Genome-wide associated loci influencing interleukin (IL)-10, IL-1Ra, and IL-6 levels in African Americans

Immunogenetics

Volumn 64, Issue 5, 2012, Pages 351-359

  Ayele, Fasil Tekola ^a   Doumatey, Ayo ^a   Huang, Hanxia ^a   Zhou, Jie ^a   Charles, Bashira ^a   Erdos, Michael ^a   Adeleye, Jokotade ^b   Balogun, Williams ^b   Fasanmade, Olufemi ^c   Johnson, Thomas ^c   Oli, Johnnie ^d   Okafor, Godfrey ^d   Amoah, Albert ^e   Eghan Jr , Benjamin A ^f   Agyenim Boateng, Kofi ^f   Acheampong, Joseph ^f   Adebamowo, Clement A ^g   Herbert, Alan ^h   Gerry, Norman ⁱ   Christman, Michael ⁱ   Chen, Guanjie ^a   Shriner, Daniel ^a   Adeyemo, Adebowale ^a   Rotimi, Charles N ^a   more..

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF IBADAN   (Nigeria)

^c UNIVERSITY OF LAGOS   (Nigeria)

^d UNIVERSITY OF NIGERIA   (Nigeria)

^e UNIVERSITY OF GHANA   (Ghana)

^f KWAME NKRUMAH UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Ghana)

^g UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^h BOSTON UNIVERSITY   (United States)

ⁱ Laboratory of Molecular and Cellular Biology of Hematopoiesis   (United States)

Author keywords

African American; Genome wide association study; Interleukin; Interleukin 10; Interleukin 1Ra; Interleukin 6

Indexed keywords

INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 6; ASB3 PROTEIN, HUMAN; IL10 PROTEIN, HUMAN; IL1RN PROTEIN, HUMAN; IL6 PROTEIN, HUMAN; INTERLEUKIN 1; PMS1 PROTEIN, HUMAN; PROTEIN 14 3 3; SUPPRESSOR OF CYTOKINE SIGNALING; TUMOR PROTEIN; YWHAZ PROTEIN, HUMAN;

ADULT; AFRICA; AFRICAN AMERICAN; ARTICLE; BODY MASS; CONTROLLED STUDY; FEMALE; GENE LOCUS; GENE REPLICATION; GENETIC ASSOCIATION; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; BLOOD; COHORT ANALYSIS; GENETICS; IMMUNOGENETICS; MIDDLE AGED; MULTIGENE FAMILY;

14-3-3 PROTEINS; ADULT; AFRICAN AMERICANS; COHORT STUDIES; FEMALE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; IMMUNOGENETIC PHENOMENA; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; INTERLEUKIN-1; INTERLEUKIN-10; INTERLEUKIN-6; MALE; MIDDLE AGED; MULTIGENE FAMILY; NEOPLASM PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS;

EID: 84862262490     PISSN: 00937711     EISSN: 14321211     Source Type: Journal    
DOI: 10.1007/s00251-011-0596-7     Document Type: Article

References (53)

