Inhibition of lipid signaling enzyme diacylglycerol kinase ε attenuates mutant huntingtin toxicity

Journal of Biological Chemistry

Volumn 287, Issue 25, 2012, Pages 21204-21213

  Zhang, Ningzhe ^a   Li, Bensheng ^a   Al Ramahi, Ismael ^b   Cong, Xin ^a   Held, Jason M ^a   Kim, Eugene ^b   Botas, Juan ^b   Gibson, Bradford W ^a   Ellerby, Lisa M ^a  

^a BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE-3; CELL MODEL; CELLULAR TOXICITIES; DIACYLGLYCEROL KINASE; HUNTINGTIN; HUNTINGTON DISEASE; IN-VIVO; ISOFORMS; KINASE INHIBITORS; LIPID METABOLISMS; MUTANT HUNTINGTIN; N-TERMINALS; NEURONAL LOSS; POLYGLUTAMINE; POTENTIAL THERAPIES; PROMINENT FEATURES; STRIATUM; TRANSGENIC MICE;

AMINO ACIDS; BODY FLUIDS; GLYCEROL; MAMMALS; TOXICITY;

ENZYME INHIBITION;

CASPASE 3; CASPASE 7; DIACYLGLYCEROL KINASE; DIACYLGLYCEROL KINASE EPSILON; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; ENZYME LOCALIZATION; ENZYME SYNTHESIS; FEMALE; HUNTINGTON CHOREA; LIPID METABOLISM; MOUSE; NEUROTOXICITY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; CASPASE 3; CASPASE 7; CELL LINE; CORPUS STRIATUM; DIACYLGLYCEROL KINASE; HUMANS; HUNTINGTON DISEASE; LIPID METABOLISM; MICE; MICE, TRANSGENIC; MUTATION; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; SIGNAL TRANSDUCTION;

EID: 84862287742     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.321661     Document Type: Article

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