Aortic valve calcium independently predicts coronary and cardiovascular events in a primary prevention population

JACC: Cardiovascular Imaging

Volumn 5, Issue 6, 2012, Pages 619-625

  Owens, David S ^a   Budoff, Matthew J ^b   Katz, Ronit ^a   Takasu, Junichiro ^b   Shavelle, David M ^c   Carr, J Jeffrey ^d   Heckbert, Susan R ^a   Otto, Catherine M ^a   Probstfield, Jeffrey L ^a   Kronmal, Richard A ^a   O'Brien, Kevin D ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UCLA MEDICAL CENTER   (United States)

^d WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

aortic sclerosis; aortic valve calcium; atherosclerosis; cardiovascular death; cardiovascular events; computed tomography; coronary artery calcium; coronary events

Indexed keywords

AORTIC VALVE CALCIUM; BIOLOGICAL MARKER; CALCIUM; UNCLASSIFIED DRUG;

ADULT; AGED; AORTA VALVE; ARTICLE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR MORTALITY; CARDIOVASCULAR RISK; COMPUTER ASSISTED TOMOGRAPHY; CORONARY ARTERY ATHEROSCLEROSIS; FEMALE; FOLLOW UP; HEART ARREST; HEART INFARCTION; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIMARY PREVENTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; STROKE;

AGED; AGED, 80 AND OVER; AORTIC VALVE; CALCINOSIS; CARDIOVASCULAR DISEASES; CHI-SQUARE DISTRIBUTION; CORONARY ARTERY DISEASE; FEMALE; HEART VALVE DISEASES; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; MULTIDETECTOR COMPUTED TOMOGRAPHY; PREDICTIVE VALUE OF TESTS; PRIMARY PREVENTION; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; RISK ASSESSMENT; RISK FACTORS; SCLEROSIS; TIME FACTORS; UNITED STATES;

EID: 84862202240     PISSN: 1936878X     EISSN: 18767591     Source Type: Journal    
DOI: 10.1016/j.jcmg.2011.12.023     Document Type: Article

References (20)

1. B.F. Stewart, D. Siscovick, B.K. Lind Clinical factors associated with calcific aortic valve disease Cardiovascular Health Study J Am Coll Cardiol 29 1997 630 634 (Pubitemid 27116107)
2. Y. Agmon, B.K. Khandheria, I. Meissner Aortic valve sclerosis and aortic atherosclerosis: different manifestations of the same disease? Insights from a population-based study J Am Coll Cardiol 38 2001 827 834 (Pubitemid 32835760)
3. M. Lindroos, M. Kupari, J. Valvanne, T. Strandberg, J. Heikkila, R. Tilvis Factors associated with calcific aortic valve degeneration in the elderly Eur Heart J 15 1994 865 870 (Pubitemid 24223943)
4. D.S. Owens, R. Katz, J. Takasu, R. Kronmal, M.J. Budoff, K.D. O'Brien Incidence and progression of aortic valve calcium in the Multi-ethnic Study of Atherosclerosis (MESA) Am J Cardiol 105 2010 701 708
5. K.D. O'Brien Pathogenesis of calcific aortic valve disease A disease process comes of age (and a good deal more) Arterioscler Thromb Vasc Biol 26 2006 1721 1728 (Pubitemid 44305324)
6. C.M. Otto, B.K. Lind, D.W. Kitzman, B.J. Gersh, D.S. Siscovick Association of aortic-valve sclerosis with cardiovascular mortality and morbidity in the elderly N Engl J Med 341 1999 142 147 (Pubitemid 29325741)
7. D.E. Bild, D.A. Bluemke, G.L. Burke Multi-ethnic study of atherosclerosis: objectives and design Am J Epidemiol 156 2002 871 881 (Pubitemid 35215769)
8. R. Detrano, A.D. Guerci, J.J. Carr Coronary calcium as a predictor of coronary events in four racial or ethnic groups N Engl J Med 358 2008 1336 1345 (Pubitemid 351468410)
9. M.J. Budoff, R. Katz, N.D. Wong Effect of scanner type on the reproducibility of extracoronary measures of calcification: the multi-ethnic study of atherosclerosis Acad Radiol 14 2007 1043 1049 (Pubitemid 47248343)
10. M.J. Budoff, J. Takasu, R. Katz Reproducibility of CT measurements of aortic valve calcification, mitral annulus calcification, and aortic wall calcification in the multi-ethnic study of atherosclerosis Acad Radiol 13 2006 166 172 (Pubitemid 43120727)
11. J.J. Carr, J.C. Nelson, N.D. Wong Calcified coronary artery plaque measurement with cardiac CT in population-based studies: standardized protocol of Multi-Ethnic Study of Atherosclerosis (MESA) and Coronary Artery Risk Development in Young Adults (CARDIA) study Radiology 234 2005 35 43 (Pubitemid 39658367)
12. M.J. Budoff, S. Mao, J. Takasu, D.M. Shavelle, X.Q. Zhao, K.D. O'Brien Reproducibility of electron-beam CT measures of aortic valve calcification Acad Radiol 9 2002 1122 1127
13. D.M. Shavelle, M.J. Budoff, N. Buljubasic Usefulness of aortic valve calcium scores by electron beam computed tomography as a marker for aortic stenosis Am J Cardiol 92 2003 349 353 (Pubitemid 36897731)
14. D. Messika-Zeitoun, M.C. Aubry, D. Detaint Evaluation and clinical implications of aortic valve calcification measured by electron-beam computed tomography Circulation 110 2004 356 362 (Pubitemid 38955506)
15. A.S. Agatston, W.R. Janowitz, F.J. Hildner, N.R. Zusmer, M. Viamonte Jr., R. Detrano Quantification of coronary artery calcium using ultrafast computed tomography J Am Coll Cardiol 15 1990 827 832 (Pubitemid 20101575)
16. P. Greenland, L. LaBree, S.P. Azen, T.M. Doherty, R.C. Detrano Coronary artery calcium score combined with Framingham score for risk prediction in asymptomatic individuals JAMA 291 2004 210 215 (Pubitemid 38082815)
17. P. Raggi, M.C. Gongora, A. Gopal, T.Q. Callister, M. Budoff, L.J. Shaw Coronary artery calcium to predict all-cause mortality in elderly men and women J Am Coll Cardiol 52 2008 17 23 (Pubitemid 351858598)
18. K. Nasir, L.J. Shaw, S.T. Liu Ethnic differences in the prognostic value of coronary artery calcification for all-cause mortality J Am Coll Cardiol 50 2007 953 960 (Pubitemid 47313606)
19. R. Rosenhek, T. Binder, G. Porenta Predictors of outcome in severe, asymptomatic aortic stenosis N Engl J Med 343 2000 611 617 (Pubitemid 30659472)
20. R. Rosenhek, R. Zilberszac, M. Schemper Natural history of very severe aortic stenosis Circulation 121 2010 151 156