 로고
    • Use of insulin-sensitizing agents in the treatment of polycystic ovary syndrome
    • Practice Committee of the American Society for Reproductive Medicine
    • Practice Committee of the American Society for Reproductive Medicine: Use of insulin-sensitizing agents in the treatment of polycystic ovary syndrome. Fertil Steril 2008; 90:S69-S73.
    • (2008) Fertil Steril , vol.90
  • 12
    • 0018580390 scopus 로고
    • Relationship of weight to successful induction of ovulation with clomiphene citrate
    • Shepard MK, Balmaceda JP, Leija CG: Relationship of weight to successful induction of ovulation with clomiphene citrate. Fertil Steril 1979; 32: 641-645.
    • (1979) Fertil Steril , vol.32 , pp. 641-645
    • Shepard, M.K.1    Balmaceda, J.P.2    Leija, C.G.3
  • 14
    • 0020071516 scopus 로고
    • Clinical and laboratory predictors of clomiphene response
    • Lobo RA, Gysler M, March CM, Goebelsmann U, Mishell DR Jr: Clinical and laboratory predictors or clomiphene response. Fertil Steril 1982; 37: 168-174. (Pubitemid 12171167)
    • (1982) Fertility and Sterility , vol.37 , Issue.2 , pp. 168-174
    • Lobo, R.A.1    Gysler, M.2    March, C.M.3
  • 15
    • 33750173067 scopus 로고    scopus 로고
    • Is the addition of metformin efficacious in the treatment of clomiphene citrate-resistant patients with polycystic ovary syndrome? A structured literature review
    • DOI 10.1016/j.fertnstert.2006.06.014, PII S0015028206030263
    • Siebert IT, Kruger TF, Steyn DW, Nosarka S: Is the addition of metformin efficacious in the treatment of clomiphene citrate-resistant patients with polycystic ovary syndrome? A structured literature review. Fertil Steril 2006; 86: 1432-1437. (Pubitemid 44602073)
    • (2006) Fertility and Sterility , vol.86 , Issue.5 , pp. 1432-1437
    • Siebert, T.I.1    Kruger, T.F.2    Steyn, D.W.3    Nosarka, S.4
  • 16
    • 0037229222 scopus 로고    scopus 로고
    • A systematic review of the reproductive system effects of metformin in patients with polycystic ovary syndrome
    • DOI 10.1016/S0015-0282(02)04554-5, PII S0015028202045545
    • Costello MF, Eden JA: A systematic review of the reproductive system effects of metformin in patients with polycystic ovary syndrome. Fertil Steril 2003; 79: 1-13. (Pubitemid 36071228)
    • (2003) Fertility and Sterility , vol.79 , Issue.1 , pp. 1-13
    • Costello, M.F.1    Eden, J.A.2
  • 17
    • 58549108971 scopus 로고    scopus 로고
    • Clomiphene citrate, metformin or both as first-step approach in treating anovulatory infertility in patients with polycystic ovary syndrome: A systematic review of head-to-head randomized controlled studies and meta-analysis
    • Palomba S, Pasquali R, Orio Jr F, Nestler JE: Clomiphene citrate, metformin or both as first-step approach in treating anovulatory infertility in patients with polycystic ovary syndrome: a systematic review of head-to-head randomized controlled studies and meta-analysis. Clin Endocrinol 2009; 70: 311-321.
    • (2009) Clin Endocrinol , vol.70 , pp. 311-321
    • Palomba, S.1    Pasquali, R.2    Orio Jr., F.3    Nestler, J.E.4
  • 18
    • 35548985357 scopus 로고    scopus 로고
    • The role of metformin in polycystic ovary syndrome: A systematic review
    • Moll E, Van der Veen F, van Wely M: The role of metformin in polycystic ovary syndrome: a systematic review. Hum Reprod 2007; 13: 527-537.
