Two weeks of metformin improves clomiphene citrate-induced ovulation and metabolic profiles in women with polycystic ovary syndrome

Fertility and Sterility

Volumn 85, Issue 5, 2006, Pages 1448-1451

  Khorram, Omid ^a   Helliwell, Jason P ^a   Katz, Simone ^a   Bonpane, Colleen M ^a   Jaramillo, Lorena ^a  

^a HARBOR UCLA MEDICAL CENTER   (United States)

Author keywords

clomiphene; insulin; Metformin; obese PCOS; ovulation; SHBG; testosterone

Indexed keywords

CLOMIFENE CITRATE; MEDROXYPROGESTERONE ACETATE; METFORMIN; PROGESTERONE; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE;

ADULT; ARTICLE; BODY MASS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG RESPONSE; FEMALE; FEMALE INFERTILITY; HORMONE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; INSULIN TOLERANCE TEST; METABOLISM; OBESITY; OVARY POLYCYSTIC DISEASE; OVULATION; PATIENT COMPLIANCE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TESTOSTERONE BLOOD LEVEL; TREATMENT DURATION; TREATMENT OUTCOME; TREATMENT RESPONSE; UNIVERSITY HOSPITAL;

ADULT; CLOMIPHENE; DRUG ADMINISTRATION SCHEDULE; DRUG COMBINATIONS; FEMALE; FERTILITY AGENTS, FEMALE; HUMANS; HYPERINSULINISM; HYPOGLYCEMIC AGENTS; INFERTILITY; INSULIN; METFORMIN; OBESITY; OVULATION; OVULATION INDUCTION; POLYCYSTIC OVARY SYNDROME; SEX HORMONE-BINDING GLOBULIN; TREATMENT OUTCOME;

EID: 33646119426     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2005.10.042     Document Type: Article

References (25)

1. Lam P.M., Cheung L.P., and Haines C. Revisit of metformin treatment in polycystic ovarian syndrome. Gynecol Endocrinol 19 (2004) 33-39
2. Archer J.S., and Chang R.J. Hirsutism and acne in polycystic ovary syndrome. Best Pract Res Clin Obstet Gynaecol 18 (2004) 737-754
3. Hart R., Hickery M., and Frank S. Definitions, prevalence and symptoms of polycystic ovaries and polycystic ovarian syndrome. Best Pract Res Clin Obstet Gynaecol 18 (2004) 671-683
4. Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 81 (2004) 19-25
5. Dunaif A. Molecular mechanism of insulin resistance in the polycystic ovary syndrome. Semin Reprod Endocrinol 12 (1994) 15-20
6. Adashi E.Y., Resnick C.E., D'Ercole A.J., Svoboda M.E., and Van Wyk J.J. Insulin-like growth factors as intraovarian regulators of granulose cell growth and function. Endocrinol Rev 6 (1985) 400-420
7. Nestler J.E., Powers L.P., Matt D.W., Steingold K.A., Plymate S.R., Rittmaster R.S., et al. A direct effect of hyperinsulinemia on sex hormone binding globulin levels in obese women with polycystic ovary syndrome. J Clin Endocrinol Metab 72 (1991) 83-89
8. Dunaif A. Insulin resistance and the PCOS. mechanism and implication for pathogenesis. Endocrinol Rev 18 (1997) 774-800
9. Franks S., Gilling-Smith C., Watson H., and Willis D. Insulin action in the normal and polycystic ovary. Endocrinol Metab Clin N Am 28 (1999) 361-378
10. Nestler J.E., Stovall D., Akhten N., Ivorno M.J., and Jakubowicz M.J. Strategies for the use of insulin-sensitizing drugs to treat infertility in women with PCOS. Fertil Steril 77 (2002) 209-215
11. Nestler J.E., Jakubowicz D.J., Evans W.S., and Pasquali R. Effects of metformin on spontaneous and clomiphene induced ovulation in polycystic ovary syndrome. N Engl J Med 338 (1998) 1876-1880
12. Ng E.H., Wat N.M., and Ho P.C. Effects of metformin on ovulation rate, hormonal and metabolic profiles in women with clomiphene-resistant polycystic ovaries-randomized double-blinded placebo-controlled trial. Hum Reprod 16 (2001) 1625-1631
13. Homburg R. The management of infertility associated with polycystic ovary syndrome. Reprod Biol Endocrinol 14 (2003) 1-109
14. Bailey C.J., and Turner R.C. Metformin. N Engl J Med 334 (1991) 574-579
15. Aruna J., Mittal S., Kumar S., Misra R., Dadhwal V., and Vimala N. Metformin therapy in women with polycystic ovary syndrome. Int J Gynaecol Obstet 87 (2004) 237-241
16. Attia G.R., Rainey W.E., and Carr B.R. Metformin directly inhibits androgen production in human theca cells. Fertil Steril 76 (2001) 517-524
17. Baillargeon J.P., Jakubowicz D.J., Iuorno M.J., Kakubowicz S., and Nestler J.E. Effects of metformin and rosiglitazone, alone and in combination in nonobese women with polycystic ovary syndrome and normal indices of insulin sensitivity. Fertil Steril 82 (2004) 893-902
18. Kashyap A., Wells G.A., and Rosenwaks Z. Insulin-sensitizing agents as primary therapy for patients with polycystic ovarian syndrome. Hum Reprod 19 (2004) 2474-2483
19. Costello M.F., and Eden J.A. A systematic review of the reproductive system effects of metformin in patients with polycystic ovary syndrome. Fertil Steril 79 (2003) 1-13
20. Lord J.M., Flight I.H.K., and Norman R.J. Metformin in polycystic ovary syndrome. systematic review and meta-analysis. Brit Med J 327 (2005) 1-6
21. Vandermolen D.T., Ratts V.S., Evan W.S., Stovall D.W., Kauma S.W., and Nestler J.E. Metformin increases the ovulatory rate and pregnancy rate from clomiphene citrate in patients with polycystic ovary syndrome who are resistant to clomiphene citrate alone. Fertil Steril 75 (2001) 310-315
22. Fleming R., Hopkinson Z.E., Wallace A.M., Greer J.A., and Sattar N. Ovarian function and metabolic functions in women with oligomenorrhea treated with metformin in a randomized double blind placebo-controlled trial. J Clin Endocrinol Metab 87 (2002) 569-574
23. Iannello S., Camuto M., Cavaleri A., Milazzo P., Pisano M.G., Bellomia D., et al. Effects of short-term metformin treatment on insulin sensitivity of blood glucose and free fatty acids. Diabet Obes Metab 6 (2004) 8-15
24. Pirwany I.R., Yates R.W., Cameron I.T., and Fleming R. Effects of the insulin sensitizing drug metformin on ovarian function, follicular growth and ovulation rate in obese women with oligomenorrhea. Hum Reprod 14 (1990) 2963-2968
25. Parsanezhad M.E., Alborzi S., Zarei A., Dehbashi S., and Omrani G. Insulin resistance in clomiphene responders and no-responders with polycystic ovarian disease and therapeutic effects of metformin. Int J Gynecol Obstet 75 (2001) 43-50