1. Adeyemo A, Gerry N, Chen G et al (2009) A genome-wide association study of hypertension and blood pressure in African Americans. PLoS Genet 5:e1000564
2. Baltrus PT, Shim RS, Ye J,Watson L, Davis SK (2010) Socioeconomic position, stress, and cortisol in relation to waist circumference in African American and white women. Ethn Dis 20:376-382
3. Bluher M, Fasshauer M, Tonjes A, Kratzsch J, Schon MR, Paschke R (2005) Association of interleukin-6, C-reactive protein, interleukin-10 and adiponectin plasma concentrations with measures of obesity, insulin sensitivity and glucose metabolism. Exp Clin Endocrinol Diabetes 113:534-537
4. Bros M, Dexheimer N, Besche V, Masri J, Trojandt S, Hövelmeyer N, Reissig S, Massoumi R, Grabbe S, Waisman A, Reske-Kunz AB (2010) Mutated cylindromatosis gene affects the functional state of dendritic cells. Eur J Immunol 40:2848-2857
5. Cannavo E, Gerrits B, Marra G, Schlapbach R, Jiricny J (2007) Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2. J Biol Chem 282:2976-2986
6. Cartier A, Bergeron J, Poirier P et al (2009) Increased plasma interleukin-1 receptor antagonist levels in men with visceral obesity. Ann Med 41:471-478
7. Charles BA, Doumatey A, Huang H, Zhou J, Chen G, Shriner D, Adeyemo A, Rotimi CN (2011) The roles of IL-6, IL-10, and IL-1RA in obesity and insulin resistance in African-Americans. J Clin Endocrinol Metab epub 1945-7197
8. Crawford AG, Cote C, Couto J, Daskiran M, Gunnarsson C, Haas K, Haas S, Nigam SC, Schuette R (2010) Prevalence of obesity, type II diabetes mellitus, hyperlipidemia, and hypertension in the United States: findings from the GE Centricity Electronic Medical Record database. Popul Health Manag 13:151-161
9. de Craen AJ, Posthuma D, Remarque EJ, van den Biggelaar AH, Westendorp RG, Boomsma DI (2005) Heritability estimates of innate immunity: an extended twin study. Genes Immun 6:167-170
10. Di Renzo L, Bigioni M, Del Gobbo Vet al (2007) Interleukin-1 (IL-1) receptor antagonist gene polymorphism in normal weight obese syndrome: relationship to body composition and IL-1 alpha and beta plasma levels. Pharmacol Res 55:131-138
11. Donath MY, Shoelson SE (2011) Type 2 diabetes as an inflammatory disease. Nat Rev Immunol 11:98-107
12. Doumatey AP, Lashley KS, Huang H et al (2010) Relationships among obesity, inflammation, and insulin resistance in African Americans and West Africans. Obesity (Silver Spring) 18:598-603
13. Feairheller DL, Park JY, Rizzo V, Kim B, Brown MD (2011) Racial differences in the responses to shear stress in human umbilical vein endothelial cells. Vasc Health Risk Manag 7:425-431
14. Sims JE, Smith DE (2010) The IL-1 family: regulators of immunity. Nat Rev Immunol 10:89-102
15. Feng S, Wang S, Chen CC, Lan L (2011) GWAPower: a statistical power calculation software for genome-wide association studies with quantitative traits. BMC Genet 12:12
16. Ferrari SL, Ahn-Luong L, Garnero P, Humphries SE, Greenspan SL (2003) Two promoter polymorphisms regulating interleukin-6 gene expression are associated with circulating levels of C-reactive protein and markers of bone resorption in postmenopausal women. J Clin Endocrinol Metab 88:255-259
17. Ferrari SL, Karasik D, Liu J et al (2004) Interactions of interleukin-6 promoter polymorphisms with dietary and lifestyle factors and their association with bone mass in men and women from the Framingham Osteoporosis Study. J Bone Miner Res 19:552-559
18. Fishman D, Faulds G, Jeffery R et al (1998) The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest 102:1369-1376
19. Fisman EZ, Tenenbaum A (2010) The ubiquitous interleukin-6: a time for reappraisal. Cardiovasc Diabetol 9:62
20. Fumagalli M, Pozzoli U, Cagliani R, Comi GP, Riva S, Clerici M, Bresolin N, Sironi M (2009) Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions. J Exp Med 206:1395-1408
21. Gao X, Starmer JD (2008) AWclust: point-and-click software for nonparametric population structure analysis. BMC Bioinforma 9:77
22. Ge D, Zhang K, Need AC et al (2008) WGAViewer: software for genomic annotation of whole genome association studies. Genome Res 18:640-643
23. Gibson AW, Edberg JC, Wu J, Westendorp RG, Huizinga TW, Kimberly RP (2001) Novel single nucleotide polymorphisms in the distal IL-10 promoter affect IL-10 production and enhance the risk of systemic lupus erythematosus. J Immunol 166:3915-3922
24. Higgins JP, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. BMJ 327:557-560
25. Hohaus S, Giachelia M, Massini G et al (2009) Clinical significance of interleukin-10 gene polymorphisms and plasma levels in Hodgkin lymphoma. Leuk Res 33:1352-1356
