RNA processing and modification protein, carbon catabolite repression 4 (Ccr4), arrests the cell cycle through p21-dependent and p53-independent pathway

Journal of Biological Chemistry

Volumn 287, Issue 25, 2012, Pages 21045-21057

  Yi, Xia ^a   Hong, Mei ^a,c   Gui, Bin ^a   Chen, Zhe ^a   Li, Lei ^a   Xie, Guojia ^a   Liang, Jing ^a   Wang, Xiaocheng ^a   Shang, Yongfeng ^a,b  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b TIANJIN MEDICAL UNIVERSITY   (China)

^c LANZHOU UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL FUNCTIONS; CARBON CATABOLITE REPRESSION; CELL CYCLE; CELL-CYCLE ARREST; CELL-CYCLE PROGRESSION; DEADENYLATION; MECHANISTIC STUDIES; MRNA STABILITY; NEW MEMBERS; NORMAL TISSUE; RNA PROCESSING; TUMOR TISSUES;

CARBON; CELL PROLIFERATION; CELLS; HISTOLOGY; PROTEINS; RNA; TISSUE;

CYTOLOGY;

CARBON CATABOLITE REPRESSION 4D PROTEIN; MESSENGER RNA; PROTEIN INHIBITOR; PROTEIN P21; PROTEIN P53; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ADULT; ARTICLE; CARCINOGENESIS; CELL CYCLE PROGRESSION; CELL CYCLE REGULATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; G1 PHASE CELL CYCLE CHECKPOINT; GROWTH INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; MOLECULAR CLONING; MOLECULAR PATHOLOGY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; PROTEIN RNA BINDING; RNA PROCESSING; RNA SEQUENCE; RNA STABILITY; UPREGULATION;

3' UNTRANSLATED REGIONS; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DOWN-REGULATION; HUMANS; NUCLEAR PROTEINS; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA STABILITY; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84862291365     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.355321     Document Type: Article

References (50)