    • (2007) Hum Reprod , vol.13 , pp. 527-537
    • Moll, E.1    Van Der Veen, F.2    Van Wely, M.3
  • 19
    • 33745713576 scopus 로고    scopus 로고
    • Effect of clomiphene citrate plus metformin and clomiphene citrate plus placebo on induction of ovulation in women with newly diagnosed polycystic ovary syndrome: Randomised double-blind clinical trial
    • Moll M, Bossuyt PMM, Korevaar JC, Lambalk CB, Van der Veen F: Effect of clomiphene citrate plus metformin and clomiphene citrate plus placebo on induction of ovulation in women with newly diagnosed polycystic ovary syndrome: randomised double-blind clinical trial. BMJ 2006; 332: 1485-1489.
    • (2006) BMJ , vol.332 , pp. 1485-1489
    • Moll, M.1    Bossuyt, P.M.M.2    Korevaar, J.C.3    Lambalk, C.B.4    Van Der Veen, F.5
  • 21
    • 33845747700 scopus 로고    scopus 로고
    • Comparison of clomiphene citrate, metformin, or the combination of both for first-line ovulation induction and achievement of pregnancy in 154 women with polycystic ovary syndrome
    • DOI 10.1016/j.fertnstert.2006.05.069, PII S0015028206031633
    • Neveu N, Granger L, St-Michel P, Lavoie HB: Comparison of clomiphene citrate, metformin, or the combination of both for first-line ovulation induction and achievement of pregnancy in 154 women with polycystic ovary syndrome. Fertil Steril 2007; 87: 113-120. (Pubitemid 46013871)
    • (2007) Fertility and Sterility , vol.87 , Issue.1 , pp. 113-120
    • Neveu, N.1    Granger, L.2    St-Michel, P.3    Lavoie, H.B.4
  • 22
    • 67349122768 scopus 로고    scopus 로고
    • Evaluating the equivalence of clomiphene citrate with and without metformin in ovulation induction in PCOS patients
    • Siebert TI, Kruger TF, Lombard CJ: Evaluating the equivalence of clomiphene citrate with and without metformin in ovulation induction in PCOS patients. J Assist Reprod Genet 2009; 26: 165-171.
    • (2009) J Assist Reprod Genet , vol.26 , pp. 165-171
    • Siebert, T.I.1    Kruger, T.F.2    Lombard, C.J.3
  • 23
    • 23044513823 scopus 로고    scopus 로고
    • Prospective parallel randomized, double-blind, double-dummy controlled clinical trial comparing clomiphene citrate and metformin as the first-line treatment for ovulation induction in nonobese anovulatory women with polycystic ovary syndrome
    • DOI 10.1210/jc.2005-0110
    • Palomba S, Orio F, Falbo A, Manguso F, Russo T, Cascella T, et al: Prospective parallel randomised, double-blind, double-dummy controlled clinical trial comparing clomiphene citrate and metformin as the first-line treatment for ovulation induction in non-obese anovulatory women with polycystic ovary syndrome. J Clin End Metab 2005; 90: 4068-4074. (Pubitemid 41058174)
    • (2005) Journal of Clinical Endocrinology and Metabolism , vol.90 , Issue.7 , pp. 4068-4074
    • Palomba, S.1    Orio Jr., F.2    Falbo, A.3    Manguso, F.4    Russo, T.5    Cascella, T.6    Tolino, A.7    Carmina, E.8    Colao, A.9    Zullo, F.10
  • 24
    • 59249092532 scopus 로고    scopus 로고
    • Comparison of clomiphene citrate, metformin, or the combination of both for first-line ovulation induction, achievement of pregnancy, and live birth in Asian women with polycystic ovary syndrome: A randomized controlled trial
    • Zain MM, Jamaluddin R, Ibrahim A, Norman RJ: Comparison of clomiphene citrate, metformin, or the combination of both for first-line ovulation induction, achievement of pregnancy, and live birth in Asian women with polycystic ovary syndrome: a randomized controlled trial. Fertil Steril 2009; 91: 514-521.
