Characterization of a novel Fibroblast growth factor 10 (Fgf10) knock-in mouse line to target mesenchymal progenitors during embryonic development

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  El Agha, Elie ^a   Al Alam, Denise ^b   Carraro, Gianni ^a   MacKenzie, BreAnne ^a   Goth, Kerstin ^a   de Langhe, Stijn P ^c   Voswinckel, Robert ^d   Hajihosseini, Mohammad K ^e   Rehan, Virender K ^f   Bellusci, Saverio ^a,b  

^a JUSTUS LIEBIG UNIVERSITY GIESSEN   (Germany)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c DEPARTMENT OF MEDICINE   (United States)

^d MAX PLANCK INSTITUTE FOR HEART AND LUNG RESEARCH   (Germany)

^e UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR 10; YELLOW FLUORESCENT PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL LABELING; CONTROLLED STUDY; DEVELOPMENTAL STAGE; EMBRYO; EMBRYO DEVELOPMENT; EXON; FEMALE; FFG10 GENE; GENE; GENE CASSETTE; GENE DISRUPTION; GENE EXPRESSION; GENE INACTIVATION; GENE INSERTION; GENE TARGETING; INTERNAL RIBOSOME ENTRY SITE; INTRON; MALE; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN;

ANIMALS; BASE SEQUENCE; DNA PRIMERS; EMBRYONIC DEVELOPMENT; EXONS; FIBROBLAST GROWTH FACTOR 10; GENE SILENCING; MESENCHYMAL STROMAL CELLS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; POLYMERASE CHAIN REACTION; TAMOXIFEN;

EID: 84862167454     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0038452     Document Type: Article

References (26)