1. 1 cell cycle control and cancer. Nature 432, 298-306
2. 1 cyclin-dependent kinases. Genes Dev. 9, 1149-1163
3. Sherr, C. J. (1998) Tumor surveillance via the ARF-p53 pathway. Genes Dev. 12, 2984-2991
4. Harper, J. W., Elledge, S. J., Keyomarsi, K., Dynlacht, B., Tsai, L. H., Zhang, P., Dobrowolski, S., Bai, C., Connell-Crowley, L., and Swindell, E. (1995) Inhibition of cyclin-dependent kinases by p21. Molecular biology of the cell 6, 387-400
5. Jung, Y. S., Qian, Y., and Chen, X. (2010) Examination of the expanding pathways for the regulation of p21 expression and activity. Cell. Signal. 22, 1003-1012
6. Abbas, T., and Dutta, A. (2009) p21 in cancer. Intricate networks and multiple activities. Nat. Rev. Cancer 9, 400-414
7. López de Silanes, I., Zhan, M., Lal, A., Yang, X., and Gorospe, M. (2004) Identification of a target RNA motif for RNA-binding protein HuR. Proc. Natl. Acad. Sci. U.S.A. 101, 2987-2992 (Pubitemid 38327723)
8. Waf1 mRNA contains a conserved element in its 3′-untranslated region that is bound by the Elavlike mRNA-stabilizing proteins. J. Biol. Chem. 273, 20511-20516
9. King, P. H., Levine, T. D., Fremeau, R. T., Jr., and Keene, J. D. (1994) Mammalian homologs of Drosophila ELAV localized to a neuronal subset can bind in vitro to the 3′-UTR of mRNA encoding the Id transcriptional repressor. J. Neurosci. 14, 1943-1952
10. Ma, W. J., Cheng, S., Campbell, C., Wright, A., and Furneaux, H. (1996) Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein. J. Biol. Chem. 271, 8144-8151 (Pubitemid 26108641)
11. Myer, V. E., Fan, X. C., and Steitz, J. A. (1997) Identification of HuR as a protein implicated in AUUUA-mediated mRNA decay. EMBO J. 16, 2130-2139 (Pubitemid 27170973)
12. Shu, L., Yan, W., and Chen, X. (2006) RNPC1, an RNA-binding protein and a target of the p53 family, is required for maintaining the stability of the basal and stress-induced p21 transcript. Genes Dev. 20, 2961-2972 (Pubitemid 44771731)
13. Cho, S. J., Zhang, J., and Chen, X. (2010) RNPC1 modulates the RNA-binding activity of, and cooperates with, HuR to regulate p21 mRNA stability. Nucleic Acids Res. 38, 2256-2267
14. Yano, M., Okano, H. J., and Okano, H. (2005) Involvement of Hu and heterogeneous nuclear ribonucleoprotein K in neuronal differentiation through p21 mRNA post-transcriptional regulation. J. Biol. Chem. 280, 12690-12699
15. Lal, A., Mazan-Mamczarz, K., Kawai, T., Yang, X., Martindale, J. L., and Gorospe, M. (2004) Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs. EMBO J. 23, 3092-3102 (Pubitemid 39093603)
16. Fukuda, T., Naiki, T., Saito, M., and Irie, K. (2009) hnRNP K interacts with RNA binding motif protein 42 and functions in the maintenance of cellular ATP level during stress conditions. Genes Cells 14, 113-128
17. Kao, P. N., Chen, L., Brock, G., Ng, J., Kenny, J., Smith, A. J., and Corthésy, B. (1994) Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells. NF45 and NF90. J. Biol. Chem. 269, 20691-20699 (Pubitemid 24260483)
18. Wilusz, C. J., Wormington, M., and Peltz, S. W. (2001) The cap-to-tail guide to mRNA turnover. Nat. Rev. Mol. Cell Biol. 2, 237-246 (Pubitemid 33676966)
19. Collart, M. A., and Panasenko, O. O. (2012) The Ccr4-Not complex. Gene 492, 42-53
20. Kruk, J. A., Dutta, A., Fu, J., Gilmour, D. S., and Reese, J. C. (2011) The multifunctional Ccr4-Not complex directly promotes transcription elongation. Genes Dev. 25, 581-593
21. Denis, C. L., and Chen, J. (2003) The CCR4-NOT complex plays diverse roles inmRNAmetabolism. Prog. Nucleic Acid Res. Mol. Biol. 73, 221-250 (Pubitemid 137639544)
22. Collart, M. A., and Timmers, H. T. (2004) The eukaryotic Ccr4-Not complex. A regulatory platform integrating mRNA metabolism with cellular signaling pathways? Prog. Nucleic Acid Res. Mol. Biol. 77, 289-322 (Pubitemid 39752475)
23. Lau, N. C., Kolkman, A., van Schaik, F. M., Mulder, K. W., Pijnappel, W. W., Heck, A. J., and Timmers, H. T. (2009) Human Ccr4-Not complexes contain variable deadenylase subunits. Biochem. J. 422, 443-453
24. Aslam, A., Mittal, S., Koch, F., Andrau, J. C., and Winkler, G. S. (2009) The Ccr4-NOT deadenylase subunits CNOT7 and CNOT8 have overlapping roles and modulate cell proliferation. Mol. Biol. Cell 20, 3840-3850
25. Wagner, E., Clement, S. L., and Lykke-Andersen, J. (2007) An unconventional human Ccr4-Caf1 deadenylase complex in nuclear cajal bodies. Mol. Cell. Biol. 27, 1686-1695
26. 2+-dependent endonuclease-related proteins in higher eukaryotes and characterization of orthologs of yCCR4 with a conserved leucine-rich repeat essential for hCAF1/hPOP2 binding. BMC Genomics 2, 9
27. Mittal, S., Aslam, A., Doidge, R., Medica, R., and Winkler, G. S. (2011) The Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the human Ccr4-Not complex contribute to the prevention of cell death and senescence. Mol. Biol. Cell 22, 748-758
28. Baggs, J. E., and Green, C. B. (2003) Nocturnin, a deadenylase in Xenopus laevis retina. A mechanism for posttranscriptional control of circadianrelated mRNA. Curr. Biol. 13, 189-198 (Pubitemid 36178296)
