Therapeutic hypothermia for the management of intracranial hypertension in severe traumatic brain injury: A systematic review

Brain Injury

Volumn 26, Issue 7-8, 2012, Pages 899-908

  Sadaka, Farid ^a   Veremakis, Christopher ^b  

^a SAINT LOUIS UNIVERSITY   (United States)

^b SAINT LOUIS UNIVERSITY HOSPITAL   (United States)

Author keywords

Hypothermia; ICP; Intracranial hypertension; TBI; Traumatic brain injury

Indexed keywords

BARBITURIC ACID DERIVATIVE;

BODY TEMPERATURE; CLINICAL RESEARCH; DISEASE SEVERITY; DRUG MEGADOSE; FEVER; HEART ARRHYTHMIA; HUMAN; HYPOTENSION; IMMUNOREACTIVITY; INDUCED HYPOTHERMIA; INJECTION SITE REACTION; INTRACRANIAL HYPERTENSION; INTRACRANIAL PRESSURE; LIVER TOXICITY; REVIEW; SIDE EFFECT; SYSTEMATIC REVIEW; TRAUMATIC BRAIN INJURY; TREATMENT OUTCOME;

EID: 84862277346     PISSN: 02699052     EISSN: 1362301X     Source Type: Journal    
DOI: 10.3109/02699052.2012.661120     Document Type: Review

References (92)