    • (2009) Fertil Steril , vol.91 , pp. 514-521
    • Zain, M.M.1    Jamaluddin, R.2    Ibrahim, A.3    Norman, R.J.4
  • 25
    • 8344236321 scopus 로고    scopus 로고
    • Increased pregnancy rates with metformin and clomiphene citrate in non-obese patients with polycystic ovary syndrome: Prospective randomised study
    • Singh I, Bedaiwy MA, Hatwal A, Kumar A, Agarwal A: Increased pregnancy rates with metformin and clomiphene citrate in non-obese patients with polycystic ovary syndrome: prospective randomised study. Fertil Steril 2001; 73:S94.
    • (2001) Fertil Steril , vol.73
    • Singh, I.1    Bedaiwy, M.A.2    Hatwal, A.3    Kumar, A.4    Agarwal, A.5
  • 26
    • 77955895421 scopus 로고    scopus 로고
    • PCOSMIC: A multi-centre randomized trial in women with polycystic ovary syndrome evaluating metformin for infertility with clomiphene
    • Johnson NP, Stewart AW, Falkiner J, Farquhar CM, Milsom S, Singh VP, Okonkwo QL, Buckingham KL: PCOSMIC: A multi-centre randomized trial in women with polycystic ovary syndrome evaluating metformin for infertility with clomiphene. Hum Reprod 2010; 25: 1675-1683.
    • (2010) Hum Reprod , vol.25 , pp. 1675-1683
    • Johnson, N.P.1    Stewart, A.W.2    Falkiner, J.3    Farquhar, C.M.4    Milsom, S.5    Singh, V.P.6    Okonkwo, Q.L.7    Buckingham, K.L.8
  • 27
    • 77952542933 scopus 로고    scopus 로고
    • An assessment of lifestyle modification versus medical treatment with clomiphene citrate, metformin, and clomiphene citrate-metformin in patients with polycystic ovary syndrome
    • Karimzadeh MA, Javedani M: An assessment of lifestyle modification versus medical treatment with clomiphene citrate, metformin, and clomiphene citrate-metformin in patients with polycystic ovary syndrome. Fertil Steril 2010; 94: 216-220.
    • (2010) Fertil Steril , vol.94 , pp. 216-220
    • Karimzadeh, M.A.1    Javedani, M.2
  • 28
    • 33646119426 scopus 로고    scopus 로고
    • Two weeks of metformin improves clomiphene citrate-induced ovulation and metabolic profiles in women with polycystic ovary syndrome
    • Khorram O, Helliwell JP, Katz S, Bompane CM, Jaramillo L: Two weeks of metformin improves clomiphene citrate-induced ovulation and metabolic profiles in women with polycystic ovary syndrome. Fertil Steril 2006; 85: 1448-1451.
    • (2006) Fertil Steril , vol.85 , pp. 1448-1451
    • Khorram, O.1    Helliwell, J.P.2    Katz, S.3    Bompane, C.M.4    Jaramillo, L.5
  • 29
    • 1842611113 scopus 로고    scopus 로고
    • The effects of metformin on insulin resistance, clomiphene-induced ovulation and pregnancy rates in women with polycystic ovary syndrome
    • DOI 10.1016/j.ejogrb.2003.09.036, PII S030121150300527X
    • Sahin Y, Yirmibes U, Kalestimur F, Aygen E: The effects of metformin on insulin resistance, clomiphene-induced ovulation and pregnancy rates in women with polycystic ovary syndrome. Eur J Obstet Gynecol Reprod Biol 2004; 113: 214-220. (Pubitemid 38456778)
    • (2004) European Journal of Obstetrics Gynecology and Reproductive Biology , vol.113 , Issue.2 , pp. 214-220
    • Sahin, Y.1    Yirmibes, U.2    Kelestimur, F.3    Aygen, E.4
  • 30
    • 0035013454 scopus 로고    scopus 로고
    • The use of metformin to augment the induction of ovulation in obese infertile patients with polycystic ovary syndrome
    • El-Biely MM, Habba M: The use of metformin to augment the induction of ovulation in obese infertile patients with polycystic ovary syndrome. Middle East Fertil Soc J 2001; 6: 43-49. (Pubitemid 32489075)
    • (2001) Middle East Fertility Society Journal , vol.6 , Issue.1 , pp. 43-49
    • El-Biely, M.M.1    Habba, M.2
  • 32
    • 77953470311 scopus 로고    scopus 로고
    • The efficacy of metformin and clomiphene citrate combination compared with clomiphene citrate alone for ovulation induction in infertile patients with PCOS
    • Dasari P, Pranahita GK: The efficacy of metformin and clomiphene citrate combination compared with clomiphene citrate alone for ovulation induction in infertile patients with PCOS. J Hum Reprod Sci 2009; 2: 18-22.