29. Wang, L., and Brown, S. J. (2006) BindN. A web-based tool for efficient prediction of DNA and RNA binding sites in amino acid sequences. Nucleic Acids Res. 34, W243-W248 (Pubitemid 44529772)
30. Thompson, J. D., Higgins, D. G., and Gibson, T. J. (1994) ClustalW. Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22, 4673-4680 (Pubitemid 24354800)
31. Hein, J. (1990) Unified approach to alignment and phylogenies. Methods Enzymol. 183, 626-645
32. Zhang, H., Yi, X., Sun, X., Yin, N., Shi, B., Wu, H., Wang, D., Wu, G., and Shang, Y. (2004) Differential gene regulation by the SRC family of coactivators. Genes Dev. 18, 1753-1765 (Pubitemid 38938190)
33. Yi, X., de Vries, H. I., Siudeja, K., Rana, A., Lemstra, W., Brunsting, J. F., Kok, R. M., Smulders, Y. M., Schaefer, M., Dijk, F., Shang, Y., Eggen, B. J., Kampinga, H. H., and Sibon, O. C. (2009) Stwl modifies chromatin compaction and is required to maintain DNA integrity in the presence of perturbed DNA replication. Mol. Biol. Cell 20, 983-994
34. Yi, X., Lemstra, W., Vos, M. J., Shang, Y., Kampinga, H. H., Su, T. T., and Sibon, O. C. (2008)Along-term flow cytometry assay to analyze the role of specific genes of Drosophila melanogaster S2 cells in surviving genotoxic stress. Cytometry A 73, 637-642 (Pubitemid 351930750)
35. Wang, W., Martindale, J. L., Yang, X., Chrest, F. J., and Gorospe, M. (2005) Increased stability of the p16 mRNA with replicative senescence. EMBO Rep. 6, 158-164 (Pubitemid 40309413)
36. Yang, X., Yu, W., Shi, L., Sun, L., Liang, J., Yi, X., Li, Q., Zhang, Y., Yang, F., Han, X., Zhang, D., Yang, J., Yao, Z., and Shang, Y. (2011) HAT4, a Golgi apparatus-anchored B-type histone acetyltransferase, acetylates free histone H4 and facilitates chromatin assembly. Mol. Cell 44, 39-50
37. Shi, L., Sun, L., Li, Q., Liang, J., Yu, W., Yi, X., Yang, X., Li, Y., Han, X., Zhang, Y., Xuan, C., Yao, Z., and Shang, Y. (2011) Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis. Proc. Natl. Acad. Sci. U.S.A. 108, 7541-7546
38. Li, R., Zhang, H., Yu, W., Chen, Y., Gui, B., Liang, J., Wang, Y., Sun, L., Yang, X., Zhang, Y., Shi, L., Li, Y., and Shang, Y. (2009) ZIP, a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis. EMBO J. 28, 2763-2776
39. Zhang, Y., Zhang, H., Liang, J., Yu, W., and Shang, Y. (2007) EMBO J. 26, 2645-2657
40. Wu, H., Chen, Y., Liang, J., Shi, B., Wu, G., Zhang, Y., Wang, D., Li, R., Yi, X., Zhang, H., Sun, L., and Shang, Y. (2005) Hypomethylation-linked activation of PAX2 mediates tamoxifen-stimulated endometrial carcinogenesis. Nature 438, 981-987 (Pubitemid 43093965)
41. Nakano, K., and Vousden, K. H. (2001) PUMA, a novel proapoptotic gene, is induced by p53. Mol. Cell 7, 683-694 (Pubitemid 32706359)
42. Mignone, F., Gissi, C., Liuni, S., and Pesole, G. (2002) Untranslated regions of mRNAs. Genome Biol. 3, REVIEWS0004
43. Wang, W., Furneaux, H., Cheng, H., Caldwell, M. C., Hutter, D., Liu, Y., Holbrook, N., and Gorospe, M. (2000) HuR regulates p21 mRNA stabilization by UV light. Mol. Cell. Biol. 20, 760-769 (Pubitemid 30044212)
44. Rhodes, D. R., Yu, J., Shanker, K., Deshpande, N., Varambally, R., Ghosh, D., Barrette, T., Pandey, A., and Chinnaiyan, A. M. (2004) ONCOMINE.A cancer microarray database and integrated data-mining platform. Neoplasia 6, 1-6 (Pubitemid 38391943)
45. Su, A. I., Welsh, J. B., Sapinoso, L. M., Kern, S. G., Dimitrov, P., Lapp, H., Schultz, P. G., Powell, S. M., Moskaluk, C. A., Frierson, H. F., Jr., and Hampton, G. M. (2001) Molecular classification of human carcinomas by use of gene expression signatures. Cancer Res. 61, 7388-7393 (Pubitemid 32995021)
46. Wang, Y., Klijn, J. G., Zhang, Y., Sieuwerts, A. M., Look, M. P., Yang, F., Talantov, D., Timmermans, M., Meijer-van Gelder, M. E., Yu, J., Jatkoe, T., Berns, E. M., Atkins, D., and Foekens, J. A. (2005) Gene-expression profiles to predict distant metastasis of lymph node-negative primary breast cancer. Lancet 365, 671-679 (Pubitemid 40260888)
47. Yang, X., Wang, W., Fan, J., Lal, A., Yang, D., Cheng, H., and Gorospe, M. (2004) Prostaglandin A2-mediated stabilization of p21 mRNA through an ERK-dependent pathway requiring the RNA-binding protein HuR. J. Biol. Chem. 279, 49298-49306 (Pubitemid 39625816)
48. Giles, K. M., Daly, J. M., Beveridge, D. J., Thomson, A. M., Voon, D. C., Furneaux, H. M., Jazayeri, J. A., and Leedman, P. J. (2003) The 3′-untranslated region of p21WAF1 mRNA is a composite cis-acting sequence bound by RNA-binding proteins from breast cancer cells, including HuR and poly(C)-binding protein. J. Biol. Chem. 278, 2937-2946 (Pubitemid 36801199)
49. Duale, N., Lindeman, B., Komada, M., Olsen, A. K., Andreassen, A., Soderlund, E. J., and Brunborg, G. (2007) Molecular portrait of cisplatin induced response in human testis cancer cell lines based on gene expression profiles. Mol. Cancer 6, 53
50. Hollams, E. M., Giles, K. M., Thomson, A. M., and Leedman, P. J. (2002) MRNA stability and the control of gene expression. Implications for human disease. Neurochem. Res. 27, 957-980 (Pubitemid 35316096)