1. Dombovy ML, Olek AC. Recovery and rehabilitation following traumatic brain injury. Brain Injury 1997;11:305-318.
2. Rutland-Brown W, Langlois JA, Thomas KE, Xi YL. Incidence of traumatic brain injury in the United States, 2003. Journal of Head Trauma Rehabilitation 2006;21: 544-548.
3. Miller JD, Becker DP, Ward JD, Sullivan HG, Adams WE, Rosner MJ. Significance of intracranial hypertension in severe head injury. Journal of Neurosurgery 1977;47:503-516.
4. Miller JD, Dearden NM, Piper IR, Chan KH. Control of intracranial pressure in patients with severe head injury. Journal of Neurotrauma 1992;9(Suppl 1):S317-S326.
5. Marmarou A, Anderson PL, Ward JD, Choi SC, Young HF. Impact of ICP instability and hypotension on outcome in patients with severe head trauma. Journal of Neurosurgery 1991;75(Suppl):59-66.
6. Ghajar J, Hariri RJ, Patterson RH. Improved outcome from traumatic coma using only ventricular cerebrospinal fluid drainage for intracranial pressure control. Advances in Neurosurgery 1993;21:173-177.
7. Juul N, Morris GF, Marshall SB, Marshall LF. Intracranial hypertension and cerebral perfusion pressure: Influence on neurological deterioration and outcome in severe head injury. The Executive Committee of the International Selfotel Trial. Journal of Neurosurgery 2000;92:1-6.
8. Steiner T, Ringleb P, Hacke W. Treatment options for large hemispheric stroke. Neurology 2001;57:S61-S68.
9. Becker DP, Miller JD, Ward JD, Greenberg RP, Young HF, Sakalas R. The outcome from severe head injury with early diagnosis and intensive management. Journal of Neurosurgery 1977;47:491-502.
10. Qureshi AI, Geocadin RG, Suarez JI, Ulatowski JA. Long-term outcome after medical reversal of transtentorial herniation in patients with supratentorial mass lesions. Critical Care Medicine 2000;28:1556-1564.
11. Patel HC, Menon DK, Tebbs S, Hawker R, Hutchinson PJ, Kirkpatrick PJ. Specialist neurocritical care and outcome from head injury. Intensive Care Medicine 2002;28:547-553.
12. Brain Trauma Foundation; American Association of Neurological Surgeons; Congress of Neurological Surgeons; Joint Section on Neurotrauma and Critical Care, AANS/CNS. Guidelines for the management of severe traumatic brain injury. Journal of Neurotrauma 2007;24(Suppl 1):1-117.
13. Small DL, Morley P, Buchan AM. Biology of ischemic cerebral cell death. Progress in Cardiovascular Diseases 1999;42:185-207.
14. Milde LN. Clinical use of mild hypothermia for brain protection. A dream revisited. Journal of Neurosurgery Anesthesiology 1992;4:211-215.
15. Hagerdal M, Harp J, Nilsson L, Siesjö BK. The effect of induced hypothermia upon oxygen consumption in the rat brain. Journal of Neurochemistry 1975;24:311-316.
16. Povlishock JT, Buki A, Koiziumi H, Stone J, Okonkwo DO. Initiating mechanisms involved in the pathobiology of traumatically induced axonal injury and interventions targeted at blunting their progression. Acta Neurochirurgica Supplement (Wien) 1999;73:15-20.
17. Xu L, Yenari MA, Steinberg GK, Giffard RG. Mild hypothermia reduces apoptosis of mouse neurons in vitro early in the cascade. Journal of Cerebral Blood Flow and Metabolism 2002;22:21-28.
18. Liou AK, Clark RS, Henshall DC, Yin XM, Chen J. To die or not to die for neurons in ischemia, traumatic brain injury and epilepsy: A review on the stress-activated signaling pathways and apoptotic pathways. Progress in Neurobiology 2003;69:103-142.
19. Raghupathi R, Graham DI, McIntosh TK. Apoptosis after traumatic brain injury. Journal of Neurotrauma 2000;17: 927-938.
20. Leker RR, Shohami E. Cerebral ischemia and trauma- different etiologies yet similar mechanisms: Neuroprotective opportunities. Brain Research Brain Research Review 2002;39:55-73.
21. Siesjo BK, Bengtsson F, Grampp W, Theander S. Calcium, excitotoxins, and neuronal death in brain. Annals of the New York Academy of Sciences 1989;568:234-251.
22. Auer RN. Non-pharmacologic (physiologic) neuroprotection in the treatment of brain ischemia. Annals of the New York Academy of Sciences 2001;939:271-282.