    • (2009) J Hum Reprod Sci , vol.2 , pp. 18-22
    • Dasari, P.1    Pranahita, G.K.2
  • 33
    • 47649114543 scopus 로고    scopus 로고
    • Does adding metformin to clomifene citrate lead to higher pregnancy rates in a subset of women with polycystic ovary syndrome?
    • DOI 10.1093/humrep/den182
    • Moll E, Korevaar JC, Bossuyt PMM, Van der Veen F: Does adding metformin to clomiphene citrate lead to higher pregnancy rates in a subset of women with polycystic ovary syndrome? Hum Reprod 2008; 23: 1830-1834. (Pubitemid 352020013)
    • (2008) Human Reproduction , vol.23 , Issue.8 , pp. 1830-1834
    • Moll, E.1    Korevaar, J.C.2    Bossuyt, P.M.M.3    Van Der, V.F.4
  • 36
    • 0036283875 scopus 로고    scopus 로고
    • Metformin therapy in obese adolescents with polycystic ovary syndrome and impaired glucose tolerance: Amelioration of exaggerated adrenal response to adrenocorticotropin with reduction of insulinemia/insulin resistance
    • DOI 10.1210/jc.87.4.1555
    • Arslanian SA, Lewy V, Danadian K, Saad R: Metformin therapy in obese adolescents with polycystic ovary syndrome and impaired glucose tolerance: amelioration of exaggerated adrenal response to adrenocorticotropin with reduction of insulinemia/insulin resistance. J Clin Endocrinol Metab 2002; 87: 1555-1559. (Pubitemid 34615238)
    • (2002) Journal of Clinical Endocrinology and Metabolism , vol.87 , Issue.4 , pp. 1555-1559
    • Arslanian, S.A.1    Lewy, V.2    Danadian, K.3    Saad, R.4
  • 37
    • 0032806555 scopus 로고    scopus 로고
    • The effects of metformin on insulin resistance and ovarian steroidogenesis in women with polycystic ovary syndrome
    • Oxf
    • Unlühizarci K, Keleştimur F, Bayram F, Sahin Y, Tutuş A: The effects of metformin on insulin resistance and ovarian steroidogenesis in women with polycystic ovary syndrome. Clin Endocrinol (Oxf) 1999; 51: 231-236.
    • (1999) Clin Endocrinol , vol.51 , pp. 231-236
    • Unlühizarci, K.1    Keleştimur, F.2    Bayram, F.3    Sahin, Y.4    Tutuş, A.5
  • 38
    • 0142247208 scopus 로고    scopus 로고
    • Metformin in polycystic ovary syndrome: Systematic review and meta-analysis
    • Lord JM, Flight IH, Norman RJ: Metformin in polycystic ovary syndrome: systematic review and meta-analysis. BMJ 2003; 327: 951-953.
    • (2003) BMJ , vol.327 , pp. 951-953
    • Lord, J.M.1    Flight, I.H.2    Norman, R.J.3
  • 39
    • 0028843928 scopus 로고
    • Weight loss results in significant improvement in pregnancy and ovulation rates in anovulatory obese women
    • Clark AM, Ledger W, Galletly C, Tomlinson L, Blaney F, Wang X, Norman RJ: Weight loss results in significant improvement in pregnancy and ovulation rates in anovulatory obese women. Hum Reprod 1995; 10: 2705-2712.
