Synthesis and biological evaluation of new amino acid and dipeptide derivatives of neocryptolepine as anticancer agents

Journal of Medicinal Chemistry

Volumn 55, Issue 11, 2012, Pages 5077-5087

  Sidoryk, Katarzyna ^a   Świtalska, Marta ^b   Wietrzyk, Joanna ^b   Jaromin, Anna ^c   Piȩtka Ottlik, Magdalena ^d   Cmoch, Piotr ^a,e   Zagrodzka, Joanna ^a   Szczepek, Wojciech ^a   Kaczmarek, Łukasz ^a   Peczyńska Czoch, Wanda ^d  

^a INDUSTRIAL CHEMISTRY RESEARCH INSTITUTE   (Poland)

^b INSTITUTE OF IMMUNOLOGY AND EXPERIMENTAL THERAPY   (Poland)

^c UNIVERSITY OF WROC AW   (Poland)

^d WROCLAW UNIVERSITY OF TECHNOLOGY   (Poland)

^e INSTITUTE OF ORGANIC CHEMISTRY   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ANTINEOPLASTIC AGENT; CRYPTOLEPINE DERIVATIVE; CYCLOPHOSPHAMIDE; DIPEPTIDE DERIVATIVE; GLYCYLGLYCINE; HEMOLYTIC AGENT; INDOLOQUINOLINE DERIVATIVE; N (5,11 DIMETHYL 5H INDOLO[2,3 B]QUINOLIN 9 YL)GLYCYLGLYCYLAMIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER INHIBITION; CHEMICAL REACTION; COLON CANCER; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN TISSUE; HYDROPHILICITY; HYDROPHOBICITY; IN VITRO STUDY; IN VIVO STUDY; LIPOPHILICITY; LUNG CANCER; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY;

ALKALOIDS; AMINO ACIDS; ANIMALS; ANTINEOPLASTIC AGENTS; CARBOLINES; CELL LINE, TUMOR; DIPEPTIDES; DRUG SCREENING ASSAYS, ANTITUMOR; HEMOLYSIS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MICE; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84862283206     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300468t     Document Type: Article

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