Serum IL-6 levels are associated with significant coronary stenosis in cardiovascularly asymptomatic inner-city black adults in the US

Inflammation Research

Volumn 58, Issue 1, 2009, Pages 15-21

  Lai, S ^a   Fishman, E K ^a   Lai, H ^a   Pannu, H ^a   Detrick, B ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Black race; CT coronary angiography; Interleukin 6 (IL 6); Marker for clinically silent CAD; Significant coronary stenosis

Indexed keywords

C REACTIVE PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ANGIOCARDIOGRAPHY; ARTICLE; CALCIFICATION; CARDIOVASCULAR RISK; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CORONARY ARTERY OBSTRUCTION; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PROTEIN BLOOD LEVEL; UNITED STATES;

ADULT; AFRICAN AMERICANS; BIOLOGICAL MARKERS; BLOOD PRESSURE; CALCINOSIS; CORONARY ARTERY DISEASE; CORONARY STENOSIS; FEMALE; HUMANS; INTERLEUKIN-6; LIPIDS; MIDDLE AGED; UNITED STATES;

EID: 58549093236     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-008-8150-2     Document Type: Article

References (45)

1. Stanford W. The role of coronary artery calcification in coronary artery disease. Int J of Cardiovasc Imaging 2001; 17: 473-4.
2. Gillum RF. The epidemiology of cardiovascular disease in black Americans. New Engl J Med 1996; 335: 1597-9.
3. Ferdinand KC. Coronary heart disease and lipid-modifying treatment in African American patients. Am Heart J 2004; 147: 774-82.
4. U.S. Department of Health and Human Services, Task Force on Black & Minority Health. Report of the Secretary's Task Force on Black & Minority Health. Washington, D.C, 1985.
5. U.S. Department of Health and Human Services. Healthy People 2000: National Health Promotion and Disease Prevention Objectives: full report, with commentary. Washington, D.C.: Government Printing Office, 1990. (DHHS publication no. (PHS) 91-50212.)
6. House JS, Kessler RC, Herzog AR. Age, socioeconomic status, and health. Milbank Q 1990; 68: 383-411.
7. Geronimus AT. The weathering hypothesis and the health of African-American women and infants: evidence and speculations. Ethn Dis 1992; 2: 207-21.
8. Sorlie PD, Backlund E, Keller JB. US mortality by economic, demographic, and social characteristics: the National Longitudinal Mortality Study. Am J Public Health 1995; 85: 949-56.
9. Pappas G, Queen S, Hadden W, Fisher G. The increasing disparity in mortality between socioeconomic groups in the United States, 1960 and 1986. N Engl J Med 1993; 329: 103-9.
10. Wilson PW, D'Agostino RB, Levy D, Belanger AM, Silbershatz H, Kannel WB. Prediction of coronary heart disease using risk factor categories. Circulation 1998; 97: 1837-47.
11. Ross R. Atherosclerosis-an inflammatory disease. N Engl J Med 1999; 340: 115-26.
12. Lee WY, Allison MA, Kim DJ, Song CH, Barrett-Connor E. Association of interleukin-6 and C-reactive protein with subclinical carotid atherosclerosis (the Rancho Bernado Study). Am J Cardiol 2007; 99: 99-102.
13. Bild DE, Folsom AR, Lowe LP, Sidney S, Kiefe C, Westfall AO, et al. Prevalence and correlates of coronary calcification in black and white young adults The Coronary Artery Risk Development in Young Adults (CARDIA) Study. Arterioscler Thromb Vasc Biol 2001; 21: 852-7.
14. Libby P. Inflammation in atherosclerosis. Nature 2002; 420: 868-74.
15. Hoffmeister A, Rothenbacher D, Kunze M, Brenner H, Koenig W. Prognostic value of Inflammatory markers alone and in combination with blood lipids in patients with stable coronary artery disease. Eur J Intern Med 2005; 16: 47-52.
16. Ikonomidis I ,Stamatelopoulos K, Lekakis J, Vamvakou GD, Kremastinos DT. Inflammatory and non-invasive vascular markers: the multimarker approach for risk stratification in coronary artery disease. Atherosclerosis 2008; 199: 3-11.
17. Woods A, Brull DJ, Humphries SE, Montgomery HE. Genetics of inflammation and risk of coronary artery disease: the central role of interleukin-6. Eur Heart J, 2000; 21: 1574-83.
18. Yudkin JS, Kumari M, Humphries, Mohamed-Ali. Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link? Atherosclerosis. 2000; 148: 209-14.
19. Erren M, Reinecke H, Junker R, Fobker M, Schulte H, Schurek JO, et al. Systemic inflammatory parameters in patients with atherosclerosis of the coronary and peripheral arteries. Arterioscler Thromb Vasc Biol 1999; 19: 2355-63.
20. Volpato S, Guralnik JM, Ferrucci L, Balfour J, Chaves P, Fried LP, et al. Cardiovascular disease, interleukin-6, and risk of mortality in older women: the women's health and aging study. Circulation 2001; 103: 947-53.