23. Globus MY-T, Busto R, Lin B, Schnippering H, Ginsberg MD. Detection of free radical activity during transient global ischemia and recirculation: Effects of intraischemic brain temperature modulation. Journal of Neurochemistry 1995;65:1250-1256.
24. Dempsey RJ, Combs DJ, Maley ME, Cowen DE, Roy MW, Donaldson DL. Moderate hypothermia reduces postischemic edema development and leukotriene production. Neurosurgery 1987;21:177-181.
25. Busto R, Dietrich WD, Globus MY, Valdés I, Scheinberg P, Ginsberg MD. Small differences in intraischemic brain temperature critically determine the extent of ischemic neuronal injury. Journal of Cerebral Blood Flow Metabolism 1987;7:729-738.
26. Globus MY-T, Alonso O, Dietrich WD, Busto R, Ginsberg MD. Glutamate release and free radical production following brain injury: Effects of posttraumatic hypothermia. Journal of Neurochemistry 1995;65:1704-1711.
27. Baker AJ, Zornow MH, Grafe MR, Scheller MS, Skilling SR, Smullin DH, Larson AA. Hypothermia prevents ischemiainduced increases in hippocampal glycine concentrations in rabbits. Stroke 1991;22:666-673.
28. Kaibara T, Sutherland GR, Colbourne F, Tyson RL. Hypothermia: Depression of tricarboxylic acid cycle flux and evidence for pentose phosphate shunt upregulation. Journal of Neurosurgery 1999;90:339-347.
29. Takata K, Takeda Y, Morita K. Effects of hypothermia for a short period on histological outcome and extracellular glutamate concentration during and after cardiac arrest in rats. Critical Care Medicine 2005;33:1340-1345.
30. Schmidt OI, Heyde CE, Ertel W, Stahel PF. Closed head injury-an inflammatory disease? Brain Research Brain Research Review 2005;48:388-399.
31. Aibiki M, Maekawa S, Ogura S, Kinoshita Y, Kawai N, Yokono S. Effect of moderate hypothermia on systemic and internal jugular plasma IL-6 levels after traumatic brain injury in humans. Journal of Neurotrauma 1999;16:225-232.
32. Kimura A, Sakurada S, Ohkuni H, Todome Y, Kurata K. Moderate hypothermia delays proinflammatory cytokine production of human peripheral blood mononuclear cells. Critical Care Medicine 2002;30:1499-1502.
33. Suehiro E, Fujisawa H, Akimura T, Ishihara H, Kajiwara K, Kato S, Fujii M, Yamashita S, Maekawa T, Suzuki M. Increased matrix metalloproteinase-9 in blood in association with activation of interleukin-6 after traumatic brain injury: Influence of hypothermic therapy. Journal of Neurotrauma 2004;21:1706-1711.
34. Dietrich WD, Chatzipanteli K, Vitarbo E, Wada K, Kinoshita K. The role of inflammatory processes in the pathophysiology and treatment of brain and spinal cord trauma. Acta Neurochirurgica Supplement 2004;89:69-74.
35. Novack TA, Dillon MC, Jackson WT. Neurochemical mechanisms in brain injury and treatment: A review. Journal of Clinical Experimental Neuropsychology 1996;18: 685-706.
36. Raghupathi R, McIntosh TK. Pharmacotherapy for traumatic brain injury: A review. Proceedings of the Western Pharmacological Society 1998;41:241-246.
37. Smith SL, Hall ED. Mild pre- and posttraumatic hypothermia attenuates blood- brain barrier damage following controlled cortical impact injury in the rat. Journal of Neurotrauma 1996;13:1-9.
38. Jurkovich GJ, Pitt RM, Curreri PW, Granger DN. Hypothermia prevents increased capillary permeability following ischemia-reperfusion injury. Journal of Surgical Research 1988;44:514-521.
39. Chatauret N, Zwingmann C, Rose C, Leibfritz D, Butterworth RF. Effects of hypothermia on brain glucose metabolism in acute liver failure: A H/C nuclear magnetic resonance study. Gastroenterology 2003;125:815-824.
40. Vaquero J, Blei AT. Mild hypothermia for acute liver failure: A review of mechanisms of action. Journal of Clinical Gastroenterology 2005;39:S147-S157.
41. Soukup J, Zauner A, Doppenberg EM, Menzel M, Gilman C, Bullock R, Young HF. Relationship between brain temperature, brain chemistry and oxygen delivery after severe human head injury: The effect of mild hypothermia. Neurological Reserch 2002;24:161-168.
