Tacrolimus and cyclosporine A inhibit human osteoclast formation via targeting the calcineurin-dependent NFAT pathway and an activation pathway for c-Jun or MITF in rheumatoid arthritis

Clinical Rheumatology

Volumn 26, Issue 2, 2007, Pages 231-239

  Miyazaki, Masashi ^a   Fujikawa, Yosuke ^a   Takita, Chikahiro ^a   Tsumura, Hiroshi ^a  

^a OITA UNIVERSITY   (Japan)

Author keywords

Cyclosporine A; NFATc1; Osteoclast; Rheumatoid arthritis; Tacrolimus

Indexed keywords

ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; CALCINEURIN; COLONY STIMULATING FACTOR 1; COMPLEMENTARY DNA; CYCLOSPORIN A; MESSENGER RNA; MICROPHTHALMIA ASSOCIATED TRANSCRIPTION FACTOR; OSTEOCLAST DIFFERENTIATION FACTOR; PROTEIN C FOS; PROTEIN C JUN; TACROLIMUS; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR PU 1; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6;

ADULT; AGED; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL ISOLATION; CELL VIABILITY; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA SYNTHESIS; DRUG MECHANISM; DRUG TARGETING; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION; HISTOCHEMISTRY; HUMAN; HUMAN CELL; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; MALE; MONOCYTE; MULTINUCLEAR CELL; OSTEOCLAST; OSTEOLYSIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; RNA ISOLATION; SIGNAL TRANSDUCTION;

ADOLESCENT; ADULT; AGED; CELL COUNT; CELL DIFFERENTIATION; CELL SURVIVAL; CELLS, CULTURED; CYCLOSPORINE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENE EXPRESSION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LEUKOCYTES, MONONUCLEAR; MALE; MICROPHTHALMIA-ASSOCIATED TRANSCRIPTION FACTOR; MIDDLE AGED; NFATC TRANSCRIPTION FACTORS; OSTEOCLASTS; PROTO-ONCOGENE PROTEINS C-JUN; RNA, MESSENGER; TACROLIMUS;

EID: 33845870908     PISSN: 07703198     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10067-006-0287-1     Document Type: Article

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