21. Ridker PM, Rifai N, Stampfer MJ, Hennekens CH. Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. Circulation 2000; 101: 1767-72.
22. Biasucci LM, Vitelli A, Liuzzo G, Altamura S, Caligiuri G, Monaco C, et al. Elevated levels of interleukin-6 in unstable angina. Circulation 1996; 94: 874-7.
23. McCarthy MJ, Loftus IM, Thompson MM, Jones L, London NJ, Bell PR, et al. Angiogenesis and the atherosclerotic carotid plaque: an association between symptomatology and plaque morphology. J Vasc Surg 1999; 30: 261-8.
24. Fisman EZ, Benderly M, Esper RJ, Behar S, Boyko V, Adler Y, et al. Interleukin-6 and the risk of future cardiovascular events in patients with angina pectoris and/or healed myocardial infarction. Am J Cardiol 2006; 98: 14-8.
25. Lindahl B, Toss H, Siegbahn A, Venge P, Wallentin L. Markers of myocardial damage and inflammation in relation to long-term mortality in unstable coronary artery disease. FRISC Study Group. Fragmin during Instability in Coronary Artery Disease. N Engl J Med 2000; 343: 1139-47.
26. Rus HG, Vlaicu R, Niculescu F. Interleukin-6 and interleukin-8 protein and gene expression in human arterial atherosclerotic wall. Atherosclerosis 1996; 127: 263-71.
27. Amar J, Fauvel J, Drouet L, Ruidavets JB, Perret B, Chamontin B, et al. Interleukin 6 is associated with subclinical atherosclerosis: a link with soluble intercellular adhesion molecule 1. J Hypertens 2006: 24: 1083-8.
28. Noto D, Cottone S, Cefalu AB, Vadala A, Barbagallo CM, Rizzo M, et al. Interleukin 6 plasma levels predict with high sensitivity and specificity coronary stenosis detected by coronary angiography. Thromb Haemost 2007; 98: 1362-7.
29. Mogensen TH, Paludan SR. Molecular pathways in virus-induced cytokine production. Microbiol Mol Biol Rev 2001; 65: 131-50.
30. Sanders CM, Cruse JM, Lewis RE. Toll-like receptors, cytokines and HIV-1. Exp Mol Pathol 2008; 84: 31-6.
31. Elkind MS. Inflammation, atherosclerosis, and stroke. Neurologist 2006;12:140-8.
32. Munro JM, van der Walt JD, Munro CS, Chalmers JA, Cox EL. An immunohistochemical analysis of human aortic fatty streaks. Hum Pathol 1987; 18: 375-80.
33. Stary HC, Chandler AB, Glagov S, Guyton JR, Insull W Jr, Rosenfeld ME, et al. A definition of initial, fatty streak, and intermediate lesions of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Circulation 1994; 89: 2462-78.
34. van der Wal AC, Das PK, Bentz van de Berg D, van der Loos CM, Becker AE. Atherosclerotic lesions in humans: in situ immunophenotypic analysis suggesting an immune mediated response. Lab Invest 1989; 61: 166-70.
35. Nilsson J. Cytokines and smooth muscle cells in atherosclerosis. Cardiovasc Res 1993; 27: 1184-90.
36. Lee RT, Libby P. The unstable atheroma. Arterioscler Thromb Vasc Biol 1997; 17: 1859-67.
37. Schönbeck U, Mach F, Sukhova GK, Murphy C, Bonnefoy JY, Fabunmi RP, et al. Regulation of matrix metalloproteinase expression in human vascular smooth muscle cells by T lymphocytes: a role for CD40 signaling in plaque rupture? Circ Res 1997; 81: 448-54.
38. Reilly MP, Rohatgi A, McMahon K, Wolfe ML, Pinto SC, Rhodes T, et al. Plasma cytokines, metabolic syndrome, and atherosclerosis in humans. J Investig Med 2007; 55: 26-35.
39. Munoz C, Misset B, Fitting C, Bleriot JP, Carlet J, Cavaillon JM. Dissociation between plasma and monocyte-associated cytokines during sepsis. Eur J Immunol 1991; 21: 2177-84.
40. Kiecolt-Glaser JK, Preacher KJ, MacCallum RC, Atkinson C, Malarkey WB, Glaser R. Chronic stress and age-related increases in the proinflammatory cytokine IL-6. Proc Natl Acad Sci USA 2003; 100: 9090-5.
41. Pannu HK, Jacobs JE, Lai S, Fishman EK. Coronary CT angiography with 64-MDCT: assessment of vessel visibility. AJR Am J Roentgenol 2006; 187: 119-26.
42. Raff GL, Gallagher MJ, O'Neill WW, Goldstein JA. Diagnostic accuracy of noninvasive coronary angiography using 64-slice spiral computed tomography. J Am Coll Cardiol 2005; 46: 552-7.
43. Leber AW, Knez A, von Ziegler F, Becker A, Nikolaou K, Paul S, et al. Quantification of obstructive and nonobstructive coronary lesions by 64-slice computed tomography: a comparative study with quantitative coronary angiography and intravascular ultrasound. J Am Coll Cardiol 2005; 46: 147-54.
44. Leschka S, Alkadhi H, Plass A, Desbiolles L, Grünenfelder J, Marincek B, et al. Accuracy of MSCT coronary angiography with 64-slice technology: first experience. Eur Heart J 2005; 26: 1482-7.
45. Mollet NR, Cademartiri F, van Mieghem CA, Runza G, McFadden EP, Baks T, et al. High-resolution spiral computed tomography coronary angiography in patients referred for diagnostic conventional coronary angiography. Circulation 2005; 112: 2318-23.