42. Kimura T, Sako K, Tanaka K, Kusakabe M, Tanaka T, Nakada T. Effect of mild hypothermia on energy state recovery following transient forebrain ischemia in the gerbil. Experimental Brain Research 2002;145:83-90.
43. Bottiger BW, Motsch J, Bohrer H, Böker T, Aulmann M, Nawroth PP, Martin E. Activation of blood coagulation after cardiac arrest is not balanced adequately by activation of endogenous fibrinolysis. Circulation 1995;92:2572-2578.
44. Gando S, Kameue T, Nanzaki S, Nakanishi Y. Massive fibrin formation with consecutive impairment of fibrinolysis in patients with out-of-hospital cardiac arrest. Thrombosis and Haemostasis 1997;77:278-282.
45. Michelson AD, MacGregor H, Barnard MR, Kestin AS, Rohrer MJ, Valeri CR. Hypothermia-induced reversible platelet dysfunction. Thrombosis and Haemostasis 1994;71: 633-640.
46. Watts DD, Trask A, Soeken K, Perdue P, Dols S, Kaufmann C. Hypothermic coagulopathy in trauma: Effect of varying levels of hypothermia on enzyme speed, platelet function, and fibrinolytic activity. Journal of Trauma 1998;44:846-854.
47. Hsu CY, Halushka PV, Hogan EL, Banik NL, Lee WA, Perot Jr PL. Alteration of thromboxane and prostacyclin levels in experimental spinal cord injury. Neurology 1985;35: 1003-1009.
48. Aibiki M, Maekawa S, Yokono S. Moderate hypothermia improves imbalances of thromboxane A2 and prostaglandin I2 production after traumatic brain injury in humans. Critical Care Medicine 2000;28:3902-3906.
49. Chen L, Piao Y, Zeng F, Lu M, Kuang Y, Ki X. Moderate hypothermia therapy for patients with severe head injury. Chinese Journal of Traumatology 2001;4:164-167.
50. Schaller B, Graf R. Hypothermia and stroke. The pathophysiological background. Pathophysiology 2003;10:7-35.
51. Rossi S, Zanier ER, Mauri I, Columbo A, Stocchetti N. Brain temperature, body core temperature, and intracranial pressure in acute cerebral damage. Journal of Neurology, Neurosurgery and Psychiatry 2001;71:448-454.
52. Soukup J, Zauner A, Doppenberg EM, Menzel M, Gilman C, Young HF, Bullock R. The importance of brain temperature in patients after severe head injury: Relationship to intracranial pressure, cerebral perfusion pressure, cerebral blood flow, and outcome. Journal of Neurotrauma 2002;19: 559-571.
53. Diringer MN, Reaven NL, Funk SE, Uman GC. Elevated body temperature independently contributes to increased length of stay in neurologic intensive care unit patients. Critical Care Medicine 2004;32:1611-1612.
54. Clifton GL, Miller ER, Choi SC, Levin HS, McCauley S, Smith Jr KR, Muizelaar JP, Wagner Jr FC, Marion DW, Luerssen TG, et al. Lack of effect of induction of hypothermia after acute brain injury. New England Journal of Medicine 2001;344:556-563.
55. Shiozaki T, Hayakata T, Taneda M, Nakajima Y, Hashiguchi N, Fujimi S, Nakamori Y, Tanaka H, Shimazu T, Sugimoto H. A multicenter prospective randomized induced trial of the efficacy of mild hypothermia for severely head injured patients with low intracranial pressure. Mild hypothermia study group in Japan. Journal of Neurosurgery 2001;94:50-54.
56. Clifton GL, Valadka A, Zygun D, Coffey CS, Drever P, Fourwinds S, Janis LS, Wilde E, Taylor P, Harshman K, et al. Very early hypothermia induction in patients with severe brain injury (the National Acute Brain Injury Study: Hypothermia II): A randomised trial. The Lancet Neurology 2011;10:131-139.
57. Maas A, Stocchetti N. Hypothermia and the complexity of trials in patients with traumatic brain injury. The Lancet Neurology 2011;10:111-113.
58. Shiozaki T, Sugimoto H, Taneda M, Yoshida H, Iwai A, Yoshioka T, Sugimoto T. Effect of mild hypothermia on uncontrollable intracranial hypertension after severe head injury. Journal of Neurosurgery 1993;79:363-368.
59. Marion DW, Obrist WD, Carlier PM, Penrod LE, Darby JM. The use of moderate therapeutic hypothermia for patients with severe head injuries: A preliminary report. Journal of Neurosurgery 1993;79:354-362.