1. Min H, Danilenko DM, Scully SA, Bolon B, Ring BD, et al. (1998) Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless. Genes Dev 12: 3156-3161.
2. Sekine K, Ohuchi H, Fujiwara M, Yamasaki M, Yoshizawa T, et al. (1999) Fgf10 is essential for limb and lung formation. Nat Genet 21: 138-141.
3. De Moerlooze L, Spencer-Dene B, Revest JM, Hajihosseini M, Rosewell I, et al. (2000) An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis. Development 127: 483-492.
4. Fairbanks TJ, Kanard RC, De Langhe SP, Sala FG, Del Moral PM, et al. (2004) A genetic mechanism for cecal atresia: the role of the Fgf10 signaling pathway. J Surg Res 120: 201-209.
5. Fairbanks TJ, Kanard RC, Del Moral PM, Sala FG, De Langhe SP, et al. (2005) Colonic atresia without mesenteric vascular occlusion. The role of the fibroblast growth factor 10 signaling pathway. J Pediatr Surg 40: 390-396.
6. Gupte VV, Ramasamy SK, Reddy R, Lee J, Weinreb PH, et al. (2009) Overexpression of fibroblast growth factor-10 during both inflammatory and fibrotic phases attenuates bleomycin-induced pulmonary fibrosis in mice. Am J Respir Crit Care Med 180: 424-436.
7. Kelly RG, Brown NA, Buckingham ME, (2001) The arterial pole of the mouse heart forms from Fgf10-expressing cells in pharyngeal mesoderm. Dev Cell 1: 435-440.
8. Mailleux AA, Kelly R, Veltmaat JM, De Langhe SP, Zaffran S, et al. (2005) Fgf10 expression identifies parabronchial smooth muscle cell progenitors and is required for their entry into the smooth muscle cell lineage. Development 132: 2157-2166.
9. Kanard RC, Fairbanks TJ, De Langhe SP, Sala FG, Del Moral PM, et al. (2005) Fibroblast growth factor-10 serves a regulatory role in duodenal development. J Pediatr Surg 40: 313-316.
10. Veltmaat JM, Relaix F, Le LT, Kratochwil K, Sala FG, et al. (2006) Gli3-mediated somitic Fgf10 expression gradients are required for the induction and patterning of mammary epithelium along the embryonic axes. Development 133: 2325-2335.
11. Hajihosseini MK, De Langhe S, Lana-Elola E, Morrison H, Sparshott N, et al. (2008) Localization and fate of Fgf10-expressing cells in the adult mouse brain implicate Fgf10 in control of neurogenesis. Mol Cell Neurosci 37: 857-868.
12. Ramasamy SK, Mailleux AA, Gupte VV, Mata F, Sala FG, et al. (2007) Fgf10 dosage is critical for the amplification of epithelial cell progenitors and for the formation of multiple mesenchymal lineages during lung development. Dev Biol 307: 237-247.
13. Madisen L, Zwingman TA, Sunkin SM, Oh SW, Zariwala HA, et al. (2010) A robust and high-throughput Cre reporting and characterization system for the whole mouse brain. Nat Neurosci 13: 133-140.
14. Abler LL, Mansour SL, Sun X, (2009) Conditional gene inactivation reveals roles for Fgf10 and Fgfr2 in establishing a normal pattern of epithelial branching in the mouse lung. Dev Dyn 238: 1999-2013.
15. Urness LD, Paxton CN, Wang X, Schoenwolf GC, Mansour SL, (2010) FGF signaling regulates otic placode induction and refinement by controlling both ectodermal target genes and hindbrain Wnt8a. Dev Biol 340: 595-604.
16. Al Alam D, Green M, Tabatabai Irani R, Parsa S, Danopoulos S, et al. (2011) Contrasting expression of canonical Wnt signaling reporters TOPGAL, BATGAL and Axin2(LacZ) during murine lung development and repair. PLoS One 6: e23139.
17. Brocard J, Feil R, Chambon P, Metzger D, (1998) A chimeric Cre recombinase inducible by synthetic,but not by natural ligands of the glucocorticoid receptor. Nucleic Acids Res 26: 4086-4090.
18. Nakamura E, Nguyen MT, Mackem S, (2006) Kinetics of tamoxifen-regulated Cre activity in mice using a cartilage-specific CreER(T) to assay temporal activity windows along the proximodistal limb skeleton. Dev Dyn 235: 2603-2612.
19. Alvarez Y, Alonso MT, Vendrell V, Zelarayan LC, Chamero P, et al. (2003) Requirements for FGF3 and FGF10 during inner ear formation. Development 130: 6329-6338.
20. Hamada K, Ozawa K, Itami S, Yoshikawa K, (1999) Human fibroblast growth factor 10 expression in dermal papilla cells, outer root sheath cells and keratinocytes. Exp Dermatol 8: 347-349.
21. Sala FG, Del Moral PM, Tiozzo C, Alam DA, Warburton D, et al. (2011) FGF10 controls the patterning of the tracheal cartilage rings via Shh. Development 138: 273-282.
22. Tiozzo C, De Langhe S, Carraro G, Alam DA, Nagy A, et al. (2009) Fibroblast growth factor 10 plays a causative role in the tracheal cartilage defects in a mouse model of Apert syndrome. Pediatr Res 66: 386-390.
23. Liu Y, Liu C, Yamada Y, Fan CM, (2002) Growth arrest specific gene 1 acts as a region-specific mediator of the Fgf10/Fgf8 regulatory loop in the limb. Development 129: 5289-5300.
24. Santos-Rosa H, Schneider R, Bannister AJ, Sherriff J, Bernstein BE, et al. (2002) Active genes are tri-methylated at K4 of histone H3. Nature 419: 407-411.
25. Cebra-Thomas JA, Bromer J, Gardner R, Lam GK, Sheipe H, et al. (2003) T-box gene products are required for mesenchymal induction of epithelial branching in the embryonic mouse lung. Dev Dyn 226: 82-90.
26. Golzio C, Havis E, Daubas P, Nuel G, Babarit C, et al. (2012) ISL1 Directly Regulates FGF10 Transcription during Human Cardiac Outflow Formation. PLoS One 7: e30677.