    • (1995) Hum Reprod , vol.10 , pp. 2705-2712
    • Clark, A.M.1    Ledger, W.2    Galletly, C.3    Tomlinson, L.4    Blaney, F.5    Wang, X.6    Norman, R.J.7
  • 40
    • 0042262529 scopus 로고    scopus 로고
    • Overweight and obese anovulatory patients with polycystic ovaries: Parallel improvements in anthropometric indices, ovarian physiology and fertility rate induced by diet
    • DOI 10.1093/humrep/deg367
    • Crosignani PG, Colombo M, Begetti W, Somigliana E, Gessati A, Ragni G: Overweight and obese anovulatory patients with polycystic ovaries: parallel improvements in anthropomorphic indices, ovarian physiology and fertility rate induced by diet. Hum Reprod 2003; 18: 1928-1932. (Pubitemid 37107570)
    • (2003) Human Reproduction , vol.18 , Issue.9 , pp. 1928-1932
    • Crosignani, P.G.1    Colombo, M.2    Vegetti, W.3    Somigliana, E.4    Gessati, A.5    Ragni, G.6
  • 41
    • 70349101714 scopus 로고    scopus 로고
    • Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome
    • CD006105
    • Tso LO, Costello MF, Andriolo RB, Freitas V: Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome. Cochrane Database Syst Rev 2009(2):CD006105.
    • (2009) Cochrane Database Syst Rev , Issue.2
    • Tso, L.O.1    Costello, M.F.2    Andriolo, R.B.3    Freitas, V.4
  • 42
    • 3042634808 scopus 로고    scopus 로고
    • Metformin treatment before IVF/ICSI in women with polycystic ovary syndrome; a prospective, randomized, double blind study
    • DOI 10.1093/humrep/deh248
    • Kjotrod SB, Von During V, Carlsen SM: Metformin treatment before IVF/ICSI in women with polycystic ovary syndrome; a prospective, randomized, double-blind study. Hum Reprod 2004; 6: 1315-1322. (Pubitemid 38807702)
    • (2004) Human Reproduction , vol.19 , Issue.6 , pp. 1315-1322
    • Kjotrod, S.B.1    Von, D.V.2    Carlsen, S.M.3
  • 43
    • 24044476642 scopus 로고    scopus 로고
    • Metformin treatment in patients with polycystic ovary syndrome undergoing in vitro fertilization: A prospective randomized trial
    • DOI 10.1016/j.fertnstert.2005.03.043, PII S0015028205010502
    • Onalan G, Pabuccu R, Goktolga U, et al: Metformin treatment in patients with polycystic ovary syndrome undergoing in vitro fertilization: a prospective randomized trial. Fertil Steril 2005; 4: 798-801. (Pubitemid 41317755)
    • (2005) Fertility and Sterility , vol.84 , Issue.3 , pp. 798-801
    • Onalan, G.1    Pabuccu, R.2    Goktolga, U.3    Ceyhan, T.4    Bagis, T.5    Cincik, M.6
  • 44
    • 33745670469 scopus 로고    scopus 로고
    • The use of metformin for women with PCOS undergoing IVF treatment
    • DOI 10.1093/humrep/del025
    • Tang T, Glanville J, Orsi N, Barth JH, Balen AH: The use of metformin for women with PCOS undergoing IVF treatment. Hum Reprod 2006; 6: 1416-1425. (Pubitemid 44445016)
    • (2006) Human Reproduction , vol.21 , Issue.6 , pp. 1416-1425
    • Tang, T.1    Glanville, J.2    Orsi, N.3    Barth, J.H.4    Balen, A.H.5
  • 46
    • 68549128622 scopus 로고    scopus 로고
    • Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiroinositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility
    • CD003053
    • Tang T, Lord JM, Norman RJ, Yasmin E, Balen AH: Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiroinositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility. Cochrane Database Syst Rev 2010(1): CD003053.
    • (2010) Cochrane Database Syst Rev , Issue.1
    • Tang, T.1    Lord, J.M.2    Norman, R.J.3    Yasmin, E.4    Balen, A.H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.