60. Metz C, Holzschuh M, Bein T, Woertgen C, Frey A, Frey I, Taeger K, Brawanski A. Moderate hypothermia in patients with severe head injury: Cerebral and extracerebral effects. Journal of Neurosurgery 1996;86:911-914.
61. Marion DW, Penrod LE, Kelsey SF, Obrist WD, Kochanek PM, Palmer AM, Wisniewski SR, DeKosky ST. Treatment of traumatic brain injury with moderate hypothermia. New England Journal of Medicinne 1997;336:540-546.
62. Nara I, Shiogai T, Hara M, Saito I. Comparative effects of hypothermia, barbiturate, and osmotherapy for cerebral oxygen metabolism, intracranial pressure, and cerebral perfusion pressure in patients ith severe head injury. Acta Neurochirurgica Supplement 1998;71:22-26.
63. Tateishi A, Soejima Y, Taira Y, Nakashima K, Fujisawa H, Tsuchida E, Maekawa T, Ito H. Feasibility of the titration method of mild hypothermia in severely head-injured patients with intracranial hypertension. Neurosurgery 1998;42: 1065-1069.
64. Jiang J, Yu M, Zhu C. Effect of long-term mild hypothermia therapy in patients with severe traumatic brain injury: 1-year follow-up review of 87 cases. Journal of Neurosurgery 2000;93:546-549.
65. Polderman KH, Peerdeman SM, Girbes AR. Hypophosphatemia and hypomagnesemia induced by cooling in patients with severe head injury. Journal of Neurosurgery 2001;94:697-705.
66. Polderman KH, Tjong Tjin Joe R, Peerdeman SM, Vandertop WP, Girbes AR. Effects of therapeutic hypothermia on intracranial pressure and outcome in patients with severe head injury. Intensive Care Medicine 2002;28: 1563-1567.
67. Gal R, Cundrle I, Zimova I, Smrcka M. Mild hypothermia therapy for patients with severe brain injury. Clinical Neurology and Neurosurgery 2002;104:318-321.
68. Zhi D, Zhang S, Lin X. Study on therapeutic mechanism and clinical effect of mild hypothermia in patients with severe head injury. Surgical Neurology 2003;59:381-385.
69. Tokutomi T, Morimoto K, Miyagi T, Yamaguchi S, Ishikawa K, Shigemori M. Optimal temperature for the management of severe traumatic brain injury: Effect of hypothermia on intracranial pressure, systemic and intracranial hemodynamics, and metabolism. Neurosurgery 2003;52:102-111.
70. Smrcka M, Vidlák M, Máca K, Smrcka V, Gál R. The influence of mild hypothermia on ICP, CPP and outcome in patients with primary and secondary brain injury. Acta Neurochirurgica Supplement 2005;95:273-275.
71. Qiu WS, Liu WG, Shen H, Wang WM, Hang ZL, Zhang Y, Jiang SJ, Yang XF. Therapeutic effect of mild hypothermia on severe traumatic head injury. Chinese Journal of Traumatology 2005;8:27-32.
72. Jiang JY, Xu W, Li WP, Gao GY, Bao YH, Liang YM, Luo QZ. Effect of long-term mild hypothermia or short-term mild hypothermia on outcome of patients with severe traumatic brain injury. Journal of Cerebral Blood Flow Metabolism 2006;26:771-776.
73. Qiu W, Zhang Y, Sheng H, Zhang J, Wang W, Liu W, Chen K, Zhou J, Xu Z. Effects of therapeutic mild hypothermia on patients with severe traumatic brain injury after craniotomy. Journal of Critical Care 2007;22:229-236.
74. Sahuquillo J, Pérez-Bárcena J, Biestro A, Zavala E, Merino MA, Vilalta A, Poca MA, Garnacho A, Adalia R, Homar J, et al. Intravascular cooling for rapid induction of moderate hypothermia in severely head-injured patients: Results of a multicenter study (IntraCool). Intensive Care Medicine 2009;35:890-898.
75. Narayan RK, Kishore PR, Becker DP, Ward JD, Enas GG, Greenberg RP, Domingues Da Silva A, Lipper MH, Choi SC, Mayhall CG, et al. Intracranial pressure: To monitor or not to monitor? A review of our experience with severe head injury. Journal of Neurosurgery 1982;56: 650-659.
76. Lundberg N, Troupp H, Lorin H. Continuous recording of the ventricular-fluid pressure in patients with severe acute traumatic brain injury. A preliminary report. Journal of Neurosurgery 1965;22:581-590.
