Synthesis and evaluation of novel podophyllotoxin analogs

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 13, 2012, Pages 4293-4295

  Li, Jie ^a,b   Hua, Hui Ming ^b   Tang, Yan Bo ^a   Zhang, Shipeng ^a   Ohkoshi, Emika ^c   Lee, Kuo Hsiung ^c,d   Xiao, Zhi Yan ^a  

^a PEKING UNION MEDICAL COLLEGE   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^c University of North Carolina   (United States)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Cytotoxicity; Podophyllotoxin; Structural modification

Indexed keywords

PODOPHYLLOTOXIN DERIVATIVE;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; TUMOR CELL;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DNA TOPOISOMERASES, TYPE II; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; PODOPHYLLOTOXIN; STRUCTURE-ACTIVITY RELATIONSHIP; TOPOISOMERASE II INHIBITORS;

EID: 84862195172     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.05.033     Document Type: Article

References (8)

1. st ed., pp. 71
2. M. Gordaliza, M.A. Castro, J.M. Miguel del Corral, M.L. López-Vázquez, P.A. García, A.S. Feliciano, M.D. García-Grávalos, and H. Broughton Tetrahedron 53 1997 15743
3. M.A. Castro, J.M. MigueldelCorral, M. Gordaliza, P. García, M.A. Gómez-Zurita, M.D. García-Grávalos, J. de la Iglesia-Vincente, C. Gajate, F. An, F. Mollinedo, and A.S. Feliciano J. Med. Chem. 47 2004 1214
4. S.J. Cho, Y. Kashiwada, K.F. Bastow, Y.C. Cheng, and K.H. Lee J. Med. Chem. 39 1996 1396
5. Z.Q. Wang, H. Hu, H.X. Chen, Y.C. Cheng, and K.H. Lee J. Med. Chem. 35 1992 871
6. A.J. Mancuso, and D. Swern Synthesis 1981 165
7. W.J. Gensler, and C.D. Gatsons J. Org. Chem. 31 1966 3224
8. Y. Aso, Y. Hayashi, S. Yoshioka, Y. Takeda, Y. Kita, Y. Nishimura, and Y. Arata Chem. Pharm. Bull. 37 1989 422