26. Hurme M, Santtila S (1998) IL-1 receptor antagonist (IL-1Ra) plasma levels are co-ordinately regulated by both IL-1Ra and IL-1beta genes. Eur J Immunol 28:2598-2602
27. Juge-Aubry CE, Somm E, Giusti V et al (2003) Adipose tissue is a major source of interleukin-1 receptor antagonist: upregulation in obesity and inflammation. Diabetes 52:1104-1110
28. Juge-Aubry CE, Henrichot E, Meier CA (2005) Adipose tissue: a regulator of inflammation. Best Pract Res Clin Endocrinol Metab 19:547-566
29. Kile BT, Nicola NA, Alexander WS (2001) Negative regulators of cytokine signaling. Int J Hematol 73:292-298
30. King GL (2008) The role of inflammatory cytokines in diabetes and its complications. J Periodontol 79:1527-1534
31. Lai S, Fishman EK, Lai H, Pannu H, Detrick B (2009) Serum IL-6 levels are associated with significant coronary stenosis in cardiovascularly asymptomatic inner-city black adults in the US. Inflamm Res 58:15-21
32. Lai Z, Kalkunte S, Sharma S (2011) A critical role of interleukin-10 in modulating hypoxia-induced preeclampsia-like disease in mice. Hypertension 57:505-514
33. Levy D, Ehret GB, Rice K et al (2009) Genome-wide association study of blood pressure and hypertension. Nat Genet 41:677-687
34. Li Y, Willer CJ, Ding J, Scheet P, Abecasis GR (2010) MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes. Genet Epidemiol 34:816-834
35. McCarroll SA, Kuruvilla FG, Korn JM et al (2008) Integrated detection and population-genetic analysis of SNPs and copy number variation. Nat Genet 40:1166-1174
36. Mulero JJ, Pace AM, Nelken ST et al (1999) IL1HY1: a novel interleukin-1 receptor antagonist gene. Biochem Biophys Res Commun 263:702-706
37. Nicklin MJ, Barton JL, Nguyen M, FitzGerald MG, Duff GW, Kornman K (2002) A sequence-based map of the nine genes of the human interleukin-1 cluster. Genomics 79:718-725
38. Price AL, Patterson NJ, Plenge RM,Weinblatt ME, Shadick NA, Reich D (2006) Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet 38:904-909
39. Purcell S, Neale B, Todd-Brown K et al (2007) PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81:559-575
40. Rafiq S, Stevens K, Hurst AJ et al (2007) Common genetic variation in the gene encoding interleukin-1-receptor antagonist (IL-1RA) is associated with altered circulating IL-1RA levels. Genes Immun 8:344-351
41. Reiner AP, Wurfel MM, Lange LA et al (2008) Polymorphisms of the IL1-receptor antagonist gene (IL1RN) are associated with multiple markers of systemic inflammation. Arterioscler Thromb Vasc Biol 28:1407-1412
42. Reuss E, Fimmers R, Kruger A, Becker C, Rittner C, Hohler T (2002) Differential regulation of interleukin-10 production by genetic and environmental factors-a twin study. Genes Immun 3:407-413
43. Rotimi CN, Chen G, Adeyemo AA et al (2004) A genome-wide search for type 2 diabetes susceptibility genes in West Africans: the Africa America Diabetes Mellitus (AADM) Study. Diabetes 53:838-841
44. Ruchat SM, Despres JP, Weisnagel SJ, Chagnon YC, Bouchard C, Perusse L (2008) Genome-wide linkage analysis for circulating levels of adipokines and C-reactive protein in the Quebec family study (QFS). J Hum Genet 53:629-636
45. Shoelson SE, Lee J, Goldfine AB (2006) Inflammation and insulin resistance. J Clin Invest 116:1793-1801
46. Shriner D, Adeyemo A, Chen G, Rotimi CN (2010) Practical considerations for imputation of untyped markers in admixed populations. Genet Epidemiol 34:258-265
47. Smith AJ, Humphries SE (2009) Cytokine and cytokine receptor gene polymorphisms and their functionality. Cytokine Growth Factor Rev 20:43-59
48. Tinsley JH, South S, Chiasson VL, Mitchell BM (2010) Interleukin-10 reduces inflammation, endothelial dysfunction, and blood pressure in hypertensive pregnant rats. Am J Physiol Regul Integr Comp Physiol 298:R713-R719
49. Walston JD, Fallin MD, Cushman M et al (2007) IL-6 gene variation is associated with IL-6 and C-reactive protein levels but not cardiovascular outcomes in the Cardiovascular Health Study. Hum Genet 122:485-494
50. Wellen KE, Hotamisligil GS (2005) Inflammation, stress, and diabetes. J Clin Invest 115:1111-1119
51. Westendorp RG, Langermans JA, Huizinga TW, Verweij CL, Sturk A (1997) Genetic influence on cytokine production in meningococcal disease. Lancet 349:1912-1913
52. Willer CJ, Li Y, Abecasis GR (2010) METAL: fast and efficient metaanalysis of genomewide association scans. Bioinformatics 26:2190-2191
53. Yang W, Shen N, Ye DQ et al (2010) Genome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus. PLoS Genet 6:e1000841