77. Marshall LF, Smith RW, Shapiro HM. The outcome with aggressive treatment in severe head injuries. Part I: The significance of intracranial pressure monitoring. Journal of Neurosurgery 1979;50:20-25.
78. Narayan RK, Greenberg RP, Miller JD, Enas GG, Choi SC, Kishore PR, Selhorst JB, Lutz 3rd HA, Becker DP. Improved confidence of outcome prediction in severe head injury. comparative analysis of the clinical examination, multimodality evoked potentials, CT scanning, and intracranial pressure. Journal of Neurosurgery 1981;54:751-762.
79. Eisenberg HM, Frankowski RF, Contant CF, Marshall LF, Walker MD. Highdose barbiturate control of elevated intracranial pressure in patients with severe head injury. Journal of Neurosurgery 1988;69:15-23.
80. Howells T, Elf K, Jones P, Ronne-Engström E, Piper I, Nilsson P, Andrews P, Enblad P. Pressure reactivity as guide in the treatment of cerebral perfusion pressure in patients with brain trauma. Journal of Neurosurgery 2005;102:311-317.
81. Saul TG, Ducker TB. Effect of intracranial pressure monitoring and aggressive treatment on mortality in severe head injury. Journal of Neurosurgery 1982;56:498-503.
82. Timofeev I, Kirkpatrick P, Corteen E, Hiler M, Czosnyka M, Menon DK, Pickard JD, Hutchinson PJ. Decompressive craniectomy in traumatic brain injury: Outcome following protocol-driven therapy. Acta Neurochirurgica Supplement 2006;96:11-16.
83. Sydenham E, Roberts I, Alderson P. Hypothermia for traumatic head injury. Cochrane Database of Systematic Reviews 2009, Issue 2. Art. No.: CD001048. DOI: 10.1002/ 14651858.CD001048.pub4.
84. Povlishock JT, Wei EP. Posthypothermic rewarming considerations following traumatic brain injury. Journal of Neurotrauma 2009;26:333-340.
85. McIntyre LA, Fergusson DA, Hebert PC, Moher D, Hutchison JS. Prolonged therapeutic hypothermia after traumatic brain injury in adults: A systematic review. JAMA: Journal of the American Medical Associtation 2003;289:2992-2999.
86. Abella BS, Rhee JW, Huang KN, Vanden Hoek TL, Becker LB. Induced hypothermia is underused after resuscitation from cardiac arrest: A current practice survey. Resuscitation 2005;64:181-186.
87. Wolfrum S, Radke PW, Pischon T, Willich SN, Schunkert H, Kurowski V. Mild therapeutic hypothermia after cardiacarrest- a nationwide survey on the implementation of the ILCOR guidelines in German intensive care units. Resuscitation 2007;72:207-213.
88. Hypothermia After Cardiac Arrest Study Group. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. New England Journal of Medicine 2002;346:549-556.
89. Bernard SA, Gray TW, Buist MD, Jones BM, Silvester W, Gutteridge G, Smith K. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. New England Journal of Medicine 2002;346:557-563.
90. Holzer M, Bernard SA, Hachimi-Idrissi S, Roine RO, Sterz F, Müllner M. Collaborative Group on Induced Hypothermia for Neuroprotection After Cardiac Arrest. Hypothermia for neuroprotection after cardiac arrest: Systematic review and individual patient data meta-analysis. Critical Care Medicine 2005;33:414-418.
91. Neumar RW, Nolan JP, Adrie C, Aibiki M, Berg RA, Bö ttiger BW, Callaway C, Clark RSB, Geocadin RG, Jauch EC, et al. Post-cardiac arrest syndrome: Epidemiology, pathophysiology, treatment, and prognostication: A consensus statement from the International Liaison Committee on Resuscitation (American Heart Association, Australian and New Zealand Council on Resuscitation, European Resuscitation Council, Heart and Stroke Foundation of Canada, InterAmerican Heart Foundation, Resuscitation Council of Asia, and the Resuscitation Council of Southern Africa); the American Heart Association Emergency Cardiovascular Care Committee; the Council on Cardiovascular Surgery and Anesthesia; the Council on Cardiopulmonary, Perioperative, and Critical Care; the Council on Clinical Cardiology; and the Stroke Council. Circulation 2008;118:2452-2483.
92. American Heart Association. American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Part 7.5: Postresuscitation Support. Circulation 2005;112:IV-84-IV-88.